CRISPR somatic genome engineering and cancer modeling in the mouse pancreas and liver
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D. Saur | M. Schmidt-Supprian | M. Reichert | G. Schneider | S. Engelhardt | Petros Avramopoulos | J. Weber | U. Ehmer | Roman Maresch | Thorsten Kaltenbacher | Joscha Griger | D. Ramanujam | S. Brummer | R. Rad | Sebastian Müller | A. Pfaus | S. Bärthel | Jessica Löprich | N. Gross | A. Alnatsha | N. de Andrade Krätzig | Rupert Oellinger | Sebastian A. Widholz | Christian J. Braun | C. Falcomatà | Julia Mayerle | J. Mayerle | Sabine Brummer
[1] Timothy E. Reddy,et al. Transgenic mice for in vivo epigenome editing with CRISPR-based systems , 2021, Nature Methods.
[2] D. Weissman,et al. Murine liver repair via transient activation of regenerative pathways in hepatocytes using lipid nanoparticle-complexed nucleoside-modified mRNA , 2021, Nature Communications.
[3] T. Flotte,et al. Improved prime editors enable pathogenic allele correction and cancer modelling in adult mice , 2020, Nature Communications.
[4] Nicholas A. Peppas,et al. Engineering precision nanoparticles for drug delivery , 2020, Nature reviews. Drug discovery.
[5] Gennaro Sanità,et al. Nanoparticle Surface Functionalization: How to Improve Biocompatibility and Cellular Internalization , 2020, Frontiers in Molecular Biosciences.
[6] Yunxue Xu,et al. Key considerations in designing CRISPR/Cas9-carrying nanoparticles for therapeutic genome editing. , 2020, Nanoscale.
[7] S. Barry,et al. Development of an ObLiGaRe Doxycycline Inducible Cas9 system for pre-clinical cancer drug discovery , 2020, Nature Communications.
[8] Xiyu Liu,et al. Precise and efficient silencing of mutant KrasG12D by CRISPR-CasRx controls pancreatic cancer progression , 2020, Theranostics.
[9] J. Keith Joung,et al. CRISPR C-to-G base editors for inducing targeted DNA transversions in human cells , 2020, Nature Biotechnology.
[10] E. Olson,et al. Systemic nanoparticle delivery of CRISPR-Cas9 ribonucleoproteins for effective tissue specific genome editing , 2020, Nature Communications.
[11] David R. Liu,et al. Genome editing with CRISPR–Cas nucleases, base editors, transposases and prime editors , 2020, Nature Biotechnology.
[12] David R. Liu,et al. Programmable m6A modification of cellular RNAs with a Cas13-directed methyltransferase , 2020, Nature Biotechnology.
[13] Pawel Sledzinski,et al. Computational Tools and Resources Supporting CRISPR-Cas Experiments , 2020, Cells.
[14] J. Doench,et al. Design and analysis of CRISPR–Cas experiments , 2020, Nature Biotechnology.
[15] Oana M. Enache,et al. Cas9 activates the p53 pathway and selects for p53-inactivating mutations , 2020, Nature Genetics.
[16] Qiang Cheng,et al. Selective ORgan Targeting (SORT) nanoparticles for tissue specific mRNA delivery and CRISPR/Cas gene editing , 2020, Nature Nanotechnology.
[17] Zhijie Li,et al. Modulation of metabolic functions through Cas13d-mediated gene knockdown in liver , 2020, Protein & Cell.
[18] R. Herzog,et al. Immune Responses to Viral Gene Therapy Vectors , 2020, Molecular therapy : the journal of the American Society of Gene Therapy.
[19] Sebastian Lange,et al. Analysis pipelines for cancer genome sequencing in mice , 2020, Nature Protocols.
[20] S. Orkin,et al. An Engineered CRISPR-Cas9 Mouse Line for Simultaneous Readout of Lineage Histories and Gene Expression Profiles in Single Cells , 2019, Cell.
[21] David R. Liu,et al. Search-and-replace genome editing without double-strand breaks or donor DNA , 2019, Nature.
[22] Max J. Kellner,et al. A cytosine deaminase for programmable single-base RNA editing , 2019, Science.
[23] C. Gersbach,et al. The next generation of CRISPR–Cas technologies and applications , 2019, Nature Reviews Molecular Cell Biology.
[24] Mathias J Friedrich,et al. PiggyBac transposon tools for recessive screening identify B-cell lymphoma drivers in mice , 2019, Nature Communications.
