New perspectives on innovative drug discovery: an overview.
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Yi-fan Han | Dik‐Lung Ma | S. Pan | Shan Pan | Zhi-ling Yu | Si-Bao Chen | W. Fong | K. Ko | Yi‐fan Han | Sibao Chen
[1] D. Newman,et al. Microbial antitumor drugs: natural products of microbial origin as anticancer agents. , 2009, Current opinion in investigational drugs.
[2] Thomas H Segall-Shapiro,et al. Creation of a Bacterial Cell Controlled by a Chemically Synthesized Genome , 2010, Science.
[3] J. Rosenstock,et al. Titration of inhaled human insulin (Exubera) in a treat-to-target regimen for patients with type 2 diabetes. , 2010, Diabetes technology & therapeutics.
[4] T. Illmer,et al. The efficacy of arsenic trioxide for the treatment of relapsed and refractory multiple myeloma: a systematic review. , 2009, Cancer treatment reviews.
[5] The transatlantic rift in genetically modified food policy , 2007 .
[6] F. Shanahan,et al. The gut flora as a forgotten organ , 2006, EMBO reports.
[7] T. Robak. Treatment of chronic lymphoid leukemias with monoclonal antibodies: current place and perspectives , 2008 .
[8] M. Tremblay,et al. Statins could be used to control replication of some viruses, including HIV-1. , 2005, Viral immunology.
[9] Xaviera Thomas,et al. Arsenic: a beneficial therapeutic poison - a historical overview. , 2009, Adler Museum bulletin.
[10] K. Sweder,et al. The role of genetic toxicology in drug discovery and optimization. , 2008, Current drug metabolism.
[11] D. Bentley. The Human Genome Project--an overview. , 2000, Medicinal research reviews.
[12] Min Yang,et al. CDA-II, a urinary preparation, induces growth arrest and apoptosis of human leukemia cells through inactivation of nuclear factor-kappaB in a caspase-dependent manner. , 2009, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
[13] G. Bar-Sela,et al. Curcumin as an anti-cancer agent: review of the gap between basic and clinical applications. , 2010, Current medicinal chemistry.
[14] N. Seidah,et al. Chloroquine is a potent inhibitor of SARS coronavirus infection and spread , 2005, Virology Journal.
[15] J. Hao,et al. Inhibitory effect of bionic fungicide 2-allylphenol on Botrytis cinerea (Pers. ex Fr.) in vitro. , 2009, Pest management science.
[16] Y. Li,et al. Synthesis and biological activity of Wuweizisu C and analogs. , 2009, Current topics in medicinal chemistry.
[17] J. Conlon. Reflections on a systematic nomenclature for antimicrobial peptides from the skins of frogs of the family Ranidae , 2008, Peptides.
[18] Burkhard Haefner,et al. Drugs from the deep: marine natural products as drug candidates. , 2003, Drug discovery today.
[19] J. Vernon. Examining the link between price regulation and pharmaceutical R&D investment. , 2005, Health economics.
[20] G. Edwards‐Jones,et al. Plant metabolites and nutritional quality of vegetables. , 2008, Journal of food science.
[21] Charles C. Persinger,et al. How to improve R&D productivity: the pharmaceutical industry's grand challenge , 2010, Nature Reviews Drug Discovery.
[22] G. Rishton,et al. Failure and success in modern drug discovery: guiding principles in the establishment of high probability of success drug discovery organizations. , 2005, Medicinal chemistry (Shariqah (United Arab Emirates)).
[23] Marc Van Ranst,et al. In vitro inhibition of severe acute respiratory syndrome coronavirus by chloroquine , 2004, Biochemical and Biophysical Research Communications.
[24] Clara Verges,et al. The year's new drugs & biologics - 2008. , 2009, Drug news & perspectives.
[25] W. Jelkmann,et al. Erythropoiesis stimulating agents and techniques: a challenge for doping analysts. , 2009, Current medicinal chemistry.
[26] F. Russo,et al. Lactobacillus rhamnosus GG influences polyamine metabolism in HGC-27 gastric cancer cell line: a strategy toward nutritional approach to chemoprevention of gastric cance. , 2010, Current pharmaceutical design.
