Superior electrochemical performance of carbon nanotubes directly grown on sharp microelectrodes.

We report for the first time how coatings made by directly growing carbon nanotubes (CNTs) on the tip of neural microelectrodes outperform others made by electrodeposited CNT composites. Not only do they reduce microelectrode impedance but they also are able to inject high currents without degradation and are stable in time. These results suggest that they are excellent candidates for chronic applications especially when both neural recording and stimulation have to be performed by the same microelectrode.

[1]  C. Marin,et al.  Biocompatibility of Intracortical Microelectrodes: Current Status and Future Prospects , 2010, Front. Neuroeng..

[2]  M. Prato,et al.  Carbon nanotube substrates boost neuronal electrical signaling. , 2005, Nano letters.

[3]  Amir Ayali,et al.  Process entanglement as a neuronal anchorage mechanism to rough surfaces , 2009, Nanotechnology.

[4]  Yuliang Cao,et al.  Electrodeposited polypyrrole/carbon nanotubes composite films electrodes for neural interfaces. , 2010, Biomaterials.

[5]  H. Markram,et al.  Carbon nanotubes might improve neuronal performance by favouring electrical shortcuts. , 2009, Nature nanotechnology.

[6]  E. Ben-Jacob,et al.  Engineered neuronal circuits shaped and interfaced with carbon nanotube microelectrode arrays , 2009, Biomedical microdevices.

[7]  H. Markram,et al.  Interfacing Neurons with Carbon Nanotubes: Electrical Signal Transfer and Synaptic Stimulation in Cultured Brain Circuits , 2007, The Journal of Neuroscience.

[8]  Thomas Stieglitz,et al.  Neural Implants in Clinical Practice , 2006 .

[9]  P. Caillat,et al.  ECoG recordings of a non-human primate using carbon nanotubes electrodes on a flexible polyimide implant , 2009, 2009 4th International IEEE/EMBS Conference on Neural Engineering.

[10]  Daniel R. Merrill,et al.  Electrical stimulation of excitable tissue: design of efficacious and safe protocols , 2005, Journal of Neuroscience Methods.

[11]  Hongjie Dai,et al.  Neural stimulation with a carbon nanotube microelectrode array. , 2006, Nano letters.

[12]  N. H. Lovell,et al.  Novel neural interface for implant electrodes: improving electroactivity of polypyrrole through MWNT incorporation , 2008, Journal of materials science. Materials in medicine.

[13]  Eshel Ben-Jacob,et al.  Electro-chemical and biological properties of carbon nanotube based multi-electrode arrays , 2007, Nanotechnology.

[14]  S. Cogan.  Neural stimulation and recording electrodes. , 2008, Annual review of biomedical engineering.

[15]  David C. Martin,et al.  Impedance spectroscopy and nanoindentation of conducting poly(3,4-ethylenedioxythiophene) coatings on microfabricated neural prosthetic devices , 2006 .

[16]  David C. Martin,et al.  Layered carbon nanotube-polyelectrolyte electrodes outperform traditional neural interface materials. , 2009, Nano letters.

[17]  F. Hambrecht,et al.  CRITERIA FOR SELECTING ELECTRODES FOR ELECTRICAL STIMULATION: THEORETICAL AND PRACTICAL CONSIDERATIONS , 1983, Annals of the New York Academy of Sciences.

[18]  Henry Markram,et al.  Substrate Arrays of Iridium Oxide Microelectrodes for in Vitro Neuronal Interfacing , 2008, Front. Neuroeng..

[19]  Evelyne Sernagor,et al.  Carbon Nanotube Electrodes for Effective Interfacing with Retinal Tissue , 2009, Front. Neuroeng..

[20]  Stuart F Cogan,et al.  Over-pulsing degrades activated iridium oxide films used for intracortical neural stimulation , 2004, Journal of Neuroscience Methods.

[21]  David C. Martin,et al.  Electrochemical deposition and characterization of poly(3,4-ethylenedioxythiophene) on neural microelectrode arrays , 2003 .

[22]  Luciano Fadiga,et al.  Chemical vapour deposited carbon nanotube coated microelectrodes for intracortical neural recording , 2010 .

[23]  G. Gabriel,et al.  Easily made single-walled carbon nanotube surface microelectrodes for neuronal applications. , 2009, Biosensors & bioelectronics.

[24]  Anton V. Liopo,et al.  Stimulation of Neural Cells by Lateral Currents in Conductive Layer‐by‐Layer Films of Single‐Walled Carbon Nanotubes , 2006 .

[25]  David C. Martin,et al.  Fuzzy gold electrodes for lowering impedance and improving adhesion with electrodeposited conducting polymer films , 2003 .

[26]  R. Andersen,et al.  Selecting the signals for a brain–machine interface , 2004, Current Opinion in Neurobiology.

[27]  B. Botterman,et al.  Carbon nanotube coating improves neuronal recordings. , 2008, Nature nanotechnology.

[28]  J. Hetke,et al.  Surface modification of neural recording electrodes with conducting polymer/biomolecule blends. , 2001, Journal of biomedical materials research.

[29]  Chris Boldt,et al.  Creating low-impedance tetrodes by electroplating with additives. , 2009, Sensors and actuators. A, Physical.