ATR controls cellular adaptation to hypoxia through positive regulation of hypoxia-inducible factor 1 (HIF-1) expression

[1]  G. Semenza,et al.  Hypoxia-Inducible Factors in Physiology and Medicine , 2012, Cell.

[2]  Chuanxin Wang,et al.  Underexpressed microRNA‐199b‐5p targets Hypoxia‐Inducible Factor‐1α in hepatocellular carcinoma and predicts prognosis of hepatocellular carcinoma patients , 2011, Journal of gastroenterology and hepatology.

[3]  C. Santocanale,et al.  Hypoxic activation of ATR and the suppression of the initiation of DNA replication through cdc6 degradation , 2011, Oncogene.

[4]  P. Reaper,et al.  Selective killing of ATM- or p53-deficient cancer cells through inhibition of ATR. , 2011, Nature chemical biology.

[5]  D. Biard,et al.  A DNA-dependent stress response involving DNA-PK occurs in hypoxic cells and contributes to cellular adaptation to hypoxia , 2011, Journal of Cell Science.

[6]  S. Rocha,et al.  Evolutionary Conserved Regulation of HIF-1β by NF-κB , 2011, PLoS genetics.

[7]  O. Fernandez-Capetillo,et al.  The ATR barrier to replication-born DNA damage. , 2010, DNA repair.

[8]  M. Hentze,et al.  Mechanism of translational regulation by miR-2 from sites in the 5' untranslated region or the open reading frame. , 2010, RNA.

[9]  P. Houghton,et al.  mTORC1 signaling under hypoxic conditions is controlled by ATM-dependent phosphorylation of HIF-1α. , 2010, Molecular cell.

[10]  W. Wong,et al.  Hypoxia-inducible factors and the response to hypoxic stress. , 2010, Molecular cell.

[11]  C. Dray,et al.  Loss of ATM positively regulates the expression of hypoxia inducible factor 1 (HIF-1) through oxidative stress: Role in the physiopathology of the disease , 2010, Cell cycle.

[12]  Eng-Hui Chew,et al.  Inhibition of Hypoxia-Inducible Factor-1α (HIF-1α) Protein Synthesis by DNA Damage Inducing Agents , 2010, PloS one.

[13]  A. Kulkarni,et al.  ATR preferentially interacts with common fragile site FRA3B and the binding requires its kinase activity in response to aphidicolin treatment. , 2010, Mutation research.

[14]  Zhuoshun Yang,et al.  Regulation of HIF-1α and VEGF by miR-20b Tunes Tumor Cells to Adapt to the Alteration of Oxygen Concentration , 2009, PloS one.

[15]  D. Cortez,et al.  Common mechanisms of PIKK regulation. , 2009, DNA repair.

[16]  G. Melillo,et al.  Development of HIF-1 inhibitors for cancer therapy , 2009, Journal of cellular and molecular medicine.

[17]  M. Gorospe,et al.  RNA-binding proteins implicated in the hypoxic response , 2009, Journal of cellular and molecular medicine.

[18]  A. Nussenzweig,et al.  Histone H2AX is integral to hypoxia-driven neovascularization , 2009, Nature Medicine.

[19]  J. Pouysségur,et al.  HIF at a glance , 2009, Journal of Cell Science.

[20]  D. W. Kim,et al.  DNA‐dependent protein kinase is involved in heat shock protein‐mediated accumulation of hypoxia‐inducible factor‐1α in hypoxic preconditioned HepG2 cells , 2008, The FEBS journal.

[21]  A. Giaccia,et al.  Hypoxic Conditions Atm Activation and Signaling Under , 2008 .

[22]  G. Powis,et al.  HIF-1 regulation: not so easy come, easy go. , 2008, Trends in biochemical sciences.

[23]  E. Crescenzi,et al.  Ataxia Telangiectasia Mutated and p21CIP1 Modulate Cell Survival of Drug-Induced Senescent Tumor Cells: Implications for Chemotherapy , 2008, Clinical Cancer Research.

[24]  Jun O. Liu,et al.  RNA-Binding Proteins HuR and PTB Promote the Translation of Hypoxia-Inducible Factor 1α , 2007, Molecular and Cellular Biology.

[25]  G. Melillo,et al.  UVC inhibits HIF-1α protein translation by a DNA damage- and topoisomerase I-independent pathway , 2007, Oncogene.

[26]  G. Semenza Evaluation of HIF-1 inhibitors as anticancer agents. , 2007, Drug discovery today.

[27]  K. Cimprich,et al.  The ATR pathway: fine-tuning the fork. , 2007, DNA repair.

[28]  J. Pouysségur,et al.  Harnessing the hypoxia-inducible factor in cancer and ischemic disease. , 2007, Biochemical pharmacology.

[29]  Z. Ahmed,et al.  cDNA cloning, gene organization and variant specific expression of HIF-1 alpha in high altitude yak (Bos grunniens). , 2007, Gene.