[27] Yoo-Hwa Park,et al. Multifaceted therapeutic benefits of Ginkgo biloba L.: chemistry, efficacy, safety, and uses. , 2007, Journal of food science.
[28] S. Pan,et al. Ethanol Extract of Fructus Schisandrae Decreases Hepatic Triglyceride Level in Mice Fed with a High Fat/Cholesterol Diet, with Attention to Acute Toxicity , 2011, Evidence-based complementary and alternative medicine : eCAM.
[29] J. Kuhlmann. The applications of biomarkers in early clinical drug development to improve decision-making processes. , 2007, Ernst Schering Research Foundation workshop.
[30] S. Pan,et al. Bicyclol, a synthetic dibenzocyclooctadiene derivative, decreases hepatic lipids but increases serum triglyceride level in normal and hypercholesterolaemic mice , 2007, The Journal of pharmacy and pharmacology.
[31] Ara Darzi,et al. The human gut microbiome: Implications for future health care , 2008, Current gastroenterology reports.
[32] T. Lai,et al. Effect of CDA-II, urinary preparation, on lipofuscin, lipid peroxidation and antioxidant systems in young and middle-aged rat brain. , 2001, The American journal of Chinese medicine.
[33] Erik Mosekilde,et al. Integrating systems approaches into pharmaceutical sciences. , 2008, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
[34] Janice M. Reichert,et al. A guide to drug discovery: Trends in development and approval times for new therapeutics in the United States , 2003, Nature Reviews Drug Discovery.
[35] M. López-Lázaro. Distribution and biological activities of the flavonoid luteolin. , 2009, Mini reviews in medicinal chemistry.
[36] R. Pallela,et al. Anti-photoaging and Photoprotective Compounds Derived from Marine Organisms , 2010, Marine drugs.
[37] K. S. Lam,et al. Discovery and development of the anticancer agent salinosporamide A (NPI-0052). , 2009, Bioorganic & medicinal chemistry.
[38] [From teprotide to captopril. Rational design of ACE inhibitors]. , 2003, Pharmazie in unserer Zeit.
[39] Weiliang Zhu,et al. [Advances in the study of berberine and its derivatives]. , 2008, Yao xue xue bao = Acta pharmaceutica Sinica.
[40] A. Budd,et al. The DExD/H-box helicase Dicer-2 mediates the induction of antiviral activity in drosophila , 2008, Nature Immunology.
[41] S. Chhibber,et al. Therapeutic potential of bacteriophage in treating Klebsiella pneumoniae B5055-mediated lobar pneumonia in mice. , 2008, Journal of medical microbiology.
[42] Janice M Reichert,et al. Monoclonal antibodies as innovative therapeutics. , 2008, Current pharmaceutical biotechnology.
[43] Soy Isoflavones. Soy isoflavones. , 2020, Alternative medicine review : a journal of clinical therapeutic.
[44] X. Su,et al. Discovery, mechanisms of action and combination therapy of artemisinin , 2009, Expert review of anti-infective therapy.
[45] G. Rishton,et al. Natural products as a robust source of new drugs and drug leads: past successes and present day issues. , 2008, The American journal of cardiology.
[46] Yahui Wei,et al. [Research advances of Huperzia serrata (Thunb.) Trev]. , 2009, Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
[47] Song Xue,et al. Biopotentials of marine sponges from China oceans: past and future. , 2003, Biomolecular engineering.
[48] G. Şener,et al. Resveratrol protects against methotrexate-induced hepatic injury in rats. , 2010, Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques.
[49] A. Rescigno. The two faces of pharmacokinetics. , 2010, Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques.
[50] Hong Zhou,et al. Generation of stable cell lines by site-specific integration of transgenes into engineered Chinese hamster ovary strains using an FLP-FRT system. , 2010, Journal of biotechnology.
[51] E. Romanowski,et al. A Review of Antimicrobial Peptides and Their Therapeutic Potential as Anti-Infective Drugs , 2005, Current eye research.
[52] R. Yu,et al. Clinical and cosmeceutical uses of hydroxyacids. , 2009, Clinics in dermatology.
