A robust and efficient valve model based on resistive immersed surfaces

A procedure for modeling the heart valves is presented. Instead of modeling complete leaflet motion, leaflets are modeled in open and closed configurations. The geometry of each configuration can be defined, for example, from in vivo image data. This method enables significant computational savings compared with complete fluid-structure interaction and contact modeling, while maintaining realistic three-dimensional velocity and pressure distributions near the valve, which is not possible from lumped parameter modeling. Leaflets are modeled as immersed, fixed surfaces over which a resistance to flow is assigned. On the basis of local flow conditions, the resistance values assigned for each configuration are changed to switch the valve between open and closed states. This formulation allows for the pressure to be discontinuous across the valve. To illustrate the versatility of the model, realistic and patient-specific simulations are presented, as well as comparison with complete fluid-structure interaction simulation.

[1]  X. Luob,et al.  Effect of ventricle motion on the dynamic behaviour of chorded mitral valves , 2008 .

[2]  R. Glowinski,et al.  A fictitious domain method for Dirichlet problem and applications , 1994 .

[3]  Luca Heltai,et al.  On the CFL condition for the finite element immersed boundary method , 2007 .

[4]  I. C. Howard,et al.  An approach to the simulation of fluid-structure interaction in the aortic valve. , 2006, Journal of biomechanics.

[5]  Vanessa Díaz-Zuccarini,et al.  An energetically coherent lumped parameter model of the left ventricle specially developed for educational purposes , 2007, Comput. Biol. Medicine.

[6]  Lee Waite,et al.  A new computer model of mitral valve hemodynamics during ventricular filling. , 2004, European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery.

[7]  P. Kolh,et al.  Systemic and pulmonary hemodynamics assessed with a lumped-parameter heart-arterial interaction model , 2003 .

[8]  J. Marsden,et al.  Definition and properties of Lagrangian coherent structures from finite-time Lyapunov exponents in two-dimensional aperiodic flows , 2005 .

[9]  Miguel A. Fernández,et al.  A projection semi‐implicit scheme for the coupling of an elastic structure with an incompressible fluid , 2007 .

[10]  Alfio Quarteroni,et al.  Cardiovascular mathematics : modeling and simulation of the circulatory system , 2009 .

[11]  Patrick D. Anderson,et al.  A fluid-structure interaction method with solid-rigid contact for heart valve dynamics , 2006, J. Comput. Phys..

[12]  A. Weyman,et al.  Influence of orifice geometry and flow rate on effective valve area: an in vitro study. , 1990, Journal of the American College of Cardiology.

[13]  Fotis Sotiropoulos,et al.  A review of state-of-the-art numerical methods for simulating flow through mechanical heart valves , 2009, Medical & Biological Engineering & Computing.

[14]  David Rodney Hose,et al.  Fundamental mechanics of aortic heart valve closure. , 2006, Journal of biomechanics.

[15]  Alejandro F. Frangi,et al.  Efficient computational fluid dynamics mesh generation by image registration , 2007, Medical Image Anal..

[16]  T. Hughes,et al.  A new finite element formulation for computational fluid dynamics: V. Circumventing the Babuscka-Brezzi condition: A stable Petrov-Galerkin formulation of , 1986 .

[17]  Patrick Patrick Anderson,et al.  A combined fictitious domain/adaptive meshing method for fluid–structure interaction in heart valves , 2004 .

[18]  C. Peskin The immersed boundary method , 2002, Acta Numerica.

[19]  C. Peskin,et al.  Heart Simulation by an Immersed Boundary Method with Formal Second-order Accuracy and Reduced Numerical Viscosity , 2001 .

[20]  Shigeo Wada,et al.  Influence of the Opening Mode of the Mitral Valve Orifice on Intraventricular Hemodynamics , 2006, Annals of Biomedical Engineering.

[21]  D. Chapelle,et al.  MODELING AND ESTIMATION OF THE CARDIAC ELECTROMECHANICAL ACTIVITY , 2006 .

[22]  Vincent Martin,et al.  Projection Schemes for Fluid Flows through a Porous Interface , 2011, SIAM J. Sci. Comput..

