Therapeutic potential of 4-substituted coumarins: A conspectus

[1]  M. AbuKhader,et al.  Design, synthesis and in vitro biological activities of coumarin linked 1,3,4-oxadiazole hybrids as potential multi-target directed anti-alzheimer agents , 2022, Journal of King Saud University - Science.

[2]  Katarzyna Szwaczko.  Coumarins Synthesis and Transformation via C–H Bond Activation—A Review , 2022, Inorganics.

[3]  Rongmei Geng,et al.  Discovery of unique thiazolidinone-conjugated coumarins as novel broad spectrum antibacterial agents. , 2022, European journal of medicinal chemistry.

[4]  M. Kapoor,et al.  Synthesis and antiviral activities of quinazolinamine-coumarin conjugates toward chikungunya and hepatitis C viruses. , 2022, European journal of medicinal chemistry.

[5]  Dina S. Hussein,et al.  The Predicted Models of Anti-Colon Cancer and Anti-Hepatoma Activities of Substituted 4-Anilino Coumarin Derivatives Using Quantitative Structure-Activity Relationship (QSAR) , 2022, Journal of King Saud University - Science.

[6]  P. D. de Witte,et al.  Comparative Antiseizure Analysis of Diverse Natural Coumarin Derivatives in Zebrafish , 2021, International journal of molecular sciences.

[7]  Sanna P. Niinivehmas,et al.  Coumarins as Tool Compounds to Aid the Discovery of Selective Function Modulators of Steroid Hormone Binding Proteins , 2021, Molecules.

[8]  Yucheng Gu,et al.  Semisynthesis, Antiplasmodial Activity, and Mechanism of Action Studies of Isocoumarin Derivatives. , 2021, Journal of natural products.

[9]  K. Amin,et al.  Design and synthesis of novel coumarin derivatives as potential acetylcholinesterase inhibitors for Alzheimer's disease. , 2021, Bioorganic chemistry.

[10]  L. Marcourt,et al.  Coumarins from Seseli devenyense Simonk.: Isolation by Liquid–Liquid Chromatography and Potential Anxiolytic Activity Using an In Vivo Zebrafish Larvae Model , 2021, International journal of molecular sciences.

[11]  Meng Zhou,et al.  Design, Synthesis and Biological Evaluation of 4, 6-Coumarin Derivatives as Anti-Cancer and Apoptosis-Inducing Agents. , 2021, Anti-cancer agents in medicinal chemistry.

[12]  S. Mogurampelly,et al.  Computational and Spectroscopic Studies of Biologically Active Coumarin based Fluorophores. , 2020, Luminescence : the journal of biological and chemical luminescence.

[13]  F. Gonzalez,et al.  Synthesis and structure-activity relationship of coumarins as potent Mcl-1 inhibitors for cancer treatment. , 2020, Bioorganic & medicinal chemistry.

[14]  Ya-Ping Guo,et al.  New cytotoxic 4-alkyl-dihydroxyfuran coumarins from Mesua ferrea , 2020 .

[15]  V. Eifler-Lima,et al.  Natural and synthetic coumarins as antileishmanial agents: A review. , 2020, European journal of medicinal chemistry.

[16]  R. Capasso,et al.  Coumarins and Coumarin-Related Compounds in Pharmacotherapy of Cancer , 2020, Cancers.

[17]  Akriti Sharma,et al.  Design, synthesis and biological evaluation of novel indolinedione–coumarin hybrids as xanthine oxidase inhibitors , 2020, Medicinal Chemistry Research.

[18]  Yu-Wei Liu,et al.  Synthesis, characterization, crystal structure and evaluation of four carbazole-coumarin hybrids as multifunctional agents for the treatment of Alzheimer’s disease , 2020, Journal of Molecular Structure.

[19]  Pedro G. Pascutti,et al.  Theoretical studies and NMR assay of coumarins and neoflavanones derivatives as potential inhibitors of acetylcholinesterase , 2020, Comput. Biol. Chem..

[20]  Yanmin Zhang,et al.  Discovery of coumarin derivatives as potent and selective cyclin-dependent kinase 9 (CDK9) inhibitors with high antitumour activity. , 2020, European journal of medicinal chemistry.

[21]  F. Gao,et al.  Coumarin derivatives with anticancer activities: An update. , 2020, Archiv der Pharmazie.

