TheRas-Erk-ETS-Signaling Pathway Is a Drug Target for Longevity Graphical

[1]  T. Andrews,et al.  Interplay of dFOXO and Two ETS-Family Transcription Factors Determines Lifespan in Drosophila melanogaster , 2014, PLoS genetics.

[2]  J. Shieh,et al.  DNMT3B Overexpression by Deregulation of FOXO3a-Mediated Transcription Repression and MDM2 Overexpression in Lung Cancer , 2014, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.

[3]  F. Neff,et al.  Longevity, aging and rapamycin , 2014, Cellular and Molecular Life Sciences.

[4]  R. Cabo,et al.  The Search for Antiaging Interventions: From Elixirs to Fasting Regimens , 2014, Cell.

[5]  Gil B. Carvalho,et al.  Quantifying Drosophila food intake: comparative analysis of current methodology , 2014, Nature Methods.

[6]  D. Esposito,et al.  Dragging ras back in the ring. , 2014, Cancer cell.

[7]  E. Raymond,et al.  MEK in cancer and cancer therapy. , 2014, Pharmacology & therapeutics.

[8]  S. Austad,et al.  Fibroblasts from long-lived species of mammals and birds show delayed, but prolonged, phosphorylation of ERK , 2013, Aging cell.

[9]  Manuel Serrano,et al.  The Hallmarks of Aging , 2013, Cell.

[10]  Lan Ye,et al.  Rapalogs and mTOR inhibitors as anti-aging therapeutics. , 2013, The Journal of clinical investigation.

[11]  Y. Zeng,et al.  Foxo3a transcription factor is a negative regulator of Skp2 and Skp2 SCF complex , 2013, Oncogene.

[12]  D. Walker,et al.  Intestinal barrier dysfunction links metabolic and inflammatory markers of aging to death in Drosophila , 2012, Proceedings of the National Academy of Sciences.

[13]  K. Flaherty,et al.  Safety, pharmacokinetic, pharmacodynamic, and efficacy data for the oral MEK inhibitor trametinib: a phase 1 dose-escalation trial. , 2012, The Lancet. Oncology.

[14]  A. Efeyan,et al.  Pten positively regulates brown adipose function, energy expenditure, and longevity. , 2012, Cell metabolism.

[15]  V. Anisimov,et al.  Rapamycin increases lifespan and inhibits spontaneous tumorigenesis in inbred female mice , 2011, Cell cycle.

[16]  L. Partridge,et al.  dFOXO-independent effects of reduced insulin-like signaling in Drosophila , 2011, Aging cell.

[17]  Takayuki Yamaguchi,et al.  Antitumor activities of JTP-74057 (GSK1120212), a novel MEK1/2 inhibitor, on colorectal cancer cell lines in vitro and in vivo. , 2011, International journal of oncology.

[18]  Irene Papatheodorou,et al.  Genome-wide dFOXO targets and topology of the transcriptomic response to stress and insulin signalling , 2011, Molecular systems biology.

[19]  A. Fernández-Medarde,et al.  The RasGrf family of mammalian guanine nucleotide exchange factors. , 2011, Biochimica et biophysica acta.

[20]  V. Longo,et al.  Conserved role of Ras-GEFs in promoting aging: from yeast to mice , 2011, Aging.

[21]  Heinrich Jasper,et al.  EGF signaling regulates the proliferation of intestinal stem cells in Drosophila , 2011, Development.

[22]  F. Pallardó,et al.  RasGrf1 deficiency delays aging in mice , 2011, Aging.

[23]  Cynthia Kenyon,et al.  The first long-lived mutants: discovery of the insulin/IGF-1 pathway for ageing , 2011, Philosophical Transactions of the Royal Society B: Biological Sciences.

[24]  R. Lehmann,et al.  Lifespan Extension by Preserving Proliferative Homeostasis in Drosophila , 2010, PLoS genetics.

[25]  Linda Partridge,et al.  Extending Healthy Life Span—From Yeast to Humans , 2010, Science.

[26]  L. Partridge,et al.  Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila melanogaster , 2010, Cell metabolism.

[27]  Michael J. Steinbaugh,et al.  Fibroblasts from long-lived mutant mice show diminished ERK1/2 phosphorylation but exaggerated induction of immediate early genes. , 2009, Free radical biology & medicine.

