Activation of lipophagy is required for RAB7 to regulate ferroptosis in sepsis-induced acute kidney injury.

[1]  Jian Xiao,et al.  Attenuation of Sepsis-Induced Acute Kidney Injury by Exogenous H2S via Inhibition of Ferroptosis , 2023, Molecules.

[2]  Z. Ni,et al.  Mitophagy alleviates cisplatin-induced renal tubular epithelial cell ferroptosis through ROS/HO-1/GPX4 axis , 2023, International journal of biological sciences.

[3]  Zhanjun Jia,et al.  A novel 3-phenylglutaric acid derivative (84-B10) alleviates cisplatin-induced acute kidney injury by inhibiting mitochondrial ROS-mediated ferroptosis. , 2022, Free radical biology & medicine.

[4]  Taofang Hao,et al.  A protein encoded by circular ZNF609 RNA induces acute kidney injury by activating AKT/mTOR-autophagy pathway. , 2022, Molecular therapy : the journal of the American Society of Gene Therapy.

[5]  Jianyun Yan,et al.  Repression of the antiporter SLC7A11/Glutathione/Glutathione Peroxidase 4 axis drives ferroptosis of vascular smooth muscle cells to facilitate vascular calcification. , 2022, Kidney international.

[6]  Dong-Hyun Kim,et al.  Farnesoid X receptor protects against cisplatin-induced acute kidney injury by regulating the transcription of ferroptosis-related genes , 2022, Redox biology.

[7]  Lianxiang Luo,et al.  STAT3-mediated ferroptosis is involved in ulcerative colitis. , 2022, Free radical biology & medicine.

[8]  Z. Dong,et al.  Tubular cells produce FGF2 via autophagy after acute kidney injury leading to fibroblast activation and renal fibrosis , 2022, Autophagy.

[9]  M. Miyazaki,et al.  Sulforaphane induces lipophagy through the activation of AMPK-mTOR-ULK1 pathway signaling in adipocytes. , 2022, The Journal of nutritional biochemistry.

[10]  Yali Su,et al.  ACSL4 deficiency confers protection against ferroptosis-mediated acute kidney injury , 2022, Redox biology.

[11]  X. Ci,et al.  Leonurine alleviates ferroptosis in cisplatin‐induced acute kidney injury by activating the Nrf2 signalling pathway , 2021, British journal of pharmacology.

[12]  J. Roh,et al.  PGRMC1-dependent lipophagy promotes ferroptosis in paclitaxel-tolerant persister cancer cells , 2021, Journal of experimental & clinical cancer research : CR.

[13]  D. Ford,et al.  The lipid biology of sepsis , 2021, Journal of lipid research.

[14]  S. Yue,et al.  Legumain promotes tubular ferroptosis by facilitating chaperone-mediated autophagy of GPX4 in AKI , 2021, Cell death & disease.

[15]  Guisen Li,et al.  Isoliquiritigenin attenuates septic acute kidney injury by regulating ferritinophagy-mediated ferroptosis , 2021, Renal failure.

[16]  Z. Ni,et al.  Inhibiting NLRP3 inflammasome attenuates apoptosis in contrast-induced acute kidney injury through the upregulation of HIF1A and BNIP3-mediated mitophagy , 2020, Autophagy.

[17]  Z. Dong,et al.  Autophagy in kidney homeostasis and disease , 2020, Nature Reviews Nephrology.

[18]  Wei Zhang,et al.  Exercise and dietary intervention ameliorate high-fat diet-induced NAFLD and liver aging by inducing lipophagy , 2020, Redox biology.

[19]  Shi-kun Yang,et al.  VDR activation attenuate cisplatin induced AKI by inhibiting ferroptosis , 2020, Cell Death & Disease.

[20]  M. Tang,et al.  PM2.5 induces ferroptosis in human endothelial cells through iron overload and redox imbalance. , 2019, Environmental pollution.

[21]  D. Klionsky,et al.  Autophagic degradation of the circadian clock regulator promotes ferroptosis , 2019, Autophagy.

[22]  Z. Ni,et al.  PINK1-parkin pathway of mitophagy protects against contrast-induced acute kidney injury via decreasing mitochondrial ROS and NLRP3 inflammasome activation , 2019, Redox biology.

[23]  Hong Zhu,et al.  GPx4 in Bacterial Infection and Polymicrobial Sepsis: Involvement of Ferroptosis and Pyroptosis. , 2019, Reactive oxygen species.

[24]  Y. Jia,et al.  Lipid storage and lipophagy regulates ferroptosis. , 2019, Biochemical and biophysical research communications.

