Tumor microenvironment: a prospective target of natural alkaloids for cancer treatment

[1]  Tong Li,et al.  The outstanding antitumor capacity of CD4+ T helper lymphocytes. , 2020, Biochimica et biophysica acta. Reviews on cancer.

[2]  M. Simon,et al.  The tumor microenvironment , 2020, Current Biology.

[3]  J. Cheong,et al.  Induction of Apoptosis by Coptisine in Hep3B Hepatocellular Carcinoma Cells through Activation of the ROS-Mediated JNK Signaling Pathway , 2020, International journal of molecular sciences.

[4]  R. Hass.  Role of MSC in the Tumor Microenvironment , 2020, Cancers.

[5]  Xuhong Song,et al.  Berberine inhibits cancer cells growth by suppressing fatty acid synthesis and biogenesis of extracellular vesicles. , 2020, Life sciences.

[6]  Tianzhi Huang,et al.  Stem cell programs in cancer initiation, progression, and therapy resistance , 2020, Theranostics.

[7]  Xiaoming Wang,et al.  Research progress on nanotechnology for delivery of active ingredients from traditional Chinese medicines. , 2020, Journal of materials chemistry. B.

[8]  Lei Cao,et al.  F10, a new camptothecin derivative, was identified as a new orally-bioavailable, potent antitumor agent. , 2020, European journal of medicinal chemistry.

[9]  Prem N. Gupta,et al.  Recent advances in tumor microenvironment associated therapeutic strategies and evaluation models. , 2020, Materials science & engineering. C, Materials for biological applications.

[10]  K. Tew,et al.  Oxidative Stress in Cancer. , 2020, Cancer cell.

[11]  A. Serban,et al.  Alkaloids isolated from Tropaeolum tuberosum with cytotoxic activity and apoptotic capacity in tumour cell lines. , 2020, Phytochemistry.

[12]  G. Gong,et al.  Clinicopathological factors associated with tumor-infiltrating lymphocyte reactivity in breast cancer , 2020, Cancer Immunology, Immunotherapy.

[13]  Dengke Li,et al.  Piperine inhibits colorectal cancer migration and invasion by regulating STAT3/Snail-mediated epithelial–mesenchymal transition , 2020, Biotechnology Letters.

[14]  J. Milbrandt,et al.  Peripheral nerve resident macrophages share tissue-specific programming and features of activated microglia , 2020, Nature Communications.

[15]  M. Brown,et al.  Normal human enthesis harbours conventional CD4+ and CD8+ T cells with regulatory features and inducible IL-17A and TNF expression , 2020, Annals of the Rheumatic Diseases.

[16]  G. Aguiari,et al.  The mystery of mitochondria-ER contact sites in physiology and pathology: A cancer perspective. , 2020, Biochimica et biophysica acta. Molecular basis of disease.

[17]  H. Shin,et al.  Piperine Ameliorates Trimellitic Anhydride-Induced Atopic Dermatitis-Like Symptoms by Suppressing Th2-Mediated Immune Responses via Inhibition of STAT6 Phosphorylation , 2020, Molecules.

[18]  Bin Zhang,et al.  OX40+ plasmacytoid dendritic cells in the tumor microenvironment promote antitumor immunity. , 2020, The Journal of clinical investigation.

[19]  Zhixiong Liu,et al.  Novel insights into astrocyte-mediated signaling of proliferation, invasion and tumor immune microenvironment in glioblastoma. , 2020, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[20]  W. Seeger,et al.  Macrophage and Tumor Cell Cross-Talk Is Fundamental for Lung Tumor Progression: We Need to Talk , 2020, Frontiers in Oncology.

[21]  Lingling Zhu,et al.  Sophoridine inhibits lung cancer cell growth and enhances cisplatin sensitivity through activation of the p53 and Hippo signaling pathways. , 2020, Gene.

[22]  A. Kulkarni,et al.  Targeting macrophages: a novel avenue for cancer drug discovery , 2020, Expert opinion on drug discovery.

[23]  W. Zhai,et al.  Tumor-educated B cells promote renal cancer metastasis via inducing the IL-1β/HIF-2α/Notch1 signals , 2020, Cell Death & Disease.

[24]  W. L. Ruzzo,et al.  Spatial modeling of prostate cancer metabolic gene expression reveals extensive heterogeneity and selective vulnerabilities , 2020, Scientific Reports.

[25]  Michele De Palma,et al.  Biology and therapeutic targeting of tumour‐associated macrophages , 2020, The Journal of pathology.