[53] R. Blaese. Development of Gene Therapy for Immunodeficiency: Adenosine Deaminase Deficiency , 1993, Pediatric Research.
[54] K. Erdmann,et al. The possible roles of food-derived bioactive peptides in reducing the risk of cardiovascular disease. , 2008, The Journal of nutritional biochemistry.
[55] C. Tautermann,et al. G-protein-coupled receptor-focused drug discovery using a target class platform approach. , 2009, Drug discovery today.
[56] D. Barra,et al. Amphibian skin: a promising resource for antimicrobial peptides. , 1995, Trends in biotechnology.
[57] H. Grabowski,et al. Are the economics of pharmaceutical research and development changing? , 2012, PharmacoEconomics.
[58] Michael J Zaworotko,et al. Expanding the scope of crystal form evaluation in pharmaceutical science. , 2006, Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques.
[59] Marcy J. Balunas,et al. Drug discovery from natural sources , 2006, The AAPS Journal.
[60] Ruth E Ley,et al. Obesity and the human microbiome , 2010, Current opinion in gastroenterology.
[61] Ana Martínez. Marine-derived drugs in neurology. , 2007, Current opinion in investigational drugs.
[62] S. Burzynski. Antineoplastons: history of the research (I). , 1986, Drugs under experimental and clinical research.
[63] Ling-Hao Li,et al. [Progression of foundational and clinical studies on use of arsenic trioxide in treatment of lymphoma--review]. , 2007, Zhongguo shi yan xue ye xue za zhi.
[64] O. Chun,et al. Soy isoflavones as safe functional ingredients. , 2007, Journal of medicinal food.
[65] Scott A. Brown,et al. HIV-1 vaccine development: tackling virus diversity with a multi-envelope cocktail. , 2008, Frontiers in bioscience : a journal and virtual library.
[66] Janice M Reichert,et al. Finding value in the U.S. Food and Drug Administration's Fast Track program. , 2009, Drug news & perspectives.
[67] C. M. Pérez. Can ginkgo biloba combat diseases? , 2009, Puerto Rico health sciences journal.
[68] Peter Watson,et al. Live cell imaging for target and drug discovery. , 2009, Drug news & perspectives.
[69] D J Barlow,et al. Phytochemical informatics and virtual screening of herbs used in Chinese medicine. , 2010, Current pharmaceutical design.
[70] W. Verstraete,et al. The intestinal environment in health and disease - recent insights on the potential of intestinal bacteria to influence human health. , 2009, Current pharmaceutical design.
[71] Se-kwon Kim,et al. Angiotensin-I-Converting Enzyme (ACE) Inhibitors from Marine Resources: Prospects in the Pharmaceutical Industry , 2010, Marine drugs.
[72] Rui Wang,et al. Molecular dynamics simulations of interaction between protein-tyrosine phosphatase 1B and a bidentate inhibitor , 2006, Acta Pharmacologica Sinica.
[73] S. Ichinose,et al. Statin-induced inhibition of HIV-1 release from latently infected U1 cells reveals a critical role for protein prenylation in HIV-1 replication. , 2008, Microbes and infection.
[74] R. Aluko. Technology for the production and utilization of food protein-derived anti-hypertensive peptides: a review. , 2007, Recent patents on biotechnology.
[75] Linxiang Zhao,et al. Ethacrynic acid butyl-ester induces apoptosis in leukemia cells through a hydrogen peroxide mediated pathway independent of glutathione S-transferase P1-1 inhibition. , 2007, Cancer research.
[76] T. Ganapathi,et al. Expression of Hepatitis B Surface Antigen in Transgenic Banana Plants and NTI Cell Line of Tobacco , 2003 .
[77] P. Georgel,et al. Genetic and epigenetic regulations of prostate cancer by genistein. , 2009, Drug news & perspectives.
[78] J. Wittes,et al. A randomized, double-blind, double-dummy, controlled dose comparison of thalidomide for treatment of erythema nodosum leprosum. , 2005, The American journal of tropical medicine and hygiene.
[79] F. Carroll. Epibatidine structure-activity relationships. , 2004, Bioorganic & medicinal chemistry letters.
