Engineered polymers for advanced drug delivery.

[1]  R. C. Johnson,et al.  Hysteretic Creep of Elastic Manifolds. , 1996, Physical review letters.

[2]  Ick Chan Kwon,et al.  Effect of polymer molecular weight on the tumor targeting characteristics of self-assembled glycol chitosan nanoparticles. , 2007, Journal of controlled release : official journal of the Controlled Release Society.

[3]  D. Knight,et al.  A new approach to the rationale discovery of polymeric biomaterials. , 2007, Biomaterials.

[4]  Kit S Lam,et al.  From combinatorial chemistry to cancer-targeting peptides. , 2007, Molecular pharmaceutics.

[5]  Kwangmeyung Kim,et al.  Polymers for bioimaging , 2007 .

[6]  V. Stella,et al.  Prodrug strategies to overcome poor water solubility. , 2007, Advanced drug delivery reviews.

[7]  Kwangmeyung Kim,et al.  Protein-phosphorylation-responsive polymeric nanoparticles for imaging protein kinase activities in single living cells. , 2007, Angewandte Chemie.

[8]  Janko Kos,et al.  Targeting cancer cells using PLGA nanoparticles surface modified with monoclonal antibody. , 2007, Journal of controlled release : official journal of the Controlled Release Society.

[9]  N. Nishiyama,et al.  In vivo antitumor activity of the folate-conjugated pH-sensitive polymeric micelle selectively releasing adriamycin in the intracellular acidic compartments. , 2007, Bioconjugate chemistry.

[10]  Kinam Park,et al.  Recent developments in superporous hydrogels , 2007, The Journal of pharmacy and pharmacology.

[11]  J. Nemunaitis,et al.  Phase 1 study of escalating-dose OncoGel® (ReGel®/paclitaxel) depot injection, a controlled-release formulation of paclitaxel, for local management of superficial solid tumor lesions , 2007, Anti-cancer drugs.

[12]  V. Torchilin,et al.  Micellar Nanocarriers: Pharmaceutical Perspectives , 2006, Pharmaceutical Research.

[13]  T. Niidome,et al.  A protein kinase signal-responsive gene carrier modified RGD peptide. , 2006, Bioorganic & medicinal chemistry letters.

[14]  T. Okano,et al.  Molecular design of biodegradable polymeric micelles for temperature-responsive drug release. , 2006, Journal of controlled release : official journal of the Controlled Release Society.

[15]  Kinam Park,et al.  Elastic, superporous hydrogel hybrids of polyacrylamide and sodium alginate. , 2006, Macromolecular bioscience.

[16]  M. Taylor,et al.  The effect of degree of acrylic derivatisation on dextran and concanavalin A glucose-responsive materials for closed-loop insulin delivery. , 2006, Biomaterials.

[17]  Yang Wang,et al.  In vitro and in vivo intracellular liposomal delivery of antisense oligonucleotides and anticancer drug. , 2006, Journal of controlled release : official journal of the Controlled Release Society.

[18]  M. Tsuang,et al.  Shifting emphasis from pharmacogenomics to theragnostics , 2006, Nature Biotechnology.

[19]  I. Tannock,et al.  Drug penetration in solid tumours , 2006, Nature Reviews Cancer.

[20]  C. Laurencin,et al.  Bone tissue engineering by gene delivery. , 2006, Advanced drug delivery reviews.

[21]  Nicholas Ferrell,et al.  Fabrication of polymeric microparticles for drug delivery by soft lithography. , 2006, Biomaterials.

[22]  A. Tanimoto,et al.  Application of superparamagnetic iron oxide to imaging of hepatocellular carcinoma. , 2006, European journal of radiology.

[23]  J. Richie,et al.  Targeted nanoparticle-aptamer bioconjugates for cancer chemotherapy in vivo. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[24]  S. Kawakami,et al.  Novel PEG-matrix metalloproteinase-2 cleavable peptide-lipid containing galactosylated liposomes for hepatocellular carcinoma-selective targeting. , 2006, Journal of controlled release : official journal of the Controlled Release Society.

