The Hyperspectral Infrared Imager (HyspIRI) mission was recommended for implementation by the 2007 report from the U.S. National Research Council Earth Science and Applications from Space: National Imperatives for the Next Decade and Beyond, also known as the Earth Science Decadal Survey. The HyspIRI mission is science driven and will address a set of science questions identified by the Decadal Survey and broader science community. The mission includes a visible shortwave infrared (VSWIR) imaging spectrometer, a multispectral thermal infrared (TIR) imager and an intelligent payload module (IPM). The IPM enables on-board processing and direct broadcast for those applications with short latency requirements. The science questions are organized as VSWIR-only, TIR-only and Combined science questions, the latter requiring data from both instruments. In order to prepare for the mission NASA is undertaking pre-phase A studies to determine the optimum mission implementation, in particular, cost and risk reduction activities. Each year the HyspIRI project is provided with feedback from NASA Headquarters on the pre-phase A activities in the form of a guidance letter which outlines the work that should be undertaken the subsequent year. The 2013 guidance letter included a recommendation to undertake a study to determine the science impact of deploying the instruments from separate spacecraft in sun synchronous orbits with various time separations and deploying both instruments on the International Space Station (ISS). This report summarizes the results from that study. The approach taken was to evaluate the impact on the combined science questions of time separations between the VSWIR and TIR data of <3 minutes, <1 week and a few months as well as deploying both instruments on the ISS. Note the impact was only evaluated for the combined science questions which require data from both instruments (VSWIR and TIR). The study concluded the impact of a separation of <3 minutes was minimal, e.g. if the instruments were on separate platforms that followed each other in a train. The impact of a separation of <1 week was strongly dependent on the question that was being addressed with no impact for some questions and a severe impact for others. The impact of a time separation of several months was severe and in many cases it was no longer possible to answer the sub-question. The impact of deploying the instruments on the ISS which is in a precessive (non-sun synchronous) orbit was also very question dependent, in some cases it was possible to go beyond the original question, e.g. to examine the impact of the diurnal cycle, whereas in other cases the question could not be addressed for example if the question required observations from the polar regions. As part of the study, the participants were asked to estimate, as a percentage, how completely a given sub-question could be answered with 100% indicating the question could be completely answered. These estimations should be treated with caution but nonetheless can be useful in assessing the impact. Averaging the estimates for each of the combined questions the results indicate that 97% of the questions could be answered with a separation of < 3 minutes. With a separation of < 1 week, 67% of the questions could be answered and with a separation of several months only 21% of the questions could be answered.