[80] Shuji Ogino,et al. Aspirin and the risk of colorectal cancer in relation to the expression of COX-2. , 2007, The New England journal of medicine.
[81] N. Grubhofer. Vaccine Adjuvants Revisited , 2008 .
[82] Jian-Guo Jiang,et al. Chinese medicine and its modernization demands. , 2008, Archives of medical research.
[83] U. Lindequist,et al. Evaluation of the in vitro anticancer, antimicrobial and antioxidant activities of some Yemeni plants used in folk medicine. , 2009, Die Pharmazie.
[84] S. Bembenek,et al. Ligand binding efficiency: trends, physical basis, and implications. , 2008, Journal of medicinal chemistry.
[85] T. Tabira. Immunization therapy for Alzheimer disease: a comprehensive review of active immunization strategies. , 2010, The Tohoku journal of experimental medicine.
[86] L. Mohassel,et al. Arsenic trioxide as first-line treatment for acute promyelocytic leukemia. , 2009, American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists.
[87] M. Luo,et al. Medicinal chemistry of paclitaxel and its analogues. , 2009, Current medicinal chemistry.
[88] A. Trovato-Salinaro,et al. The hormetic role of dietary antioxidants in free radical-related diseases. , 2010, Current pharmaceutical design.
[89] R. Millán-Guerrero,et al. Subcutaneous histamine versus botulinum toxin type A in migraine prophylaxis: a randomized, double‐blind study , 2009, European journal of neurology.
[90] C. Sen,et al. Tocotrienols: the emerging face of natural vitamin E. , 2007, Vitamins and hormones.
[91] Liu Gt. [From the study of Fructus schizandrae to the discovery of biphenyl dimethyl-dicarboxylate]. , 1983 .
[92] Hannah M. Jones,et al. Modelling and PBPK Simulation in Drug Discovery , 2009, The AAPS Journal.
[93] David W Green,et al. Tissue bionics: examples in biomimetic tissue engineering , 2008, Biomedical materials.
[94] G. Schwartsmann,et al. Marine-derived anticancer agents in clinical trials , 2003, Expert opinion on investigational drugs.
[95] A. Nzila,et al. Anticancer agents against malaria: time to revisit? , 2010, Trends in parasitology.
[96] Public and private sector contributions to the discovery and development of "impact" drugs. , 2002, American journal of therapeutics.
[97] A. Kong,et al. Molecular Targets of Dietary Phenethyl Isothiocyanate and Sulforaphane for Cancer Chemoprevention , 2010, The AAPS Journal.
[98] V. Adamo,et al. Insertional mutagenesis and development of malignancies induced by integrating gene delivery systems: implications for the design of safer gene-based interventions in patients. , 2009, Drug news & perspectives.
[99] Xiong Mao-min. Review of arsenic trioxide effect on human hepatocarcinoma , 2006 .
[100] M. Moța,et al. Soya--the medicine food product. , 2007, Romanian journal of internal medicine = Revue roumaine de medecine interne.
[101] Nigel Greene,et al. Early toxicity screening strategies. , 2009, Current opinion in drug discovery & development.
[102] D. Faulkner. Marine natural products. , 2000, Natural product reports.
[103] D. Robledo,et al. Antileishmanial properties of tropical marine algae extracts. , 2008, Fitoterapia.
[104] Geng-tao Liu. Bicyclol: a novel drug for treating chronic viral hepatitis B and C. , 2009, Medicinal chemistry (Shariqah (United Arab Emirates)).
[105] Christopher T. Walsh,et al. Antibiotics for Emerging Pathogens , 2009, Science.
[106] Mattheos A G Koffas,et al. Trends in microbial synthesis of natural products and biofuels. , 2009, Advances in enzymology and related areas of molecular biology.
[107] Philip G. Williams,et al. Panning for chemical gold: marine bacteria as a source of new therapeutics. , 2009, Trends in biotechnology.
[108] D. Gurwitz. Malaria drugs: clues from malaria resistance genetics , 2009 .
[109] David H Sherman,et al. Biosynthetic pathway and gene cluster analysis of curacin A, an antitubulin natural product from the tropical marine cyanobacterium Lyngbya majuscula. , 2004, Journal of natural products.
