New toolsets to understand environmental sensation and variability in the aging process

[1]  Peter Dayan,et al.  Theoretical Neuroscience: Computational and Mathematical Modeling of Neural Systems , 2001 .

[2]  A. Mata,et al.  Characterization of Polydimethylsiloxane (PDMS) Properties for Biomedical Micro/Nanosystems , 2005, Biomedical microdevices.

[3]  Hang Lu,et al.  Long-term high-resolution imaging and culture of C. elegans in chip-gel hybrid microfluidic device for developmental studies. , 2010, Lab on a chip.

[4]  D L Riddle,et al.  The Caenorhabditis elegans dauer larva: developmental effects of pheromone, food, and temperature. , 1984, Developmental biology.

[5]  Erik M. Jorgensen,et al.  The Sensory Circuitry for Sexual Attraction in C. elegans Males , 2007, Current Biology.

[6]  I. Mezić,et al.  Chaotic Mixer for Microchannels , 2002, Science.

[7]  T. Wilson,et al.  Aberration correction for confocal imaging in refractive‐index‐mismatched media , 1998 .

[8]  D. Ingram,et al.  Delay of T cell senescence by caloric restriction in aged long-lived nonhuman primates , 2006, Proceedings of the National Academy of Sciences.

[9]  T. Morgan,et al.  Caloric restriction attenuates Aβ-deposition in Alzheimer transgenic models , 2005, Neurobiology of Aging.

[10]  Anne E Carpenter,et al.  CellProfiler: image analysis software for identifying and quantifying cell phenotypes , 2006, Genome Biology.

[11]  G. Ruvkun,et al.  Food and metabolic signalling defects in a Caenorhabditis elegans serotonin-synthesis mutant , 2000, Nature.

[12]  H. Aguilaniu,et al.  PHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans , 2007, Nature.

[13]  A. M..  From genes to behaviour , 1974, Nature.

[14]  Kaveh Ashrafi,et al.  Neural and molecular dissection of a C. elegans sensory circuit that regulates fat and feeding. , 2008, Cell metabolism.

[15]  Cornelia I Bargmann,et al.  Reprogramming Chemotaxis Responses: Sensory Neurons Define Olfactory Preferences in C. elegans , 1997, Cell.

[16]  Yuqi Qin,et al.  A Neuronal Signaling Pathway of CaMKII and Gqα Regulates Experience-Dependent Transcription of tph-1 , 2013, The Journal of Neuroscience.

[17]  C. Kenyon,et al.  Regulation of C. elegans Longevity by Specific Gustatory and Olfactory Neurons , 2004, Neuron.

[18]  Rex A. Kerr,et al.  High-Throughput Behavioral Analysis in C. elegans , 2011, Nature Methods.

[19]  C. Greiner,et al.  SU-8: a photoresist for high-aspect-ratio and 3D submicron lithography , 2007 .

[20]  S. Murakami,et al.  Serotonin receptors antagonistically modulate Caenorhabditis elegans longevity , 2007, Aging cell.

[21]  William E. Brant,et al.  Fundamentals of Diagnostic Radiology , 1999 .

[22]  M. Tatar,et al.  The Endocrine Regulation of Aging by Insulin-like Signals , 2003, Science.

[23]  E. Greer,et al.  Different dietary restriction regimens extend lifespan by both independent and overlapping genetic pathways in C. elegans , 2009, Aging cell.

[24]  M A A Neil,et al.  Measurement of specimen‐induced aberrations of biological samples using phase stepping interferometry , 2004, Journal of microscopy.

[25]  David B. Dusenbery,et al.  Responses of the nematodeCaenorhabditis elegans to controlled chemical stimulation , 1980, Journal of comparative physiology.

[26]  L. Guarente,et al.  Two neurons mediate diet-restriction-induced longevity in C. elegans , 2007, Nature.

[27]  C. Kenyon.  The Plasticity of Aging: Insights from Long-Lived Mutants , 2005, Cell.

[28]  G. Seydoux,et al.  Regulation of MBK-2/DYRK by CDK-1 and the Pseudophosphatases EGG-4 and EGG-5 during the Oocyte-to-Embryo Transition , 2009, Cell.