[30]  N. Lakin,et al.  Recruitment of ATR to sites of ionising radiation-induced DNA damage requires ATM and components of the MRN protein complex , 2006, Oncogene.

[31]  J. Myers,et al.  Rapid Activation of ATR by Ionizing Radiation Requires ATM and Mre11* , 2006, Journal of Biological Chemistry.

[32]  M. Cuadrado,et al.  ATM regulates ATR chromatin loading in response to DNA double-strand breaks , 2006, The Journal of experimental medicine.

[33]  S. Gibson,et al.  Hypoxia-induced phosphorylation of Chk2 in an ataxia telangiectasia mutated-dependent manner. , 2005, Cancer research.

[34]  Petra de Graaf,et al.  Phosphorylation of Hdmx mediates its Hdm2- and ATM-dependent degradation in response to DNA damage. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[35]  C. Muller,et al.  The membrane form of the DNA repair protein Ku interacts at the cell surface with metalloproteinase 9 , 2004, The EMBO journal.

[36]  A. Giaccia,et al.  Inhibition of ATR Leads to Increased Sensitivity to Hypoxia/Reoxygenation , 2004, Cancer Research.

[37]  M. Tilby,et al.  A novel DNA-dependent protein kinase inhibitor, NU7026, potentiates the cytotoxicity of topoisomerase II poisons used in the treatment of leukemia. , 2004, Blood.

[38]  A. Giaccia,et al.  Comparison of hypoxia-induced replication arrest with hydroxyurea and aphidicolin-induced arrest. , 2003, Mutation research.

[39]  G. Semenza Targeting HIF-1 for cancer therapy , 2003, Nature Reviews Cancer.

[40]  N. Curtin,et al.  Radiosensitization and DNA repair inhibition by the combined use of novel inhibitors of DNA-dependent protein kinase and poly(ADP-ribose) polymerase-1. , 2003, Cancer research.

[41]  Stephen J. Elledge,et al.  Sensing DNA Damage Through ATRIP Recognition of RPA-ssDNA Complexes , 2003, Science.

[42]  A. Giaccia,et al.  ATR/ATM Targets Are Phosphorylated by ATR in Response to Hypoxia and ATM in Response to Reoxygenation* , 2003, The Journal of Biological Chemistry.

[43]  A. Harris,et al.  GLUT‐1 and CAIX as intrinsic markers of hypoxia in carcinoma of the cervix: Relationship to pimonidazole binding , 2003, International journal of cancer.

[44]  Christine C. Hudson,et al.  Regulation of Hypoxia-Inducible Factor 1α Expression and Function by the Mammalian Target of Rapamycin , 2002, Molecular and Cellular Biology.

[45]  G. Goodall,et al.  Hypoxia-inducible Factor-1 (cid:1) mRNA Contains an Internal Ribosome Entry Site That Allows Efficient Translation during Normoxia and Hypoxia , 2022 .

[46]  S. Schreiber,et al.  ATR inhibition selectively sensitizes G1 checkpoint-deficient cells to lethal premature chromatin condensation , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[47]  G. Semenza,et al.  HER2 (neu) Signaling Increases the Rate of Hypoxia-Inducible Factor 1α (HIF-1α) Synthesis: Novel Mechanism for HIF-1-Mediated Vascular Endothelial Growth Factor Expression , 2001, Molecular and Cellular Biology.

[48]  F. Ismail-Beigi,et al.  Regulation of glut1 mRNA by Hypoxia-inducible Factor-1 , 2001, The Journal of Biological Chemistry.

[49]  G. Semenza,et al.  Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics. , 2000, Cancer research.

[50]  A. Koong,et al.  Loss of PTEN facilitates HIF-1-mediated gene expression. , 2000, Genes & development.

[51]  S. Gygi,et al.  Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism. , 1999, Genes & development.

[52]  Jörg Stappert,et al.  β‐catenin is a target for the ubiquitin–proteasome pathway , 1997 .

[53]  E. Monti,et al.  HIF-1 as a target for cancer chemotherapy, chemosensitization and chemoprevention. , 2011, Current molecular pharmacology.

[54]  K. Chrzanowska,et al.  Mystery of DNA repair: the role of the MRN complex and ATM kinase in DNA damage repair , 2010, Journal of Applied Genetics.

[55]  Jun O. Liu,et al.  RNA-binding proteins HuR and PTB promote the translation of hypoxia-inducible factor 1alpha. , 2008, Molecular and cellular biology.

[56]  Jiri Bartek,et al.  ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks , 2006, Nature Cell Biology.

[57]  R. Abraham mTOR as a positive regulator of tumor cell responses to hypoxia. , 2004, Current topics in microbiology and immunology.

[58]  G. Goodall,et al.  Hypoxia-inducible factor-1alpha mRNA contains an internal ribosome entry site that allows efficient translation during normoxia and hypoxia. , 2002, Molecular biology of the cell.

[59]  R Kemler,et al.  beta-catenin is a target for the ubiquitin-proteasome pathway. , 1997, The EMBO journal.