[110] Wei Hu,et al. [Synthesis of metabolites of bicyclol]. , 2007, Yao xue xue bao = Acta pharmaceutica Sinica.
[111] S. Pan,et al. Bifendate treatment attenuates hepatic steatosis in cholesterol/bile salt- and high-fat diet-induced hypercholesterolemia in mice. , 2006, European journal of pharmacology.
[112] W. Au,et al. Arsenic trioxide: safety issues and their management , 2008, Acta Pharmacologica Sinica.
[113] David J Newman,et al. Natural products as sources of new drugs over the period 1981-2002. , 2003, Journal of natural products.
[114] T. Szekeres,et al. Antitumor effects of KITC, a new resveratrol derivative, in AsPC-1 and BxPC-3 human pancreatic carcinoma cells , 2009, Investigational New Drugs.
[115] T. Molinski,et al. Drug development from marine natural products , 2009, Nature Reviews Drug Discovery.
[116] M. Petroski,et al. The ubiquitin system, disease, and drug discovery , 2008, BMC Biochemistry.
[117] W. Noble,et al. Minocycline as a potential therapeutic agent in neurodegenerative disorders characterized by protein misfolding , 2009, Prion.
[118] Mukul Sharma,et al. Clinical status of anti-cancer agents derived from marine sources. , 2008, Anti-cancer agents in medicinal chemistry.
[119] A. Chesson,et al. Anti-Inflammatory Implications of the Microbial Transformation of Dietary Phenolic Compounds , 2008, Nutrition and cancer.
[120] M. Gillick. Controlling Off-Label Medication Use , 2009, Annals of Internal Medicine.
[121] A. Tabarrok. From off-label prescribing towards a new FDA. , 2009, Medical hypotheses.
[122] R. Abagyan,et al. Structure-based discovery of natural-product-like TNF-α inhibitors. , 2010, Angewandte Chemie.
[123] M. Tallman,et al. Arsenic trioxide: new clinical experience with an old medication in hematologic malignancies. , 2005, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[124] B. Aggarwal. Signalling pathways of the TNF superfamily: a double-edged sword , 2003, Nature Reviews Immunology.
[125] Detrusor overactivity successfully treated with duloxetine , 2007, Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology.
[126] J. Hervé. Therapeutic potential of peptide motifs--part II. , 2009, Current pharmaceutical design.
[127] Brian M. Murphy,et al. Stability of Protein Pharmaceuticals: An Update , 2010, Pharmaceutical Research.
[128] C. Sen,et al. Tocotrienols in health and disease: the other half of the natural vitamin E family. , 2007, Molecular aspects of medicine.
[129] S. Lampel,et al. The druggable genome: an update. , 2005, Drug discovery today.
[130] S. Basano,et al. Antimalarials and the fight against malaria in Brazil , 2009, Therapeutics and clinical risk management.
[131] D. Chauhan,et al. A novel proteasome inhibitor NPI-0052 as an anticancer therapy , 2006, British Journal of Cancer.
[132] J. Stevens,et al. Strategic applications of toxicogenomics in early drug discovery. , 2008, Current opinion in pharmacology.
[133] P. Hogg,et al. Arsenical-based cancer drugs. , 2007, Cancer treatment reviews.
[134] Mark R. Trusheim,et al. Stratified medicine: strategic and economic implications of combining drugs and clinical biomarkers , 2007, Nature Reviews Drug Discovery.
[135] Yucheng Gu,et al. Secondary metabolites from the South China Sea invertebrates: chemistry and biological activity. , 2006, Current medicinal chemistry.
[136] R. D. Phillips,et al. Plant food-derived Angiotensin I converting enzyme inhibitory peptides. , 2009, Journal of agricultural and food chemistry.
[137] J. Conlon,et al. Antimicrobial peptides from ranid frogs: taxonomic and phylogenetic markers and a potential source of new therapeutic agents. , 2004, Biochimica et biophysica acta.
[138] S. Akira,et al. RIG-I-like antiviral protein in flies , 2008, Nature Immunology.
