ATR controls cellular adaptation to hypoxia through positive regulation of hypoxia-inducible factor 1 (HIF-1) expression
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C. Muller | B. Salles | S. Britton | F. Fallone | L. Nieto | Laurence Nieto
[1] G. Semenza,et al. Hypoxia-Inducible Factors in Physiology and Medicine , 2012, Cell.
[2] Chuanxin Wang,et al. Underexpressed microRNA‐199b‐5p targets Hypoxia‐Inducible Factor‐1α in hepatocellular carcinoma and predicts prognosis of hepatocellular carcinoma patients , 2011, Journal of gastroenterology and hepatology.
[3] C. Santocanale,et al. Hypoxic activation of ATR and the suppression of the initiation of DNA replication through cdc6 degradation , 2011, Oncogene.
[4] P. Reaper,et al. Selective killing of ATM- or p53-deficient cancer cells through inhibition of ATR. , 2011, Nature chemical biology.
[5] D. Biard,et al. A DNA-dependent stress response involving DNA-PK occurs in hypoxic cells and contributes to cellular adaptation to hypoxia , 2011, Journal of Cell Science.
[6] S. Rocha,et al. Evolutionary Conserved Regulation of HIF-1β by NF-κB , 2011, PLoS genetics.
[7] O. Fernandez-Capetillo,et al. The ATR barrier to replication-born DNA damage. , 2010, DNA repair.
[8] M. Hentze,et al. Mechanism of translational regulation by miR-2 from sites in the 5' untranslated region or the open reading frame. , 2010, RNA.
[9] P. Houghton,et al. mTORC1 signaling under hypoxic conditions is controlled by ATM-dependent phosphorylation of HIF-1α. , 2010, Molecular cell.
[10] W. Wong,et al. Hypoxia-inducible factors and the response to hypoxic stress. , 2010, Molecular cell.
[11] C. Dray,et al. Loss of ATM positively regulates the expression of hypoxia inducible factor 1 (HIF-1) through oxidative stress: Role in the physiopathology of the disease , 2010, Cell cycle.
[12] Eng-Hui Chew,et al. Inhibition of Hypoxia-Inducible Factor-1α (HIF-1α) Protein Synthesis by DNA Damage Inducing Agents , 2010, PloS one.
[13] A. Kulkarni,et al. ATR preferentially interacts with common fragile site FRA3B and the binding requires its kinase activity in response to aphidicolin treatment. , 2010, Mutation research.
[14] Zhuoshun Yang,et al. Regulation of HIF-1α and VEGF by miR-20b Tunes Tumor Cells to Adapt to the Alteration of Oxygen Concentration , 2009, PloS one.
[15] D. Cortez,et al. Common mechanisms of PIKK regulation. , 2009, DNA repair.
[16] G. Melillo,et al. Development of HIF-1 inhibitors for cancer therapy , 2009, Journal of cellular and molecular medicine.
[17] M. Gorospe,et al. RNA-binding proteins implicated in the hypoxic response , 2009, Journal of cellular and molecular medicine.
[18] A. Nussenzweig,et al. Histone H2AX is integral to hypoxia-driven neovascularization , 2009, Nature Medicine.
[19] J. Pouysségur,et al. HIF at a glance , 2009, Journal of Cell Science.
[20] D. W. Kim,et al. DNA‐dependent protein kinase is involved in heat shock protein‐mediated accumulation of hypoxia‐inducible factor‐1α in hypoxic preconditioned HepG2 cells , 2008, The FEBS journal.
[21] A. Giaccia,et al. Hypoxic Conditions Atm Activation and Signaling Under , 2008 .
[22] G. Powis,et al. HIF-1 regulation: not so easy come, easy go. , 2008, Trends in biochemical sciences.
[23] E. Crescenzi,et al. Ataxia Telangiectasia Mutated and p21CIP1 Modulate Cell Survival of Drug-Induced Senescent Tumor Cells: Implications for Chemotherapy , 2008, Clinical Cancer Research.
[24] Jun O. Liu,et al. RNA-Binding Proteins HuR and PTB Promote the Translation of Hypoxia-Inducible Factor 1α , 2007, Molecular and Cellular Biology.
[25] G. Melillo,et al. UVC inhibits HIF-1α protein translation by a DNA damage- and topoisomerase I-independent pathway , 2007, Oncogene.
[26] G. Semenza. Evaluation of HIF-1 inhibitors as anticancer agents. , 2007, Drug discovery today.
[27] K. Cimprich,et al. The ATR pathway: fine-tuning the fork. , 2007, DNA repair.
[28] J. Pouysségur,et al. Harnessing the hypoxia-inducible factor in cancer and ischemic disease. , 2007, Biochemical pharmacology.
[29] Z. Ahmed,et al. cDNA cloning, gene organization and variant specific expression of HIF-1 alpha in high altitude yak (Bos grunniens). , 2007, Gene.