[25]  Sanjiv S Gambhir,et al.  Peptide-labeled near-infrared quantum dots for imaging tumor vasculature in living subjects. , 2006, Nano letters.

[26]  Ick Chan Kwon,et al.  Cell-permeable and biocompatible polymeric nanoparticles for apoptosis imaging. , 2006, Journal of the American Chemical Society.

[27]  T. Niidome,et al.  An intracellular kinase signal-responsive gene carrier for disordered cell-specific gene therapy. , 2006, Journal of controlled release : official journal of the Controlled Release Society.

[28]  E. K. Park,et al.  Folate-conjugated methoxy poly(ethylene glycol)/poly(epsilon-caprolactone) amphiphilic block copolymeric micelles for tumor-targeted drug delivery. , 2005, Journal of controlled release : official journal of the Controlled Release Society.

[29]  J. Anzai,et al.  Sugar-Sensitive Thin Films Composed of Concanavalin A and Sugar-Bearing Polymers , 2005, Analytical sciences : the international journal of the Japan Society for Analytical Chemistry.

[30]  Elizabeth L. Bentzen,et al.  Surface modification to reduce nonspecific binding of quantum dots in live cell assays. , 2005, Bioconjugate chemistry.

[31]  W. Sadee,et al.  Pharmacogenetics/genomics and personalized medicine. , 2005, Human molecular genetics.

[32]  R. Langer,et al.  Poly(ß-amino ester)s for DNA delivery , 2005 .

[33]  Yuichi Yamasaki,et al.  Supramolecular assemblies for the cytoplasmic delivery of antisense oligodeoxynucleotide: polyion complex (PIC) micelles based on poly(ethylene glycol)-SS-oligodeoxynucleotide conjugate. , 2005, Biomacromolecules.

[34]  Joseph M DeSimone,et al.  Direct fabrication and harvesting of monodisperse, shape-specific nanobiomaterials. , 2005, Journal of the American Chemical Society.

[35]  D. Parker,et al.  PEG-g-poly(GdDTPA-co-L-cystine): effect of PEG chain length on in vivo contrast enhancement in MRI. , 2005, Biomacromolecules.

[36]  Hyun-chul Lee,et al.  Cellular recognition of paclitaxel-loaded polymeric nanoparticles composed of poly(gamma-benzyl L-glutamate) and poly(ethylene glycol) diblock copolymer endcapped with galactose moiety. , 2005, International journal of pharmaceutics.

[37]  F. Veronese,et al.  PEG-doxorubicin conjugates: influence of polymer structure on drug release, in vitro cytotoxicity, biodistribution, and antitumor activity. , 2005, Bioconjugate chemistry.

[38]  You Han Bae,et al.  Doxorubicin loaded pH-sensitive polymeric micelles for reversal of resistant MCF-7 tumor. , 2005, Journal of controlled release : official journal of the Controlled Release Society.

[39]  J. Bading,et al.  Integrin αβ3-Targeted Imaging of Lung Cancer , 2005 .

[40]  Alexander Kamb,et al.  What's wrong with our cancer models? , 2005, Nature Reviews Drug Discovery.

[41]  S. Gambhir,et al.  Quantum Dots for Live Cells, in Vivo Imaging, and Diagnostics , 2005, Science.

[42]  You Han Bae,et al.  Super pH-sensitive multifunctional polymeric micelle. , 2005, Nano letters.

[43]  Kwangmeyung Kim,et al.  Physicochemical characterizations of self-assembled nanoparticles of glycol chitosan-deoxycholic acid conjugates. , 2005, Biomacromolecules.

[44]  Kinam Park,et al.  Hydrotropic polymer micelle system for delivery of paclitaxel. , 2005, Journal of controlled release : official journal of the Controlled Release Society.

