A pan-cancer analysis shows immunoevasive characteristics in NRF2 hyperactive squamous malignancies

[1]  Ping Liu,et al.  Nrf2 overexpression increases risk of high tumor mutation burden in acute myeloid leukemia by inhibiting MSH2 , 2021, Cell death & disease.

[2]  Hongyang Wang,et al.  NAD+ Metabolism Maintains Inducible PD-L1 Expression to Drive Tumor Immune Evasion. , 2020, Cell metabolism.

[3]  F. Gnad,et al.  NRF2 Activation Promotes Aggressive Lung Cancer and Associates with Poor Clinical Outcomes , 2020, Clinical Cancer Research.

[4]  F. McCaughan,et al.  SOX2 and squamous cancers. , 2020, Seminars in cancer biology.

[5]  Junnian Zheng,et al.  Turning Cold into Hot: Firing up the Tumor Microenvironment. , 2020, Trends in cancer.

[6]  K. Tew,et al.  Oxidative Stress in Cancer. , 2020, Cancer cell.

[7]  Mirjana Efremova,et al.  CellPhoneDB: inferring cell–cell communication from combined expression of multi-subunit ligand–receptor complexes , 2020, Nature Protocols.

[8]  Beibei Ru,et al.  TISIDB: an integrated repository portal for tumor-immune system interactions , 2019, Bioinform..

[9]  Jaana M. Hartikainen,et al.  Nrf2 and SQSTM1/p62 jointly contribute to mesenchymal transition and invasion in glioblastoma , 2019, Oncogene.

[10]  A. Chinnaiyan,et al.  CD8+ T cells regulate tumor ferroptosis during cancer immunotherapy , 2019, Nature.

[11]  M. Iorio,et al.  WNT signaling modulates PD-L1 expression in the stem cell compartment of triple-negative breast cancer , 2019, Oncogene.

[12]  A. Butte,et al.  Reference-based analysis of lung single-cell sequencing reveals a transitional profibrotic macrophage , 2018, Nature Immunology.

[13]  K. Ozato,et al.  An osteopontin/CD44 immune checkpoint controls CD8+ T cell activation and tumor immune evasion , 2018, The Journal of clinical investigation.

[14]  Donna D. Zhang,et al.  NRF2 and the Hallmarks of Cancer. , 2018, Cancer cell.

[15]  Rutao Cui,et al.  Targeting the upstream transcriptional activator of PD-L1 as an alternative strategy in melanoma therapy , 2018, Oncogene.

[16]  R. Ferris,et al.  Mitigating SOX2-potentiated Immune Escape of Head and Neck Squamous Cell Carcinoma with a STING-inducing Nanosatellite Vaccine , 2018, Clinical Cancer Research.

[17]  Rajarsi R. Gupta,et al.  Spatial Organization and Molecular Correlation of Tumor-Infiltrating Lymphocytes Using Deep Learning on Pathology Images. , 2018, Cell reports.

[18]  Matthew E. Ritchie,et al.  Synergy between the KEAP1/NRF2 and PI3K Pathways Drives Non-Small-Cell Lung Cancer with an Altered Immune Microenvironment. , 2018, Cell metabolism.

[19]  Steven J. M. Jones,et al.  The Immune Landscape of Cancer , 2018, Immunity.

[20]  J. Locasale,et al.  Paracrine Wnt5a‐&bgr;‐Catenin Signaling Triggers a Metabolic Program that Drives Dendritic Cell Tolerization , 2018, Immunity.

[21]  T. Gajewski,et al.  Impact of oncogenic pathways on evasion of antitumour immune responses , 2018, Nature Reviews Cancer.

[22]  M. Socinski,et al.  PD-L1 Testing in Guiding Patient Selection for PD-1/PD-L1 Inhibitor Therapy in Lung Cancer , 2018, Molecular Diagnosis & Therapy.

[23]  Shawn M. Gillespie,et al.  Single-Cell Transcriptomic Analysis of Primary and Metastatic Tumor Ecosystems in Head and Neck Cancer , 2017, Cell.

[24]  D. Ross,et al.  Functions of NQO1 in Cellular Protection and CoQ10 Metabolism and its Potential Role as a Redox Sensitive Molecular Switch , 2017, Front. Physiol..

[25]  T. Vuorenmaa,et al.  Analysis of primary microRNA loci from nascent transcriptomes reveals regulatory domains governed by chromatin architecture , 2017, Nucleic acids research.

[26]  Moriah H Nissan,et al.  OncoKB: A Precision Oncology Knowledge Base. , 2017, JCO precision oncology.

[27]  Peter Bankhead,et al.  QuPath: Open source software for digital pathology image analysis , 2017, Scientific Reports.

[28]  G. Thomas,et al.  Upregulated Glucose Metabolism Correlates Inversely with CD8+ T-cell Infiltration and Survival in Squamous Cell Carcinoma. , 2016, Cancer research.

[29]  Chandra Sekhar Pedamallu,et al.  Distinct patterns of somatic genome alterations in lung adenocarcinomas and squamous cell carcinomas , 2016, Nature Genetics.

[30]  D. Felsher,et al.  MYC regulates the antitumor immune response through CD47 and PD-L1 , 2016, Science.

[31]  Antoni Ribas,et al.  Classifying Cancers Based on T-cell Infiltration and PD-L1. , 2015, Cancer research.

[32]  Ash A. Alizadeh,et al.  Robust enumeration of cell subsets from tissue expression profiles , 2015, Nature Methods.

[33]  J. Hayes,et al.  The Nrf2 regulatory network provides an interface between redox and intermediary metabolism. , 2014, Trends in biochemical sciences.

[34]  P. Pölönen,et al.  Role of the Keap1-Nrf2 pathway in cancer. , 2014, Advances in cancer research.

[35]  A. Levonen,et al.  The Keap1-Nrf2 pathway: Mechanisms of activation and dysregulation in cancer☆ , 2013, Redox biology.

[36]  Johannes E. Schindelin,et al.  Fiji: an open-source platform for biological-image analysis , 2012, Nature Methods.

[37]  M. Roizen,et al.  Hallmarks of Cancer: The Next Generation , 2012 .

[38]  D. Hanahan,et al.  Hallmarks of Cancer: The Next Generation , 2011, Cell.

[39]  Z. Trajanoski,et al.  Type, Density, and Location of Immune Cells Within Human Colorectal Tumors Predict Clinical Outcome , 2006, Science.