Systemic inflammation in early neonatal mice induces transient and lasting neurodegenerative effects

[1]  L. Bekar,et al.  Acute systemic LPS-mediated inflammation induces lasting changes in mouse cortical neuromodulation and behavior , 2015, Neuroscience Letters.

[2]  D. Brites,et al.  Bilirubin-induced neural impairment: a special focus on myelination, age-related windows of susceptibility and associated co-morbidities. , 2015, Seminars in fetal & neonatal medicine.

[3]  A. Zea-Vera,et al.  Challenges in the diagnosis and management of neonatal sepsis. , 2015, Journal of tropical pediatrics.

[4]  S. Commins,et al.  Lipopolysaccharide-induced sepsis induces long-lasting affective changes in the mouse , 2015, Brain, Behavior, and Immunity.

[5]  Yingwei Chen,et al.  Curcumin suppresses NLRP3 inflammasome activation and protects against LPS-induced septic shock. , 2013, Molecular nutrition & food research.

[6]  G. J. Harry,et al.  Autotaxin Downregulates LPS‐Induced Microglia Activation and Pro‐Inflammatory Cytokines Production , 2014, Journal of cellular biochemistry.

[7]  D. Lambert,et al.  Exploring LPS-induced sepsis in rats and mice as a model to study potential protective effects of the nociceptin/orphanin FQ system , 2014, Peptides.

[8]  P. Trifilieff,et al.  Inflammation early in life is a vulnerability factor for emotional behavior at adolescence and for lipopolysaccharide-induced spatial memory and neurogenesis alteration at adulthood , 2014, Journal of Neuroinflammation.

[9]  N. Terrando,et al.  Prolonged Neuroinflammation after Lipopolysaccharide Exposure in Aged Rats , 2014, PloS one.

[10]  T. Inder,et al.  Infection-induced inflammation and cerebral injury in preterm infants. , 2014, The Lancet. Infectious diseases.

[11]  B. Sepodes,et al.  Neuroprotective effects of erythropoietin pretreatment in a rodent model of transient middle cerebral artery occlusion. , 2014, Journal of neurosurgery.

[12]  L. Bodea,et al.  Neurodegeneration by Activation of the Microglial Complement–Phagosome Pathway , 2014, The Journal of Neuroscience.

[13]  Adelaide Fernandes,et al.  Microglia change from a reactive to an age-like phenotype with the time in culture , 2014, Front. Cell. Neurosci..

[14]  A. Gunn,et al.  Synergistic white matter protection with acute-on-chronic endotoxin and subsequent asphyxia in preterm fetal sheep , 2014, Journal of Neuroinflammation.

[15]  J. Baizer.  Unique Features of the Human Brainstem and Cerebellum , 2014, Front. Hum. Neurosci..

[16]  Dorian B. McGavern,et al.  Microglia development and function. , 2014, Annual review of immunology.

[17]  H. Hagberg,et al.  Neonatal Peripheral Immune Challenge Activates Microglia and Inhibits Neurogenesis in the Developing Murine Hippocampus , 2014, Developmental Neuroscience.

[18]  Francesco Sforazzini,et al.  Deficient neuron-microglia signaling results in impaired functional brain connectivity and social behavior , 2014, Nature Neuroscience.

[19]  C. Pierson,et al.  Perinatal inflammation results in decreased oligodendrocyte numbers in adulthood. , 2014, Life sciences.

[20]  R. Procianoy,et al.  Association of late-onset neonatal sepsis with late neurodevelopment in the first two years of life of preterm infants with very low birth weight. , 2014, Jornal de pediatria.

[21]  Rui F. M. Silva,et al.  Cross-Talk Between Neurons and Astrocytes in Response to Bilirubin: Adverse Secondary Impacts , 2013, Neurotoxicity Research.

[22]  B. Giros,et al.  Morphometric characterization of microglial phenotypes in human cerebral cortex , 2014, Journal of Neuroinflammation.

[23]  H. Hagberg,et al.  Decreased survival of newborn neurons in the dorsal hippocampus after neonatal LPS exposure in mice , 2013, Neuroscience.

[24]  J. Neil,et al.  New MR Imaging Assessment Tool to Define Brain Abnormalities in Very Preterm Infants at Term , 2013, American Journal of Neuroradiology.

