Mycoplasma genitalium: clinical significance and diagnosis.

Mycoplasma genitalium is considered the smallest self-replicating cell. It was first isolated in 1981, from 2 of 13 men with urethritis. Mycoplasma genitalium causes urethritis, cervicitis and pelvic inflammatory disease. Because of difficulties in cultivation, the diagnosis is based exclusively on PCR methodology. The recommended therapy for Mycoplasma genitalium infections is azithromycin or doxycycline. Development of macrolide resistance was shown to correlate with treatment failure.

[1]  V. Skogen,et al.  Chlamydia trachomatis, Mycoplasma genitalium and Ureaplasma urealyticum among students in northern Norway , 2013, Journal of the European Academy of Dermatology and Venereology : JEADV.

[2]  S. Garland,et al.  Transmission and Selection of Macrolide Resistant Mycoplasma genitalium Infections Detected by Rapid High Resolution Melt Analysis , 2012, PloS one.

[3]  C. Morrison,et al.  Development of a rotor-gene real-time PCR assay for the detection and quantification of Mycoplasma genitalium. , 2012, Journal of microbiological methods.

[4]  C. Haggerty,et al.  Mycoplasma genitalium: An Emerging Cause of Pelvic Inflammatory Disease , 2011, Infectious diseases in obstetrics and gynecology.

[5]  M. Yasuda,et al.  Selection of Mycoplasma genitalium strains harbouring macrolide resistance-associated 23S rRNA mutations by treatment with a single 1 g dose of azithromycin , 2011, Sexually Transmitted Infections.

[6]  D. Taylor-Robinson,et al.  Association of Mycoplasma genitalium with balanoposthitis in men with non-gonococcal urethritis , 2010, Sexually Transmitted Infections.

[7]  W. Tang,et al.  Role of Mycoplasma genitalium and Ureaplasma urealyticum in non-gonococcal urethritis in Hong Kong. , 2008, Hong Kong medical journal = Xianggang yi xue za zhi.

[8]  T. Rebai,et al.  Ureaplasma urealyticum, Ureaplasma parvum, Mycoplasma hominis and Mycoplasma genitalium infections and semen quality of infertile men , 2007, BMC infectious diseases.

[9]  M. Yasuda,et al.  Treatment of men with urethritis negative for Neisseria gonorrhoeae, Chlamydia trachomatis, Mycoplasma genitalium, Mycoplasma hominis, Ureaplasma parvum and Ureaplasma urealyticum , 2007, International journal of urology : official journal of the Japanese Urological Association.

[10]  M. Hudspeth,et al.  Comparison of Transcription-Mediated Amplification and PCR Assay Results for Various Genital Specimen Types for Detection of Mycoplasma genitalium , 2006, Journal of Clinical Microbiology.

[11]  J. Jensen,et al.  Mycoplasma genitalium as a sexually transmitted infection: implications for screening, testing, and treatment , 2006, Sexually Transmitted Infections.

[12]  R. Ness,et al.  Mycoplasma Genitalium Among Women With Nongonococcal, Nonchlamydial Pelvic Inflammatory Disease , 2006, Infectious diseases in obstetrics and gynecology.

[13]  J. Piper,et al.  Cervicitis and Genitourinary Symptoms in Women Culture Positive for Mycoplasma genitalium , 2006, American journal of reproductive immunology.

[14]  J. Jensen,et al.  Mycoplasma genitalium infections. Diagnosis, clinical aspects, and pathogenesis. , 2006, Danish medical bulletin.

[15]  N. Sakuragi,et al.  Association between Preterm Birth and Vaginal Colonization by Mycoplasmas in Early Pregnancy , 2006, Journal of Clinical Microbiology.

[16]  D. Taylor-Robinson,et al.  Mycoplasma genitalium and asymptomatic chlamydia-negative non-gonococcal urethritis revisited , 2005, International journal of STD & AIDS.

[17]  R. Berger.  Comparison of first void urine and urogenital swab specimens for detection of Mycoplasma genitalium and Chlamydia trachomatis by polymerase chain reaction in patients attending a sexually transmitted disease clinic. , 2005, The Journal of urology.

[18]  P. Korrovits,et al.  Mycoplasmas in semen of chronic prostatitis patients , 2005, Scandinavian journal of urology and nephrology.

[19]  J. Jensen,et al.  Symptomatic urethritis is more prevalent in men infected with Mycoplasma genitalium than with Chlamydia trachomatis , 2004, Sexually Transmitted Infections.

[20]  R. Venezia,et al.  Comparison of Multiplex PCR Assay with Culture for Detection of Genital Mycoplasmas , 2004, Journal of Clinical Microbiology.

[21]  J. Baseman,et al.  Determination of Infectious Load of Mycoplasma genitalium in Clinical Samples of Human Vaginal Cells , 2004, Journal of Clinical Microbiology.

[22]  K. Holmes,et al.  Mucopurulent cervicitis and Mycoplasma genitalium. , 2003, The Journal of infectious diseases.

[23]  J. Jensen,et al.  Detection of Mycoplasma genitalium by PCR Amplification of the 16S rRNA Gene , 2003, Journal of Clinical Microbiology.

[24]  Jasna Lipozenčić,et al.  ACTA DERMATOVENEROLOGICA CROATICA , 2003 .

[25]  T. Mroczkowski,et al.  Mycoplasma genitalium infections in asymptomatic men and men with urethritis attending a sexually transmitted diseases clinic in New Orleans. , 2002, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[26]  A. Uusküla,et al.  Genital mycoplasmas, including Mycoplasma genitalium, as sexually transmitted agents , 2002, International journal of STD & AIDS.

[27]  S. Birkelund,et al.  Serological investigation of Mycoplasma genitalium in infertile women. , 2001, Human reproduction.

[28]  P. Furr,et al.  Genital mycoplasma infections. , 1989, Wiener klinische Wochenschrift.

[29]  P. Hu,et al.  Transition mutations in the 23S rRNA of erythromycin-resistant isolates of Mycoplasma pneumoniae , 1995, Antimicrobial agents and chemotherapy.

[30]  T. Hooton,et al.  Mycoplasma genitalium and non-gonococcal urethritis , 1994, The Lancet.

[31]  J. Vuust,et al.  Polymerase chain reaction for detection of Mycoplasma genitalium in clinical samples , 1991, Journal of clinical microbiology.

[32]  J. Tully,et al.  A NEWLY DISCOVERED MYCOPLASMA IN THE HUMAN UROGENITAL TRACT , 1981, The Lancet.