[25]  Z. Dong,et al.  Epigenetic regulation in AKI and kidney repair: mechanisms and therapeutic implications , 2019, Nature Reviews Nephrology.

[26]  Feng Zhang,et al.  Activation of ferritinophagy is required for the RNA-binding protein ELAVL1/HuR to regulate ferroptosis in hepatic stellate cells , 2018, Autophagy.

[27]  Haichao Wang,et al.  Lipid Peroxidation Drives Gasdermin D-Mediated Pyroptosis in Lethal Polymicrobial Sepsis. , 2018, Cell host & microbe.

[28]  N. Mizushima.  A brief history of autophagy from cell biology to physiology and disease , 2018, Nature Cell Biology.

[29]  P. Zamberlan,et al.  Changes in lipid metabolism in pediatric patients with severe sepsis and septic shock. , 2018, Nutrition.

[30]  B. Stockwell,et al.  Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease , 2017, Cell.

[31]  C. Sztalryd,et al.  The perilipin family of lipid droplet proteins: Gatekeepers of intracellular lipolysis. , 2017, Biochimica et biophysica acta. Molecular and cell biology of lipids.

[32]  P. Saha,et al.  The constitutive lipid droplet protein PLIN2 regulates autophagy in liver , 2017, Autophagy.

[33]  C. A. Prauchner.  Oxidative stress in sepsis: Pathophysiological implications justifying antioxidant co-therapy. , 2017, Burns : journal of the International Society for Burn Injuries.

[34]  Han Jun Cho,et al.  αKlotho Mitigates Progression of AKI to CKD through Activation of Autophagy. , 2016, Journal of the American Society of Nephrology : JASN.

[35]  M. Lotze,et al.  Autophagy promotes ferroptosis by degradation of ferritin , 2016, Autophagy.

[36]  B. Stockwell,et al.  Ferroptosis: Death by Lipid Peroxidation. , 2016, Trends in cell biology.

[37]  Adil Rafiq Rather,et al.  The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3) , 2015 .

[38]  Yan Wang,et al.  Acute kidney injury in China: a cross-sectional survey , 2015, The Lancet.

[39]  Rinaldo Bellomo,et al.  Epidemiology of acute kidney injury in critically ill patients: the multinational AKI-EPI study , 2015, Intensive Care Medicine.

[40]  M. McNiven,et al.  The small GTPase Rab7 as a central regulator of hepatocellular lipophagy , 2015, Hepatology.

[41]  A. Walch,et al.  Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice , 2014, Nature Cell Biology.

[42]  B. Levine,et al.  Autosis and autophagic cell death: the dark side of autophagy , 2014, Cell Death and Differentiation.

[43]  Matthew E. Welsch,et al.  Pharmacological inhibition of cystine–glutamate exchange induces endoplasmic reticulum stress and ferroptosis , 2014, eLife.

[44]  Matthew E. Welsch,et al.  Regulation of Ferroptotic Cancer Cell Death by GPX4 , 2014, Cell.

[45]  J. Kellum,et al.  A Unified Theory of Sepsis-Induced Acute Kidney Injury: Inflammation, Microcirculatory Dysfunction, Bioenergetics, and the Tubular Cell Adaptation to Injury , 2014, Shock.

[46]  Robert V Farese,et al.  Lipid droplets and cellular lipid metabolism. , 2012, Annual review of biochemistry.

[47]  M. R. Lamprecht,et al.  Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death , 2012, Cell.

[48]  J. Hartle,et al.  Increased risk of death and de novo chronic kidney disease following reversible acute kidney injury. , 2012, Kidney international.

[49]  M. Czaja,et al.  Autophagy regulates lipid metabolism , 2009, Nature.

[50]  M. Murakami,et al.  Autophagy Is Essential for Preimplantation Development of Mouse Embryos , 2008, Science.

[51]  R. Bellomo,et al.  Septic acute kidney injury in critically ill patients: clinical characteristics and outcomes. , 2007, Clinical journal of the American Society of Nephrology : CJASN.

[52]  R. Bellomo,et al.  Acute renal failure in critically ill patients: a multinational, multicenter study. , 2005, JAMA.

[53]  A. Walch,et al.  ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition. , 2017, Nature chemical biology.

[54]  A. Sanz,et al.  Ferroptosis, but Not Necroptosis, Is Important in Nephrotoxic Folic Acid-Induced AKI. , 2017, Journal of the American Society of Nephrology : JASN.

[55]  Robert G. Parton,et al.  Opinion: Lipid droplets: a unified view of a dynamic organelle , 2006, Nature Reviews Molecular Cell Biology.