[45]  A. Kabanov,et al.  Polymer genomics: shifting the gene and drug delivery paradigms. , 2005, Journal of controlled release : official journal of the Controlled Release Society.

[46]  A. Hoffman,et al.  Rational design of composition and activity correlations for pH-sensitive and glutathione-reactive polymer therapeutics. , 2005, Journal of controlled release : official journal of the Controlled Release Society.

[47]  Kinam Park,et al.  A new microencapsulation method using an ultrasonic atomizer based on interfacial solvent exchange. , 2004, Journal of controlled release : official journal of the Controlled Release Society.

[48]  W. Marsh,et al.  Determining feeding tube location by gastric and intestinal pH values. , 2004, Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition.

[49]  Joachim Kohn,et al.  New approaches to biomaterials design , 2004, Nature materials.

[50]  Kristian Pietras,et al.  High interstitial fluid pressure — an obstacle in cancer therapy , 2004, Nature Reviews Cancer.

[51]  K. Ulbrich,et al.  HPMA copolymers containing doxorubicin bound by a proteolytically or hydrolytically cleavable bond: comparison of biological properties in vitro. , 2004, Journal of controlled release : official journal of the Controlled Release Society.

[52]  X. Zhu,et al.  Polymer microspheres for controlled drug release. , 2004, International journal of pharmaceutics.

[53]  D. Kranz,et al.  A conjugate of a tumor-targeting ligand and a T cell costimulatory antibody to treat brain tumors. , 2004, Bioconjugate chemistry.

[54]  Liang-Yin Chu,et al.  Preparation of glucose-sensitive microcapsules with a porous membrane and functional gates. , 2004, Colloids and surfaces. B, Biointerfaces.

[55]  H. Matsubara,et al.  Host Stromal Bradykinin B2 Receptor Signaling Facilitates Tumor-Associated Angiogenesis and Tumor Growth , 2004, Cancer Research.

[56]  Mahmoud Ameri,et al.  Transdermal delivery of desmopressin using a coated microneedle array patch system. , 2004, Journal of controlled release : official journal of the Controlled Release Society.

[57]  Kazunori Kataoka,et al.  Block copolymer-coated calcium phosphate nanoparticles sensing intracellular environment for oligodeoxynucleotide and siRNA delivery. , 2004, Journal of controlled release : official journal of the Controlled Release Society.

[58]  Liang-Yin Chu,et al.  Control of pore size and permeability of a glucose-responsive gating membrane for insulin delivery. , 2004, Journal of controlled release : official journal of the Controlled Release Society.

[59]  E. K. Park,et al.  Preparation and characterization of methoxy poly(ethylene glycol)/poly(epsilon-caprolactone) amphiphilic block copolymeric nanospheres for tumor-specific folate-mediated targeting of anticancer drugs. , 2004, Biomaterials.

[60]  Tae Gwan Park,et al.  Folate receptor targeted biodegradable polymeric doxorubicin micelles. , 2004, Journal of controlled release : official journal of the Controlled Release Society.

[61]  Akira Matsumoto,et al.  Glucose-responsive polymer gel bearing phenylborate derivative as a glucose-sensing moiety operating at the physiological pH. , 2004, Biomacromolecules.

[62]  Mark R Prausnitz,et al.  Microneedles for transdermal drug delivery. , 2004, Advanced drug delivery reviews.

[63]  Naoki Kanayama,et al.  Lactose-conjugated polyion complex micelles incorporating plasmid DNA as a targetable gene vector system: their preparation and gene transfecting efficiency against cultured HepG2 cells. , 2004, Journal of Controlled Release.

[64]  Ralph Weissleder,et al.  A novel method for imaging apoptosis using a caspase-1 near-infrared fluorescent probe. , 2004, Neoplasia.

[65]  N. Peppas,et al.  Development of acrylic-based copolymers for oral insulin delivery. , 2004, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[66]  Martin Müller,et al.  Oxidation-responsive polymeric vesicles , 2004, Nature materials.