[30] N. Lakin,et al. Recruitment of ATR to sites of ionising radiation-induced DNA damage requires ATM and components of the MRN protein complex , 2006, Oncogene.
[31] J. Myers,et al. Rapid Activation of ATR by Ionizing Radiation Requires ATM and Mre11* , 2006, Journal of Biological Chemistry.
[32] M. Cuadrado,et al. ATM regulates ATR chromatin loading in response to DNA double-strand breaks , 2006, The Journal of experimental medicine.
[33] S. Gibson,et al. Hypoxia-induced phosphorylation of Chk2 in an ataxia telangiectasia mutated-dependent manner. , 2005, Cancer research.
[34] Petra de Graaf,et al. Phosphorylation of Hdmx mediates its Hdm2- and ATM-dependent degradation in response to DNA damage. , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[35] C. Muller,et al. The membrane form of the DNA repair protein Ku interacts at the cell surface with metalloproteinase 9 , 2004, The EMBO journal.
[36] A. Giaccia,et al. Inhibition of ATR Leads to Increased Sensitivity to Hypoxia/Reoxygenation , 2004, Cancer Research.
[37] M. Tilby,et al. A novel DNA-dependent protein kinase inhibitor, NU7026, potentiates the cytotoxicity of topoisomerase II poisons used in the treatment of leukemia. , 2004, Blood.
[38] A. Giaccia,et al. Comparison of hypoxia-induced replication arrest with hydroxyurea and aphidicolin-induced arrest. , 2003, Mutation research.
[39] G. Semenza. Targeting HIF-1 for cancer therapy , 2003, Nature Reviews Cancer.
[40] N. Curtin,et al. Radiosensitization and DNA repair inhibition by the combined use of novel inhibitors of DNA-dependent protein kinase and poly(ADP-ribose) polymerase-1. , 2003, Cancer research.
[41] Stephen J. Elledge,et al. Sensing DNA Damage Through ATRIP Recognition of RPA-ssDNA Complexes , 2003, Science.
[42] A. Giaccia,et al. ATR/ATM Targets Are Phosphorylated by ATR in Response to Hypoxia and ATM in Response to Reoxygenation* , 2003, The Journal of Biological Chemistry.
[43] A. Harris,et al. GLUT‐1 and CAIX as intrinsic markers of hypoxia in carcinoma of the cervix: Relationship to pimonidazole binding , 2003, International journal of cancer.
[44] Christine C. Hudson,et al. Regulation of Hypoxia-Inducible Factor 1α Expression and Function by the Mammalian Target of Rapamycin , 2002, Molecular and Cellular Biology.
[45] G. Goodall,et al. Hypoxia-inducible Factor-1 (cid:1) mRNA Contains an Internal Ribosome Entry Site That Allows Efficient Translation during Normoxia and Hypoxia , 2022 .
[46] S. Schreiber,et al. ATR inhibition selectively sensitizes G1 checkpoint-deficient cells to lethal premature chromatin condensation , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[47] G. Semenza,et al. HER2 (neu) Signaling Increases the Rate of Hypoxia-Inducible Factor 1α (HIF-1α) Synthesis: Novel Mechanism for HIF-1-Mediated Vascular Endothelial Growth Factor Expression , 2001, Molecular and Cellular Biology.
[48] F. Ismail-Beigi,et al. Regulation of glut1 mRNA by Hypoxia-inducible Factor-1 , 2001, The Journal of Biological Chemistry.
[49] G. Semenza,et al. Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics. , 2000, Cancer research.
[50] A. Koong,et al. Loss of PTEN facilitates HIF-1-mediated gene expression. , 2000, Genes & development.
[51] S. Gygi,et al. Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism. , 1999, Genes & development.
[52] Jörg Stappert,et al. β‐catenin is a target for the ubiquitin–proteasome pathway , 1997 .
[53] E. Monti,et al. HIF-1 as a target for cancer chemotherapy, chemosensitization and chemoprevention. , 2011, Current molecular pharmacology.
[54] K. Chrzanowska,et al. Mystery of DNA repair: the role of the MRN complex and ATM kinase in DNA damage repair , 2010, Journal of Applied Genetics.
[55] Jun O. Liu,et al. RNA-binding proteins HuR and PTB promote the translation of hypoxia-inducible factor 1alpha. , 2008, Molecular and cellular biology.
[56] Jiri Bartek,et al. ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks , 2006, Nature Cell Biology.
[57] R. Abraham. mTOR as a positive regulator of tumor cell responses to hypoxia. , 2004, Current topics in microbiology and immunology.
[58] G. Goodall,et al. Hypoxia-inducible factor-1alpha mRNA contains an internal ribosome entry site that allows efficient translation during normoxia and hypoxia. , 2002, Molecular biology of the cell.
[59] R Kemler,et al. beta-catenin is a target for the ubiquitin-proteasome pathway. , 1997, The EMBO journal.