[26]  Patrick J. Curran,et al.  Cancer-Associated Fibroblasts Promote Immunosuppression by Inducing ROS-Generating Monocytic MDSCs in Lung Squamous Cell Carcinoma , 2020, Cancer Immunology Research.

[27]  S. Manicassamy,et al.  Wnt Signaling Cascade in Dendritic Cells and Regulation of Anti-tumor Immunity , 2020, Frontiers in Immunology.

[28]  D. Ding,et al.  A novel "carrier-free" nanofiber co-delivery system with synergistic antitumor effect of Paclitaxel and Tetrandrine through the enhancement of mitochondria apoptosis. , 2020, ACS applied materials & interfaces.

[29]  F. Bianchini,et al.  β3-Adrenoreceptor Blockade Induces Stem Cells Differentiation in Melanoma Microenvironment , 2020, International journal of molecular sciences.

[30]  Ke Xu,et al.  Effect and Molecular Mechanisms of Traditional Chinese Medicine on Tumor Targeting Tumor-Associated Macrophages , 2020, Drug design, development and therapy.

[31]  J. Schlom,et al.  Dual targeting of TGF-β and PD-L1 via a bifunctional anti-PD-L1/TGF-βRII agent: status of preclinical and clinical advances , 2020, Journal for ImmunoTherapy of Cancer.

[32]  T. Muranen,et al.  The Interplay of the Extracellular Matrix and Stromal Cells as a Drug Target in Stroma-Rich Cancers. , 2020, Trends in pharmacological sciences.

[33]  A. McGuigan,et al.  The life cycle of cancer-associated fibroblasts within the tumour stroma and its importance in disease outcome , 2020, British Journal of Cancer.

[34]  F. Souza-Fonseca-Guimaraes,et al.  Tumor Microenvironment-Associated Extracellular Matrix Components Regulate NK Cell Function , 2020, Frontiers in Immunology.

[35]  Xiaoshun He,et al.  Macrophage Phenotype and Function in Liver Disorder , 2020, Frontiers in Immunology.

[36]  B. Carter,et al.  Extracellular Vesicles in Glioblastoma Tumor Microenvironment , 2020, Frontiers in Immunology.

[37]  H. Keyvani,et al.  Oncolytic Newcastle disease virus delivered by Mesenchymal stem cells-engineered system enhances the therapeutic effects altering tumor microenvironment , 2020, Virology Journal.

[38]  K. Xia,et al.  The repertoire of tumor-infiltrating lymphocytes within the microenvironment of oral squamous cell carcinoma reveals immune dysfunction , 2020, Cancer Immunology, Immunotherapy.

[39]  Jian Sun,et al.  Steroidal glycoalkaloids from Solanum lyratum inhibit the pro-angiogenic activity of A549-derived exosomes. , 2020, Fitoterapia.

[40]  R. Shao,et al.  The novel quinolizidine derivate IMB-HDC inhibits STAT5a phosphorylation at 694 and 780 and promotes DNA breakage and cell apoptosis via blocking STAT5a nuclear translocation , 2020, Acta Pharmacologica Sinica.

[41]  B. Barres,et al.  Astrocytic trans-Differentiation Completes a Multicellular Paracrine Feedback Loop Required for Medulloblastoma Tumor Growth , 2020, Cell.

[42]  M. Jolly,et al.  Cancer Stem Cell Plasticity – A Deadly Deal , 2019, Frontiers in Molecular Biosciences.

[43]  Yue Meng,et al.  Galactan isolated from Cantharellus cibarius modulates antitumor immune response by converting tumor-associated macrophages toward M1-like phenotype. , 2019, Carbohydrate polymers.

[44]  Weiru Zhang,et al.  H2S alleviates renal injury and fibrosis in response to unilateral ureteral obstruction by regulating macrophage infiltration via inhibition of NLRP3 signaling. , 2019, Experimental cell research.

[45]  Jian Wang,et al.  Cancer Immunotherapies Targeting Tumor-Associated Regulatory T Cells , 2019, OncoTargets and therapy.

[46]  G. Zhou,et al.  Piperine, a functional food alkaloid, exhibits inhibitory potential against TNBS-induced colitis via the inhibition of IκB-α/NF-κB and induces tight junction protein (claudin-1, occludin, and ZO-1) signaling pathway in experimental mice , 2019, Human & experimental toxicology.

[47]  A. Ullah,et al.  Sanguinarine inhibits epithelial–mesenchymal transition via targeting HIF-1α/TGF-β feed-forward loop in hepatocellular carcinoma , 2019, Cell Death & Disease.