[67]  Ming Yang,et al.  Integrated microsystems for controlled drug delivery. , 2004, Advanced drug delivery reviews.

[68]  Kinam Park,et al.  A new process for making reservoir-type microcapsules using ink-jet technology and interfacial phase separation. , 2003, Journal of controlled release : official journal of the Controlled Release Society.

[69]  J. O’Shaughnessy Pegylated liposomal doxorubicin in the treatment of breast cancer. , 2003, Clinical breast cancer.

[70]  Mark G. Allen,et al.  Microfabricated needles for transdermal delivery of macromolecules and nanoparticles: Fabrication methods and transport studies , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[71]  Holly Dressman,et al.  Towards integrated clinico-genomic models for personalized medicine: combining gene expression signatures and clinical factors in breast cancer outcomes prediction. , 2003, Human molecular genetics.

[72]  J. English,et al.  Intertriginous epidermal dysmaturation from pegylated liposomal doxorubicin , 2003, Journal of cutaneous pathology.

[73]  B. Říhová,et al.  Clinical implications of N-(2-hydroxypropyl)methacrylamide copolymers. , 2003, Current pharmaceutical biotechnology.

[74]  Hyun Joon Shin,et al.  Poly(L-histidine)-PEG block copolymer micelles and pH-induced destabilization. , 2003, Journal of controlled release : official journal of the Controlled Release Society.

[75]  R. Duncan The dawning era of polymer therapeutics , 2003, Nature Reviews Drug Discovery.

[76]  Vladimir P. Torchilin,et al.  Immunomicelles: Targeted pharmaceutical carriers for poorly soluble drugs , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[77]  P. Minghetti,et al.  Design of a new water-soluble pressure-sensitive adhesive for patch preparation , 2003, AAPS PharmSciTech.

[78]  K. Griebenow,et al.  Preservation of lysozyme structure and function upon encapsulation and release from poly(lactic-co-glycolic) acid microspheres prepared by the water-in-oil-in-water method. , 2002, International journal of pharmaceutics.

[79]  T. Bieber,et al.  Intracellular route and transcriptional competence of polyethylenimine-DNA complexes. , 2002, Journal of controlled release : official journal of the Controlled Release Society.

[80]  Alexander V Kabanov,et al.  Pluronic block copolymers as novel polymer therapeutics for drug and gene delivery. , 2002, Journal of controlled release : official journal of the Controlled Release Society.

[81]  Mizuo Maeda,et al.  Intracellular signal-responsive artificial gene regulation for novel gene delivery. , 2002, Biomacromolecules.

[82]  Tsuyoshi Shimoboji,et al.  Photoswitching of ligand association with a photoresponsive polymer-protein conjugate. , 2002, Bioconjugate chemistry.

[83]  Vasilis Ntziachristos,et al.  In Vivo Imaging of Proteolytic Activity in Atherosclerosis , 2002, Circulation.

[84]  Jindřich Kopeček,et al.  Polymer chemistry: Swell gels , 2002, Nature.

[85]  Liang-Yin Chu,et al.  A Molecular‐Recognition Microcapsule for Environmental Stimuli‐Responsive Controlled Release , 2002 .

[86]  Jagdish Singh,et al.  Assessment of protein release kinetics, stability and protein polymer interaction of lysozyme encapsulated poly(D,L-lactide-co-glycolide) microspheres. , 2002, Journal of controlled release : official journal of the Controlled Release Society.

[87]  Teruo Okano,et al.  Pulsatile drug release control using hydrogels. , 2002, Advanced drug delivery reviews.

[88]  Y. Nagasaki,et al.  Sugar-installed block copolymer micelles: their preparation and specific interaction with lectin molecules. , 2001, Biomacromolecules.

[89]  D. Mooney,et al.  Degradable and injectable poly(aldehyde guluronate) hydrogels for bone tissue engineering. , 2001, Journal of biomedical materials research.

