Decreased expression of neuronal nitric oxide synthase contributes to the endothelial dysfunction associated with cigarette smoking in human.

[1]  V. Lemos,et al.  Neuronal nitric oxide synthase contributes to the normalization of blood pressure in medicated hypertensive patients. , 2018, Nitric oxide : biology and chemistry.

[2]  A. Hackshaw,et al.  Low cigarette consumption and risk of coronary heart disease and stroke: meta-analysis of 141 cohort studies in 55 study reports , 2018, British Medical Journal.

[3]  V. Lemos,et al.  Neuronal nitric oxide synthase-derived hydrogen peroxide effect in grafts used in human coronary bypass surgery. , 2017, Clinical science.

[4]  A. Shah,et al.  Blood Pressure in Healthy Humans Is Regulated by Neuronal NO Synthase , 2017, Hypertension.

[5]  V. Lemos,et al.  Mechanisms of vascular dysfunction in acute phase of Trypanosoma cruzi infection in mice. , 2016, Vascular pharmacology.

[6]  V. Lemos,et al.  Endothelial dysfunction in DOCA-salt-hypertensive mice: role of neuronal nitric oxide synthase-derived hydrogen peroxide. , 2016, Clinical science.

[7]  S. Melnyk,et al.  The neuronal nitric oxide synthase inhibitor NANT blocks acetaminophen toxicity and protein nitration in freshly isolated hepatocytes. , 2015, Free radical biology & medicine.

[8]  A. Peters,et al.  Impact of smoking and smoking cessation on cardiovascular events and mortality among older adults: meta-analysis of individual participant data from prospective cohort studies of the CHANCES consortium , 2015, BMJ : British Medical Journal.

[9]  A. Papavassiliou,et al.  Smoking and atherosclerosis: mechanisms of disease and new therapeutic approaches. , 2014, Current medicinal chemistry.

[10]  Vienna E. Brunt,et al.  Impaired acetylcholine-induced cutaneous vasodilation in young smokers: roles of nitric oxide and prostanoids. , 2013, American journal of physiology. Heart and circulatory physiology.

[11]  S. Tanni,et al.  Increased production of hydrogen peroxide by peripheral blood monocytes associated with smoking exposure intensity in smokers , 2012, Journal of Inflammation.

[12]  Amir Lerman,et al.  The Assessment of Endothelial Function: From Research Into Clinical Practice , 2012, Circulation.

[13]  Rongshan Li,et al.  H2O2-Induced Dilation in Human Coronary Arterioles: Role of Protein Kinase G Dimerization and Large-Conductance Ca2+-Activated K+ Channel Activation , 2012, Circulation research.

[14]  L. Capettini,et al.  Decreased production of neuronal NOS‐derived hydrogen peroxide contributes to endothelial dysfunction in atherosclerosis , 2011, British journal of pharmacology.

[15]  Mark Woodward,et al.  Cigarette smoking as a risk factor for coronary heart disease in women compared with men: a systematic review and meta-analysis of prospective cohort studies , 2011, The Lancet.

[16]  C. Garland,et al.  EDHF: spreading the influence of the endothelium , 2011, British journal of pharmacology.

[17]  D. Carroll,et al.  The Endothelium and Its Role in Regulating Vascular Tone , 2010, The open cardiovascular medicine journal.

[18]  V. Lemos,et al.  Relative contribution of eNOS and nNOS to endothelium-dependent vasodilation in the mouse aorta. , 2010, European journal of pharmacology.

[19]  Megan E. Piper,et al.  Effects of smoking and smoking cessation on endothelial function: 1-year outcomes from a randomized clinical trial. , 2010, Journal of the American College of Cardiology.

[20]  P. McKeown,et al.  Role of gender, smoking profile, hypertension, and diabetes on saphenous vein and internal mammary artery endothelial relaxation in patients with coronary artery bypass grafting , 2010, Oxidative medicine and cellular longevity.

[21]  T. Carrel,et al.  Reactive oxygen species mediate functional differences in human radial and internal thoracic arteries from smokers. , 2010, Journal of vascular surgery.

[22]  C. Husten How should we define light or intermittent smoking? Does it matter? , 2009, Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco.

[23]  V. Lemos,et al.  Neuronal nitric oxide synthase-derived hydrogen peroxide is a major endothelium-dependent relaxing factor. , 2008, American journal of physiology. Heart and circulatory physiology.

[24]  A. Shah,et al.  Neuronal Nitric Oxide Synthase Regulates Basal Microvascular Tone in Humans In Vivo , 2008, Circulation.

[25]  J. Buring,et al.  A prospective study of cigarette smoking and risk of incident hypertension in women. , 2007, Journal of the American College of Cardiology.

[26]  L. Markó,et al.  Cigarette smoke-induced alterations in endothelial nitric oxide synthase phosphorylation: role of protein kinase C. , 2007, Endothelium : journal of endothelial cell research.

[27]  G. Kassab,et al.  Effect of cigarette smoking on nitric oxide, structural, and mechanical properties of mouse arteries. , 2006, American journal of physiology. Heart and circulatory physiology.