[25]  R. Dantzer,et al.  NMDA Receptor Blockade by Ketamine Abrogates Lipopolysaccharide-Induced Depressive-Like Behavior in C57BL/6J Mice , 2013, Neuropsychopharmacology.

[26]  Stéphane Marret,et al.  Neonatal Infection and 5-year Neurodevelopmental Outcome of Very Preterm Infants , 2013, Pediatrics.

[27]  R. Lin,et al.  Differential roles of astrocyte and microglia in supporting oligodendrocyte development and myelination in vitro , 2013, Brain and behavior.

[28]  J. Granger,et al.  Sepsis-induced morbidity in mice: Effects on body temperature, body weight, cage activity, social behavior and cytokines in brain , 2013, Psychoneuroendocrinology.

[29]  H. Luhmann,et al.  LPS-induced microglial secretion of TNFα increases activity-dependent neuronal apoptosis in the neonatal cerebral cortex. , 2013, Cerebral cortex.

[30]  L. Fan,et al.  Celecoxib attenuates systemic lipopolysaccharide-induced brain inflammation and white matter injury in the neonatal rats , 2013, Neuroscience.

[31]  J. Nabekura,et al.  Microglia and synapse interactions: fine tuning neural circuits and candidate molecules , 2013, Front. Cell. Neurosci..

[32]  K. Kelley,et al.  Interleukin-1 beta converting enzyme is necessary for development of depression-like behavior following intracerebroventricular administration of lipopolysaccharide to mice , 2013, Journal of Neuroinflammation.

[33]  H. Ozkan,et al.  Protective effects of pentoxifylline on lipopolysaccharide-induced white matter injury in a rat model of periventricular leukomalasia , 2013, The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians.

[34]  P. Gressens,et al.  Maternal Exposure to Lipopolysaccharide Leads to Transient Motor Dysfunction in Neonatal Rats , 2013, Developmental Neuroscience.

[35]  R. Sauve,et al.  Neurodevelopmental outcomes of very low birth weight infants with neonatal sepsis: systematic review and meta-analysis , 2013, Journal of Perinatology.

[36]  Yan Zeng,et al.  Nitric oxide suppresses NLRP3 inflammasome activation and protects against LPS-induced septic shock , 2013, Cell Research.

[37]  C. Cunningham.  Microglia and neurodegeneration: The role of systemic inflammation , 2013, Glia.

[38]  V. Aidinis,et al.  Lysoglycerophospholipids in chronic inflammatory disorders: the PLA(2)/LPC and ATX/LPA axes. , 2013, Biochimica et biophysica acta.

[39]  J. Filosa,et al.  A quantitative spatiotemporal analysis of microglia morphology during ischemic stroke and reperfusion , 2013, Journal of Neuroinflammation.

[40]  P. Sarret,et al.  Postnatal administration of IL-1Ra exerts neuroprotective effects following perinatal inflammation and/or hypoxic-ischemic injuries , 2012, Brain, Behavior, and Immunity.

[41]  E. Friauf,et al.  Purkinje cell loss and motor coordination defects in profilin1 mutant mice , 2012, Neuroscience.

[42]  B. Zinselmeyer,et al.  In vivo dynamics of innate immune sentinels in the CNS , 2012, Intravital.

[43]  D. Butterfield,et al.  Lipopolysaccharide impairs amyloid beta efflux from brain: altered vascular sequestration, cerebrospinal fluid reabsorption, peripheral clearance and transporter function at the blood–brain barrier , 2012, Journal of Neuroinflammation.

[44]  V. Perry,et al.  Long-term impact of systemic bacterial infection on the cerebral vasculature and microglia , 2012, Journal of Neuroinflammation.

[45]  G. Martin.  Sepsis, severe sepsis and septic shock: changes in incidence, pathogens and outcomes , 2012, Expert review of anti-infective therapy.

[46]  P. Gressens,et al.  Tertiary mechanisms of brain damage: a new hope for treatment of cerebral palsy? , 2012, The Lancet Neurology.

[47]  Á. Kittel,et al.  Exposure to Lipopolysaccharide and/or Unconjugated Bilirubin Impair the Integrity and Function of Brain Microvascular Endothelial Cells , 2012, PloS one.

