The proton treatment center at Loma Linda University Medical Center: rationale for and description of its development.

Proton radiation, a continuation of radiation oncology's historic search for an optimum dose distribution, offers superior characteristics for clinical radiation therapy. A complete facility for clinical proton radiation therapy has been designed for and constructed at Loma Linda University Medical Center. To bring about this achievement, a consortium of engineers, physicists, and physicians interested in the clinical applications of protons was necessary. The accelerator, the beam transport and delivery systems, the building, and the personnel who operate the system were all brought together to fully exploit the properties of protons for patient treatments, which are now underway.

[1]  B. Hale,et al.  The past seventy-five years in radiotherapy. , 1973, The British journal of radiology.

[2]  G T Chen,et al.  Precision, high dose radiotherapy: helium ion treatment of uveal melanoma. , 1985, International journal of radiation oncology, biology, physics.

[3]  H. Kaplan Historic milestones in radiobiology and radiation therapy. , 1979, Seminars in oncology.

[4]  Daniel W. Miller,et al.  Development of a hospital-based proton beam treatment center. , 1988, International journal of radiation oncology, biology, physics.

[5]  M. Goitein,et al.  Exploratory study of proton radiation therapy using large field techniques and fractionated dose schedules , 1975, Cancer.

[6]  B Larsson,et al.  Irradiation of small structures through the intact skull. , 1974, Acta radiologica: therapy, physics, biology.

[7]  L. Verhey,et al.  Conservative treatment of uveal melanoma: probability of eye retention after proton treatment. , 1988, International journal of radiation oncology, biology, physics.

[8]  V. Devita,et al.  Cancer : Principles and Practice of Oncology , 1982 .

[9]  P. Gutin,et al.  Precision, high dose radiotherapy. II. Helium ion treatment of tumors adjacent to critical central nervous system structures. , 1985, International journal of radiation oncology, biology, physics.

[10]  R. Miralbell,et al.  Potential impact of improvements in radiation therapy on quality of life and survival. , 1989, International journal of radiation oncology, biology, physics.

[11]  A. Frantz,et al.  Proton-beam therapy in acromegaly. , 1968, The New England journal of medicine.

[12]  C. Boring,et al.  Cancer statistics, 1990 , 1990, CA: a cancer journal for clinicians.

[13]  L. Verhey,et al.  Fractionated proton radiation therapy of chordoma and low-grade chondrosarcoma of the base of the skull. , 1989, Journal of neurosurgery.

[14]  L. Verhey,et al.  Fractionated Proton Radiation Therapy of Cranial and Intracranial Tumors , 1990, American journal of clinical oncology.

[15]  M Goitein,et al.  Long-term results of proton beam irradiated uveal melanomas. , 1987, Ophthalmology.

[16]  Proton therapy in Japan. , 1985 .

[17]  J. Mohr,et al.  Proton therapy for arteriovenous malformations of the brain. , 1984, The New England journal of medicine.

[18]  L. Verhey,et al.  Clinical experience with proton beam radiation therapy. , 1980, Journal of the Canadian Association of Radiologists.

[19]  L. Verhey,et al.  Current results of proton beam irradiation of uveal melanomas. , 1982, Ophthalmology.

[20]  S. Graffman,et al.  Clinical trials in radiotherapy and the merits of high energy protons. , 1970, Acta radiologica: therapy, physics, biology.

[21]  J. Archambeau,et al.  Proton radiation therapy. , 1974, Radiology.

[22]  L. Verhey,et al.  Conservative treatment of uveal melanoma: local recurrence after proton beam therapy. , 1989, International journal of radiation oncology, biology, physics.

[23]  B. Pierquin The destiny of brachytherapy in oncology. , 1976, AJR. American journal of roentgenology.

[24]  L. Leksell,et al.  THE USE OF HIGH ENERGY PROTONS FOR CEREBRAL SURGERY IN MAN , 1963 .

[25]  N. Tapley High-energy photon and electron beam. , 1977, Cancer.

[26]  R. Wilson Radiological use of fast protons. , 1946, Radiology.

[27]  E. Gragoudas,et al.  Progress in low-LET heavy particle therapy: intracranial and paracranial tumors and uveal melanomas. , 1985, Radiation research. Supplement.

[28]  R. Brown,et al.  Introduction to the use of protons and heavy ions in radiation therapy: historical perspective. , 1977, International journal of radiation oncology, biology, physics.