[22]  K. Rodríguez-Hernández,et al.  Mammea type coumarins isolated from Calophyllum brasiliense induced apoptotic cell death of Trypanosoma cruzi through mitochondrial dysfunction, ROS production and cell cycle alterations. , 2020, Bioorganic chemistry.

[23]  N. Duangdee,et al.  Design synthesis and anti-proliferative activity of some new coumarin substituted hydrazide–hydrazone derivatives , 2020, Journal of Chemical Sciences.

[24]  Xicheng Liu,et al.  Fluorescent iridium(iii) coumarin-salicylaldehyde Schiff base compounds as lysosome-targeted antitumor agents. , 2020, Dalton transactions.

[25]  Pavle J. Randjelović,et al.  Anxiolytic‐Like Action of Selected 4‐(Alkylamino)‐3‐nitrocoumarin Derivatives in BALB/c Mice , 2020, Chemistry & biodiversity.

[26]  H. Turkez,et al.  Synthesis, structure, cytotoxic and antioxidant properties of 6-ethoxy-4-methylcoumarin , 2020 .

[27]  C. Supuran,et al.  Design, synthesis and biological evaluation of coumarin linked 1,2,4-oxadiazoles as selective carbonic anhydrase IX and XII inhibitors. , 2020, Bioorganic chemistry.

[28]  W. H. Abd-Allah,et al.  Design, synthesis and docking studies of novel benzopyrone derivatives as anticonvulsants. , 2020, Bioorganic chemistry.

[29]  A. Pramanik,et al.  Expeditious and eco-friendly synthesis of new multifunctionalized pyrrole derivatives and evaluation of their antioxidant property. , 2020, Bioorganic chemistry.

[30]  Raed A. Al‐Qawasmeh,et al.  Design and synthesis of new energy restriction mimetic agents: Potent anti-tumor activities of hybrid motifs of aminothiazoles and coumarins , 2020, Scientific Reports.

[31]  M. Ramana,et al.  Synthesis and biological evaluation of novel N-substituted (3-(1-aminoethylidene)-2-oxochroman-4-yl)phosphonic acid diethyl ester derivatives as anti-Alzheimer agent , 2020, Chemical Papers.

[32]  A. Yadav,et al.  Coumarin-based Trisubstituted Methanes as Potent Anthelmintic: Synthesis, Molecular Docking and in vitro Efficacy , 2020, Journal of Chemical Sciences.

[33]  D. Hadjipavlou-Litina,et al.  Novel 3‐aryl‐5‐substituted‐coumarin analogues: Synthesis and bioactivity profile , 2020, Drug development research.

[34]  M. A. E. Regal,et al.  Synthesis and Antimicrobial Activity of Some New Coumarin and Dicoumarol Derivatives , 2020, Russian Journal of Bioorganic Chemistry.

[35]  Shruti Mishra,et al.  Coumarin: An emerging antiviral agent , 2020, Heliyon.

[36]  J. Małecki,et al.  Synthesis, characterization, crystal structure and antibacterial properties of N– and O–functionalized (benz)imidazolium salts and their N–heterocyclic carbene silver(I) complexes , 2019, Journal of Molecular Structure.

[37]  Ragini Gupta,et al.  Sonochemical Decoration of Graphene Oxide with Magnetic Fe3O4@CuO Nanocomposite for Efficient Click Synthesis of Coumarin-Sugar Based Bioconjugates and Their Cytotoxic Activity , 2019, Catalysis Letters.

[38]  Piyush A. Gediya,et al.  Synthesis of Novel 4‐Substituted Coumarins, Docking Studies, and DHODH Inhibitory Activity , 2019, Journal of Heterocyclic Chemistry.

[39]  E. Tramontano,et al.  Chromenone derivatives as a versatile scaffold with dual mode of inhibition of HIV-1 reverse transcriptase-associated Ribonuclease H function and integrase activity. , 2019, European journal of medicinal chemistry.

[40]  S. Tekin,et al.  Cytotoxic effects of coumarin substituted benzimidazolium salts against human prostate and ovarian cancer cells , 2019, Journal of Chemical Sciences.

[41]  Jong Seung Kim,et al.  Coumarin-Based Small-Molecule Fluorescent Chemosensors. , 2019, Chemical reviews.

