Mikulicz syndrome, an uncommon entity in Pakistan.

A 38 years old woman presented with bilaterally symmetrical, painless swelling of the parotid, submandibular and sublingual glands. A fine needle aspiration biopsy revealed granulomatous histology with a few salivary ductal structures. On the basis of the histology, she was started on antituberculosis regimen until about 6 weeks later when she developed a skin rash on her shins, diagnosed as erythema nodosum co-existent with xerostomia. Her ESR was 38 mm and Mantoux test was negative. There was no lacrymal gland swelling and corneal tear film was normal on slit lamp examination. A diagnosis of sarcoidosis affecting the major salivary glands was made. The salivary glandular swelling, subsided within two weeks of treatment with oral prednisolone.

[1]  K. Shimoyama,et al.  A case of Mikulicz’s disease complicated with interstitial nephritis successfully treated by high-dose corticosteroid , 2006, Modern rheumatology.

[2]  R. Goldberg,et al.  Mikulicz's Disease: A New Perspective and Literature Review , 2006, European journal of ophthalmology.

[3]  W. S. Morgan,et al.  A clinicopathologic study of Mikulicz's disease. , 1953, The American journal of pathology.

[4]  A. Dupré,et al.  [MIKULICZ' SYNDROME]. , 1963, Bulletin de la Societe francaise de dermatologie et de syphiligraphie.