[29]  S. Brenner,et al.  The structure of the nervous system of the nematode Caenorhabditis elegans. , 1986, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

[30]  Elizabeth Johnson,et al.  Mortality and morbidity in laboratory-maintained Rhesus monkeys and effects of long-term dietary restriction. , 2003, The journals of gerontology. Series A, Biological sciences and medical sciences.

[31]  D. Riddle,et al.  Control of C. elegans Larval Development by Neuronal Expression of a TGF-β Homolog , 1996, Science.

[32]  C. Kenyon,et al.  Caenorhabditis elegans integrates food and reproductive signals in lifespan determination , 2007, Aging cell.

[33]  J. Vaupel,et al.  A stress-sensitive reporter predicts longevity in isogenic populations of Caenorhabditis elegans , 2005, Nature Genetics.

[34]  James M. Rehg,et al.  Autonomous screening implicates new genes in synaptogenesis of C. elegans , 2012, Nature Methods.

[35]  Christopher J. Cronin,et al.  An automated system for measuring parameters of nematode sinusoidal movement , 2005, BMC Genetics.

[36]  G. Whitesides,et al.  Poly(dimethylsiloxane) as a material for fabricating microfluidic devices. , 2002, Accounts of chemical research.

[37]  R. Weindruch,et al.  The retardation of aging in mice by dietary restriction: longevity, cancer, immunity and lifetime energy intake. , 1986, The Journal of nutrition.

[38]  N. Sundararajan,et al.  Characterization of laterally deformable elastomer membranes for microfluidics , 2007 .

[39]  C. Finch,et al.  Ageing: The old worm turns more slowly , 2002, Nature.

[40]  Cori Bargmann,et al.  High-content behavioral analysis of Caenorhabditis elegans in precise spatiotemporal chemical environments , 2011, Nature Methods.

[41]  Cori Bargmann,et al.  High-throughput imaging of neuronal activity in Caenorhabditis elegans , 2013, Proceedings of the National Academy of Sciences.

[42]  P. Defossez,et al.  Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae. , 2000, Science.

[43]  M. Yanik,et al.  Microfluidic immobilization of physiologically active Caenorhabditis elegans , 2010, Nature Protocols.

[44]  C. Kenyon.  The genetics of ageing , 2010, Nature.

[45]  F. Slack,et al.  MicroRNA Predictors of Longevity in Caenorhabditis elegans , 2011, PLoS genetics.

[46]  R. Shingai,et al.  Computer-driven automatic identification of locomotion states in Caenorhabditis elegans , 2006, Journal of Neuroscience Methods.

[47]  A. Antebi,et al.  Genetics of Aging in Caenorhabditis elegans , 2007, PLoS genetics.

[48]  K. Lüersen,et al.  Gait-specific adaptation of locomotor activity in response to dietary restriction in Caenorhabditis elegans , 2014, Journal of Experimental Biology.

[49]  I. Goldberg,et al.  Behavioral deficits during early stages of aging in Caenorhabditis elegans result from locomotory deficits possibly linked to muscle frailty. , 2004, The journals of gerontology. Series A, Biological sciences and medical sciences.

[50]  R. Hosono,et al.  Age-dependent changes in mobility and separation of the nematode Caenorhabditis elegans , 1980, Experimental Gerontology.

[51]  G. Ruvkun,et al.  daf-28 encodes a C. elegans insulin superfamily member that is regulated by environmental cues and acts in the DAF-2 signaling pathway. , 2003, Genes & development.

[52]  Nikos Chronis,et al.  An automated microfluidic platform for calcium imaging of chemosensory neurons in Caenorhabditis elegans. , 2010, Lab on a chip.

[53]  D. Michaelson,et al.  Sensory Regulation of the C. elegans Germline through TGF-β-Dependent Signaling in the Niche , 2012, Current Biology.

[54]  J. Qin,et al.  Multiparameter evaluation of the longevity in C. elegans under stress using an integrated microfluidic device , 2012, Biomedical microdevices.

[55]  Cynthia Kenyon,et al.  The first long-lived mutants: discovery of the insulin/IGF-1 pathway for ageing , 2011, Philosophical Transactions of the Royal Society B: Biological Sciences.

[56]  Bingcheng Lin,et al.  Droplet microfluidics for characterizing the neurotoxin-induced responses in individual Caenorhabditis elegans. , 2010, Lab on a chip.

[57]  C. Kenyon,et al.  Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling , 2001, Nature Genetics.

