Late onset Rasmussen encephalitis: complete remission after one session of plasmapheresis

Rasmussen’s encephalitis (RE) is an immunomediated disorder characterized by unilateral hemispheric atrophy, drugresistant focal epilepsy and progressive neurological deficits [1]. The etiology of RE is unknown. In the adult form the semiology may include motor signs, visual, olfactory and dysmnesic features, as well as loss of contact [2]. The outcome of RE is disappointing. Treatment includes corticosteroids, immunoglobulins, plasma exchange (PE), cyclophosphamide and tacrolimus but also antiepileptic drugs (AEDs) and, in the most severe cases, functional hemispherectomy or hemispherotomy [3,4]. We describe a case of late-onset RE with an excellent outcome after one PE cycle.