[48]  J. Ribeiro-Filho,et al.  Curine Inhibits Macrophage Activation and Neutrophil Recruitment in a Mouse Model of Lipopolysaccharide-Induced Inflammation , 2019, Toxins.

[49]  Juan Ye,et al.  Ginseng-derived nanoparticles alter macrophage polarization to inhibit melanoma growth , 2019, Journal of Immunotherapy for Cancer.

[50]  J. Gong,et al.  SIRT4 silencing in tumor-associated macrophages promotes HCC development via PPARδ signalling-mediated alternative activation of macrophages , 2019, Journal of experimental & clinical cancer research : CR.

[51]  F. He,et al.  The Role of Kupffer Cells as Mediators of Adipose Tissue Lipolysis , 2019, The Journal of Immunology.

[52]  Xiaoyu Zhang,et al.  Sophoridine suppresses macrophage-mediated immunosuppression through TLR4/IRF3 pathway and subsequently upregulates CD8+ T cytotoxic function against gastric cancer. , 2019, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[53]  H. Leung,et al.  Camptothecin-based dendrimersomes for gene delivery and redox-responsive drug delivery to cancer cells. , 2019, Nanoscale.

[54]  Beicheng Sun,et al.  Listeria-based hepatocellular carcinoma vaccine facilitates anti-PD-1 therapy by regulating macrophage polarization , 2019, Oncogene.

[55]  Peipei Xu,et al.  Vincristine-loaded platelets coated with anti-CD41 mAbs: a new macrophage targeting proposal for the treatment of immune thrombocytopenia. , 2019, Biomaterials science.

[56]  Xinliang Pan,et al.  Autophagy inhibition induces the repolarisation of tumour-associated macrophages and enhances chemosensitivity of laryngeal cancer cells to cisplatin in mice , 2019, Cancer Immunology, Immunotherapy.

[57]  Wen-jun Wang,et al.  Manganese-based Nanoplatform as Metal Ion-Enhanced ROS Generator for Combined Chemodynamic/Photodynamic Therapy. , 2019, ACS applied materials & interfaces.

[58]  M. Najafi,et al.  Cancer stem cell (CSC) resistance drivers. , 2019, Life sciences.

[59]  Xun Sun,et al.  Exosome-like nanoplatform modified with targeting ligand improves anti-cancer and anti-inflammation effects of imperialine. , 2019, Journal of controlled release : official journal of the Controlled Release Society.

[60]  P. Morel,et al.  Extracellular vesicles: Future diagnostic and therapeutic tools for liver disease and regeneration , 2019, Liver international : official journal of the International Association for the Study of the Liver.

[61]  J. López,et al.  The role of cancer-associated fibroblasts in renal cell carcinoma. An example of tumor modulation through tumor/non-tumor cell interactions , 2019, Journal of advanced research.

[62]  Zhe-shan Quan,et al.  Synthesis, in vitro and in vivo biological evaluation of novel lappaconitine derivatives as potential anti-inflammatory agents , 2019, Acta pharmaceutica Sinica. B.

[63]  P. Chu,et al.  Role of Cancer Stem Cells in Cholangiocarcinoma and Therapeutic Implications , 2019, International journal of molecular sciences.

[64]  Chunpu Li,et al.  Development of EGFR-targeted evodiamine nanoparticles for the treatment of colorectal cancer. , 2019, Biomaterials science.

[65]  Jianxun Liu,et al.  Berberine inhibits NLRP3 Inflammasome pathway in human triple-negative breast cancer MDA-MB-231 cell , 2019, BMC Complementary and Alternative Medicine.

[66]  Chao Huang,et al.  Berberine inhibits epithelial-mesenchymal transition and promotes apoptosis of tumour-associated fibroblast-induced colonic epithelial cells through regulation of TGF-β signalling , 2019, Journal of Cell Communication and Signaling.

[67]  R. Brandes,et al.  Narciclasine inhibits angiogenic processes by activation of Rho kinase and by downregulation of the VEGF receptor 2. , 2019, Journal of molecular and cellular cardiology.

[68]  Rui Gao,et al.  Pharmacokinetics and safety evaluation in healthy Chinese volunteers of alkaloids from leaf of Alstonia scholaris: A multiple doses phase I clinical trial. , 2019, Phytomedicine : international journal of phytotherapy and phytopharmacology.

[69]  F. Weinberg,et al.  Reactive Oxygen Species in the Tumor Microenvironment: An Overview , 2019, Cancers.

