Induction of early pregnancy factor activity in vitro by platelet-activating factor in mice.

The rosette inhibition test was used to determine early pregnancy factor activity in culture media from oestrous mouse ovaries and oviducts stimulated in vitro for early pregnancy factor production under different experimental conditions. Embryo conditioned media, platelet-activating factor and cortical granule release media could all stimulate the production of early pregnancy factor by oestrous mouse ovaries and oviducts. This stimulation was completely blocked by the presence of BN 52021, a platelet-activating factor receptor antagonist. This study indicates that platelet-activating factor is the 'ovum factor' released by the zygote on fertilization to initiate the synthesis of early pregnancy factor.

[1]  H. Croxatto,et al.  Possible role of platelet-activating factor in embryonic signaling during oviductal transport in the hamster. , 1995, Biology of reproduction.

[2]  C. O'neill,et al.  Detection and preliminary characterization of two enzymes involved in biosynthesis of platelet-activating factor in mouse oocytes, zygotes and preimplantation embryos: dithiothreitol-insensitive cytidinediphosphocholine: 1-O-alkyl-2-acetyl-sn-glycerol cholinephosphotransferase and acetyl-coenzyme A: , 1994, Journal of reproduction and fertility.

[3]  M. Harper,et al.  Platelet-activating factor antagonists and implantation in rabbits. , 1994, Journal of reproduction and fertility.

[4]  C. O'neill,et al.  Biosynthesis of platelet-activating factor by two-cell mouse embryos. , 1992, Journal of reproduction and fertility.

[5]  B. Rolfe,et al.  Relationship between early pregnancy factor, mouse embryo-conditioned medium and platelet-activating factor. , 1991, Journal of reproduction and fertility.

[6]  C. O'neill,et al.  Production of platelet-activating factor by the pre-implantation sheep embryo. , 1991, Journal of reproduction and fertility.

[7]  C. O'neill,et al.  Comparison of a radioimmunoassay and bioassay for embryo-derived platelet-activating factor. , 1991, Human reproduction.

[8]  A. Perkins,et al.  Partial characterization of the PAF-induced soluble factors which mimic the activity of 'early pregnancy factor'. , 1990, Journal of reproduction and fertility.

[9]  A. Perkins,et al.  Platelet-activating factor and serum components from oestrous mice co-operate to mimic the activity of 'early pregnancy factor' in the rosette inhibition assay. , 1990, Journal of reproduction and fertility.

[10]  E. Wallach,et al.  Platelet activating factor-induced early pregnancy factor activity from the perfused rabbit ovary and oviduct. , 1988, American journal of obstetrics and gynecology.

[11]  D. Albertini,et al.  Quantitative studies of changes in cortical granule number and distribution in the mouse oocyte during meiotic maturation. , 1988, Developmental biology.

[12]  T. Perkins,et al.  Platelet-activating factor induces the expression of early pregnancy factor activity in female mice. , 1986, Journal of reproduction and fertility.

[13]  C. O'neill.  Partial characterization of the embryo-derived platelet-activating factor in mice. , 1985, Journal of reproduction and fertility.

[14]  C. O'neill.  Examination of the causes of early pregnancy-associated thrombocytopenia in mice. , 1985, Journal of reproduction and fertility.

[15]  C. O'neill.  Thrombocytopenia is an initial maternal response to fertilization in mice. , 1985, Journal of reproduction and fertility.

[16]  A. Cavanagh.  Production in vitro of mouse early pregnancy factor and purification to homogeneity. , 1984, Journal of reproduction and fertility.

[17]  B. Rolfe,et al.  Modified rosette inhibition test with mouse lymphocytes for detection of early pregnancy factor in human pregnancy serum. , 1984, Journal of immunological methods.

[18]  B. Rolfe,et al.  Ovum Factor: A First Signal of Pregnancy? , 1982, American journal of reproductive immunology : AJRI : official journal of the American Society for the Immunology of Reproduction and the International Coordination Committee for Immunology of Reproduction.

[19]  C. Nancarrow,et al.  The early pregnancy factor of sheep and cattle. , 2019, Journal of reproduction and fertility. Supplement.

[20]  R. Scaramuzzi,et al.  Detection of early pregnancy in sheep by the rosette inhibition test. , 1979, Journal of reproduction and fertility.

[21]  B. Rolfe,et al.  AN EARLY PREGNANCY FACTOR DETECTED IN HUMAN SERUM BY THE ROSETTE INHIBITION TEST , 1977, The Lancet.

[22]  G. Clunie,et al.  Antilymphocyte serum: studies of the specificity of the rosette-inhibiting antibody in rabbit anti-mouse ALS. , 1976, The Australian journal of experimental biology and medical science.