[48]  J. Pugin,et al.  Innate Immune Deficiency of Extremely Premature Neonates Can Be Reversed by Interferon-γ , 2012, PloS one.

[49]  A. Kraft,et al.  Microglia in the developing brain: a potential target with lifetime effects. , 2012, Neurotoxicology.

[50]  D. Brites,et al.  Neurovascular Unit: a Focus on Pericytes , 2012, Molecular Neurobiology.

[51]  B. Zhao,et al.  Aquaporin-4 deficiency attenuates acute lesions but aggravates delayed lesions and microgliosis after cryoinjury to mouse brain , 2012, Neuroscience Bulletin.

[52]  E. Bourdon,et al.  Autotaxin protects microglial cells against oxidative stress. , 2012, Free radical biology & medicine.

[53]  Xiaoyang Wang,et al.  Infection-Induced Vulnerability of Perinatal Brain Injury , 2011, Neurology research international.

[54]  W. Banks,et al.  Lipopolysaccharide-enhanced transcellular transport of HIV-1 across the blood-brain barrier is mediated by luminal microvessel IL-6 and GM-CSF , 2011, Journal of Neuroinflammation.

[55]  W. Banks,et al.  Cytokine and chemokine responses in serum and brain after single and repeated injections of lipopolysaccharide: Multiplex quantification with path analysis , 2011, Brain, Behavior, and Immunity.

[56]  S. Sizonenko,et al.  Systemic inflammation disrupts the developmental program of white matter , 2011, Annals of neurology.

[57]  J. Volpe.  Systemic inflammation, oligodendroglial maturation, and the encephalopathy of prematurity , 2011, Annals of neurology.

[58]  M. Stins,et al.  How can microbial interactions with the blood–brain barrier modulate astroglial and neuronal function? , 2011, Cellular microbiology.

[59]  Daniel C. Lu,et al.  Aquaporin-4 Reduces Post-Traumatic Seizure Susceptibility by Promoting Astrocytic Glial Scar Formation in Mice. , 2011, Journal of neurotrauma.

[60]  P. Latzin,et al.  Impact of Sepsis on Neurodevelopmental Outcome in a Swiss National Cohort of Extremely Premature Infants , 2011, Pediatrics.

[61]  S. Girard,et al.  Developmental regulation of the neuroinflammatory responses to LPS and/or hypoxia-ischemia between preterm and term neonates: An experimental study , 2011, Journal of Neuroinflammation.

[62]  Ofer Levy,et al.  Systemic Stimulation of TLR2 Impairs Neonatal Mouse Brain Development , 2011, PloS one.

[63]  K. Tracey,et al.  HMGB1 is a therapeutic target for sterile inflammation and infection. , 2011, Annual review of immunology.

[64]  K. Taber,et al.  Sepsis-associated encephalopathy: review of the neuropsychiatric manifestations and cognitive outcome. , 2011, The Journal of neuropsychiatry and clinical neurosciences.

[65]  Hey-kyeong Jeong,et al.  Systemic LPS administration induces brain inflammation but not dopaminergic neuronal death in the substantia nigra , 2010, Experimental & Molecular Medicine.

[66]  J. Li,et al.  Impact of P-Glycoprotein Inhibition and Lipopolysaccharide Administration on Blood-Brain Barrier Transport of Colistin in Mice , 2010, Antimicrobial Agents and Chemotherapy.

[67]  B. Barres,et al.  Pericytes are required for blood–brain barrier integrity during embryogenesis , 2010, Nature.

[68]  J. Saul,et al.  Cardiac Function and Circulating Cytokines After Endotoxin Exposure in Neonatal Mice , 2010, Pediatric Research.

[69]  T. Ogunlesi,et al.  Predictors of mortality in neonatal septicemia in an underresourced setting. , 2010, Journal of the National Medical Association.

[70]  Dora Brites,et al.  Looking at the blood–brain barrier: Molecular anatomy and possible investigation approaches , 2010, Brain Research Reviews.

[71]  H. Togari,et al.  Endothelin receptor antagonist attenuates inflammatory response and prolongs the survival time in a neonatal sepsis model , 2010, Intensive Care Medicine.