[70]  M. Tan,et al.  Synergistic killing effects of homoharringtonine and arsenic trioxide on acute myeloid leukemia stem cells and the underlying mechanisms , 2019, Journal of Experimental & Clinical Cancer Research.

[71]  Zhen Gu,et al.  Bioresponsive Protein Complex of aPD1 and aCD47 Antibodies for Enhanced Immunotherapy. , 2019, Nano letters.

[72]  Xiaolei Shi,et al.  The hypoxia conditioned mesenchymal stem cells promote hepatocellular carcinoma progression through YAP mediated lipogenesis reprogramming , 2019, Journal of experimental & clinical cancer research : CR.

[73]  D. Adelson,et al.  Alkaloids from nux vomica suppresses colon cancer cell growth through Wnt/β‐catenin signaling pathway , 2019, Phytotherapy research : PTR.

[74]  A. Bikfalvi,et al.  Beyond the tumour microenvironment , 2019, International journal of cancer.

[75]  M. Haris,et al.  Extracellular vesicles-mediated intercellular communication: roles in the tumor microenvironment and anti-cancer drug resistance , 2019, Molecular Cancer.

[76]  N. Tan,et al.  Reactive oxygen species: a volatile driver of field cancerization and metastasis , 2019, Molecular Cancer.

[77]  A. Angenendt,et al.  STIM-Orai Channels and Reactive Oxygen Species in the Tumor Microenvironment , 2019, Cancers.

[78]  B. Wegiel,et al.  Blockade of Lactate Dehydrogenase-A (LDH-A) Improves Efficacy of Anti-Programmed Cell Death-1 (PD-1) Therapy in Melanoma , 2019, Cancers.

[79]  M. Hung,et al.  Disruption of tumour-associated macrophage trafficking by the osteopontin-induced colony-stimulating factor-1 signalling sensitises hepatocellular carcinoma to anti-PD-L1 blockade , 2019, Gut.

[80]  Hui Liu,et al.  Oxymatrine-mediated maturation of dendritic cells leads to activation of FOXP3+/CD4+ Treg cells and reversal of cisplatin-resistance in lung cancer cells , 2019, Molecular medicine reports.

[81]  H. Hsu,et al.  MCT-1/miR-34a/IL-6/IL-6R signaling axis promotes EMT progression, cancer stemness and M2 macrophage polarization in triple-negative breast cancer , 2019, Molecular Cancer.

[82]  G. Sethi,et al.  Pleiotropic Pharmacological Actions of Capsazepine, a Synthetic Analogue of Capsaicin, against Various Cancers and Inflammatory Diseases , 2019, Molecules.

[83]  M. Samuel,et al.  Rho-ROCK signaling regulates tumor-microenvironment interactions. , 2019, Biochemical Society transactions.

[84]  Zengenni Liang,et al.  Protective Effect of Koumine, an Alkaloid from Gelsemium Sempervirens, on Injury Induced by H2O2 in IPEC-J2 Cells , 2019, International journal of molecular sciences.

[85]  A. Atanasov,et al.  Therapeutic value of steroidal alkaloids in cancer: Current trends and future perspectives , 2019, International journal of cancer.

[86]  Junmin Li,et al.  Homoharringtonine deregulates MYC transcriptional expression by directly binding NF-κB repressing factor , 2019, Proceedings of the National Academy of Sciences.

[87]  M. Miao,et al.  Effect of stachydrine hydrochloride to the prostate hyperplasia model in mice , 2018, Saudi Journal of Biological Sciences.

[88]  K. Shirabe,et al.  Conophylline suppresses pancreatic cancer desmoplasia and cancer‐promoting cytokines produced by cancer‐associated fibroblasts , 2018, Cancer science.

[89]  B. Han,et al.  Chlorogenic acid methyl ester exerts strong anti-inflammatory effects via inhibiting the COX-2/NLRP3/NF-κB pathway. , 2018, Food & function.

[90]  E. Chan,et al.  Tumour microenvironment and metabolic plasticity in cancer and cancer stem cells: Perspectives on metabolic and immune regulatory signatures in chemoresistant ovarian cancer stem cells. , 2018, Seminars in cancer biology.

[91]  J. Jonkers,et al.  Cancer-associated fibroblasts as key regulators of the breast cancer tumor microenvironment , 2018, Cancer and Metastasis Reviews.

[92]  R. Jiang,et al.  Evodiamine Induces Apoptosis in SMMC-7721 and HepG2 Cells by Suppressing NOD1 Signal Pathway , 2018, International journal of molecular sciences.

