Application of Information Technology: Automating Complex Guidelines for Chronic Disease: Lessons Learned

There is scant published experience with implementing complex, multistep computerized practice guidelines for the long-term management of chronic diseases. We have implemented a system for creating, maintaining, and navigating computer-based clinical algorithms integrated with our electronic medical record. This article describes our progress and reports on lessons learned that might guide future work in this field. We discuss issues and obstacles related to choosing and adapting a guideline for electronic implementation, representing and executing the guideline as a computerized algorithm, and integrating it into the clinical workflow of outpatient care. Although obstacles were encountered at each of these steps, the most difficult were related to workflow integration.

[1]  A. Taylor-Vaisey,et al.  Translating guidelines into practice. A systematic review of theoretic concepts, practical experience and research evidence in the adoption of clinical practice guidelines. , 1997, CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne.

[2]  Henry C. Chueh,et al.  Using the extensible markup language (XML) in automated clinical practice guidelines , 1998, AMIA.

[3]  C. McDonald,et al.  Computerizing guidelines: factors for success. , 1996, Proceedings : a conference of the American Medical Informatics Association. AMIA Fall Symposium.

[4]  L. Casebeer,et al.  Patient informatics: using a computerized system to monitor patient compliance in the treatment of hypertension. , 1995, Medinfo. MEDINFO.

[5]  G O Barnett,et al.  “Just‐in‐time” clinical information , 1997, Academic medicine : journal of the Association of American Medical Colleges.

[6]  D W Bates,et al.  Use and monitoring of "statin" lipid-lowering drugs compared with guidelines. , 2001, Archives of internal medicine.

[7]  Richard N. Shiffman,et al.  Review: Computer-based Guideline Implementation Systems: A Systematic Review of Functionality and Effectiveness , 1999, J. Am. Medical Informatics Assoc..

[8]  Robert A. Greenes,et al.  Research Paper: The GuideLine Interchange Format: A Model for Representing Guidelines , 1998, J. Am. Medical Informatics Assoc..

[9]  J. Mckenney,et al.  National Cholesterol Education Program Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) , 2002 .

[10]  Omolola Ogunyemi,et al.  Using features of Arden Syntax with object-oriented medical data models for guideline modeling , 2001, AMIA.

[11]  Jonathan M. Teich,et al.  P-CAPE: a high-level tool for entering and processing clinical practice guidelines. Partners Computerized Algorithm and Editor , 1998, AMIA.

[12]  D. Cannon,et al.  A comparison of the effects of computer and manual reminders on compliance with a mental health clinical practice guideline. , 2000, Journal of the American Medical Informatics Association : JAMIA.

[13]  Jon Rogers,et al.  Evaluation of an implementation of PRODIGY phase two , 1999, AMIA.

[14]  R. Linkins,et al.  A randomized trial of the effectiveness of computer-generated telephone messages in increasing immunization visits among preschool children. , 1994, Archives of pediatrics & adolescent medicine.

[15]  D. Lobach Electronically distributed, computer-generated, individualized feedback enhances the use of a computerized practice guideline. , 1996, Proceedings : a conference of the American Medical Informatics Association. AMIA Fall Symposium.

[16]  C J McDonald,et al.  A tool for provider interaction during patient care: G-CARE. , 1995, Proceedings. Symposium on Computer Applications in Medical Care.

[17]  J. Mckenney,et al.  Summary of the second report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel II) , 1993, JAMA.

[18]  S. Quaglini,et al.  A computerized guideline for pressure ulcer prevention. , 2000, International journal of medical informatics.

[19]  Jonathan M. Teich,et al.  The Brigham integrated computing system (BICS): advanced clinical systems in an academic hospital environment , 1999, Int. J. Medical Informatics.

[20]  C J McDonald,et al.  Physician response to computer reminders. , 1980, JAMA.

[21]  H R Warner,et al.  Computerized practice guidelines for heart failure management: the HeartMan system. , 1995, Proceedings. Symposium on Computer Applications in Medical Care.

[22]  C Safran,et al.  Guidelines for management of HIV infection with computer-based patient's record , 1995, The Lancet.