[58]  Wendy S. Schackwitz,et al.  Chemosensory Neurons Function in Parallel to Mediate a Pheromone Response in C. elegans , 1996, Neuron.

[59]  Wagner Steuer Costa,et al.  Keeping track of worm trackers. , 2012, WormBook : the online review of C. elegans biology.

[60]  L. Partridge,et al.  Interpreting interactions between treatments that slow aging , 2002, Aging cell.

[61]  Guojun Lu,et al.  Review of shape representation and description techniques , 2004, Pattern Recognit..

[62]  Bo Xian,et al.  WormFarm: a quantitative control and measurement device toward automated Caenorhabditis elegans aging analysis , 2013, Aging cell.

[63]  H. Tissenbaum,et al.  Reproduction and longevity: secrets revealed by C. elegans. , 2007, Trends in cell biology.

[64]  S. Kovacs,et al.  Long-term caloric restriction ameliorates the decline in diastolic function in humans. , 2006, Journal of the American College of Cardiology.

[65]  Tiewen Liu,et al.  Counterbalance between BAG and URX neurons via guanylate cyclases controls lifespan homeostasis in C. elegans , 2013, The EMBO journal.

[66]  Daniel Ramot,et al.  The Parallel Worm Tracker: A Platform for Measuring Average Speed and Drug-Induced Paralysis in Nematodes , 2008, PloS one.

[67]  S. Lockery,et al.  Analysis of the effects of turning bias on chemotaxis in C. elegans , 2005, Journal of Experimental Biology.

[68]  J. Apfeld,et al.  Regulation of lifespan by sensory perception in Caenorhabditis elegans , 1999, Nature.

[69]  S. Gygi,et al.  An Ampk-foxo Pathway Mediates the Extension of Lifespan Induced by a Novel Method of Dietary Restriction in C. Elegans , 2022 .

[70]  Cornelia I Bargmann,et al.  A Distributed Chemosensory Circuit for Oxygen Preference in C. elegans , 2006, PLoS biology.

[71]  M. Hall,et al.  TOR Signaling in Growth and Metabolism , 2006, Cell.

[72]  Dimitris N. Metaxas,et al.  CeleST: Computer Vision Software for Quantitative Analysis of C. elegans Swim Behavior Reveals Novel Features of Locomotion , 2014, PLoS Comput. Biol..

[73]  P. Sternberg,et al.  A shortcut to identifying small molecule signals that regulate behavior and development in Caenorhabditis elegans , 2009, Proceedings of the National Academy of Sciences.

[74]  U. Brunk,et al.  Lipofuscin: mechanisms of age-related accumulation and influence on cell function. , 2002, Free radical biology & medicine.

[75]  S. Hell.  Toward fluorescence nanoscopy , 2003, Nature Biotechnology.

[76]  S. Lockery,et al.  Step-Response Analysis of Chemotaxis in Caenorhabditis elegans , 2003, The Journal of Neuroscience.

[77]  Kwanghun Chung,et al.  Computer-enhanced high-throughput genetic screens of C. elegans in a microfluidic system. , 2009, Lab on a chip.

[78]  Kwanghun Chung,et al.  Microfluidic chamber arrays for whole-organism behavior-based chemical screening. , 2011, Lab on a chip.

[79]  C. Kenyon,et al.  A Transcription Elongation Factor That Links Signals from the Reproductive System to Lifespan Extension in Caenorhabditis elegans , 2009, PLoS genetics.

[80]  G. Whitesides,et al.  Rapid Prototyping of Microfluidic Systems in Poly(dimethylsiloxane). , 1998, Analytical chemistry.

[81]  M. Kaeberlein.  Resveratrol and rapamycin: are they anti‐aging drugs? , 2010, BioEssays : news and reviews in molecular, cellular and developmental biology.

[82]  James J Collins,et al.  The measurement and analysis of age-related changes in Caenorhabditis elegans. , 2008, WormBook : the online review of C. elegans biology.

[83]  Dongshin Kim,et al.  Microfluidic operations using deformable polymer membranes fabricated by single layer soft lithography. , 2005, Lab on a chip.

[84]  F. Piano,et al.  EGG-4 and EGG-5 Link Events of the Oocyte-to-Embryo Transition with Meiotic Progression in C. elegans , 2009, Current Biology.