[90]  R. Langer,et al.  Accelerated discovery of synthetic transfection vectors: parallel synthesis and screening of a degradable polymer library. , 2001, Journal of the American Chemical Society.

[91]  Ralph Weissleder,et al.  In vivo molecular target assessment of matrix metalloproteinase inhibition , 2001, Nature Medicine.

[92]  J. Mestecky,et al.  Biodegradable block copolymers for delivery of proteins and water-insoluble drugs. , 2001, Journal of controlled release : official journal of the Controlled Release Society.

[93]  K. Kataoka,et al.  Glutathione-sensitive stabilization of block copolymer micelles composed of antisense DNA and thiolated poly(ethylene glycol)-block-poly(L-lysine): a potential carrier for systemic delivery of antisense DNA. , 2001, Biomacromolecules.

[94]  J. Schellens,et al.  Phase I clinical and pharmacokinetic study of PNU166945, a novel water-soluble polymer-conjugated prodrug of paclitaxel , 2001, Anti-cancer drugs.

[95]  K. Lees,et al.  The therapeutic time window--theoretical and practical considerations. , 2000, Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association.

[96]  W. Hennink,et al.  The effect of a water/organic solvent interface on the structural stability of lysozyme. , 2000, Journal of controlled release : official journal of the Controlled Release Society.

[97]  Kinam Park,et al.  Synthesis and characterization of superporous hydrogel composites. , 2000, Journal of controlled release : official journal of the Controlled Release Society.

[98]  Kinam Park,et al.  Gastric retention properties of superporous hydrogel composites. , 2000, Journal of controlled release : official journal of the Controlled Release Society.

[99]  Y. Bae,et al.  Drug release from biodegradable injectable thermosensitive hydrogel of PEG-PLGA-PEG triblock copolymers. , 2000, Journal of controlled release : official journal of the Controlled Release Society.

[100]  Kinam Park,et al.  pH-sensitivity of fast responsive superporous hydrogels , 2000, Journal of biomaterials science. Polymer edition.

[101]  Y. Bae,et al.  New biodegradable polymers for injectable drug delivery systems. , 1999, Journal of controlled release : official journal of the Controlled Release Society.

[102]  R Weissleder,et al.  Preparation of a cathepsin D sensitive near-infrared fluorescence probe for imaging. , 1999, Bioconjugate chemistry.

[103]  J. Griffiths,et al.  Causes and consequences of acidic pH in tumors: a magnetic resonance study. , 1999, Advances in enzyme regulation.

[104]  R. Weissleder,et al.  In vivo imaging of tumors with protease-activated near-infrared fluorescent probes , 1999, Nature Biotechnology.

[105]  S Brocchini,et al.  Structure-property correlations in a combinatorial library of degradable biomaterials. , 1998, Journal of biomedical materials research.

[106]  A. R. Klemm,et al.  Effects of polyethyleneimine on endocytosis and lysosome stability. , 1998, Biochemical pharmacology.

[107]  J Kost,et al.  Mass transport enhancement by ultrasound in non-degradable polymeric controlled release systems. , 1998, Journal of controlled release : official journal of the Controlled Release Society.

[108]  Sung Wan Kim,et al.  Biodegradable block copolymers as injectable drug-delivery systems , 1997, Nature.

[109]  Kinam Park,et al.  Characterization of protein release through glucose-sensitive hydrogel membranes. , 1997, Biomaterials.

[110]  S. Brocchini,et al.  A Combinatorial Approach for Polymer Design , 1997 .

[111]  T. Okano,et al.  Glucose-Responsive Gel from Phenylborate Polymer and Poly (Vinyl Alcohol): Prompt Response at Physiological pH Through the Interaction of Borate with Amino Group in the Gel , 1997, Pharmaceutical Research.

[112]  H. Maehr Combinatorial chemistry in drug research from a new vantage point. , 1997, Bioorganic & medicinal chemistry.