[93]  D. Feineis,et al.  Ancistrolikokine E3, a 5,8'-Coupled Naphthylisoquinoline Alkaloid, Eliminates the Tolerance of Cancer Cells to Nutrition Starvation by Inhibition of the Akt/mTOR/Autophagy Signaling Pathway. , 2018, Journal of natural products.

[94]  Xiaoyi Sun,et al.  Mesenchymal stem cells loaded with paclitaxel-poly(lactic-co-glycolic acid) nanoparticles for glioma-targeting therapy , 2018, International journal of nanomedicine.

[95]  Da Jia,et al.  Steroidal alkaloid solanine A from Solanum nigrum Linn. exhibits anti-inflammatory activity in lipopolysaccharide/interferon γ-activated murine macrophages and animal models of inflammation. , 2018, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[96]  W. Jin,et al.  Angiogenesis in pancreatic cancer: current research status and clinical implications , 2018, Angiogenesis.

[97]  C. A. Speck-Hernandez,et al.  Paclitaxel Reduces Tumor Growth by Reprogramming Tumor-Associated Macrophages to an M1 Profile in a TLR4-Dependent Manner. , 2018, Cancer research.

[98]  W. Wheat,et al.  Programmed Cell Death Ligand 1 (PD-L1) Signaling Regulates Macrophage Proliferation and Activation , 2018, Cancer Immunology Research.

[99]  B. Budziszewska,et al.  Targeting the NLRP3 Inflammasome-Related Pathways via Tianeptine Treatment-Suppressed Microglia Polarization to the M1 Phenotype in Lipopolysaccharide-Stimulated Cultures , 2018, International journal of molecular sciences.

[100]  L. Ni,et al.  Isoharringtonine inhibits breast cancer stem-like properties and STAT3 signaling. , 2018, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[101]  T. Fujiwara,et al.  Cancer-Associated Fibroblasts Affect Intratumoral CD8+ and FoxP3+ T Cells Via IL6 in the Tumor Microenvironment , 2018, Clinical Cancer Research.

[102]  Wen-ying Lee,et al.  Activation of fibroblasts by nicotine promotes the epithelial‐mesenchymal transition and motility of breast cancer cells , 2018, Journal of cellular physiology.

[103]  Yan Luo,et al.  Stachydrine suppresses viability & migration of astrocytoma cells via CXCR4/ERK & CXCR4/Akt pathway activity. , 2018, Future oncology.

[104]  Yu-Wei Chang,et al.  Homoharringtonine induced immune alteration for an Efficient Anti-tumor Response in Mouse Models of Non-small Cell Lung Adenocarcinoma Expressing Kras Mutation , 2018, Scientific Reports.

[105]  E. Zambrano,et al.  Macrophage Populations in Visceral Adipose Tissue from Pregnant Women: Potential Role of Obesity in Maternal Inflammation , 2018, International journal of molecular sciences.

[106]  R. Hwang,et al.  Palmatine suppresses glutamine-mediated interaction between pancreatic cancer and stellate cells through simultaneous inhibition of survivin and COL1A1 , 2018, Cancer letters.

[107]  K. Schröder,et al.  Redox control in cancer development and progression. , 2018, Molecular aspects of medicine.

[108]  Y. Jiao,et al.  Sinomenine Hydrochloride Inhibits the Metastasis of Human Glioblastoma Cells by Suppressing the Expression of Matrix Metalloproteinase-2/-9 and Reversing the Endogenous and Exogenous Epithelial-Mesenchymal Transition , 2018, International journal of molecular sciences.

[109]  David Pitt,et al.  Significance and In Vivo Detection of Iron-Laden Microglia in White Matter Multiple Sclerosis Lesions , 2018, Front. Immunol..

[110]  D. Hanahan,et al.  A Subset of Cancer-Associated Fibroblasts Determines Therapy Resistance , 2018, Cell.

[111]  Sangmin Kim,et al.  Berberine Suppresses Cell Motility Through Downregulation of TGF-β1 in Triple Negative Breast Cancer Cells , 2018, Cellular Physiology and Biochemistry.

[112]  J. Debus,et al.  Human mesenchymal stem cells lose their functional properties after paclitaxel treatment , 2018, Scientific Reports.

[113]  N. Chandel,et al.  Regulation of redox balance in cancer and T cells , 2017, The Journal of Biological Chemistry.

