The Maximal Amount of Dietary α-Tocopherol Intake in U.S. Adults (NHANES 2001–2002)

The current study was designed to determine the maximal amount of alpha-tocopherol intake obtained from food in the U.S. diet, and to examine the effect of different food group intakes on this amount. Data from 2138 men and 2213 women aged >18 y were obtained from the National Health and Nutrition Examination Survey (NHANES) 2001-2002. Linear programming was used to generate diets with maximal alpha-tocopherol intake, with the conditions of meeting the recommended daily allowances or adequate intakes for a set of nutrients, sodium and fat recommendations, and energy limits, and that were compatible with the observed dietary patterns in the population. With food use and energy constraints in models, diets formulated by linear programming provided 19.3-24.9 mg alpha-tocopherol for men and women aged 19-50 or >50 y. These amounts decreased to 15.4-19.9 mg with the addition of the sodium, dietary reference intake, and fat constraints. The relations between maximal alpha-tocopherol intake and food group intakes were influenced by total fat restrictions. Although meeting current recommendations (15 mg/d) appears feasible for individuals, dramatic dietary changes that include greater intakes of nuts and seeds, and fruit and vegetables, are needed. Careful selection of the highest vitamin E source foods within these groups could further increase the likelihood of meeting the current recommended daily allowance.

[1]  S. Yusuf,et al.  Effects of long-term vitamin E supplementation on cardiovascular events and cancer: a randomized controlled trial. , 2005, JAMA.

[2]  R. Mattes,et al.  Peanut Consumption Improves Indices of Cardiovascular Disease Risk in Healthy Adults , 2003, Journal of the American College of Nutrition.

[3]  M. Horwitt.  Critique of the requirement for vitamin E. , 2001, The American journal of clinical nutrition.

[4]  P. Loehrer.  Vitamin E in the Primary Prevention of Cardiovascular Disease and Cancer: The Women's Health Study: A Randomized Controlled Trial , 2006 .

[5]  M. Slattery,et al.  Antioxidants, carotenoids, and risk of rectal cancer. , 2004, American journal of epidemiology.

[6]  S. Virtanen,et al.  Dietary intakes and plasma concentrations of carotenoids and tocopherols in relation to glucose metabolism in subjects at high risk of type 2 diabetes: the Botnia Dietary Study. , 2003, The American journal of clinical nutrition.

[7]  N. Darmon,et al.  A cost constraint alone has adverse effects on food selection and nutrient density: an analysis of human diets by linear programming. , 2002, The Journal of nutrition.

[8]  D. Albanes,et al.  The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers. , 1994, The New England journal of medicine.

[9]  Vitamin E consumption and the risk of coronary disease in women. , 1993 .

[10]  D. Sklan,et al.  Diet planning for humans using mixed-integer linear programming , 1993, British Journal of Nutrition.

[11]  Elaine Ferguson,et al.  Do economic constraints encourage the selection of energy dense diets? , 2003, Appetite.

[12]  M. Rafiei,et al.  Vitamin E can Reduce Blood Pressure in Mild Hypertensives , 2002 .

[13]  F. Hu,et al.  Nut consumption and risk of coronary heart disease: A review of epidemiologic evidence , 1999, Current atherosclerosis reports.

[14]  P. Conforti,et al.  What is the cost of a healthy diet in terms of achieving RDAs? , 2000, Public Health Nutrition.

[15]  K. Tucker,et al.  Intake of α-tocopherol is limited among US adults , 2004 .

[16]  A. Waterhouse,et al.  Walnut polyphenolics inhibit in vitro human plasma and LDL oxidation. , 2001, The Journal of nutrition.

[17]  Roberto Pastor-Barriuso,et al.  Meta-Analysis: High-Dosage Vitamin E Supplementation May Increase All-Cause Mortality , 2005 .

[18]  K. Tucker,et al.  Intake of alpha-tocopherol is limited among US adults. , 2004, Journal of the American Dietetic Association.

[19]  J. Manson,et al.  Frequent nut consumption and risk of coronary heart disease in women: prospective cohort study , 1998, BMJ.

[20]  E. Ros,et al.  A Walnut Diet Improves Endothelial Function in Hypercholesterolemic Subjects: A Randomized Crossover Trial , 2004, Circulation.

[21]  J. G. Bieri.  Comments on the new dietary reference intake for vitamin E. , 2002, The American journal of clinical nutrition.

[22]  K Darby-Dowman,et al.  Developments in linear and integer programming , 2002, J. Oper. Res. Soc..

[23]  J. Manson,et al.  Nut consumption and decreased risk of sudden cardiac death in the Physicians' Health Study. , 2002, Archives of internal medicine.

[24]  J. Manson,et al.  Does vitamin E supplementation prevent cardiovascular events? , 2003, Journal of women's health.

[25]  Antonio Martín.  Antioxidant vitamins E and C and risk of Alzheimer's disease. , 2003, Nutrition reviews.

[26]  Deborah Gustafson,et al.  Reduced risk of Alzheimer disease in users of antioxidant vitamin supplements: the Cache County Study. , 2004, Archives of neurology.

[27]  Julia L. Higle,et al.  Sensitivity Analysis and Uncertainty in Linear Programming , 2003, Interfaces.

[28]  G. Block,et al.  Vitamin E intakes and sources in the United States. , 1990, The American journal of clinical nutrition.

[29]  S. Panico,et al.  Dietary and circulating antioxidant vitamins in relation to carotid plaques in middle-aged women. , 2002, The American journal of clinical nutrition.

[30]  A. Hölscher,et al.  Vitamin intake and risk of subtypes of esophageal cancer in Germany , 2002, Journal of Cancer Research and Clinical Oncology.

[31]  J. Ahuja,et al.  Current Status of Vitamin E Nutriture , 2004, Annals of the New York Academy of Sciences.

[32]  R. Russell,et al.  Essential nutrients: food or supplements? Where should the emphasis be? , 2005, JAMA.

[33]  S. Passi,et al.  Rate of degradation of alpha-tocopherol, squalene, phenolics, and polyunsaturated fatty acids in olive oil during different storage conditions. , 2002, Journal of agricultural and food chemistry.

[34]  A. Reunanen,et al.  Low vitamin E status is a potential risk factor for insulin‐dependent diabetes mellitus , 1999, Journal of internal medicine.

[35]  N. Darmon,et al.  Determining limiting nutrients by linear programming: A new approach to predict insufficient intakes from complementary foods. , 2000, Pediatrics.

[36]  E. Mayer-Davis,et al.  Plasma and dietary vitamin E in relation to incidence of type 2 diabetes: The Insulin Resistance and Atherosclerosis Study (IRAS). , 2002, Diabetes care.

[37]  A. Hofman,et al.  Dietary Intake of Antioxidants and Risk of Alzheimer Disease , 2002 .

[38]  I. M. Premachandra,et al.  Food-based dietary guidelines can be developed and tested using linear programming analysis. , 2004, The Journal of nutrition.

[39]  Kuresh Youdim,et al.  Roles of vitamins E and C on neurodegenerative diseases and cognitive performance. , 2002, Nutrition reviews.

[40]  M. Cheung,et al.  Phase II study of alpha‐tocopherol in improving the cognitive function of patients with temporal lobe radionecrosis , 2004, Cancer.

[41]  D. Bennett,et al.  Dietary Intake of Antioxidant Nutrients and the Risk of Incident Alzheimer Disease in a Biracial Community Study , 2022 .