A Longitudinal Study of Operant Responding in RatsIrradiated when 2 Months Old

Abstract Rabin, B. M., Joseph, J. A. and Shukitt-Hale, B. A Longitudinal Study of Operant Responding in Rats Irradiated when 2 Months Old. Radiat. Res. 164, 552–555 (2005). Two-month-old rats were exposed to 56Fe particles (1, 1. 5, 2 Gy; 1 GeV/nucleon). They were tested on the performance of an ascending fixed-ratio operant task (bar pressing for food reward) at 7, 11 and 15 months after irradiation. Previous research had shown that for the same rats tested at 3 months after exposure, only the rats exposed to 2 Gy of 56Fe particles showed a significant disruption of performance compared to control (0 Gy) rats. When these rats were tested 7, 11 and 15 months after exposure, all irradiated groups showed significantly poorer performance than the controls. These results suggest that there is an interaction between irradiation and age such that 56Fe-particle-induced performance deficits can develop several months after exposure.

[1]  John D. Salamone,et al.  The role of brain dopamine in response initiation: effects of haloperidol and regionally specific dopamine depletions on the local rate of instrumental responding , 1993, Brain Research.

[2]  J. Vry,et al.  Effects of serotonin 5-HT1/2 receptor agonists in a limited-access operant food intake paradigm in the rat , 2003, European Neuropsychopharmacology.

[3]  J. Salamone,et al.  Nucleus accumbens dopamine depletions make animals highly sensitive to high fixed ratio requirements but do not impair primary food reinforcement , 2001, Neuroscience.

[4]  B. Shukitt-Hale,et al.  Effects of exposure to 56Fe particles or protons on fixed-ratio operant responding in rats. , 2002, Journal of radiation research.

[5]  G. Gerhardt,et al.  Regional effects of aging on dopaminergic function in the Fischer-344 rat , 1992, Neurobiology of Aging.

[6]  B. Shukitt-Hale,et al.  Spatial Learning and Memory Deficits Induced by Exposure to Iron-56-Particle Radiation , 2000, Radiation research.

[7]  J. Joseph,et al.  Possible "accelerated striatal aging" induced by 56Fe heavy-particle irradiation: implications for manned space flights. , 1992, Radiation research.

[8]  J. Miller,et al.  Detailed characterization of the 1087 MeV/nucleon iron-56 beam used for radiobiology at the alternating gradient synchrotron. , 1998, Radiation research.

[9]  J. de Vry,et al.  Partial agonist-like profile of the cannabinoid receptor antagonist SR141716A in a food-reinforced operant paradigm , 2004, Behavioural pharmacology.

[10]  J. Joseph,et al.  Reductions of 56Fe heavy-particle irradiation-induced deficits in striatal muscarinic receptor sensitivity by selective cross-activation/inhibition of second-messenger systems. , 1994, Radiation research.

[11]  J. Salamone,et al.  Motivational views of reinforcement: implications for understanding the behavioral functions of nucleus accumbens dopamine , 2002, Behavioural Brain Research.

[12]  M. Paule,et al.  Effects of atropine on operant test battery performance in rhesus monkeys. , 1992, Life sciences.

[13]  B. Shukitt-Hale,et al.  CNS-induced deficits of heavy particle irradiation in space: the aging connection. , 2000, Advances in space research : the official journal of the Committee on Space Research.

[14]  M. Hoane,et al.  Incomplete nigrostriatal dopaminergic cell loss and partial reductions in striatal dopamine produce akinesia, rigidity, tremor and cognitive deficits in middle-aged rats , 1999, Behavioural Brain Research.

[15]  C. Nemeroff,et al.  Behavioral effects of neurotensin: operant responding and assessment of 'anhedonia'. , 1989, European journal of pharmacology.

[16]  Dwaine F Emerich,et al.  Rats with partial striatal dopamine depletions exhibit robust and long-lasting behavioral deficits in a simple fixed-ratio bar-pressing task , 1997, Behavioural Brain Research.

[17]  B. Shukitt-Hale,et al.  The effects of heavy particle irradiation on exploration and response to environmental change. , 2004, Advances in space research : the official journal of the Committee on Space Research.