[114]  Abdolreza Esmaeilzadeh,et al.  Mesenchymal Stromal/Stem Cells: A New Era in the Cell-Based Targeted Gene Therapy of Cancer , 2017, Front. Immunol..

[115]  M. Cuendet,et al.  Indoline alkaloids from Tabernaemontana contorta with cancer chemopreventive activity. , 2017, Phytochemistry.

[116]  M. Assi.  The differential role of reactive oxygen species in early and late stages of cancer. , 2017, American journal of physiology. Regulatory, integrative and comparative physiology.

[117]  Yanhua Chang,et al.  &agr;-Solanine reverses pulmonary vascular remodeling and vascular angiogenesis in experimental pulmonary artery hypertension , 2017, Journal of hypertension.

[118]  Jian-Ting Zhang,et al.  Novel Synthetic bisindolylmaleimide alkaloids inhibit STAT3 activation by binding to the SH2 domain and suppress breast xenograft tumor growth , 2017, Oncogene.

[119]  Jian Xu,et al.  Effect and Mechanism of Sophoridine to suppress Hepatocellular carcinoma in vitro and vivo. , 2017, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[120]  M. Řezáčová,et al.  Anticancer potential of Amaryllidaceae alkaloids evaluated by screening with a panel of human cells, real-time cellular analysis and Ehrlich tumor-bearing mice. , 2017, Chemico-biological interactions.

[121]  Fei Zhang,et al.  Sophoridine induces apoptosis and S phase arrest via ROS-dependent JNK and ERK activation in human pancreatic cancer cells , 2017, Journal of Experimental & Clinical Cancer Research.

[122]  Yuchen Liu,et al.  Hepatic Hippo signaling inhibits protumoural microenvironment to suppress hepatocellular carcinoma , 2017, Gut.

[123]  Wanyeon Kim,et al.  TRAF4 promotes lung cancer aggressiveness by modulating tumor microenvironment in normal fibroblasts , 2017, Scientific Reports.

[124]  H. Kim,et al.  Mitogen-activated protein kinase phosphatase 1 (MKP-1) in macrophage biology and cardiovascular disease. A redox-regulated master controller of monocyte function and macrophage phenotype. , 2017, Free radical biology & medicine.

[125]  R. Buchsbaum,et al.  Synthesis and Evaluation of Agelastatin Derivatives as Potent Modulators for Cancer Invasion and Metastasis. , 2017, The Journal of organic chemistry.

[126]  Qinan Wu,et al.  Stachydrine ameliorates isoproterenol‐induced cardiac hypertrophy and fibrosis by suppressing inflammation and oxidative stress through inhibiting NF‐&kgr;B and JAK/STAT signaling pathways in rats , 2017, International immunopharmacology.

[127]  Bruno Larrivée,et al.  Tumor angiogenesis and vascular normalization: alternative therapeutic targets , 2017, Angiogenesis.

[128]  B. Larrivée,et al.  Tumor angiogenesis and vascular normalization: alternative therapeutic targets , 2017, Angiogenesis.

[129]  R. Mohammad,et al.  Anticancer potential of sanguinarine for various human malignancies. , 2017, Future medicinal chemistry.

[130]  G. Liang,et al.  Paclitaxel nanoparticle awakens immune system to fight against cancer. , 2017, Nanoscale.

[131]  B. Kamińska,et al.  Immune microenvironment of gliomas , 2017, Laboratory Investigation.

[132]  B. Hock,et al.  Idelalisib and caffeine reduce suppression of T cell responses mediated by activated chronic lymphocytic leukemia cells , 2017, PloS one.

[133]  Y. Zhang,et al.  The anti-tumor activities of Neferine on cell invasion and oxaliplatin sensitivity regulated by EMT via Snail signaling in hepatocellular carcinoma , 2017, Scientific Reports.

[134]  D. Vaux,et al.  Active MLKL triggers the NLRP3 inflammasome in a cell-intrinsic manner , 2017, Proceedings of the National Academy of Sciences.

[135]  J. Dou,et al.  PEGylated long-circulating liposomes deliver homoharringtonine to suppress multiple myeloma cancer stem cells , 2017, Experimental biology and medicine.

[136]  E. Horwitz,et al.  Causes of death among cancer patients , 2016, Annals of oncology : official journal of the European Society for Medical Oncology.

[137]  Daniel G Anderson,et al.  MicroRNA regulation of endothelial TREX1 reprograms the tumour microenvironment , 2016, Nature Communications.

