Annotation: THE ORIGIN, DEVELOPMENT AND REGULATION OF MEGAKARYOCYTES

Much insight into platelet production and function has been gained by examination of megakaryocytes and their precursors. Since the last major reviews on this subject (Ebbe, 19 76; Breton-Gorius & Reyes, 19 76). significant advances have occurred in our knowledge of megakaryocytopoiesis. This field was recently stimulated by the first conference devoted to the in vitro study of megakaryocytes (Evatt et al, 1981). This Annotation considers the progressive differentiation of marrow stem cells into platelets and the regulatory activities involved therein.

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