Immunocytochemical localization of sodium-calcium exchanger in canine nephron.

The sodium-calcium exchanger was localized in tissue sections of canine kidneys with two different polyclonal antisera raised against purified sodium-calcium exchanger protein derived from dog cardiac sarcolemma. The sodium-calcium exchanger was prominent in the basolateral plasmalemma of the majority of cells in all connecting tubules. In contrast, it was observed rarely and inconspicuously over the basolateral aspects of proximal tubular cells. The sodium-calcium exchanger was undetectable in all other portions of the nephron.

[1]  R. Reilly,et al.  Immunolocalization of the Na+/Ca2+ exchanger in rabbit kidney. , 1993, The American journal of physiology.

[2]  R. Reilly,et al.  cDNA cloning of a renal Na(+)-Ca2+ exchanger. , 1992, The American journal of physiology.

[3]  J. Dominguez,et al.  The renal sodium-calcium exchanger. , 1992, The Journal of laboratory and clinical medicine.

[4]  M. Breyer.  Feedback inhibition of cyclic adenosine monophosphate-stimulated Na+ transport in the rabbit cortical collecting duct via Na(+)-dependent basolateral Ca++ entry. , 1991, The Journal of clinical investigation.

[5]  J. Dominguez,et al.  Na(+)-Ca2+ exchange and Ca2+ depletion in rat proximal tubules. , 1991, The American journal of physiology.

[6]  E. Windhager,et al.  Expression of renal Na(+)-Ca2+ exchange activity in Xenopus laevis oocytes. , 1991, The American journal of physiology.

[7]  D. Nicoll,et al.  Molecular cloning and functional expression of the cardiac sarcolemmal Na(+)-Ca2+ exchanger , 1990, Science.

[8]  T. Shimizu,et al.  Effects of PTH, calcitonin, and cAMP on calcium transport in rabbit distal nephron segments. , 1990, The American journal of physiology.

[9]  J. Bourdeau,et al.  Basolateral cell membrane Ca-Na exchange in single rabbit connecting tubules. , 1990, The American journal of physiology.

[10]  J. Dominguez,et al.  Na+ electrochemical gradient and Na+-Ca2+ exchange in rat proximal tubule. , 1989, The American journal of physiology.

[11]  C. Ramachandran,et al.  The renal Na+/Ca2+ exchange system is located exclusively in the distal tubule. , 1989, The Biochemical journal.

[12]  K. Philipson,et al.  Purification of the cardiac Na+-Ca2+ exchange protein. , 1988, Biochimica et biophysica acta.

[13]  K. Hruska,et al.  Na+-Ca2+ exchange and calcium permeability in canine basolateral membrane vesicles: the effects of dibutyryl cAMP and specific inhibitors. , 1988, Biochimica et biophysica acta.

[14]  J. Arruda,et al.  Partial purification and reconstitution of renal basolateral Na+-Ca2+ exchanger into liposomes. , 1985, The Journal of biological chemistry.

[15]  K. Hruska,et al.  Calcium transport in canine renal basolateral membrane vesicles. Effects of parathyroid hormone. , 1985, The Journal of clinical investigation.

[16]  A. Jayakumar,et al.  Sodium gradient-dependent calcium uptake in renal basolateral membrane vesicles. Effect of parathyroid hormone. , 1984, The Journal of biological chemistry.

[17]  J. Bourdeau,et al.  Immunocytochemical localization of vitamin D-dependent calcium-binding protein in renal tubules of rabbit, rat, and chick. , 1982, Kidney international.

[18]  Dr. med. Walter Pfaller.  Structure Function Correlation on Rat Kidney , 1981, Advances in Anatomy Embryology and Cell Biology.

[19]  A. N. Taylor.  Immunocytochemical localization of the vitamin D-induced calcium-binding protein: relocation of antigen during frozen section processing. , 1981, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[20]  S. Nielsen.  [Anatomy of the kidney]. , 1981, Revue de l'infirmiere.

[21]  R. Kinne,et al.  Calcium ion transport across plasma membranes isolated from rat kidney cortex. , 1979, The Biochemical journal.