[72]  M. Moskowitz,et al.  High-Mobility Group Box 1 Promotes Metalloproteinase-9 Upregulation Through Toll-Like Receptor 4 After Cerebral Ischemia , 2010, Stroke.

[73]  A. Lazosky,et al.  Quality of life after septic illness. , 2010, Journal of critical care.

[74]  H. Saito,et al.  Age-dependent vulnerability to endotoxemia is associated with reduction of anticoagulant factors activated protein C and thrombomodulin. , 2010, Blood.

[75]  C. Mathers,et al.  Global, regional, and national causes of child mortality in 2008: a systematic analysis , 2010, The Lancet.

[76]  S. Maier,et al.  Enduring consequences of early-life infection on glial and neural cell genesis within cognitive regions of the brain , 2010, Brain, Behavior, and Immunity.

[77]  Afonso C. Silva,et al.  Cyclooxygenase-1 and -2 Differentially Modulate Lipopolysaccharide-Induced Blood–Brain Barrier Disruption through Matrix Metalloproteinase Activity , 2010, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[78]  S. M. Robinson,et al.  Minimal penetration of lipopolysaccharide across the murine blood–brain barrier , 2010, Brain, Behavior, and Immunity.

[79]  W. Banks,et al.  The blood–brain barrier and immune function and dysfunction , 2010, Neurobiology of Disease.

[80]  K. Yoo,et al.  Systemic Administration of Lipopolysaccharide Induces Cyclooxygenase-2 Immunoreactivity in Endothelium and Increases Microglia in the Mouse Hippocampus , 2010, Cellular and Molecular Neurobiology.

[81]  H. Togari,et al.  EDARAVONE, A NOVEL FREE RADICAL SCAVENGER, REDUCES HIGH-MOBILITY GROUP BOX 1 AND PROLONGS SURVIVAL IN A NEONATAL SEPSIS MODEL , 2009, Shock.

[82]  H. Hagberg,et al.  Lipopolysaccharide Sensitizes Neonatal Hypoxic-Ischemic Brain Injury in a MyD88-Dependent Manner1 , 2009, The Journal of Immunology.

[83]  D. Sullivan,et al.  Plasmodium falciparum-infected erythrocytes induce NF-kappaB regulated inflammatory pathways in human cerebral endothelium. , 2009, Blood.

[84]  H. Hagberg,et al.  White Matter Damage After Chronic Subclinical Inflammation in Newborn Mice , 2009, Journal of child neurology.

[85]  Chao-Ching Huang,et al.  Lipopolysaccharide Preconditioning Reduces Neuroinflammation Against Hypoxic Ischemia and Provides Long-Term Outcome of Neuroprotection in Neonatal Rat , 2009, Pediatric Research.

[86]  C. Brosnan,et al.  Deletion of Astrocyte Connexins 43 and 30 Leads to a Dysmyelinating Phenotype and Hippocampal CA1 Vacuolation , 2009, The Journal of Neuroscience.

[87]  R. Milner.  Microglial expression of αvβ3 and αvβ5 integrins is regulated by cytokines and the extracellular matrix: β5 Integrin null microglia show no defects in adhesion or MMP‐9 expression on vitronectin , 2009, Glia.

[88]  T. Nishioku,et al.  Detachment of Brain Pericytes from the Basal Lamina is Involved in Disruption of the Blood–Brain Barrier Caused by Lipopolysaccharide-Induced Sepsis in Mice , 2009, Cellular and Molecular Neurobiology.

[89]  Kwang Dong Kim,et al.  Hyper innate responses in neonates lead to increased morbidity and mortality after infection , 2008, Proceedings of the National Academy of Sciences.

[90]  M. Opp,et al.  Modeling sepsis in the laboratory: merging sound science with animal well-being. , 2008, Comparative medicine.

[91]  D. Gomez-Nicola,et al.  Interleukin 15 expression in the CNS: Blockade of its activity prevents glial activation after an inflammatory injury , 2008, Glia.

[92]  R. Kesner.  Behavioral functions of the CA3 subregion of the hippocampus. , 2007, Learning & memory.

[93]  P. Gressens,et al.  Neuronal damage accompanies perinatal white-matter damage , 2007, Trends in Neurosciences.

[94]  Huan Yang,et al.  Chronic Sepsis Mortality Characterized by an Individualized Inflammatory Response1 , 2007, The Journal of Immunology.