[138]  Y. Liu,et al.  A novel matrine derivate inhibits differentiated human hepatoma cells and hepatic cancer stem-like cells by suppressing PI3K/AKT signaling pathways , 2016, Acta Pharmacologica Sinica.

[139]  Kyung-Tae Lee,et al.  α‐Solanine Isolated From Solanum Tuberosum L. cv Jayoung Abrogates LPS‐Induced Inflammatory Responses Via NF‐κB Inactivation in RAW 264.7 Macrophages and Endotoxin‐Induced Shock Model in Mice , 2016, Journal of cellular biochemistry.

[140]  Kinam Park,et al.  Sophoridine-loaded PLGA microspheres for lung targeting: preparation, in vitro, and in vivo evaluation , 2016, Drug delivery.

[141]  R. Kalluri.  The biology and function of fibroblasts in cancer , 2016, Nature Reviews Cancer.

[142]  D. Sharma,et al.  Indolo‐pyrido‐isoquinolin based alkaloid inhibits growth, invasion and migration of breast cancer cells via activation of p53‐miR34a axis , 2016, Molecular oncology.

[143]  A. Ohtsu,et al.  Randomized phase II study of second-line chemotherapy with the best available 5-fluorouracil regimen versus weekly administration of paclitaxel in far advanced gastric cancer with severe peritoneal metastases refractory to 5-fluorouracil-containing regimens (JCOG0407) , 2016, Gastric Cancer.

[144]  H. Kuang,et al.  A stabilizer-free and organic solvent-free method to prepare 10-hydroxycamptothecin nanocrystals: in vitro and in vivo evaluation , 2016, International journal of nanomedicine.

[145]  R. Buchsbaum,et al.  The fibroblast Tiam1-osteopontin pathway modulates breast cancer invasion and metastasis , 2016, Breast Cancer Research.

[146]  G. Moroni,et al.  Antitumor effects of the benzophenanthridine alkaloid sanguinarine: Evidence and perspectives. , 2016, World journal of gastrointestinal oncology.

[147]  Mengtao Zhou,et al.  α-Solanine inhibits vascular endothelial growth factor expression by down-regulating the ERK1/2-HIF-1α and STAT3 signaling pathways. , 2016, European journal of pharmacology.

[148]  A. Mitra,et al.  Novel delivery approaches for cancer therapeutics. , 2015, Journal of controlled release : official journal of the Controlled Release Society.

[149]  J. Kim,et al.  Emetine inhibits migration and invasion of human non-small-cell lung cancer cells via regulation of ERK and p38 signaling pathways. , 2015, Chemico-biological interactions.

[150]  Jun Huang,et al.  Antiproliferation effect of evodiamine in human colon cancer cells is associated with IGF-1/HIF-1α downregulation. , 2015, Oncology reports.

[151]  F. Ginhoux,et al.  Ontogeny of Tissue-Resident Macrophages , 2015, Front. Immunol..

[152]  Y. Liu,et al.  Homoharringtonine induces apoptosis and inhibits STAT3 via IL-6/JAK1/STAT3 signal pathway in Gefitinib-resistant lung cancer cells , 2015, Scientific Reports.

[153]  Y. Tabata,et al.  Synergistic effects of co-administration of suicide gene expressing mesenchymal stem cells and prodrug-encapsulated liposome on aggressive lung melanoma metastases in mice. , 2015, Journal of controlled release : official journal of the Controlled Release Society.

[154]  Kyung-Tae Lee,et al.  α-Chaconine isolated from a Solanum tuberosum L. cv Jayoung suppresses lipopolysaccharide-induced pro-inflammatory mediators via AP-1 inactivation in RAW 264.7 macrophages and protects mice from endotoxin shock. , 2015, Chemico-biological interactions.

[155]  J. Ledermann,et al.  Targeting the folate receptor: diagnostic and therapeutic approaches to personalize cancer treatments. , 2015, Annals of oncology : official journal of the European Society for Medical Oncology.

[156]  A. Tanuri,et al.  Natural Plant Alkaloid (Emetine) Inhibits HIV-1 Replication by Interfering with Reverse Transcriptase Activity , 2015, Molecules.

[157]  V. Weaver,et al.  Fighting the force: Potential of homeobox genes for tumor microenvironment regulation. , 2015, Biochimica et biophysica acta.

[158]  Ke Wang,et al.  Vascular Normalization Induced by Sinomenine Hydrochloride Results in Suppressed Mammary Tumor Growth and Metastasis , 2015, Scientific Reports.

[159]  A. Eid,et al.  Berberis libanotica Ehrenb Extract Shows Anti-Neoplastic Effects on Prostate Cancer Stem/Progenitor Cells , 2014, PloS one.