[85]  T. Johnson,et al.  Aging can be genetically dissected into component processes using long-lived lines of Caenorhabditis elegans. , 1987, Proceedings of the National Academy of Sciences of the United States of America.

[86]  D. Kristan.  Calorie restriction and susceptibility to intact pathogens , 2008, AGE.

[87]  K. L. Gardner,et al.  The voltage‐gated calcium channel UNC‐2 is involved in stress‐mediated regulation of tryptophan hydroxylase , 2003, Journal of neurochemistry.

[88]  C. Murphy,et al.  The C. elegans TGF-beta Dauer pathway regulates longevity via insulin signaling. , 2007, Current biology : CB.

[89]  Cornelia I. Bargmann,et al.  Pathogenic bacteria induce aversive olfactory learning in Caenorhabditis elegans , 2005, Nature.

[90]  P. Sternberg,et al.  Evidence of a mate-finding cue in the hermaphrodite nematode Caenorhabditis elegans , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[91]  D. Sinclair.  Toward a unified theory of caloric restriction and longevity regulation , 2005, Mechanisms of Ageing and Development.

[92]  William B. Mair,et al.  Aging and survival: the genetics of life span extension by dietary restriction. , 2008, Annual review of biochemistry.

[93]  Chih-Jen Lin,et al.  Probability Estimates for Multi-class Classification by Pairwise Coupling , 2003, J. Mach. Learn. Res..

[94]  Milan Sonka,et al.  Image Processing, Analysis and Machine Vision , 1993, Springer US.

[95]  Kazushi Yoshida,et al.  Parallel Use of Two Behavioral Mechanisms for Chemotaxis in Caenorhabditis elegans , 2009, The Journal of Neuroscience.

[96]  Polina Golland,et al.  An image analysis toolbox for high-throughput C. elegans assays , 2012, Nature Methods.

[97]  M. Tatar.  Regulation of aging by germline stem cells. , 2002, Science of Aging Knowledge Environment.

[98]  D. Ingram,et al.  Calorie restriction in nonhuman primates: effects on diabetes and cardiovascular disease risk. , 1999, Toxicological sciences : an official journal of the Society of Toxicology.

[99]  D. Riddle,et al.  A pheromone-induced developmental switch in Caenorhabditis elegans: Temperature-sensitive mutants reveal a wild-type temperature-dependent process. , 1984, Proceedings of the National Academy of Sciences of the United States of America.

[100]  S. Klein,et al.  Long-term calorie restriction is highly effective in reducing the risk for atherosclerosis in humans. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[101]  M. Moussaif,et al.  Serotonin targets the DAF-16/FOXO signaling pathway to modulate stress responses. , 2006, Cell metabolism.

[102]  J. Stieglitz,et al.  An integrated serotonin and octopamine neuronal circuit directs the release of an endocrine signal to control C. elegans body fat. , 2013, Cell metabolism.

[103]  Joshua D. Meisel,et al.  Chemosensation of Bacterial Secondary Metabolites Modulates Neuroendocrine Signaling and Behavior of C. elegans , 2014, Cell.

[104]  Aravinthan D. T. Samuel,et al.  Optogenetic manipulation of neural activity in freely moving Caenorhabditis elegans , 2011, Nature Methods.

[105]  M. Driscoll,et al.  A Role for Autophagy in the Extension of Lifespan by Dietary Restriction in C. elegans , 2008, PLoS genetics.

[106]  C. Kahn,et al.  Insulin signalling and the regulation of glucose and lipid metabolism , 2001, Nature.

[107]  B. Zwaan,et al.  Reduced insulin/IGF‐1 signalling and human longevity , 2005, Aging cell.

[108]  S. Ward.  Chemotaxis by the nematode Caenorhabditis elegans: identification of attractants and analysis of the response by use of mutants. , 1973, Proceedings of the National Academy of Sciences of the United States of America.

[109]  Matthew M. Crane,et al.  Automated on-chip rapid microscopy, phenotyping and sorting of C. elegans , 2008, Nature Methods.

[110]  Kevin W Eliceiri,et al.  NIH Image to ImageJ: 25 years of image analysis , 2012, Nature Methods.

[111]  Linda Partridge,et al.  Extending Healthy Life Span—From Yeast to Humans , 2010, Science.

[112]  Cori Bargmann,et al.  Control of larval development by chemosensory neurons in Caenorhabditis elegans. , 1991, Science.