[25] Matthew C. Canver,et al. CRISPResso2 provides accurate and rapid genome editing sequence analysis , 2019, Nature Biotechnology.
[26] A. Maitra,et al. A pipeline for rapidly generating genetically engineered mouse models of pancreatic cancer using in vivo CRISPR-Cas9-mediated somatic recombination , 2018, bioRxiv.
[27] R. Rad,et al. Engineering CRISPR mouse models of cancer. , 2019, Current opinion in genetics & development.
[28] David R. Liu,et al. Base editing: precision chemistry on the genome and transcriptome of living cells , 2018, Nature Reviews Genetics.
[29] M. Robinson,et al. Treatment of a metabolic liver disease by in vivo genome base editing in adult mice , 2018, Nature Medicine.
[30] A. Cheng,et al. CRISPR artificial splicing factors , 2018, bioRxiv.
[31] T. Luedde,et al. Necroptosis microenvironment directs lineage commitment in liver cancer , 2018, Nature.
[32] Dana Carroll,et al. Nucleosomes inhibit target cleavage by CRISPR-Cas9 in vivo , 2018, Proceedings of the National Academy of Sciences.
[33] D. Hougaard,et al. Improved Lentiviral Gene Delivery to Mouse Liver by Hydrodynamic Vector Injection through Tail Vein , 2018, Molecular therapy. Nucleic acids.
[34] Max A. Horlbeck,et al. Combinatorial genetics in liver repopulation and carcinogenesis with a in vivo CRISPR activation platform , 2018, Hepatology.
[35] Martin J. Aryee,et al. In vivo CRISPR editing with no detectable genome-wide off-target mutations , 2018, Nature.
[36] A. Bradley,et al. Repair of double-strand breaks induced by CRISPR–Cas9 leads to large deletions and complex rearrangements , 2018, Nature Biotechnology.
[37] Kang Zhang,et al. In Situ Gene Therapy via AAV-CRISPR-Cas9-Mediated Targeted Gene Regulation. , 2018, Molecular therapy : the journal of the American Society of Gene Therapy.
[38] Maximilian Haeussler,et al. CRISPOR: intuitive guide selection for CRISPR/Cas9 genome editing experiments and screens , 2018, Nucleic Acids Res..
[39] Eugene Chung,et al. Adenine base editing in mouse embryos and an adult mouse model of Duchenne muscular dystrophy , 2018, Nature Biotechnology.
[40] P. Thakore,et al. RNA-guided transcriptional silencing in vivo with S. aureus CRISPR-Cas9 repressors , 2018, Nature Communications.
[41] S. Konermann,et al. Transcriptome Engineering with RNA-Targeting Type VI-D CRISPR Effectors , 2018, Cell.
[42] J. Pelletier,et al. Inducible Genome Editing with Conditional CRISPR/Cas9 Mice , 2018, G3: Genes, Genomes, Genetics.
[43] W. Harrington,et al. A Single Administration of CRISPR/Cas9 Lipid Nanoparticles Achieves Robust and Persistent In Vivo Genome Editing. , 2018, Cell reports.
[44] G. Ronzitti,et al. Influence of Pre-existing Anti-capsid Neutralizing and Binding Antibodies on AAV Vector Transduction , 2018, Molecular therapy. Methods & clinical development.
[45] R. Schmid,et al. Constitutive and Inducible Systems for Genetic In Vivo Modification of Mouse Hepatocytes Using Hydrodynamic Tail Vein Injection. , 2018, Journal of visualized experiments : JoVE.
[46] Randall J. Platt,et al. Mapping a functional cancer genome atlas of tumor suppressors in mouse liver using AAV-CRISPR–mediated direct in vivo screening , 2018, Science Advances.
[47] Mathias J Friedrich,et al. Evolutionary routes and KRAS dosage define pancreatic cancer phenotypes , 2018, Nature.
[48] M. Korc,et al. Safety and Efficacy of AAV Retrograde Pancreatic Ductal Gene Delivery in Normal and Pancreatic Cancer Mice , 2017, Molecular therapy. Methods & clinical development.
[49] Alexander A. Sousa,et al. Enhanced proofreading governs CRISPR-Cas9 targeting accuracy Please share how this access benefits you. Your story matters , 2018 .
[50] Huatai Xu,et al. In vivo simultaneous transcriptional activation of multiple genes in the brain using CRISPR–dCas9-activator transgenic mice , 2018, Nature Neuroscience.
