Rapid-Throughput Skeletal Phenotyping of 100 Knockout Mice Identifies 9 New Genes That Determine Bone Strength
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Alan Boyde | Peter I. Croucher | Jacqueline K. White | Ramiro Ramirez-Solis | R. Ramirez-Solis | A. Boyde | P. Croucher | E. Ryder | D. Sunter | J. Bassett | A. H. van der Spek | A. Gogakos | G. Williams | R. Jacques | J. H. Duncan Bassett | Graham R. Williams | David Sunter | H. Evans | Apostolos Gogakos | Holly Evans | Richard M. Jacques | Anne H. van der Spek | Edward Ryder | Michael J. Campbell | A. V. D. Spek | Sanger Mouse Genetics | G. Williams | R. Ramírez‐Solís
[1] David L. Lacey,et al. Osteoclast differentiation and activation , 2003, Nature.
[2] Xiaolu Yang,et al. SUMO E3 ligase activity of TRIM proteins , 2011, Oncogene.
[3] M. Ishii,et al. The role of sphingosine 1-phosphate in migration of osteoclast precursors; an application of intravital two-photon microscopy , 2011, Molecules and cells.
[4] R. Baron,et al. Wnt signaling and the regulation of bone mass , 2007, Current osteoporosis reports.
[5] P. Chambon,et al. Retinoic acid receptors are required for skeletal growth, matrix homeostasis and growth plate function in postnatal mouse. , 2009, Developmental biology.
[6] B. Everitt. An R and S-Plus® Companion to Multivariate Analysis , 2007 .
[7] J. Harrow,et al. A conditional knockout resource for the genome-wide study of mouse gene function , 2011, Nature.
[8] Richard P Lifton,et al. High bone density due to a mutation in LDL-receptor-related protein 5. , 2002, The New England journal of medicine.
[9] T. Rachner,et al. Osteoporosis: now and the future , 2011, The Lancet.
[10] F. Baas,et al. Identification of Novel Candidate Oncogenes in Chromosome Region 17p11.2-p12 in Human Osteosarcoma , 2012, PloS one.
[11] P. Rousseeuw,et al. Unmasking Multivariate Outliers and Leverage Points , 1990 .
[12] A. Ito,et al. Nerve-mast cell and smooth muscle-mast cell interaction mediated by cell adhesion molecule-1, CADM1. , 2008, Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi.
[13] D. Rimoin,et al. Nucleotide-sugar transporter SLC35D1 is critical to chondroitin sulfate synthesis in cartilage and skeletal development in mouse and human , 2007, Nature Medicine.
[14] Kari Stefansson,et al. Multiple genetic loci for bone mineral density and fractures. , 2008, The New England journal of medicine.
[15] E. Lander,et al. A Family of Chondrodysplasias Caused by Mutations in the Diastrophic Dysplasia Sulfate Transporter Gene and Associated with Impaired Sulfation of Proteoglycans a , 1996, Annals of the New York Academy of Sciences.
[16] Yurii S. Aulchenko,et al. Twenty bone mineral density loci identified by large-scale meta-analysis of genome-wide association studies , 2009, Nature Genetics.
[17] W. Van Hul,et al. The genetics of low-density lipoprotein receptor-related protein 5 in bone: a story of extremes. , 2007, Endocrinology.
[18] P. Rousseeuw. Multivariate estimation with high breakdown point , 1985 .
[19] R. Recker,et al. Bone biomechanical properties in LRP5 mutant mice. , 2004, Bone.
[20] S. Khosla,et al. Regulation of bone formation by osteoclasts involves Wnt/BMP signaling and the chemokine sphingosine-1-phosphate , 2008, Proceedings of the National Academy of Sciences.
[21] Miikka Vikkula,et al. LDL Receptor-Related Protein 5 (LRP5) Affects Bone Accrual and Eye Development , 2001, Cell.
[22] L. Vissers,et al. De novo nonsense mutations in ASXL1 cause Bohring-Opitz syndrome , 2011, Nature Genetics.
[23] S. Mundlos,et al. Heritable diseases of the skeleton. Part I: Molecular insights into skeletal development‐transcription factors and signaling pathways 1 , 1997, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[24] R. H. Bassett,et al. Optimal bone strength and mineralization requires the type 2 iodothyronine deiodinase in osteoblasts , 2010, Proceedings of the National Academy of Sciences.
[25] M. Justice. Removing the cloak of invisibility: phenotyping the mouse , 2008, Disease Models & Mechanisms.
