The hubs of the human connectome are generally implicated in the anatomy of brain disorders

See Sporns (doi:10.1093/brain/awu148) for a scientific commentary on this article. Brain networks contain a minority of highly connected hub nodes with high topological value and biological cost. Using network analysis of DTI data from healthy volunteers, and meta-analyses of published MRI studies in 26 brain disorders, Crossley et al. show that lesions across disorders tend to be concentrated at hubs.

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