[51] C. R. Esteban,et al. In Vivo Target Gene Activation via CRISPR/Cas9-Mediated Trans-epigenetic Modulation , 2017, Cell.
[52] Christopher D. McFarland,et al. Multiplexed in vivo homology-directed repair and tumor barcoding enables parallel quantification of Kras variant oncogenicity , 2017, Nature Communications.
[53] Max J. Kellner,et al. RNA editing with CRISPR-Cas13 , 2017, Science.
[54] Daniel G. Anderson,et al. Structure-guided chemical modification of guide RNA enables potent non-viral in vivo genome editing , 2017, Nature Biotechnology.
[55] Kiran Musunuru,et al. In Vivo Base Editing of PCSK9 (Proprotein Convertase Subtilisin/Kexin Type 9) as a Therapeutic Alternative to Genome Editing , 2017, Arteriosclerosis, thrombosis, and vascular biology.
[56] Jennifer A. Doudna,et al. Enhanced proofreading governs CRISPR-Cas9 targeting accuracy , 2017, Nature.
[57] Neville E Sanjana,et al. GUIDES: sgRNA design for loss-of-function screens , 2017, Nature Methods.
[58] M. Capecchi,et al. piggyBac mediates efficient in vivo CRISPR library screening for tumorigenesis in mice , 2017, Proceedings of the National Academy of Sciences.
[59] Jos Jonkers,et al. Genetically engineered mouse models in oncology research and cancer medicine , 2016, EMBO molecular medicine.
[60] Jin-Soo Kim,et al. Cas-analyzer: an online tool for assessing genome editing results using NGS data , 2016, Bioinform..
[61] Ian D. McGilvray,et al. Nanoparticle-liver interactions: Cellular uptake and hepatobiliary elimination. , 2016, Journal of controlled release : official journal of the Controlled Release Society.
[62] Prashant Mali,et al. A multifunctional AAV–CRISPR–Cas9 and its host response , 2016, Nature Methods.
[63] Yonatan Stelzer,et al. Editing DNA Methylation in the Mammalian Genome , 2016, Cell.
[64] M. Manns,et al. Administration of Gemcitabine After Pancreatic Tumor Resection in Mice Induces an Antitumor Immune Response Mediated by Natural Killer Cells. , 2016, Gastroenterology.
[65] Jos Jonkers,et al. Modeling invasive lobular breast carcinoma by CRISPR/Cas9-mediated somatic genome editing of the mammary gland , 2016, Genes & development.
[66] Christian Veltkamp,et al. Multiplexed pancreatic genome engineering and cancer induction by transfection-based CRISPR/Cas9 delivery in mice , 2016, Nature Communications.
[67] Meagan E. Sullender,et al. Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9 , 2015, Nature Biotechnology.
[68] Mathias J Friedrich,et al. CRISPR/Cas9 somatic multiplex-mutagenesis for high-throughput functional cancer genomics in mice , 2015, Proceedings of the National Academy of Sciences.
[69] Xiaowei Wang,et al. WU-CRISPR: characteristics of functional guide RNAs for the CRISPR/Cas9 system , 2015, Genome Biology.
[70] Dian Yang,et al. Pancreatic cancer modeling using retrograde viral vector delivery and in vivo CRISPR/Cas9-mediated somatic genome editing , 2015, Genes & development.
[71] Zhiping Weng,et al. Adenovirus-Mediated Somatic Genome Editing of Pten by CRISPR/Cas9 in Mouse Liver in Spite of Cas9-Specific Immune Responses. , 2015, Human gene therapy.
[72] Christopher M. Vockley,et al. Epigenome editing by a CRISPR/Cas9-based acetyltransferase activates genes from promoters and enhancers , 2015, Nature Biotechnology.
[73] Lukas E Dow,et al. Inducible in vivo genome editing with CRISPR/Cas9 , 2015, Nature Biotechnology.
[74] Ron Weiss,et al. Highly-efficient Cas9-mediated transcriptional programming , 2014, Nature Methods.
[75] Alexandro E. Trevino,et al. Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex , 2014, Nature.
[76] Elif Karaca,et al. Simple and rapid in vivo generation of chromosomal rearrangements using CRISPR/Cas9 technology. , 2014, Cell reports.
[77] Ronald D. Vale,et al. A Protein-Tagging System for Signal Amplification in Gene Expression and Fluorescence Imaging , 2014, Cell.
[78] George M. Church,et al. Genome editing assessment using CRISPR Genome Analyzer (CRISPR-GA) , 2014, Bioinform..