[23]  R A Milch,et al.  The effect of an alphanumeric paging system on patient compliance with medicinal regimens , 1996, The American journal of hospice & palliative care.

[24]  Aziz A. Boxwala,et al.  Architecture for a multipurpose guideline execution engine , 1999, AMIA.

[25]  R. Thomson,et al.  Clinical guidelines: quantity without quality. , 1997, Quality in health care : QHC.

[26]  W. Hammond,et al.  Computerized decision support based on a clinical practice guideline improves compliance with care standards. , 1997, The American journal of medicine.

[27]  J. Buchanan,et al.  Computerized reminders for five preventive screening tests: generation of patient-specific letters incorporating physician preferences , 2000, AMIA.

[28]  R. Haynes,et al.  Effects of Computer-based Clinical Decision Support Systems on Clinician Performance and Patient Outcome: A Critical Appraisal of Research , 1994, Annals of Internal Medicine.

[29]  B. Davis,et al.  The effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels. Cholesterol and Recurrent Events Trial investigators. , 1996, The New England journal of medicine.

[30]  Scandinavian Simvastatin Survival Study Group Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S) , 1994, The Lancet.

[31]  Post Coronary Artery Bypass Graft Trial Investigators The effect of aggressive lowering of low-density lipoprotein cholesterol levels and low-dose anticoagulation on obstructive changes in saphenous-vein coronary-artery bypass grafts. , 1997, The New England journal of medicine.

[32]  M J Lincoln,et al.  A computer-generated reminder system improves physician compliance with diabetes preventive care guidelines. , 1995, Proceedings. Symposium on Computer Applications in Medical Care.

[33]  S W Tu,et al.  PROTEGE-II: computer support for development of intelligent systems from libraries of components. , 1995, Medinfo. MEDINFO.

[34]  Silvana Quaglini,et al.  A computerised guideline for pressure ulcer prevention , 2000, Int. J. Medical Informatics.

[35]  D. Bates,et al.  Using an electronic medical record to identify opportunities to improve compliance with cholesterol guidelines , 2001, Journal of general internal medicine.

[36]  Roger A. Renfrew,et al.  Lipid Research Clinics Program. , 1984, JAMA.

[37]  G J Kuperman,et al.  Patient safety and computerized medication ordering at Brigham and Women's Hospital. , 2001, The Joint Commission journal on quality improvement.

[38]  William M. Tierney,et al.  Improving clinical decisions and outcomes with information: a review , 2001, Int. J. Medical Informatics.

[39]  Richard N. Shiffman,et al.  Model Formulation: GEM: A Proposal for a More Comprehensive Guideline Document Model Using XML , 2000, J. Am. Medical Informatics Assoc..

[40]  J M Teich,et al.  Coverage List: a provider-patient database supporting advanced hospital information services. , 1994, Proceedings. Symposium on Computer Applications in Medical Care.

[41]  S. Cretin,et al.  Implementation of clinical guidelines using a computer charting system. Effect on the initial care of health care workers exposed to body fluids. , 1997, JAMA.

[42]  Henry C. Chueh,et al.  An XML-based format for guideline interchange and execution , 2000, AMIA.

[43]  Aziz A. Boxwala,et al.  A framework and tools for authoring, editing, documenting, sharing, searching, navigating, and executing computer-based clinical guidelines , 1999, AMIA.

[44]  S W Tu,et al.  The EON model of intervention protocols and guidelines. , 1996, Proceedings : a conference of the American Medical Informatics Association. AMIA Fall Symposium.

[45]  T. Clemmer,et al.  A computer-assisted management program for antibiotics and other antiinfective agents. , 1998, The New England journal of medicine.

[46]  C. McDonald,et al.  A computerized reminder system to increase the use of preventive care for hospitalized patients. , 2001, The New England journal of medicine.

[47]  D. Bates,et al.  Detecting alerts, notifying the physician, and offering action items: a comprehensive alerting system. , 1996, Proceedings : a conference of the American Medical Informatics Association. AMIA Fall Symposium.

[48]  D L Schriger,et al.  The impact of a guideline-driven computer charting system on the emergency care of patients with acute low back pain. , 1995, Proceedings. Symposium on Computer Applications in Medical Care.