[28]  D. Kaye,et al.  Adverse Effects of Cigarette Smoke on NO Bioavailability: Role of Arginine Metabolism and Oxidative Stress , 2006, Hypertension.

[29]  S. Al-Safi,et al.  Does Smoking Affect Blood Pressure and Heart Rate? , 2005, European journal of cardiovascular nursing : journal of the Working Group on Cardiovascular Nursing of the European Society of Cardiology.

[30]  Qian Wang,et al.  Global impairment of brachial, carotid, and aortic vascular function in young smokers: direct quantification by high-resolution magnetic resonance imaging. , 2004, Journal of the American College of Cardiology.

[31]  C. Pomerleau,et al.  Defining a never-smoker: results from the nonsmokers survey. , 2004, Addictive behaviors.

[32]  D. Demady,et al.  Metabolism-based inactivation of neuronal nitric-oxide synthase by components of cigarette and cigarette smoke. , 2003, Drug metabolism and disposition: the biological fate of chemicals.

[33]  Jiang He,et al.  Relationship between Cigarette Smoking and Novel Risk Factors for Cardiovascular Disease in the United States , 2003, Annals of Internal Medicine.

[34]  L. Janssen,et al.  Mechanisms of hydrogen‐peroxide‐induced biphasic response in rat mesenteric artery , 2003, British journal of pharmacology.

[35]  C. Stehouwer,et al.  Cigarette smoking is associated with an acute impairment of microvascular function in humans. , 2003, Clinical science.

[36]  P. Nilsson,et al.  Smoking as a modifier of the systolic blood pressure-induced risk of cardiovascular events and mortality: a population-based prospective study of middle-aged men , 2002, Journal of hypertension.

[37]  I. Crocker,et al.  Characterization of small arteries isolated from the human placental chorionic plate. , 2002, Placenta.

[38]  Hiroaki Shimokawa,et al.  Hydrogen peroxide is an endothelium-derived hyperpolarizing factor in human mesenteric arteries. , 2002, Biochemical and biophysical research communications.

[39]  J. Ambrose,et al.  Dysfunctional Endothelial Nitric Oxide Biosynthesis in Healthy Smokers With Impaired Endothelium-Dependent Vasodilatation , 2001, Circulation.

[40]  V. Peinado,et al.  Reduced expression of endothelial nitric oxide synthase in pulmonary arteries of smokers. , 2001, American journal of respiratory and critical care medicine.

[41]  P. Martásek,et al.  Reduced amide bond peptidomimetics. (4S)-N-(4-amino-5-[aminoakyl]aminopentyl)-N'-nitroguanidines, potent and highly selective inhibitors of neuronal nitric oxide synthase. , 2001, Journal of medicinal chemistry.

[42]  D. Gozal,et al.  Prenatal cigarette smoke exposure selectively alters protein kinase C and nitric oxide synthase expression within the neonatal rat brainstem , 2001, Neuroscience Letters.

[43]  M. Mariani,et al.  Continued cigarette smoking after coronary artery bypass surgery reduces endothelium-dependent vasodilation in internal thoracic artery grafts. , 2001, Italian heart journal : official journal of the Italian Federation of Cardiology.

[44]  A M Zeiher,et al.  Prognostic impact of coronary vasodilator dysfunction on adverse long-term outcome of coronary heart disease. , 2000, Circulation.

[45]  Yunchao Su,et al.  Effect of cigarette smoke extract on nitric oxide synthase in pulmonary artery endothelial cells. , 1998, American journal of respiratory cell and molecular biology.

[46]  J. Rajfer,et al.  Effect of long-term passive smoking on erectile function and penile nitric oxide synthase in the rat. , 1997, The Journal of urology.

[47]  K. Kugiyama,et al.  Deficiency in nitric oxide bioactivity in epicardial coronary arteries of cigarette smokers. , 1996, Journal of the American College of Cardiology.

[48]  J. Cohn,et al.  Effects of long-term cigarette smoking on endothelium-dependent responses in humans. , 1996, The American journal of cardiology.

[49]  T. Pietras,et al.  Increased content of hydrogen peroxide in the expired breath of cigarette smokers. , 1996, The European respiratory journal.

[50]  J. Powell,et al.  Smoking impairs the activity of endothelial nitric oxide synthase in saphenous vein. , 1996, Arteriosclerosis, thrombosis, and vascular biology.

[51]  A. Nissinen,et al.  Comparison of multivariate predictive power of major risk factors for coronary heart diseases in different countries: results from eight nations of the Seven Countries Study, 25-year follow-up , 1996 .

[52]  J. Powell,et al.  Smoking impairs endothelium‐dependent relaxation of saphenous vein , 1993, The British journal of surgery.

[53]  P. Smits,et al.  Effect of chronic smoking on endothelium-dependent vascular relaxation in humans. , 1993, Clinical science.

[54]  C. Rångemark,et al.  Endothelium‐Dependent and ‐Independent Vasodilation and Reactive Hyperemia in Healthy Smokers , 1992, Journal of cardiovascular pharmacology.

[55]  M. M. Bradford A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. , 1976, Analytical biochemistry.

[56]  R. A. Murphy,et al.  Length‐Tension Relationship of Smooth Muscle of the Hog Carotid Artery , 1973, Circulation research.