[113]  H. Schwartz.  A protocol describing pharynx counts and a review of other assays of apoptotic cell death in the nematode worm Caenorhabditis elegans , 2007, Nature Protocols.

[114]  Anne E Carpenter,et al.  Annotated high-throughput microscopy image sets for validation , 2012, Nature Methods.

[115]  Paul W. Sternberg,et al.  A blend of small molecules regulates both mating and development in Caenorhabditis elegans , 2008, Nature.

[116]  E. Hafen,et al.  Insulin/IGF and target of rapamycin signaling: a TOR de force in growth control. , 2003, Trends in cell biology.

[117]  Hang Lu,et al.  Laterally Orienting C. elegans Using Geometry at Microscale for High-Throughput Visual Screens in Neurodegeneration and Neuronal Development Studies , 2012, PloS one.

[118]  A. Abate,et al.  Microfluidic sorting with high-speed single-layer membrane valves , 2010 .

[119]  Peter Varga,et al.  The role of specimen‐induced spherical aberration in confocal microscopy , 1997 .

[120]  Cori Bargmann,et al.  Microfluidics for in vivo imaging of neuronal and behavioral activity in Caenorhabditis elegans , 2007, Nature Methods.

[121]  L. Guarente,et al.  Genetic links between diet and lifespan: shared mechanisms from yeast to humans , 2007, Nature Reviews Genetics.

[122]  R. Kerr,et al.  Optical Imaging of Calcium Transients in Neurons and Pharyngeal Muscle of C. elegans , 2000, Neuron.

[123]  Hang Lu,et al.  Enabling systems biology approaches through microfabricated systems. , 2013, Analytical chemistry.

[124]  M. Blagosklonny.  Calorie restriction: Decelerating mTOR-driven aging from cells to organisms (including humans) , 2010, Cell cycle.

[125]  Lief E. Fenno,et al.  The development and application of optogenetics. , 2011, Annual review of neuroscience.

[126]  A. Hyman,et al.  A recombineering pipeline for functional genomics applied to Caenorhabditis elegans , 2006, Nature Methods.

[127]  David Gems,et al.  Dietary restriction in C. elegans: From rate-of-living effects to nutrient sensing pathways , 2005, Mechanisms of Ageing and Development.

[128]  Oliver Hobert,et al.  Hypoxia activates a latent circuit for processing gustatory information in C. elegans , 2010, Nature Neuroscience.

[129]  Hang Lu,et al.  Microfluidics as a tool for C. elegans research. , 2013, WormBook : the online review of C. elegans biology.

[130]  Jung Ho Je,et al.  3-D Worm Tracker for Freely Moving C. elegans , 2013, PloS one.

[131]  R. Pulak,et al.  Techniques for analysis, sorting, and dispensing of C. elegans on the COPAS flow-sorting system. , 2006, Methods in molecular biology.

[132]  E. Nishida,et al.  Signalling through RHEB-1 mediates intermittent fasting-induced longevity in C. elegans , 2009, Nature.

[133]  S. Hell,et al.  Aberrations in confocal fluorescence microscopy induced by mismatches in refractive index , 1993 .

[134]  R. Hosono.  Age dependent changes in the behavior of Caenorhabditis elegans on attraction to Escherichia coli , 1978, Experimental Gerontology.

[135]  Walter Fontana,et al.  The Caenorhabditis elegans Lifespan Machine , 2013, Nature Methods.

[136]  S. M. Coulthard,et al.  Artificial dirt: microfluidic substrates for nematode neurobiology and behavior. , 2008, Journal of Neurophysiology.

[137]  C. McMahan,et al.  Diet and the suitability of the male Fischer 344 rat as a model for aging research. , 1993, Journal of gerontology.

[138]  Amy E Palmer,et al.  Design and application of genetically encoded biosensors. , 2011, Trends in biotechnology.

[139]  Edward J. Masoro,et al.  Overview of caloric restriction and ageing , 2005, Mechanisms of Ageing and Development.

[140]  Aravinthan D. T. Samuel,et al.  Olfactory behavior of swimming C. elegans analyzed by measuring motile responses to temporal variations of odorants. , 2008, Journal of Neurophysiology.

[141]  S. Quake,et al.  Monolithic microfabricated valves and pumps by multilayer soft lithography. , 2000, Science.