[42]  J. Singh,et al.  Rational approaches, design strategies, structure activity relationship and mechanistic insights for therapeutic coumarin hybrids. , 2019, Bioorganic & medicinal chemistry.

[43]  Mohamed N F Shaheen,et al.  New 4-phenylcoumarin derivatives as potent 3C protease inhibitors: Design, synthesis, anti-HAV effect and molecular modeling. , 2019, European journal of medicinal chemistry.

[44]  A. Saeed,et al.  Functionalized furo[3,2-c]coumarins as anti-proliferative, anti-lipolytic, and anti-inflammatory compounds: Synthesis and molecular docking studies , 2019, Journal of Molecular Structure.

[45]  K. M. Hosamani,et al.  Design and Synthesis of Novel C4-Linked Substituted 2H-Chromen-2-one-hypoxanthine Hybrids as Potential Antimicrobial Agents: An Approach to Molecular Docking Studies , 2019, Journal of Heterocyclic Chemistry.

[46]  S. Patil,et al.  Coumarin-substituted 1,2,4-triazole-derived silver(i) and gold(i) complexes: synthesis, characterization and anticancer studies , 2019, New Journal of Chemistry.

[47]  S. Joshi,et al.  Synthesis, Antitubercular and Antimicrobial Activity of 1,2,4-Triazolidine-3-thione Functionalized Coumarin and Phenyl Derivatives and Molecular Docking Studies , 2019, ChemistrySelect.

[48]  Kaushal P. Patel,et al.  Naphthalene substituted benzo[c]coumarins: Synthesis, characterization and evaluation of antibacterial activity and cytotoxicity , 2019, Heterocyclic Communications.

[49]  N. Radulović,et al.  Synthesis and Spectral Characterization of Asymmetric Azines Containing a Coumarin Moiety: The Discovery of New Antimicrobial and Antioxidant Agents , 2018, Chemistry & biodiversity.

[50]  R. Bhatia,et al.  Coumarin Hybrids: Promising Scaffolds in the Treatment of Breast Cancer. , 2019, Mini reviews in medicinal chemistry.

[51]  Suneel S. Dodamani,et al.  Design and synthesis of structurally identical coumarinotriazoles as cytotoxic and antimicrobial agents , 2018, Chemical Data Collections.

[52]  Seegehalli M. Anil,et al.  Synthesis of new coumarin tethered isoxazolines as potential anticancer agents. , 2018, Bioorganic & medicinal chemistry letters.

[53]  B. Potter,et al.  C-3- and C-4-Substituted Bicyclic Coumarin Sulfamates as Potent Steroid Sulfatase Inhibitors , 2018, ACS omega.

[54]  S. Joshi,et al.  A reusable magnetic nickel nanoparticle based catalyst for the aqueous synthesis of diverse heterocycles and their evaluation as potential anti-bacterial agent. , 2018, Bioorganic & medicinal chemistry.

[55]  S. R. Balusamy,et al.  In silico and in vitro analysis of coumarin derivative induced anticancer effects by undergoing intrinsic pathway mediated apoptosis in human stomach cancer. , 2018, Phytomedicine : international journal of phytotherapy and phytopharmacology.

[56]  M. Sarg,et al.  Facile Synthesis and Anticancer Activity Study of Novel Series of Substituted and Fused Coumarin Derivatives , 2018 .

[57]  K. Chikhalia,et al.  Design, synthesis, bioactivity, and computational studies of some morpholine-clubbed coumarinyl acetamide and cinnamide derivatives , 2018, Journal of the Iranian Chemical Society.

[58]  Szu-Hua Pan,et al.  Sterically modulated silver(I) complexes of coumarin substituted benzimidazol-2-ylidenes: Synthesis, crystal structures and evaluation of their antimicrobial and antilung cancer potentials. , 2018, Journal of inorganic biochemistry.

[59]  K. M. Hosamani,et al.  Microwave-assisted synthesis, computational studies and antibacterial/ anti-inflammatory activities of compounds based on coumarin-pyrazole hybrid , 2018, Royal Society Open Science.

[60]  E. M. Keshk,et al.  Synthesis, biological evaluation and in silico molecular docking of novel 1-hydroxy-naphthyl substituted heterocycles , 2018, Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society.

[61]  M. Molnar,et al.  Coumarinyl Thiosemicarbazides as Antimicrobial Agents , 2018, Pharmaceutical Chemistry Journal.

