A true chondroma cutis

© 2008 The Authors JEADV 2009, 23, 570–620 Journal compilation © 2008 European Academy of Dermatology and Venereology then induced antibodies, forming immune complexes or precipitating allergic hypersensitivity reactions. Histologically, GF is characterized by the presence of a Grenz zone, as well as by many eosinophils and neutrophils within the infiltrate. Although our patient did not show a Grenz zone, his other clinical and histopathologic findings were compatible with GF. Moreover, 26% of GFs do not show a Grenz zone,2 and in one case of GF following trauma, a Grenz zone was not present in a biopsy specimen obtained after four intralesional steroid injections.3 In cases of trauma, antigens or allergens likely originate from the epidermis or the superficial part of the dermis, so that inflammatory infiltrates are also located below the epidermis, resulting in no Grenz zone. The treatment of GF is quite difficult. Although many anecdotal reports have described the successful treatment of GF, no standardized treatment exists. In our patient, the lesion did not improve following dapsone treatment; hence, we are considering treatment with a pulsed dye laser and topical tacrolimus ointment.