[139] E. Borden,et al. Personalizing medicine for cancer: the next decade , 2010, Nature Reviews Drug Discovery.
[140] H. Dürk. Maintenance Therapy for Multiple Myeloma with Particular Emphasis on Thalidomide , 2006, Oncology Research and Treatment.
[141] Mohamed O. Othman,et al. Alterations in intestinal microbial flora and human disease , 2008, Current opinion in gastroenterology.
[142] Sumio Sugano,et al. Human Gene and Protein Database (HGPD): a novel database presenting a large quantity of experiment-based results in human proteomics , 2009, Nucleic Acids Res..
[143] Li Li Tang,et al. Potential therapeutic targets of huperzine A for Alzheimer's disease and vascular dementia. , 2008, Chemico-biological interactions.
[144] C. Drewke,et al. Ginkgo biloba and ginkgotoxin. , 2010, Journal of natural products.
[145] Luisa Bracci,et al. Branched peptides as therapeutics. , 2008, Current protein & peptide science.
[146] K. Pathak,et al. Pharmaceutical product development technologies based on the biopharmaceutical classification system. , 2009, Die Pharmazie.
[147] S. Soignet,et al. Risk/benefit profile of arsenic trioxide. , 2001, The oncologist.
[148] J. Berenson,et al. Arsenic compounds in the treatment of multiple myeloma: a new role for a historical remedy. , 2006, Clinical lymphoma & myeloma.
[149] S. Pan,et al. Schisandrin B from Schisandra chinensis reduces hepatic lipid contents in hypercholesterolaemic mice , 2008, The Journal of pharmacy and pharmacology.
[150] R. Eglen,et al. Photoproteins: important new tools in drug discovery. , 2008, Assay and drug development technologies.
[151] J. Hervé. Therapeutic potential of peptide motifs - part III. , 2010, Current pharmaceutical design.
[152] T. Kawada,et al. Bixin regulates mRNA expression involved in adipogenesis and enhances insulin sensitivity in 3T3-L1 adipocytes through PPARgamma activation. , 2009, Biochemical and biophysical research communications.
[153] Matthew Clark,et al. Developing technologies in biodefense research: computational drug design , 2009 .
[154] Edwin L. Cooper,et al. Drug Discovery: Is it Relevant to Complementary and Alternative Medicine (CAM)? , 2004 .
[155] J. Meyerhardt,et al. Aspirin dose and duration of use and risk of colorectal cancer in men. , 2008, Gastroenterology.
[156] P. Bye,et al. Recombinant activated factor VII for massive hemoptysis in patients with cystic fibrosis. , 2009, Chest.
[157] 李贺,et al. Review of arsenic trioxide effect on human hepatocarcinoma , 2006 .
[158] Woan‐Ruoh Lee,et al. The wrinkles soothing effect on the middle and lower face by intradermal injection of botulinum toxin type A , 2008, International journal of dermatology.
[159] L. Gerwick,et al. Marine natural product drug discovery: Leads for treatment of inflammation, cancer, infections, and neurological disorders , 2010, Immunopharmacology and immunotoxicology.
[160] D. Faulkner,et al. Marine natural products. , 2000, Natural product reports.
[161] Yoshimasa Nakamura,et al. Electrophiles in Foods: The Current Status of Isothiocyanates and Their Chemical Biology , 2010, Bioscience, biotechnology, and biochemistry.
[162] B. Cukrowska,et al. Commensal bacteria (normal microflora), mucosal immunity and chronic inflammatory and autoimmune diseases. , 2004, Immunology letters.
[163] B. Neilan,et al. Development of Taxol and other endophyte produced anti-cancer agents. , 2008, Recent patents on anti-cancer drug discovery.
[164] R. Herzog,et al. Gene therapy approaches to induce tolerance in autoimmunity by reshaping the immune system. , 2009, Current opinion in investigational drugs.
[165] Kotaro Aihara,et al. Casein-derived tripeptide, Val-Pro-Pro (VPP), modulates monocyte adhesion to vascular endothelium. , 2009, Journal of atherosclerosis and thrombosis.
[166] Joana M. Xavier,et al. The role of p53 in apoptosis. , 2010, Discovery medicine.