[62]  C. Supuran,et al.  Structural investigations on coumarins leading to chromeno[4,3-c]pyrazol-4-ones and pyrano[4,3-c]pyrazol-4-ones: New scaffolds for the design of the tumor-associated carbonic anhydrase isoforms IX and XII. , 2018, European journal of medicinal chemistry.

[63]  S. Awasthi,et al.  In vitro antiplasmodial efficacy of synthetic coumarin-triazole analogs. , 2018, European journal of medicinal chemistry.

[64]  M. Janeczko,et al.  Synthesis and Antimicrobial Activity of 4-Substituted 1,2,3-Triazole-Coumarin Derivatives , 2018, Molecules.

[65]  Zhi Xu,et al.  Recent Development of Coumarin Derivatives as Potential Antiplasmodial and Antimalarial Agents. , 2017, Current topics in medicinal chemistry.

[66]  S. R. Balusamy,et al.  Cellular effect of styrene substituted biscoumarin caused cellular apoptosis and cell cycle arrest in human breast cancer cells. , 2017, The international journal of biochemistry & cell biology.

[67]  V. Terzi,et al.  Antifungal Activity of Aqueous Extracts of Some Dominant Algerian Medicinal Plants , 2017, BioMed research international.

[68]  S. Bavari,et al.  Identification of a coumarin‐based antihistamine‐like small molecule as an anti‐filoviral entry inhibitor , 2017, Antiviral research.

[69]  Zhi Xu,et al.  Recent developments of coumarin-containing derivatives and their anti-tubercular activity. , 2017, European journal of medicinal chemistry.

[70]  Mamdouh M. Ali,et al.  New Coumarin Derivatives as Anti‐Breast and Anti‐Cervical Cancer Agents Targeting VEGFR‐2 and p38α MAPK , 2017, Archiv der Pharmazie.

[71]  Marijana Jukić,et al.  Synthesis of 4-aryl-1,2,3-triazolyl appended natural coumarin-related compounds with antiproliferative and radical scavenging activities and intracellular ROS production modification , 2017 .

[72]  S. Soman,et al.  Design, Synthesis, and Anticancer Activity of 3H–benzo[f]chromen-3-one Derivatives , 2017 .

[73]  V. Zarubaev,et al.  Anti-influenza activity of monoterpene-containing substituted coumarins. , 2017, Bioorganic & medicinal chemistry letters.

[74]  Q. You,et al.  Design, synthesis, biological evaluation and molecular docking studies of novel 3-aryl-4-anilino-2H-chromen-2-one derivatives targeting ERα as anti-breast cancer agents. , 2017, Bioorganic & medicinal chemistry letters.

[75]  L. Yamini,et al.  Synthesis of pyrazole-4-carbaldehyde derivatives for their antifungal activity , 2017, Medicinal Chemistry Research.

[76]  Q. You,et al.  Design, synthesis and biological evaluation of novel 3-substituted 4-anilino-coumarin derivatives as antitumor agents. , 2017, Bioorganic & medicinal chemistry letters.

[77]  Suneel S. Dodamani,et al.  Synthesis, characterization and molecular docking studies of substituted 4-coumarinylpyrano[2,3-c]pyrazole derivatives as potent antibacterial and anti-inflammatory agents. , 2017, European journal of medicinal chemistry.

[78]  Tatjana Gazivoda Kraljević,et al.  Synthesis, in vitro anticancer and antibacterial activities and in silico studies of new 4-substituted 1,2,3-triazole-coumarin hybrids. , 2016, European journal of medicinal chemistry.

[79]  R. Prasad,et al.  Synthesis of Novel Fatty Substituted 4-methyl-2HChromen-2-one via Cross Metathesis: Potential Antioxidants and Chemotherapeutic Agents. , 2016, Journal of oleo science.

[80]  Shailza Singh,et al.  Biological Activity of Coumarin Derivatives as Anti-Leishmanial Agents , 2016, PloS one.

[81]  M. Marvanova,et al.  Introduction to Parkinson disease (PD) and its complications , 2016, The mental health clinician.

[82]  R. Singla,et al.  Recent developments of C-4 substituted coumarin derivatives as anticancer agents. , 2016, European journal of medicinal chemistry.

