Assessment of the lung microstructure in patients with asthma using hyperpolarized 3He diffusion MRI at two time scales: Comparison with healthy subjects and patients with COPD

To investigate short‐ and long‐time‐scale 3He diffusion in asthma.

[1]  W. Busse,et al.  Severe asthma in adults: what are the important questions? , 2007, The Journal of allergy and clinical immunology.

[2]  Aaron Fenster,et al.  Hyperpolarized 3He Ventilation Defects and Apparent Diffusion Coefficients in Chronic Obstructive Pulmonary Disease: Preliminary Results at 3.0 Tesla , 2007, Investigative radiology.

[3]  J. Wild,et al.  Single‐scan acquisition of registered hyperpolarized 3He ventilation and ADC images using a hybrid 2D gradient‐echo sequence , 2007, Magnetic resonance in medicine.

[4]  H. Kauczor,et al.  Clinical aspects of the apparent diffusion coefficient in 3He MRI: Results in healthy volunteers and patients after lung transplantation , 2007, Journal of magnetic resonance imaging : JMRI.

[5]  D. Curran‐Everett,et al.  Characterization of the severe asthma phenotype by the National Heart, Lung, and Blood Institute's Severe Asthma Research Program. , 2007, The Journal of allergy and clinical immunology.

[6]  Dmitriy A Yablonskiy,et al.  In vivo lung morphometry with hyperpolarized 3He diffusion MRI in canines with induced emphysema: disease progression and comparison with computed tomography. , 2007, Journal of applied physiology.

[7]  Sean B Fain,et al.  Early emphysematous changes in asymptomatic smokers: detection with 3He MR imaging. , 2006, Radiology.

[8]  Dmitriy A Yablonskiy,et al.  Hyperpolarized 3He diffusion MRI and histology in pulmonary emphysema , 2006, Magnetic resonance in medicine.

[9]  John P Mugler,et al.  Assessment of lung development using hyperpolarized helium‐3 diffusion MR imaging , 2006, Journal of magnetic resonance imaging : JMRI.

[10]  Ray F. Lee,et al.  Diffusional kurtosis imaging in the lung using hyperpolarized 3He , 2006, Magnetic resonance in medicine.

[11]  John P Mugler,et al.  Evaluation of asthma with hyperpolarized helium-3 MRI: correlation with clinical severity and spirometry. , 2006, Chest.

[12]  G. Miller,et al.  Time dependence of 3He diffusion in the human lung: Measurement in the long‐time regime using stimulated echoes , 2006, Magnetic resonance in medicine.

[13]  A. Sukstanskii,et al.  3He diffusion MRI of the lung. , 2005, Academic radiology.

[14]  John P Mugler,et al.  Detection of age-dependent changes in healthy adult lungs with diffusion-weighted 3He MRI. , 2005, Academic radiology.

[15]  J. Hogg,et al.  Long-range diffusion of hyperpolarized 3He in explanted normal and emphysematous human lungs via magnetization tagging. , 2005, Journal of applied physiology.

[16]  Jörg Schmiedeskamp,et al.  Diffusion‐weighted MRI of the lung with hyperpolarized helium‐3: A study of reproducibility , 2005, Journal of magnetic resonance imaging : JMRI.

[17]  R. Stockley,et al.  COPD: current therapeutic interventions and future approaches , 2005, European Respiratory Journal.

[18]  Neil Woodhouse,et al.  Emphysematous changes and normal variation in smokers and COPD patients using diffusion 3He MRI. , 2005, European journal of radiology.

[19]  E. V. van Beek,et al.  Measurements and modeling of long range 3He diffusion in the lung using a "slice-washout" method. , 2005, Journal of magnetic resonance.

[20]  Jiangsheng Yu,et al.  Hyperpolarized helium-3 MR imaging of pulmonary function. , 2005, Radiologic clinics of North America.

[21]  John P Mugler,et al.  Functional MRI of the lung using hyperpolarized 3‐helium gas , 2004, Journal of magnetic resonance imaging : JMRI.

[22]  K. Leslie,et al.  Practical Pulmonary Pathology: A Diagnostic Approach , 2004 .

[23]  Balthasar Eberle,et al.  Functional Evaluation of Emphysema Using Diffusion-Weighted 3Helium-Magnetic Resonance Imaging, High-Resolution Computed Tomography, and Lung Function Tests , 2004, Investigative radiology.

[24]  Dmitriy A Yablonskiy,et al.  Magnetization tagging decay to measure long‐range 3He diffusion in healthy and emphysematous canine lungs , 2004, Magnetic resonance in medicine.

[25]  N. Obuchowski Receiver operating characteristic curves and their use in radiology. , 2003, Radiology.

[26]  V. Callot,et al.  Helium-3 MRI diffusion coefficient: correlation to morphometry in a model of mild emphysema , 2003, European Respiratory Journal.

[27]  Dmitriy A Yablonskiy,et al.  Quantitative in vivo assessment of lung microstructure at the alveolar level with hyperpolarized 3He diffusion MRI , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[28]  John P Mugler,et al.  Emphysema: hyperpolarized helium 3 diffusion MR imaging of the lungs compared with spirometric indexes--initial experience. , 2002, Radiology.

[29]  J. Mayo,et al.  Hyperpolarized helium 3 diffusion imaging of the lung. , 2002, Radiology.

[30]  L W Hedlund,et al.  Detection of emphysema in rat lungs by using magnetic resonance measurements of 3He diffusion. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[31]  D. Yablonskiy,et al.  MR imaging of diffusion of 3He gas in healthy and diseased lungs , 2000, Magnetic resonance in medicine.

[32]  L W Hedlund,et al.  Spatially resolved measurements of hyperpolarized gas properties in the lung in vivo. Part I: Diffusion coefficient , 1999, Magnetic resonance in medicine.

[33]  R. Reddy,et al.  An MR imaging method for simultaneous measurement of gaseous diffusion constant and longitudinal relaxation time. , 1999, Magnetic resonance imaging.

[34]  W. Webb,et al.  Air trapping on expiratory high-resolution CT scans in the absence of inspiratory scan abnormalities: correlation with pulmonary function tests and differential diagnosis. , 1998, AJR. American journal of roentgenology.

[35]  M. Bock Simultaneous T2* and diffusion measurements with 3He , 1997, Magnetic resonance in medicine.

[36]  R. Djukanović,et al.  Alveolar tissue inflammation in asthma. , 1996, American journal of respiratory and critical care medicine.

[37]  E. Miron,et al.  Polarization of the nuclear spins of noble-gas atoms by spin exchange with optically pumped alkali-metal atoms , 1984 .

[38]  M. Lebowitz,et al.  Changes in the normal maximal expiratory flow-volume curve with growth and aging. , 1983, The American review of respiratory disease.

[39]  O. Raabe,et al.  Structure of the human respiratory acinus. , 1981, The American journal of anatomy.