[167] Shu-Hua Tai,et al. A systematic review and meta‐analysis on the therapeutic equivalence of statins , 2010, Journal of clinical pharmacy and therapeutics.
[168] A. Graul. Promoting, improving and accelerating the drug development and approval processes. , 2009, Drug news & perspectives.
[169] Sushama Talegaonkar,et al. Emerging significance of flavonoids as P-glycoprotein inhibitors in cancer chemotherapy. , 2009, Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques.
[170] F. Baba,et al. Lycopene, an antioxidant carotenoid, attenuates testicular injury caused by ischemia/reperfusion in rats. , 2009, The Tohoku journal of experimental medicine.
[171] R. Williams. Review article: bacterial flora and pathogenesis in hepatic encephalopathy , 2007, Alimentary pharmacology & therapeutics.
[172] H. Hanai,et al. Curcumin has bright prospects for the treatment of inflammatory bowel disease. , 2009, Current pharmaceutical design.
[173] R. Schilsky. Personalized medicine in oncology: the future is now , 2010, Nature Reviews Drug Discovery.
[174] Alicia R. Desilets,et al. Role of Huperzine a in the Treatment of Alzheimer's Disease , 2009, The Annals of pharmacotherapy.
[175] M. Mancuso,et al. Neuroprotective effects of tetracyclines: molecular targets, animal models and human disease. , 2009, CNS & neurological disorders drug targets.
[176] Ara Darzi,et al. Autobionics: a new paradigm in regenerative medicine and surgery. , 2010, Regenerative medicine.
[177] Á. Simonyi,et al. Resveratrol as a Therapeutic Agent for Neurodegenerative Diseases , 2010, Molecular Neurobiology.
[178] N. Nagelkerke,et al. Resistance to HIV-1 infection among persistently seronegative prostitutes in Nairobi, Kenya , 1996, The Lancet.
[179] Angus Nedderman,et al. In vitro screening techniques for reactive metabolites for minimizing bioactivation potential in drug discovery. , 2008, Current drug metabolism.
[180] Kazunori Kato,et al. Cancer-targeting gene therapy using tropism-modified adenovirus. , 2007, Anticancer research.
[181] T. Shirakawa. Clinical trial design for adenoviral gene therapy products. , 2009, Drug news & perspectives.
[182] G. Vinderola,et al. Proposed Model: Mechanisms of Immunomodulation Induced by Probiotic Bacteria , 2007, Clinical and Vaccine Immunology.
[183] G. T. Liu. [From the study of Fructus schizandrae to the discovery of biphenyl dimethyl-dicarboxylate]. , 1983, Yao xue xue bao = Acta pharmaceutica Sinica.
[184] J. Rauha,et al. Natural products in the process of finding new drug candidates. , 2004, Current medicinal chemistry.
[185] W. Debinski. Molecular targeting with recombinant cytotoxins for the treatment of brain tumors , 2008 .
[186] Stefan Günther,et al. SuperPred: drug classification and target prediction , 2008, Nucleic Acids Res..
[187] S. Pan,et al. New Perspectives on Chinese Herbal Medicine (Zhong-Yao) Research and Development , 2011, Evidence-based complementary and alternative medicine : eCAM.
[188] A. Shah,et al. Effect of camel urine on the cytological and biochemical changes induced by cyclophosphamide in mice. , 1996, Journal of ethnopharmacology.
[189] B. Munos. Lessons from 60 years of pharmaceutical innovation , 2009, Nature Reviews Drug Discovery.
[190] S. Erdine. Compliance With the Treatment of Hypertension: The Potential of Combination Therapy , 2010, Journal of clinical hypertension.
[191] William Fenical,et al. Widespread and Persistent Populations of a Major New Marine Actinomycete Taxon in Ocean Sediments , 2002, Applied and Environmental Microbiology.
[192] S. Soignet,et al. Diagnosis and treatment of acute promyelocytic leukemia , 2007, Current oncology reports.
[193] Jian-ping Liu,et al. [Efficacy of arsenic trioxide for acute promyelocytic leukemia: a systematic review and meta-analysis]. , 2009, Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine.