[113]  R. Jain,et al.  Fluorescence ratio imaging of interstitial pH in solid tumours: effect of glucose on spatial and temporal gradients. , 1996, British Journal of Cancer.

[114]  R K Jain,et al.  Vascular permeability in a human tumor xenograft: molecular size dependence and cutoff size. , 1995, Cancer research.

[115]  E. Southern,et al.  Parallel synthesis and analysis of large numbers of related chemical compounds: applications to oligonucleotides. , 1994, Journal of biotechnology.

[116]  V. Torchilin,et al.  Biodegradable long-circulating polymeric nanospheres. , 1994, Science.

[117]  Y. Bae,et al.  Electrically credible polymer gel for controlled release of drugs , 1991, Nature.

[118]  M C Davies,et al.  Steric stabilization of microspheres with grafted polyethylene oxide reduces phagocytosis by rat Kupffer cells in vitro. , 1991, Biomaterials.

[119]  N. Melik-Nubarov,et al.  The neuroleptic activity of haloperidol increases after its solubilization in surfactant micelles , 1989, FEBS letters.

[120]  J. Kost,et al.  Ultrasound-enhanced polymer degradation and release of incorporated substances. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[121]  H. Okada,et al.  In vivo release profiles of leuprolide acetate from microcapsules prepared with polylactic acids or copoly(lactic/glycolic) acids and in vivo degradation of these polymers. , 1988, Chemical & pharmaceutical bulletin.

[122]  J. Kopeček,et al.  Targetable polymeric prodrugs , 1987 .

[123]  H. Maeda,et al.  A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs. , 1986, Cancer research.

[124]  M. Keating,et al.  Clinical pharmacology of polyethylene glycol-L-asparaginase. , 1986, Drug metabolism and disposition: the biological fate of chemicals.

[125]  K. Ariga,et al.  Functional capsule membranes. Part 22. The electrical breakdown and permeability control of a bilayer-corked capsule membrane in an external electric field , 1986 .

[126]  R. Langer,et al.  Magnetic modulation of release of macromolecules from polymers. , 1981, Proceedings of the National Academy of Sciences of the United States of America.

[127]  C. Milstein,et al.  Continuous cultures of fused cells secreting antibody of predefined specificity , 1975, Nature.

[128]  F Bischoff,et al.  Organic polymer biocompatibility and toxicology. , 1972, Clinical chemistry.

[129]  J. Bading,et al.  Integrin alpha v beta 3-targeted imaging of lung cancer. , 2005, Neoplasia.

[130]  A. Hoffman,et al.  Rational design of composition and activity correlations for pH-responsive and glutathione-reactive polymer therapeutics. , 2005, Journal of controlled release : official journal of the Controlled Release Society.

[131]  Zi‐Chen Li,et al.  Glucose-Sensitive Aggregates Formed by Poly(ethylene oxide)-block-poly(2-glucosyl- oxyethyl acrylate) with Concanavalin A in Dilute Aqueous Medium , 2003 .

[132]  K. Kataoka,et al.  Lactose-installed poly(ethylene glycol)-poly(d,l-lactide) block copolymer micelles exhibit fast-rate binding and high affinity toward a protein bed simulating a cell surface. A surface plasmon resonance study. , 2003, Bioconjugate chemistry.

[133]  I. Gilham THERANOSTICS an emerging tool in drug discovery and commercialisation , 2002 .

[134]  T. Okano,et al.  Synthesis and swelling-deswelling kinetics of poly(N-isopropylacrylamide) hydrogels grafted with LCST modulated polymers. , 1999, Journal of biomaterials science. Polymer edition.

[135]  C. Higgins,et al.  Value of blood pool contrast agents in magnetic resonance angiography of the pelvis and lower extremities , 1998, European Radiology.

[136]  Kinam Park,et al.  Gastric retentive drug-delivery systems. , 1998, Critical reviews in therapeutic drug carrier systems.

[137]  W. McGuire,et al.  Breast Cancer 4 , 1981, Springer US.