[95]  Changlian Zhu,et al.  Effects of intrauterine inflammation on the developing mouse brain , 2007, Brain Research.

[96]  J. Siddiqui,et al.  Mechanisms of Mortality in Early and Late Sepsis , 2006, Infection and Immunity.

[97]  M. Hermansen,et al.  Perinatal infections and cerebral palsy. , 2006, Clinics in perinatology.

[98]  Steffen Jung,et al.  The FASEB Journal • Research Communication The neuronal chemokine CX3CL1/fractalkine , 2022 .

[99]  P. Gressens,et al.  Maternal Exposure to LPS Induces Hypomyelination in the Internal Capsule and Programmed Cell Death in the Deep Gray Matter in Newborn Rats , 2006, Pediatric Research.

[100]  Li Yang,et al.  Endotoxin-Induced Hypoxic-Ischemic Tolerance Is Mediated by Up-regulation of Corticosterone in Neonatal Rat , 2006, Pediatric Research.

[101]  Rui F. M. Silva,et al.  Bilirubin-induced inflammatory response, glutamate release, and cell death in rat cortical astrocytes are enhanced in younger cells , 2005, Neurobiology of Disease.

[102]  Catherine M Sherwin,et al.  Acute Lipopolysaccharide-Mediated Injury in Neonatal White Matter Glia: Role of TNF-α, IL-1β, and Calcium1 , 2005, The Journal of Immunology.

[103]  J. Hell,et al.  Thrombospondins Are Astrocyte-Secreted Proteins that Promote CNS Synaptogenesis , 2005, Cell.

[104]  Catherine M Sherwin,et al.  Acute lipopolysaccharide-mediated injury in neonatal white matter glia: role of TNF-alpha, IL-1beta, and calcium. , 2005, Journal of immunology.

[105]  B. Bilgiç,et al.  Effects of lipopolysaccharide on the radiation-induced changes in the blood–brain barrier and the astrocytes , 2004, Brain Research.

[106]  J. Julien,et al.  Exacerbation of Motor Neuron Disease by Chronic Stimulation of Innate Immunity in a Mouse Model of Amyotrophic Lateral Sclerosis , 2004, The Journal of Neuroscience.

[107]  R. Ravid,et al.  CX3CL1 and CX3CR1 Expression in Human Brain Tissue: Noninflammatory Control versus Multiple Sclerosis , 2003, Journal of neuropathology and experimental neurology.

[108]  A. Sollevi,et al.  Differential release of matrix metalloproteinase‐9 and nitric oxide following infusion of endotoxin to human volunteers , 2003, Acta anaesthesiologica Scandinavica.

[109]  K. Tracey,et al.  HMGB-1, a DNA-binding protein with cytokine activity, induces brain TNF and IL-6 production, and mediates anorexia and taste aversion. , 2002, Cytokine.

[110]  Z. Werb,et al.  How matrix metalloproteinases regulate cell behavior. , 2001, Annual review of cell and developmental biology.

[111]  A. Sher,et al.  Analysis of Fractalkine Receptor CX3CR1 Function by Targeted Deletion and Green Fluorescent Protein Reporter Gene Insertion , 2000, Molecular and Cellular Biology.

[112]  Yoshinori Nagai,et al.  MD-2, a Molecule that Confers Lipopolysaccharide Responsiveness on Toll-like Receptor 4 , 1999, The Journal of experimental medicine.

[113]  G. Rosenberg,et al.  Matrix metalloproteinases and TIMPs are associated with blood-brain barrier opening after reperfusion in rat brain. , 1998, Stroke.

[114]  T. Tilling,et al.  Basement Membrane Proteins Influence Brain Capillary Endothelial Barrier Function In Vitro , 1998, Journal of neurochemistry.

[115]  D. Breuillé,et al.  Pentoxifylline decreases body weight loss and muscle protein wasting characteristics of sepsis. , 1993, The American journal of physiology.

[116]  I. Chaudry,et al.  Sepsis and septic shock--a review of laboratory models and a proposal. , 1980, The Journal of surgical research.

[117]  J. Kinney,et al.  Energy and tissue fuel in human injury and sepsis. , 1972, Advances in experimental medicine and biology.