The Homeodomain Resource: sequences, structures, DNA binding sites and genomic information

The Homeodomain Resource is an annotated collection of non-redundant protein sequences, three-dimensional structures and genomic information for the homeodomain protein family. Release 3.0 contains 795 full-length homeodomain-containing sequences, 32 experimentally-derived structures and 143 homeo-box loci implicated in human genetic disorders. Entries are fully hyperlinked to facilitate easy retrieval of the original records from source databases. A simple search engine with a graphical user interface is provided to query the component databases and assemble customized data sets. A new feature for this release is the addition of DNA recognition sites for all human homeodomain proteins described in the literature. The Homeodomain Resource is freely available through the World Wide Web at http://genome.nhgri.nih.gov/homeodomain.

[1]  Kurt Wüthrich,et al.  Homeodomain-DNA recognition , 1994, Cell.

[2]  C. Pabo,et al.  Crystallization and preliminary X-ray diffraction studies of the engrailed homeodomain and of an engrailed homeodomain/DNA complex. , 1990, Biochemical and biophysical research communications.

[3]  Carl O. Pabo,et al.  Crystal structure of an engrailed homeodomain-DNA complex at 2.8 Å resolution: A framework for understanding homeodomain-DNA interactions , 1990, Cell.

[4]  S. Formisano,et al.  Structural study of rat thyroid transcription factor 1 homeodomain (TTF‐1 HD) by nuclear magnetic resonance , 1993, FEBS Letters.

[5]  W. J. Gehring,et al.  The structure of the Antennapedia homeodomain determined by NMR spectroscopy in solution: Comparison with prokaryotic repressors , 1989, Cell.

[6]  Andreas D. Baxevanis,et al.  The Homeodomain Resource: sequences, structures and genomic information , 1999, Nucleic Acids Res..

[7]  Cynthia Wolberger,et al.  Crystal structure of a MAT alpha 2 homeodomain-operator complex suggests a general model for homeodomain-DNA interactions. , 1991, Cell.

[8]  R. Kaptein,et al.  Solution structure of the POU-specific DNA-binding domain of Oct-1 , 1993, Nature.

[9]  T. Ceska,et al.  The X‐ray structure of an atypical homeodomain present in the rat liver transcription factor LFB1/HNF1 and implications for DNA binding. , 1993, The EMBO journal.

[10]  M. Nirenberg,et al.  Interactions of the vnd/NK-2 homeodomain with DNA by nuclear magnetic resonance spectroscopy: basis of binding specificity. , 1997, Biochemistry.

[11]  K. Wüthrich,et al.  Nuclear magnetic resonance solution structure of the fushi tarazu homeodomain from Drosophila and comparison with the Antennapedia homeodomain. , 1994, Journal of molecular biology.

[12]  D. Duboule.  Guidebook to the homeobox genes , 1994 .

[13]  C. Freund,et al.  Guidebook to the Homeobox Genes , 1995 .

[14]  A. Laughon,et al.  DNA binding specificity of homeodomains. , 1991, Biochemistry.