[26] Wolfgang Wurst,et al. A Mouse for All Reasons , 2007, Cell.
[27] David A. Case,et al. Structural basis for DNA bending by the architectural transcription factor LEF-1 , 1995, Nature.
[28] Jacqueline K. White,et al. Optimising experimental design for high-throughput phenotyping in mice: a case study , 2010, Mammalian Genome.
[29] A Hofman,et al. Bone mineral density, osteoporosis, and osteoporotic fractures: a genome-wide association study , 2008, The Lancet.
[30] E. Vilain,et al. Dimerization of SOX9 is required for chondrogenesis, but not for sex determination. , 2003, Human molecular genetics.
[31] J. Hess,et al. Additional sex combs-like 1 belongs to the enhancer of trithorax and polycomb group and genetically interacts with Cbx2 in mice. , 2010, Developmental biology.
[32] R. Rizzoli,et al. Bone strength and its determinants , 2003, Osteoporosis International.
[33] Narmada Thanki,et al. CDD: specific functional annotation with the Conserved Domain Database , 2008, Nucleic Acids Res..
[34] S. Cummings,et al. Fracture risk reduction with alendronate in women with osteoporosis: the Fracture Intervention Trial. FIT Research Group. , 2000, The Journal of clinical endocrinology and metabolism.
[35] Daniel L. Koller,et al. Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture , 2012, Nature Genetics.
[36] E. Wagner. Bone development and inflammatory disease is regulated by AP-1 (Fos/Jun) , 2009, Annals of the rheumatic diseases.
[37] A. Yamaguchi,et al. The Sphingosine 1-Phosphate Transporter, SPNS2, Functions as a Transporter of the Phosphorylated Form of the Immunomodulating Agent FTY720* , 2010, The Journal of Biological Chemistry.
[38] M. Taira,et al. Mammalian phosphoribosyl-pyrophosphate synthetase. , 1995, Advances in Enzyme Regulation.
[39] M. Drezner,et al. Bone histomorphometry: Standardization of nomenclature, symbols, and units: Report of the asbmr histomorphometry nomenclature committee , 1987, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
[40] P Chambon,et al. EMPReSS: standardized phenotype screens for functional annotation of the mouse genome , 2005, Nature Genetics.
[41] W C Hutton,et al. The mechanical properties of bone in osteoporosis. , 1981, The Journal of bone and joint surgery. British volume.
[42] Hong-Hee Kim,et al. Sphingosine 1‐phosphate as a regulator of osteoclast differentiation and osteoclast–osteoblast coupling , 2006, The EMBO journal.
[43] A. Boskey,et al. Infrared Analysis of the Mineral and Matrix in Bones of Osteonectin‐Null Mice and Their Wildtype Controls , 2003, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
[44] R. Hay,et al. Functional interactions between ubiquitin E2 enzymes and TRIM proteins. , 2011, The Biochemical journal.
[45] P. Kostenuik,et al. Targeted Deletion of the Sclerostin Gene in Mice Results in Increased Bone Formation and Bone Strength , 2008, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
[46] O. Johnell,et al. An estimate of the worldwide prevalence and disability associated with osteoporotic fractures , 2006, Osteoporosis International.
[47] D. Lilley,et al. HMG box proteins bind to four‐way DNA junctions in their open conformation , 1998, The EMBO journal.
[48] F. Luyten,et al. Wnt signaling and osteoarthritis. , 2009, Bone.
[49] F. Watt,et al. Necl2 regulates epidermal adhesion and wound repair , 2009, Development.
[50] M. Amling,et al. Osteopenia and decreased bone formation in osteonectin-deficient mice , 2000, The Journal of clinical investigation.
[51] A. Prentice,et al. Effects of recombinant leptin therapy in a child with congenital leptin deficiency. , 1999, The New England journal of medicine.
[52] B. Sundberg,et al. The Evolutionary History and Tissue Mapping of Amino Acid Transporters Belonging to Solute Carrier Families SLC32, SLC36, and SLC38 , 2008, Journal of Molecular Neuroscience.
[53] Xi He,et al. Wnt/beta-catenin signaling: components, mechanisms, and diseases. , 2009, Developmental cell.
[54] G. Maul,et al. SETDB1: a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins. , 2002, Genes & development.
[55] T. Hansen,et al. Mutations in the hepatocyte nuclear factor-1α gene in maturity-onset diabetes of the young (MODY3) , 1996, Nature.
[56] C. Basilico,et al. Coevolution of HMG domains and homeodomains and the generation of transcriptional regulation by Sox/POU complexes , 2001, Journal of cellular physiology.