[49]  Sean Tunis,et al.  Attitudes about Guidelines , 1994 .

[50]  Samson W. Tu,et al.  Integrating a modern knowledge-based system architecture with a legacy VA database: the ATHENA and EON projects at Stanford , 1999, AMIA.

[51]  M. Enkin,et al.  Do practice guidelines guide practice? The effect of a consensus statement on the practice of physicians. , 1989, The New England journal of medicine.

[52]  John Fox,et al.  PROforma: a general technology for clinical decision support systems. , 1997, Computer methods and programs in biomedicine.

[53]  M. Field,et al.  Guidelines for Clinical Practice: From Development to Use , 1992 .

[54]  J. Slattery,et al.  Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S). 1994. , 1994, Atherosclerosis. Supplements.

[55]  R L Brown,et al.  Primary care practice adherence to National Cholesterol Education Program guidelines for patients with coronary heart disease. , 1998, Archives of internal medicine.

[56]  R F Beckley,et al.  Design of an easy-to-use physician order entry system with support for nursing and ancillary departments. , 1992, Proceedings. Symposium on Computer Applications in Medical Care.

[57]  M. Field,et al.  Guidelines for Clinical Practice: From Development to Use , 1992 .

[58]  K. Feingold,et al.  Inadequate treatment with HMG-CoA reductase inhibitors by health care providers. , 1996, The American journal of medicine.

[59]  M. Cabana,et al.  Why don't physicians follow clinical practice guidelines? A framework for improvement. , 1999, JAMA.

[60]  I S Kohane,et al.  The challenges of automating a real-time clinical practice guideline. , 1999, Clinical performance and quality health care.

[61]  R. Haynes,et al.  Effects of computer-based clinical decision support systems on physician performance and patient outcomes: a systematic review. , 1998, JAMA.

[62]  D. Bates,et al.  Effects of computerized physician order entry on prescribing practices. , 2000, Archives of internal medicine.

[63]  T. Wagner,et al.  The effectiveness of mailed patient reminders on mammography screening: a meta-analysis. , 1998, American journal of preventive medicine.

[64]  The Lipid Research Clinics Coronary Primary Prevention Trial results. II. The relationship of reduction in incidence of coronary heart disease to cholesterol lowering. , 1984, JAMA.

[65]  H. Rubin,et al.  Internists' Attitudes about Clinical Practice Guidelines , 1994, Annals of Internal Medicine.

[66]  G. Octo Barnett,et al.  Long-term changes in compliance with clinical guidelines through computer-based reminders , 1998, AMIA.

[67]  Paul Wallace,et al.  Embedding guidelines into direct physician order entry: simple methods, powerful results , 1999, AMIA.

[68]  D F Lobach,et al.  A model for adapting clinical guidelines for electronic implementation in primary care. , 1995, Proceedings. Symposium on Computer Applications in Medical Care.

[69]  Joan S. Ash,et al.  The dissemination of clinical practice guidelines over an intranet: an evaluation , 1999, AMIA.

[70]  J. Marc Overhage,et al.  Case Report: Computerizing Guidelines to Improve Care and Patient Outcomes: The Example of Heart Failure , 1995, J. Am. Medical Informatics Assoc..

[71]  William DuMouchel,et al.  A meta-analysis of 16 randomized controlled trials to evaluate computer-based clinical reminder systems for preventive care in the ambulatory setting. , 1996, Journal of the American Medical Informatics Association : JAMIA.

[72]  J. Stengård,et al.  Antibodies to glutamic acid decarboxylase as predictors of insulin-dependent diabetes mellitus before clinical onset of disease , 1994, The Lancet.

[73]  R. Zielstorff Online practice guidelines: issues, obstacles, and future prospects. , 1998, Journal of the American Medical Informatics Association : JAMIA.

[74]  Julie M. Fiskio,et al.  Patient-specific Computerized Outpatient Reminders to Improve Physician Compliance with Clinical Guidelines , 2000, AMIA.

[75]  David Blumenthal,et al.  Improving Preventive Care by Prompting Physicians , 2001 .