Endocrine FGFs and Klothos: emerging concepts

[1]  Masashi Suzuki,et al.  betaKlotho is required for fibroblast growth factor (FGF) 21 signaling through FGF receptor (FGFR) 1c and FGFR3c. , 2008, Molecular endocrinology.

[2]  J. D. Dunbar,et al.  FGF‐21/FGF‐21 receptor interaction and activation is determined by βKlotho , 2008, Journal of cellular physiology.

[3]  R. Kumar,et al.  The phosphatonins and the regulation of phosphate homeostasis. , 2008, Annales d'endocrinologie.

[4]  N. Itoh,et al.  Functional evolutionary history of the mouse Fgf gene family , 2008, Developmental dynamics : an official publication of the American Association of Anatomists.

[5]  M. Mohammadi,et al.  The parathyroid is a target organ for FGF23 in rats. , 2007, The Journal of clinical investigation.

[6]  B. Lemon,et al.  Co-receptor Requirements for Fibroblast Growth Factor-19 Signaling* , 2007, Journal of Biological Chemistry.

[7]  C. Blackmore,et al.  Liver-specific Activities of FGF19 Require Klotho beta* , 2007, Journal of Biological Chemistry.

[8]  S. Kliewer,et al.  Tissue-specific Expression of βKlotho and Fibroblast Growth Factor (FGF) Receptor Isoforms Determines Metabolic Activity of FGF19 and FGF21* , 2007, Journal of Biological Chemistry.

[9]  K. White,et al.  A homozygous missense mutation in human KLOTHO causes severe tumoral calcinosis. , 2007, Journal of musculoskeletal & neuronal interactions.

[10]  Jason R. Stubbs,et al.  Role of hyperphosphatemia and 1,25-dihydroxyvitamin D in vascular calcification and mortality in fibroblastic growth factor 23 null mice. , 2007, Journal of the American Society of Nephrology : JASN.

[11]  Shinzo Tanaka,et al.  α-Klotho as a Regulator of Calcium Homeostasis , 2007, Science.

[12]  David D Moore.  Sister Act , 2007, Science.

[13]  S. Kliewer,et al.  Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21. , 2007, Cell metabolism.

[14]  J. Flier,et al.  Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic states. , 2007, Cell metabolism.

[15]  B. Staels,et al.  Bile acids, farnesoid X receptor, atherosclerosis and metabolic control , 2007, Current opinion in lipidology.

[16]  K. Rosenblatt,et al.  βKlotho is required for metabolic activity of fibroblast growth factor 21 , 2007, Proceedings of the National Academy of Sciences.

[17]  S. Kliewer,et al.  Molecular Insights into the Klotho-Dependent, Endocrine Mode of Action of FGF19 Subfamily Members , 2007 .

[18]  S. Kliewer,et al.  Molecular Insights into the Klotho-Dependent, Endocrine Mode of Action of Fibroblast Growth Factor 19 Subfamily Members , 2007, Molecular and Cellular Biology.

[19]  B. Lanske,et al.  Ablation of vitamin D signaling rescues bone, mineral, and glucose homeostasis in Fgf-23 deficient mice. , 2007, Matrix biology : journal of the International Society for Matrix Biology.

[20]  K. Okawa,et al.  Klotho converts canonical FGF receptor into a specific receptor for FGF23 , 2006, Nature.

[21]  S. Kliewer,et al.  Identification of a hormonal basis for gallbladder filling , 2006, Nature Medicine.

[22]  M. Kuro-o.  Klotho as a regulator of fibroblast growth factor signaling and phosphate/calcium metabolism , 2006, Current opinion in nephrology and hypertension.

[23]  Xi Jiang,et al.  Pathogenic role of Fgf23 in Hyp mice. , 2006, American journal of physiology. Endocrinology and metabolism.

[24]  Shaun K Olsen,et al.  Receptor Specificity of the Fibroblast Growth Factor Family , 2006, Journal of Biological Chemistry.

[25]  M. Razzaque,et al.  Premature aging‐like phenotype in fibroblast growth factor 23 null mice is a vitamin D‐mediated process , 2006, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[26]  K. Rosenblatt,et al.  Regulation of Fibroblast Growth Factor-23 Signaling by Klotho* , 2006, Journal of Biological Chemistry.

[27]  Philippe Lefebvre,et al.  Sorting out the roles of PPARα in energy metabolism and vascular homeostasis , 2006 .

[28]  D. Mangelsdorf,et al.  LXRS and FXR: the yin and yang of cholesterol and fat metabolism. , 2006, Annual review of physiology.

[29]  B. Thisse,et al.  Functions and regulations of fibroblast growth factor signaling during embryonic development. , 2005, Developmental biology.

[30]  K. Rosenblatt,et al.  Regulation of Oxidative Stress by the Anti-aging Hormone Klotho*♦ , 2005, Journal of Biological Chemistry.

[31]  K. White,et al.  Analysis of the biochemical mechanisms for the endocrine actions of fibroblast growth factor-23. , 2005, Endocrinology.

[32]  S. Kliewer,et al.  Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis. , 2005, Cell metabolism.

