Case report: ranitidine-induced bradycardia in a patient with dextrocardia.

Although rare, bradycardia and other cardiac arrhythmias have been associated with the use of H2-receptor antagonists. Ranitidine is among the most frequently prescribed drugs. In this article, the authors observed a ranitidine-mediated sinus bradycardia in a man with dextrocardia (situs inversus) who had acute bleeding from a duodenal ulcer. The bradycardia was resolved after ranitidine was discontinued.

[1]  S. Nightingale Seafood Safety Hot Line , 1995 .

[2]  P. Nickell Histamine-2 receptor blockers and delirium. , 1991, Annals of internal medicine.

[3]  J. Schwartz,et al.  Cloning and tissue expression of a rat histamine H2-receptor gene. , 1991, Biochemical and biophysical research communications.

[4]  T. Yamada,et al.  Molecular cloning of the human histamine H2 receptor. , 1991, Biochemical and biophysical research communications.

[5]  A. Halabi,et al.  Negative chronotropic effects of nizatidine. , 1991, Gut.

[6]  H. Sjövall,et al.  Effects of histamine H2-receptor blockade on the cardiovascular reflex response to lower-body negative pressure in man. , 1990, Acta physiologica Scandinavica.

[7]  S. Hill,et al.  Distribution, properties, and functional characteristics of three classes of histamine receptor. , 1990, Pharmacological reviews.

[8]  A. Hart Cardiac arrest associated with ranitidine. , 1989, BMJ.

[9]  D. R. Miller,et al.  Ranitidine and bradycardia. , 1988, Annals of internal medicine.

[10]  D. M. Gandhi,et al.  Perforated duodenal ulcer with dextrocardia with situs inversus. , 1986, Journal of postgraduate medicine.

[11]  J. Milstein Fiberoptic guide for endotracheal intubation. , 1985, American journal of diseases of children.

[12]  M. Triggiani,et al.  Chemical mediators and the human heart. , 1985, Progress in biochemical pharmacology.

[13]  M. Triggiani,et al.  Histamine and human heart. , 1985, International archives of allergy and applied immunology.

[14]  D. Harrison,et al.  Histamine receptors in the human heart. , 1980, Life sciences.

[15]  J. Black,et al.  Definition and Antagonism of Histamine H2-receptors , 1972, Nature.