[142]  A. Hsu,et al.  Solid plate-based dietary restriction in Caenorhabditis elegans. , 2011, Journal of visualized experiments : JoVE.

[143]  Min Zhu,et al.  Calorie restriction mimetics: an emerging research field , 2006, Aging cell.

[144]  J. N. Thomson,et al.  The pharynx of Caenorhabditis elegans. , 1976, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

[145]  Mehmet Fatih Yanik,et al.  Sub-cellular precision on-chip small-animal immobilization, multi-photon imaging and femtosecond-laser manipulation. , 2008, Lab on a chip.

[146]  L. Partridge,et al.  Demography of Dietary Restriction and Death in Drosophila , 2003, Science.

[147]  L. Partridge,et al.  Dietary restriction in Drosophila , 2005, Mechanisms of Ageing and Development.

[148]  Mehmet Fatih Yanik,et al.  Microfluidic system for on-chip high-throughput whole-animal sorting and screening at subcellular resolution , 2007, Proceedings of the National Academy of Sciences.

[149]  David B. Allison,et al.  Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study , 2012, Nature.

[150]  Claudio Franceschi,et al.  What accounts for the wide variation in life span of genetically identical organisms reared in a constant environment? , 2005, Mechanisms of Ageing and Development.

[151]  Adela Ben-Yakar,et al.  CO2 and compressive immobilization of C. elegans on-chip. , 2009, Lab on a chip.

[152]  Walter Fontana,et al.  Lifespan-on-a-chip: microfluidic chambers for performing lifelong observation of C. elegans. , 2010, Lab on a chip.

[153]  Matthew M. Crane,et al.  Quantitative screening of genes regulating tryptophan hydroxylase transcription in Caenorhabditis elegans using microfluidics and an adaptive algorithm. , 2013, Integrative biology : quantitative biosciences from nano to macro.

[154]  R. Weindruch,et al.  Dietary restriction in mice beginning at 1 year of age: effect on life-span and spontaneous cancer incidence. , 1982, Science.

[155]  Cynthia Kenyon,et al.  Signals from the reproductive system regulate the lifespan of C. elegans , 1999, Nature.

[156]  Ben Lehner,et al.  Fitness Trade-Offs and Environmentally Induced Mutation Buffering in Isogenic C. elegans , 2012, Science.

[157]  P. Cosman,et al.  Machine vision based detection of omega bends and reversals in C. elegans , 2006, Journal of Neuroscience Methods.

[158]  Kailiang Jia,et al.  Autophagy is Required for Dietary Restriction-Mediated Life Span Extension in C. elegans , 2007, Autophagy.

[159]  Zhixing Wang,et al.  Crosslinking Effect on Polydimethylsiloxane Elastic Modulus Measured by Custom-Built Compression Instrument , 2014 .

[160]  Matthew M. Crane.  Automated quantitative phenotyping and high-throughput screening in c. elegans using microfluidics and computer vision , 2011 .

[161]  Anne E Carpenter,et al.  Workflow and Metrics for Image Quality Control in Large-Scale High-Content Screens , 2012, Journal of biomolecular screening.

[162]  Lior Shamir,et al.  Pattern Recognition Software and Techniques for Biological Image Analysis , 2010, PLoS Comput. Biol..

[163]  Santosh Pandey,et al.  A microfluidic platform for high-sensitivity, real-time drug screening on C. elegans and parasitic nematodes. , 2011, Lab on a chip.

[164]  Stephen R. Quake,et al.  A Microfabricated Rotary Pump , 2001 .

[165]  Aravinthan D. T. Samuel,et al.  Thermotaxis in Caenorhabditis elegans Analyzed by Measuring Responses to Defined Thermal Stimuli , 2002, The Journal of Neuroscience.

[166]  Chengjie Xiong,et al.  Measurements of age-related changes of physiological processes that predict lifespan of Caenorhabditis elegans. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[167]  D. Hall,et al.  Stochastic and genetic factors influence tissue-specific decline in ageing C. elegans , 2002, Nature.

[168]  Bonnie L. Bassler,et al.  Bacterial Small-Molecule Signaling Pathways , 2006, Science.

[169]  M. Baker.  Digital PCR hits its stride , 2012, Nature Methods.

[170]  Matthew M. Crane,et al.  Real-time multimodal optical control of neurons and muscles in freely-behaving Caenorhabditis elegans , 2011, Nature Methods.