[23]  Edward J Vigmond,et al.  Effect of bundle branch block on cardiac output: a whole heart simulation study. , 2008, Progress in biophysics and molecular biology.

[24]  Jean-Frédéric Gerbeau,et al.  A partitioned fluid-structure algorithm for elastic thin valves with contact , 2008 .

[25]  J. Fisher,et al.  The Influence of Open Leaflet Geometry on the Haemodynamic Flow Characteristics of Polyurethane Trileaflet Artificial Heart Valves , 1996, Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine.

[26]  R. S. Alexander,et al.  The Genesis of the Aortic Standing Wave , 1953, Circulation research.

[27]  L. Formaggia,et al.  Numerical modeling of 1D arterial networks coupled with a lumped parameters description of the heart , 2006, Computer methods in biomechanics and biomedical engineering.

[28]  F. Baaijens A fictitious domain/mortar element method for fluid-structure interaction , 2001 .

[29]  D. Chapelle,et al.  The Finite Element Analysis of Shells - Fundamentals , 2003 .

[30]  Theodosios Korakianitis,et al.  A concentrated parameter model for the human cardiovascular system including heart valve dynamics and atrioventricular interaction. , 2006, Medical engineering & physics.

[31]  R. Glowinski,et al.  A fictitious domain approach to the direct numerical simulation of incompressible viscous flow past moving rigid bodies: application to particulate flow , 2001 .

[32]  Miguel A. Fernández,et al.  Numerical simulation of blood flows through a porous interface , 2008 .

[33]  C S Peskin,et al.  Fluid dynamics of the mitral valve: physiological aspects of a mathematical model. , 1982, The American journal of physiology.

[34]  Zhaosheng Yu A DLM/FD method for fluid/flexible-body interactions , 2005 .

[35]  Matteo Astorino,et al.  Computational analysis of an aortic valve jet with Lagrangian coherent structures. , 2010, Chaos.

[36]  T. Korakianitis,et al.  Numerical simulation of cardiovascular dynamics with healthy and diseased heart valves. , 2006, Journal of biomechanics.

[37]  Brant H Maines,et al.  Lumped parameter model for computing the minimum pressure during mechanical heart valve closure. , 2005, Journal of biomechanical engineering.

[38]  Eli J Weinberg,et al.  A finite shell element for heart mitral valve leaflet mechanics, with large deformations and 3D constitutive material model. , 2007, Journal of biomechanics.

[39]  Eun-Ok Jung,et al.  LUMPED PARAMETER MODELS OF CARDIOVASCULAR CIRCULATION IN NORMAL AND ARRHYTHMIA CASES , 2006 .

[40]  Charles A. Taylor,et al.  Characterization of Coherent Structures in the Cardiovascular System , 2008, Annals of Biomedical Engineering.

[41]  Lucia Gastaldi,et al.  The immersed boundary methoda finite element approach , 2003 .

[42]  T. Dawber,et al.  Characteristics of the Dicrotic Notch of the Arterial Pulse Wave in Coronary Heart Disease , 1973, Angiology.

[43]  D W Samways THE GENESIS OF THE DICROTIC PULSE WAVE , 1912, British medical journal.

[44]  Miguel A. Fernández,et al.  Numerical Simulation of the Electromechanical Activity of the Heart , 2009, FIMH.

[45]  Lutz Tobiska,et al.  Analysis of a streamline diffusion finite element method for the Stokes and Navier-Stokes equations , 1996 .

[46]  Matteo Astorino,et al.  Fluid-structure interaction and multi-body contact. Application to aortic valves , 2009 .

[47]  Damien Garcia,et al.  What do you mean by aortic valve area: geometric orifice area, effective orifice area, or gorlin area? , 2006, The Journal of heart valve disease.

[48]  Charles A. Taylor,et al.  Augmented Lagrangian method for constraining the shape of velocity profiles at outlet boundaries for three-dimensional finite element simulations of blood flow , 2009 .

[49]  Boyce E. Griffith,et al.  An adaptive, formally second order accurate version of the immersed boundary method , 2007, J. Comput. Phys..

[50]  Gianni Pedrizzetti,et al.  Three-dimensional filling flow into a model left ventricle , 2005, Journal of Fluid Mechanics.