[83]  Promila,et al.  DABCO-catalyzed one-pot three component synthesis of dihydropyrano[3,2-c]chromene substituted quinazolines and their evaluation towards anticancer activity. , 2016, Bioorganic & medicinal chemistry letters.

[84]  M. Khedr,et al.  3-Substituted-4-hydroxycoumarin as a new scaffold with potent CDK inhibition and promising anticancer effect: Synthesis, molecular modeling and QSAR studies. , 2016, Bioorganic chemistry.

[85]  S. Gražulis,et al.  Intrinsic thermodynamics of 4-substituted-2,3,5,6-tetrafluorobenzenesulfonamide binding to carbonic anhydrases by isothermal titration calorimetry. , 2015, Biophysical chemistry.

[86]  S. Emami,et al.  Current developments of coumarin-based anti-cancer agents in medicinal chemistry. , 2015, European journal of medicinal chemistry.

[87]  Rangappa S. Keri,et al.  Recent progress in the drug development of coumarin derivatives as potent antituberculosis agents. , 2015, European journal of medicinal chemistry.

[88]  L. Kremer,et al.  Recent advances and therapeutic journey of coumarins: current status and perspectives , 2015, Medicinal Chemistry Research.

[89]  C. Nantasenamat,et al.  Synthesis, biological evaluation and molecular docking of novel chalcone-coumarin hybrids as anticancer and antimalarial agents. , 2014, European journal of medicinal chemistry.

[90]  M. Ewadh,et al.  Novel Natural Anti Gout Medication Extract from Momdica charantia , 2014 .

[91]  Cheng‐He Zhou,et al.  Current developments of coumarin compounds in medicinal chemistry. , 2013, Current pharmaceutical design.

[92]  Guan-Jhong Huang,et al.  Ameliorative Effects of Scopoletin from Crossostephium chinensis against Inflammation Pain and Its Mechanisms in Mice , 2012, Evidence-based complementary and alternative medicine : eCAM.

[93]  T. Vos,et al.  prevalence of anxiety disorders : a systematic review and meta regression , 2013 .

[94]  H. Joshi,et al.  Coumarin: Chemical and pharmacological profile. , 2012 .

[95]  V. S. Parmar,et al.  Coumarins as antioxidants. , 2011, Current medicinal chemistry.

[96]  Yizhou Dong,et al.  Antitumor agents 281. Design, synthesis, and biological activity of substituted 4-amino-7,8,9,10-tetrahydro-2H-benzo[h]chromen-2-one analogs (ATBO) as potent in vitro anticancer agents. , 2011, Bioorganic & medicinal chemistry letters.

[97]  M. Musa,et al.  A review of coumarin derivatives in pharmacotherapy of breast cancer. , 2008, Current medicinal chemistry.

[98]  Chao-Hsiung Lin,et al.  Recent advances in coumarins and 1-azacoumarins as versatile biodynamic agents. , 2006, Current medicinal chemistry.

[99]  F. Xie,et al.  Synthesis and anti-angiogenesis activity of coumarin derivatives. , 2006, Bioorganic & medicinal chemistry letters.

[100]  H. Morita,et al.  Antimitotic activity of glaupalol-related coumarins from Glaucidium palmatum. , 2004, Bioorganic & medicinal chemistry letters.

[101]  Youn-Chul Kim,et al.  Scopoletin suppresses pro-inflammatory cytokines and PGE2 from LPS-stimulated cell line, RAW 264.7 cells. , 2004, Fitoterapia.

[102]  G. Cordell,et al.  Biologically active alkylated coumarins from Kayea assamica. , 2003, Phytochemistry.

[103]  S. Sotheeswaran,et al.  Anti-HIV coumarins from Calophyllum seed oil. , 1998, Bioorganic & medicinal chemistry letters.

[104]  Bernard Testa,et al.  Selective inhibitors of monoamine oxidase (MAO‐A and MAO‐B) as probes of its catalytic site and mechanism , 1995, Medicinal research reviews.

[105]  M F Bean,et al.  The inophyllums, novel inhibitors of HIV-1 reverse transcriptase isolated from the Malaysian tree, Calophyllum inophyllum Linn. , 1993, Journal of medicinal chemistry.

[106]  G. Schuler,et al.  Intravenous carbochromen: a potent and effective drug for estimation of coronary dilatory capacity. , 1990, European heart journal.

[107]  S. Sethna,et al.  The Chemistry of Coumarins. , 1945 .