Bio-inspired optofluidic lasers with luciferin

The authors demonstrate a bio-inspired optofluidic laser with luciferin, a class of light-emitting compounds synthesized by many different organisms, as the gain medium. The laser characteristics under various conditions such as solution pH value and luciferin concentration are investigated. The authors demonstrate an optofluidic fluorescence resonance energy transfer laser by using luciferin and Rhodamine 6G as the donor and the acceptor, respectively, which takes advantage of the large Stokes shift of luciferin to avoid potential cross excitation of the acceptor. Their work leads to the photonic devices using biosynthesized materials as the gain medium and optofluidic intra-cavity bio/chemical sensing.

[1]  Seok Hyun Yun,et al.  Lasing from Escherichia coli bacteria genetically programmed to express green fluorescent protein. , 2011, Optics letters.

[2]  Wonsuk Lee,et al.  Bio-switchable optofluidic lasers based on DNA Holliday junctions. , 2012, Lab on a chip.

[3]  Demetri Psaltis,et al.  Low-order distributed feedback optofluidic dye laser with reduced threshold , 2009 .

[4]  Christelle Monat,et al.  Integrated optofluidics: A new river of light , 2007 .

[5]  Malte C. Gather,et al.  Single-cell biological lasers , 2011 .

[6]  Demetri Psaltis,et al.  Single mode optofluidic distributed feedback dye laser. , 2006, Optics express.

[7]  Xudong Fan,et al.  Optofluidic ring resonator based dye laser , 2007 .

[8]  H. Akiyama,et al.  pH-Dependent Fluorescence Spectra, Lifetimes, and Quantum Yields of Firefly-Luciferin Aqueous Solutions Studied by Selective-Excitation Fluorescence Spectroscopy , 2010 .

[9]  Adrian Saldanha,et al.  Structural basis for the spectral difference in luciferase bioluminescence , 2006, Nature.

[10]  J. E. D. Esteves da Silva,et al.  Advances in the knowledge of light emission by firefly luciferin and oxyluciferin. , 2012, Journal of photochemistry and photobiology. B, Biology.

[11]  Xudong Fan,et al.  Distinguishing DNA by analog-to-digital-like conversion by using optofluidic lasers. , 2012, Angewandte Chemie.

[12]  Xudong Fan,et al.  Bioinspired optofluidic FRET lasers via DNA scaffolds , 2010, Proceedings of the National Academy of Sciences.

[13]  Jianghong Rao,et al.  Biosensing and imaging based on bioluminescence resonance energy transfer. , 2009, Current opinion in biotechnology.

[14]  W. D. Mcelroy,et al.  Quantum yield in the oxidation of firefly luciferin , 1959 .

[15]  Scott Lacey,et al.  Opto-fluidic ring resonator lasers based on highly efficient resonant energy transfer. , 2007, Optics express.

[16]  P. Song,et al.  Electronic excited states of D-(--)-luciferin and related chromophores. , 1976, Journal of the American Chemical Society.

[17]  D. Psaltis,et al.  Developing optofluidic technology through the fusion of microfluidics and optics , 2006, Nature.

[18]  Intracavity DNA melting analysis with optofluidic lasers. , 2012, Analytical chemistry.

[19]  Hidefumi Akiyama,et al.  Firefly bioluminescence quantum yield and colour change by pH-sensitive green emission , 2008 .

[20]  J. W. Hastings,et al.  Chemistries and colors of bioluminescent reactions: a review. , 1996, Gene.

[21]  Nathan C Shaner,et al.  A guide to choosing fluorescent proteins , 2005, Nature Methods.

[22]  Xudong Fan,et al.  Optofluidic Microsystems for Chemical and Biological Analysis. , 2011, Nature photonics.

[23]  Demetri Psaltis,et al.  Optofluidic dye lasers , 2008 .

[24]  W. D. Mcelroy,et al.  Spectral emission and quantum yield of firefly bioluminescence. , 1960, Archives of biochemistry and biophysics.