Methadone tolerance testing in drug misusers
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The model of methadone tolerance testing Bakker and Fazey describe is not the solution to this problem.1 They make the assumption that low mean maintenance doses of methadone are a consequence of low starting doses, which are separate issues. The model of induction into methadone treatment recommended in the national clinical guidelines for the management of drug dependence allows for the attainment of adequate optimised maintenance doses. …
[1] C. Fazey,et al. Methadone tolerance testing in drug misusers , 2006, BMJ : British Medical Journal.
[2] M. Brugal,et al. Evaluating the impact of methadone maintenance programmes on mortality due to overdose and aids in a cohort of heroin users in Spain. , 2005, Addiction.
[3] S. Sunjic,et al. Methadone-related deaths and mortality rate during induction into methadone maintenance, New South Wales, 1996. , 2002, Drug and alcohol review.
[4] M. Stark. Drug misuse and dependence — guidelines on clinical management , 1999 .