[194] S. Di Bella,et al. Management of antibiotic resistance in the intensive care unit setting , 2010, Expert review of anti-infective therapy.
[195] E. Tobinick. The value of drug repositioning in the current pharmaceutical market. , 2009, Drug news & perspectives.
[196] S Grabley,et al. Bioactive agents from natural sources: trends in discovery and application. , 1999, Advances in biochemical engineering/biotechnology.
[197] I. Goryanin,et al. Human metabolic network reconstruction and its impact on drug discovery and development. , 2008, Drug discovery today.
[198] L. Goldfrank,et al. Medical toxicology. , 1992, JAMA.
[199] E. Arinç,et al. Evaluation of the protective effects of quercetin, rutin, naringenin, resveratrol and trolox against idarubicin-induced DNA damage. , 2010, Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques.
[200] Gabriella Molinari,et al. Natural products in drug discovery: present status and perspectives. , 2009, Advances in Experimental Medicine and Biology.
[201] T. Adrian. Novel marine-derived anti-cancer agents. , 2007, Current pharmaceutical design.
[202] Humayoun Akhtar,et al. Food and therapeutic product interactions - a therapeutic perspective. , 2009, Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques.
[203] M. Liong,et al. Effects of a Lactobacillus casei synbiotic on serum lipoprotein, intestinal microflora, and organic acids in rats. , 2006, Journal of dairy science.
[204] Custer Ll,et al. The role of genetic toxicology in drug discovery and optimization. , 2008 .
[205] John S Janiszewski,et al. Perspectives on bioanalytical mass spectrometry and automation in drug discovery. , 2008, Current drug metabolism.
[206] J Drews,et al. The role of innovation in drug development. , 1997, Nature biotechnology.
[207] W. Fenical. New pharmaceuticals from marine organisms. , 1997, Trends in biotechnology.
[208] K. Piwocka,et al. The promise of slow down ageing may come from curcumin. , 2010, Current pharmaceutical design.
[209] R. Quirion,et al. Polyphenols as potential inhibitors of amyloid aggregation and toxicity: possible significance to Alzheimer's disease. , 2008, Mini reviews in medicinal chemistry.
[210] Jonathan W. Essex,et al. Prediction of protein–ligand binding affinity by free energy simulations: assumptions, pitfalls and expectations , 2010, J. Comput. Aided Mol. Des..
[211] Roksana Parvin,et al. Protective effect of tomato against adrenaline-induced myocardial infarction in rats. , 2009, Bangladesh Medical Research Council bulletin.
[212] A. Lugasi,et al. [A comparison of chemical composition and nutritional value of organically and conventionally grown plant derived foods]. , 2006, Orvosi hetilap.
[213] Aibin Shi,et al. Antitumor effect of substituted quinolines in breast cancer cells , 2008 .
[214] N. Kovačević,et al. Arbutin content and antioxidant activity of some Ericaceae species. , 2009, Die Pharmazie.
[215] A. Casini,et al. New uses for old drugs. Auranofin, a clinically established antiarthritic metallodrug, exhibits potent antimalarial effects in vitro: Mechanistic and pharmacological implications , 2008, FEBS letters.
[216] Min Yang,et al. Human urine extract CDA-2 induces apoptosis of myelodysplastic syndrome-derived MUTZ-1 cells through the PI3K/Akt signaling pathway in a caspase-3-dependent manner , 2008, Acta Pharmacologica Sinica.
[217] Jie Liu,et al. Mineral Arsenicals in Traditional Medicines: Orpiment, Realgar, and Arsenolite , 2008, Journal of Pharmacology and Experimental Therapeutics.
[218] Xiaoyuan Chen,et al. Has Molecular and Cellular Imaging Enhanced Drug Discovery and Drug Development? , 2008, Drugs in R&D.
[219] Jiri Aubrecht,et al. Voluntary exploratory data submissions to the US FDA and the EMA: experience and impact , 2010, Nature Reviews Drug Discovery.
[220] C. Ponticelli,et al. Once-a-day administration of everolimus, cyclosporine, and steroid after renal transplantation: a review of the rationale. , 2010, Transplantation proceedings.