[33]  Animesh Nandi,et al.  Suppression of Aging in Mice by the Hormone Klotho , 2005, Science.

[34]  Y. Nabeshima,et al.  Impaired negative feedback suppression of bile acid synthesis in mice lacking betaKlotho. , 2005, The Journal of clinical investigation.

[35]  K. White,et al.  Genetic dissection of phosphate- and vitamin D-mediated regulation of circulating Fgf23 concentrations. , 2005, Bone.

[36]  J. Gromada,et al.  FGF-21 as a novel metabolic regulator. , 2005, The Journal of clinical investigation.

[37]  Shaun K Olsen,et al.  Structural basis for fibroblast growth factor receptor activation. , 2005, Cytokine & growth factor reviews.

[38]  Christof Niehrs,et al.  Fibroblast growth factor signaling during early vertebrate development. , 2005, Endocrine reviews.

[39]  N. Itoh,et al.  Evolution of the Fgf and Fgfr gene families. , 2004, Trends in genetics : TIG.

[40]  M. Inaba,et al.  FGF-23 in patients with end-stage renal disease on hemodialysis. , 2004, Kidney international.

[41]  Y. Takeuchi,et al.  Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism. , 2004, The Journal of clinical investigation.

[42]  T. Blundell,et al.  The crystal structure of fibroblast growth factor (FGF) 19 reveals novel features of the FGF family and offers a structural basis for its unusual receptor affinity. , 2004, Biochemistry.

[43]  Y. Takeuchi,et al.  FGF‐23 Is a Potent Regulator of Vitamin D Metabolism and Phosphate Homeostasis , 2003, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[44]  K. Fukuda,et al.  Klotho, a gene related to a syndrome resembling human premature aging, functions in a negative regulatory circuit of vitamin D endocrine system. , 2003, Molecular endocrinology.

[45]  L. Quarles,et al.  FGF23, PHEX, and MEPE regulation of phosphate homeostasis and skeletal mineralization. , 2003, American journal of physiology. Endocrinology and metabolism.

[46]  E. Brown,et al.  Calcium: Extracellular calcium sensing and signalling , 2003, Nature Reviews Molecular Cell Biology.

[47]  D. Miao,et al.  The Autosomal Dominant Hypophosphatemic Rickets R176Q Mutation in Fibroblast Growth Factor 23 Resists Proteolytic Cleavage and Enhances in Vivo Biological Potency* , 2003, The Journal of Biological Chemistry.

[48]  Y. Nabeshima,et al.  Mediation of Unusually High Concentrations of 1,25-Dihydroxyvitamin D in Homozygous klotho Mutant Mice by Increased Expression of Renal 1α-Hydroxylase Gene. , 2002, Endocrinology.

[49]  T. Strom,et al.  Autosomal-dominant hypophosphatemic rickets (ADHR) mutations stabilize FGF-23. , 2001, Kidney international.

[50]  Y. Nabeshima,et al.  The progression of aging in klotho mutant mice can be modified by dietary phosphorus and zinc. , 2001, The Journal of nutrition.

[51]  S. Takeda,et al.  Cloning and characterization of FGF23 as a causative factor of tumor-induced osteomalacia , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[52]  Y. Nabeshima,et al.  Molecular cloning and expression analyses of mouse βklotho, which encodes a novel Klotho family protein , 2000, Mechanisms of Development.

[53]  T. Meitinger,et al.  Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23 , 2000, Nature Genetics.

[54]  L. Moore,et al.  A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis. , 2000, Molecular cell.

[55]  J. Schlessinger,et al.  Crystal structure of a ternary FGF-FGFR-heparin complex reveals a dual role for heparin in FGFR binding and dimerization. , 2000, Molecular cell.

[56]  T. A. Kerr,et al.  Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors. , 2000, Molecular cell.

[57]  Sander Kersten,et al.  Roles of PPARs in health and disease , 2000, Nature.

[58]  C. Deng,et al.  Elevated Cholesterol Metabolism and Bile Acid Synthesis in Mice Lacking Membrane Tyrosine Kinase Receptor FGFR4* , 2000, The Journal of Biological Chemistry.

[59]  W. Wahli,et al.  Peroxisome proliferator–activated receptor α mediates the adaptive response to fasting , 1999 .

[60]  M. Kostrzewa,et al.  Genomic structure and complete sequence of the human FGFR4 gene , 1998, Mammalian Genome.

[61]  R. Nagai,et al.  Identification of the human klotho gene and its two transcripts encoding membrane and secreted klotho protein. , 1998, Biochemical and biophysical research communications.

[62]  Tadashi Kaname,et al.  Mutation of the mouse klotho gene leads to a syndrome resembling ageing , 1997, Nature.

[63]  C. MacArthur,et al.  Receptor Specificity of the Fibroblast Growth Factor Family* , 1996, The Journal of Biological Chemistry.

[64]  D. Givol,et al.  Complexity of FGF receptors: genetic basis for structural diversity and functional specificity , 1992, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[65]  G. Bell,et al.  Mammalian facilitative glucose transporter family: structure and molecular regulation. , 1992, Annual review of physiology.