Singlet oxygen luminescence detection with a fiber-coupled superconducting nanowire single-photon detector.

We report on the direct monitoring of singlet oxygen luminescence at 1270 nm wavelength using a fiber coupled superconducting nanowire single-photon detector. These results open the pathway to practical dose monitoring in photodynamic therapy.

[1]  P. Kapusta,et al.  Time-resolved methods in biophysics. 7. Photon counting vs. analog time-resolved singlet oxygen phosphorescence detection , 2008, Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology.

[2]  D. O'connor,et al.  Time-Correlated Single Photon Counting , 1984 .

[3]  U. Schmidt-Erfurth,et al.  Mechanisms of action of photodynamic therapy with verteporfin for the treatment of age-related macular degeneration. , 2000, Survey of ophthalmology.

[4]  B. Wilson,et al.  The Influence of Oxygen Depletion and Photosensitizer Triplet‐state Dynamics During Photodynamic Therapy on Accurate Singlet Oxygen Luminescence Monitoring and Analysis of Treatment Dose Response , 2011, Photochemistry and photobiology.

[5]  Shigehito Miki,et al.  Crosstalk-free operation of multielement superconducting nanowire single-photon detector array integrated with single-flux-quantum circuit in a 0.1 W Gifford-McMahon cryocooler. , 2012, Optics letters.

[6]  Sae Woo Nam,et al.  Fast lifetime measurements of infrared emitters using a low-jitter superconducting single-photon detector , 2006 .

[7]  Peter R Ogilby,et al.  Singlet oxygen: there is indeed something new under the sun. , 2010, Chemical Society reviews.

[8]  Susumu Terakawa,et al.  Monitoring of Singlet Oxygen Is Useful for Predicting the Photodynamic Effects in the Treatment for Experimental Glioma , 2006, Clinical Cancer Research.

[9]  Michael G. Tanner,et al.  Enhanced telecom wavelength single-photon detection with NbTiN superconducting nanowires on oxidized silicon , 2010 .

[10]  C. M. Natarajan,et al.  Superconducting nanowire single-photon detectors: physics and applications , 2012, 1204.5560.

[11]  R. Jain,et al.  Photodynamic therapy for cancer , 2003, Nature Reviews Cancer.

[12]  A. Tosi,et al.  Advances in InGaAsP-based avalanche diode single photon detectors , 2011 .

[13]  Sae Woo Nam,et al.  Single photon source characterization with a superconducting single photon detector , 2005, 2006 Conference on Lasers and Electro-Optics and 2006 Quantum Electronics and Laser Science Conference.

[14]  H Szmacinski,et al.  Fluorescence lifetime imaging. , 1992, Analytical biochemistry.

[15]  S. Arridge,et al.  INSTITUTE OF PHYSICS PUBLISHING PHYSICS IN MEDICINE AND BIOLOGY , 2003 .

[16]  Reinhard Schmidt,et al.  Physical mechanisms of generation and deactivation of singlet oxygen. , 2003, Chemical reviews.

[17]  Robert M. Hoffman,et al.  The multiple uses of fluorescent proteins to visualize cancer in vivo , 2005, Nature Reviews Cancer.

[18]  F. Marsili,et al.  Detecting single infrared photons with 93% system efficiency , 2012, 1209.5774.

[19]  Franco Zappa,et al.  Evolution and prospects for single-photon avalanche diodes and quenching circuits , 2004 .

[20]  R. Hadfield Single-photon detectors for optical quantum information applications , 2009 .

[21]  R. Collins,et al.  Single-photon generation and detection , 2009 .

[22]  Michael S Patterson,et al.  Singlet Oxygen Luminescence Dosimetry (SOLD) for Photodynamic Therapy: Current Status, Challenges and Future Prospects , 2006, Photochemistry and photobiology.

[23]  Stanley B. Brown,et al.  The present and future role of photodynamic therapy in cancer treatment. , 2004, The Lancet. Oncology.

[24]  X. Xie,et al.  Protein Conformational Dynamics Probed by Single-Molecule Electron Transfer , 2003, Science.

[25]  B. Wilson,et al.  Development of an In Vivo Raman Spectroscopic System for Diagnostic Applications , 1997 .

[26]  V. B. Verma,et al.  A three-dimensional, polarization-insensitive superconducting nanowire avalanche photodetector , 2012, CLEO: 2013.

[27]  Michael S Patterson,et al.  In vitro tests of the validity of singlet oxygen luminescence measurements as a dose metric in photodynamic therapy. , 2003, Cancer research.

[28]  Michael S Patterson,et al.  Imaging of Photodynamically Generated Singlet Oxygen Luminescence In Vivo¶ , 2005, Photochemistry and photobiology.

[29]  Michael S Patterson,et al.  Direct Near-infrared Luminescence Detection of Singlet Oxygen Generated by Photodynamic Therapy in Cells In Vitro and Tissues In Vivo¶ , 2002, Photochemistry and photobiology.

[30]  O. Okunev,et al.  Picosecond superconducting single-photon optical detector , 2001 .

[31]  Sae Woo Nam,et al.  High-order temporal coherences of chaotic and laser light. , 2010, Optics express.