[28]  Marco Pahor,et al.  Rapamycin fed late in life extends lifespan in genetically heterogeneous mice , 2009, Nature.

[29]  M. Emond,et al.  Disruption of Protein Kinase A in Mice Enhances Healthy Aging , 2009, PloS one.

[30]  P. Klatt,et al.  Anti‐aging activity of the Ink4/Arf locus , 2009, Aging cell.

[31]  Laurent Seroude,et al.  Characterization of the Drosophila Gene‐Switch system in aging studies: a cautionary tale , 2008, Aging cell.

[32]  D. Leahy,et al.  Functionally significant insulin-like growth factor I receptor mutations in centenarians , 2008, Proceedings of the National Academy of Sciences.

[33]  Guang Yao,et al.  Sensing and Integration of Erk and PI3K Signals by Myc , 2008, PLoS Comput. Biol..

[34]  Lin Yan,et al.  Type 5 Adenylyl Cyclase Disruption Increases Longevity and Protects Against Stress , 2007, Cell.

[35]  J. Dow,et al.  Using FlyAtlas to identify better Drosophila melanogaster models of human disease , 2007, Nature Genetics.

[36]  R. Mägi,et al.  Haplotypes in the human Foxo1a and Foxo3a genes; impact on disease and mortality at old age , 2007, European Journal of Human Genetics.

[37]  S. Leevers,et al.  Input from Ras is required for maximal PI(3)K signalling in Drosophila , 2006, Nature Cell Biology.

[38]  J. Vaupel,et al.  Chronological aging‐independent replicative life span regulation by Msn2/Msn4 and Sod2 in Saccharomyces cerevisiae , 2004, FEBS letters.

[39]  C. Franceschi,et al.  Polymorphic variants of insulin-like growth factor I (IGF-I) receptor and phosphoinositide 3-kinase genes affect IGF-I plasma levels and human longevity: cues for an evolutionarily conserved mechanism of life span control. , 2003, The Journal of clinical endocrinology and metabolism.

[40]  E. Hafen,et al.  The Drosophila insulin/IGF receptor controls growth and size by modulating PtdInsP(3) levels. , 2002, Development.

[41]  V. Longo,et al.  Regulation of Longevity and Stress Resistance by Sch9 in Yeast , 2001, Science.

[42]  J. Schlessinger,et al.  Cell Signaling by Receptor Tyrosine Kinases , 2000, Cell.

[43]  J. Schlessinger.  Cell Signaling by Receptor Tyrosine Kinases , 2000, Cell.

[44]  Stephen S. Gisselbrecht,et al.  Ras Pathway Specificity Is Determined by the Integration of Multiple Signal-Activated and Tissue-Restricted Transcription Factors , 2000, Cell.

[45]  P. Defossez,et al.  Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae. , 2000, Science.

[46]  A. Sharrocks,et al.  The ETS-domain transcription factor family. , 1997, Nature reviews. Molecular cell biology.

[47]  M. White,et al.  The insulin signalling system and the IRS proteins , 1997, Diabetologia.

[48]  Gerald M Rubin,et al.  Yan functions as a general inhibitor of differentiation and is negatively regulated by activation of the Ras1/MAPK pathway , 1995, Cell.

[49]  Ernst Hafen,et al.  The ETS domain protein Pointed-P2 is a target of MAP kinase in the Sevenless signal transduction pathway , 1994, Nature.

[50]  S. Jazwinski,et al.  Divergent roles of RAS1 and RAS2 in yeast longevity. , 1994, The Journal of biological chemistry.

[51]  Gerald M. Rubin,et al.  The activities of two Ets-related transcription factors required for drosophila eye development are modulated by the Ras/MAPK pathway , 1994, Cell.

[52]  L. Goitre,et al.  The Ras superfamily of small GTPases: the unlocked secrets. , 2014, Methods in molecular biology.

[53]  A. Teleman,et al.  Nutritional control of protein biosynthetic capacity by insulin via Myc in Drosophila. , 2008, Cell metabolism.

[54]  Pernille R0RTH.  A modular misexpression screen in Drosophila detecting tissue-specific phenotypes , 2005 .

[55]  A. Diaspro,et al.  SOD2 functions downstream of Sch9 to extend longevity in yeast. , 2003, Genetics.