[160]  Jeffrey W Pollard,et al.  Tumor-associated macrophages: from mechanisms to therapy. , 2014, Immunity.

[161]  J. Baurain,et al.  Profile of vintafolide (EC145) and its use in the treatment of platinum-resistant ovarian cancer , 2014, International journal of women's health.

[162]  M. Parat,et al.  Morphine and breast tumor metastasis: the role of matrix-degrading enzymes , 2014, Clinical & Experimental Metastasis.

[163]  J. Reddy,et al.  Rational Combination Therapy of Vintafolide (EC145) with Commonly Used Chemotherapeutic Drugs , 2014, Clinical Cancer Research.

[164]  D. Chandra,et al.  Myeloid-derived suppressor cells , 2013, Oncoimmunology.

[165]  P. Storz.  Oxidative Stress in Cancer , 2013 .

[166]  Jia Zhou,et al.  Modulation of drug-resistant membrane and apoptosis proteins of breast cancer stem cells by targeting berberine liposomes. , 2013, Biomaterials.

[167]  V. Jacobs,et al.  Increased glutamate uptake in astrocytes via propentofylline results in increased tumor cell apoptosis using the CNS-1 glioma model , 2013, Journal of Neuro-Oncology.

[168]  Ping Li,et al.  Ephedrine hydrochloride inhibits PGN-induced inflammatory responses by promoting IL-10 production and decreasing proinflammatory cytokine secretion via the PI3K/Akt/GSK3β pathway , 2013, Cellular and Molecular Immunology.

[169]  Bin Wang,et al.  The Th1/Th2/Th17/Treg paradigm induced by stachydrine hydrochloride reduces uterine bleeding in RU486-induced abortion mice. , 2013, Journal of ethnopharmacology.

[170]  J. Chirgwin,et al.  Halofuginone inhibits the establishment and progression of melanoma bone metastases. , 2012, Cancer research.

[171]  Hyung Gyun Kim,et al.  Piperine inhibits PMA-induced cyclooxygenase-2 expression through downregulating NF-κB, C/EBP and AP-1 signaling pathways in murine macrophages. , 2012, Food and Chemical Toxicology.

[172]  R. P. Landry,et al.  Propentofylline decreases tumor growth in a rodent model of glioblastoma multiforme by a direct mechanism on microglia. , 2012, Neuro-oncology.

[173]  Yuan-feng Tian,et al.  Berberine inhibits angiogenic potential of Hep G2 cell line through VEGF down‐regulation in vitro , 2011, Journal of gastroenterology and hepatology.

[174]  F. Gao,et al.  The associations of Janus kinase-2 (JAK2) A830G polymorphism and the treatment outcomes in patients with acute myeloid leukemia , 2010, Leukemia & lymphoma.

[175]  Wei Liu,et al.  Berberine inhibits SDF-1-induced AML cells and leukemic stem cells migration via regulation of SDF-1 level in bone marrow stromal cells. , 2008, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[176]  M. Salmon,et al.  A stromal address code defined by fibroblasts. , 2005, Trends in immunology.

[177]  Michael Schwenk,et al.  Tumor , 1828, The London medical and physical journal.

[178]  F. Marincola,et al.  The Tumor Microenvironment , 2016, Methods in Molecular Biology.

[179]  C. T. Hagan,et al.  Nanotechnology Approaches to Improving Cancer Immunotherapy. , 2018, Advances in cancer research.

[180]  A. Moustakas,et al.  TGF-β Family Signaling in Epithelial Differentiation and Epithelial-Mesenchymal Transition. , 2018, Cold Spring Harbor perspectives in biology.

[181]  A. Yang,et al.  Stachydrine ameliorates carbon tetrachloride-induced hepatic fibrosis by inhibiting inflammation, oxidative stress and regulating MMPs/TIMPs system in rats. , 2018, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[182]  I. Pipinos,et al.  IL-1&bgr; (Interleukin-1&bgr;) and TNF-&agr; (Tumor Necrosis Factor-&agr;) Impact Abdominal Aortic Aneurysm Formation by Differential Effects on Macrophage Polarization , 2018, Arteriosclerosis, thrombosis, and vascular biology.

[183]  S. Naber,et al.  The fibroblast Tiam 1-osteopontin pathway modulates breast cancer invasion and metastasis , 2016 .

[184]  Hilde van der Togt,et al.  Publisher's Note , 2003, J. Netw. Comput. Appl..