[57] Yi Zhang,et al. Molecular cloning of ESET, a novel histone H3-specific methyltransferase that interacts with ERG transcription factor , 2002, Oncogene.
[58] H. Fukuhara,et al. TSLC1 is a tumor-suppressor gene in human non-small-cell lung cancer , 2001, Nature Genetics.
[59] Gideon A. Rodan,et al. Control of osteoblast function and regulation of bone mass , 2003, Nature.
[60] H. Shibuya,et al. Nemo-like kinase (NLK) expression in osteoblastic cells and suppression of osteoblastic differentiation. , 2010, Experimental cell research.
[61] R. Visigalli,et al. The role of the neutral amino acid transporter SNAT2 in cell volume regulation , 2006, Acta physiologica.
[62] H. Kronenberg,et al. Developmental regulation of the growth plate , 2003, Nature.
[63] Michael C. Nevitt,et al. Fracture Risk Reduction With Alendronate in Women With Osteoporosis: The Fracture Intervention Trial , 2001 .
[64] A. F. Mitchell,et al. The Mahalanobis distance and elliptic distributions , 1985 .
[65] D. Wellik. Hox patterning of the vertebrate axial skeleton , 2007, Developmental dynamics : an official publication of the American Association of Anatomists.
[66] Y Wang,et al. Positional cloning of the gene for multiple endocrine neoplasia-type 1. , 1997, Science.
[67] D. Goldstein,et al. Uncovering the roles of rare variants in common disease through whole-genome sequencing , 2010, Nature Reviews Genetics.
[68] S. Ortolani,et al. Genetics of osteoporosis , 1994, Calcified Tissue International.
[69] S. O’Rahilly,et al. Congenital leptin deficiency is associated with severe early-onset obesity in humans , 1997, Nature.
[70] F. Ashcroft,et al. Switching from insulin to oral sulfonylureas in patients with diabetes due to Kir6.2 mutations. , 2006, The New England journal of medicine.
[71] D. Galas,et al. Bone dysplasia sclerosteosis results from loss of the SOST gene product, a novel cystine knot-containing protein. , 2001, American journal of human genetics.
[72] Zhiling Yu,et al. Impairment of social and emotional behaviors in Cadm1-knockout mice. , 2010, Biochemical and biophysical research communications.
[73] S. Um,et al. ASXL1 Represses Retinoic Acid Receptor-mediated Transcription through Associating with HP1 and LSD1* , 2009, The Journal of Biological Chemistry.
[74] Toshihisa Komori,et al. Regulation of osteoblast differentiation by transcription factors , 2006, Journal of cellular biochemistry.
[75] Steve D. M. Brown,et al. A hearing and vestibular phenotyping pipeline to identify mouse mutants with hearing impairment , 2010, Nature Protocols.
[76] F. Watt,et al. Epidermal Cadm1 Expression Promotes Autoimmune Alopecia via Enhanced T Cell Adhesion and Cytotoxicity , 2012, The Journal of Immunology.
[77] S. Cummings,et al. Effects of antiresorptive treatment on nonvertebral fracture outcomes , 2011, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
[78] T. Südhof,et al. SynCAM, a Synaptic Adhesion Molecule That Drives Synapse Assembly , 2002, Science.
[79] William N. Venables,et al. Modern Applied Statistics with S , 2010 .
[80] K. Ozato,et al. TRIM family proteins and their emerging roles in innate immunity , 2008, Nature Reviews Immunology.
[81] P. Esposito,et al. Osteogenesis Imperfecta. , 1928, Proceedings of the Royal Society of Medicine.
[82] C. Löwik,et al. A new paradigm in the treatment of osteoporosis: Wnt pathway proteins and their antagonists. , 2007, Current opinion in investigational drugs.
[83] M. Ishii,et al. Sphingosine-1-phosphate mobilizes osteoclast precursors and regulates bone homeostasis , 2009, Nature.
[84] H. Clevers,et al. Ancestry and diversity of the HMG box superfamily. , 1993, Nucleic acids research.
[85] K. Toshimori,et al. Oligo-Astheno-Teratozoospermia in Mice Lacking RA175/TSLC1/SynCAM/IGSF4A, a Cell Adhesion Molecule in the Immunoglobulin Superfamily , 2006, Molecular and Cellular Biology.
[86] F. Liu,et al. TRIM45, a novel human RBCC/TRIM protein, inhibits transcriptional activities of ElK-1 and AP-1. , 2004, Biochemical and biophysical research communications.