[79] Joana A. Vidigal,et al. In vivo engineering of oncogenic chromosomal rearrangements with the CRISPR/Cas9 system , 2014, Nature.
[80] Robert Langer,et al. CRISPR-Cas9 Knockin Mice for Genome Editing and Cancer Modeling , 2014, Cell.
[81] S. Kochanek,et al. Pancreatic transduction by helper-dependent adenoviral vectors via intraductal delivery. , 2014, Human gene therapy.
[82] Hao Yin,et al. CRISPR-mediated direct mutation of cancer genes in the mouse liver , 2014, Nature.
[83] George M. Church,et al. CHOPCHOP: a CRISPR/Cas9 and TALEN web tool for genome editing , 2014, Nucleic Acids Res..
[84] Hao Yin,et al. Genome editing with Cas9 in adult mice corrects a disease mutation and phenotype , 2014, Nature Biotechnology.
[85] M. Boutros,et al. E-CRISP: fast CRISPR target site identification , 2014, Nature Methods.
[86] E. Inada,et al. Site-targeted non-viral gene delivery by direct DNA injection into the pancreatic parenchyma and subsequent in vivo electroporation in mice , 2013, Biotechnology journal.
[87] Luke A. Gilbert,et al. CRISPR-Mediated Modular RNA-Guided Regulation of Transcription in Eukaryotes , 2013, Cell.
[88] C. von Kalle,et al. Lentiviral vector-based insertional mutagenesis identifies genes associated with liver cancer , 2013, Nature Methods.
[89] N. Ahituv,et al. The hydrodynamic tail vein assay as a tool for the study of liver promoters and enhancers. , 2013, Methods in molecular biology.
[90] Lili Wang,et al. Inverse zonation of hepatocyte transduction with AAV vectors between mice and non-human primates. , 2011, Molecular genetics and metabolism.
[91] J. Wienberg,et al. Gain of chromosome band 7q11 in papillary thyroid carcinomas of young patients is associated with exposure to low-dose irradiation , 2011, Proceedings of the National Academy of Sciences.
[92] Fergus J Couch,et al. Inactivation of Brca2 promotes Trp53-associated but inhibits KrasG12D-dependent pancreatic cancer development in mice. , 2011, Gastroenterology.
[93] Johannes Zuber,et al. A Rapid and Scalable System for Studying Gene Function in Mice Using Conditional RNA Interference , 2011, Cell.
[94] J. Agudo,et al. In vivo genetic engineering of murine pancreatic beta cells mediated by single-stranded adeno-associated viral vectors of serotypes 6, 8 and 9 , 2011, Diabetologia.
[95] James M. Wilson,et al. AAV vectors avoid inflammatory signals necessary to render transduced hepatocyte targets for destructive T cells. , 2010, Molecular therapy : the journal of the American Society of Gene Therapy.
[96] A. Berk,et al. Robust In Vivo Transduction of a Genetically Stable Epstein-Barr Virus Episome to Hepatocytes in Mice by a Hybrid Viral Vector , 2009, Journal of Virology.
[97] D. Mccarty. Self-complementary AAV vectors; advances and applications. , 2008, Molecular therapy : the journal of the American Society of Gene Therapy.
[98] C. von Kalle,et al. Adeno-Associated Virus Vector Genomes Persist as Episomal Chromatin in Primate Muscle , 2008, Journal of Virology.
[99] I. Alexander,et al. Gene Delivery to the Juvenile Mouse Liver Using AAV2/8 Vectors. , 2008, Molecular therapy : the journal of the American Society of Gene Therapy.
[100] A. Annoni,et al. A microRNA-regulated lentiviral vector mediates stable correction of hemophilia B mice. , 2007, Blood.
[101] L. Luo,et al. A global double‐fluorescent Cre reporter mouse , 2007, Genesis.
[102] A. Annoni,et al. In vivo administration of lentiviral vectors triggers a type I interferon response that restricts hepatocyte gene transfer and promotes vector clearance. , 2007, Blood.
[103] L. Belur,et al. Preferential delivery of the Sleeping Beauty transposon system to livers of mice by hydrodynamic injection , 2007, Nature Protocols.
[104] D. Stolz,et al. Structural impact of hydrodynamic injection on mouse liver , 2007, Gene Therapy.
[105] R. Samulski,et al. Adeno-associated virus serotypes: vector toolkit for human gene therapy. , 2006, Molecular therapy : the journal of the American Society of Gene Therapy.
[106] E. Petricoin,et al. Laser Capture Microdissection , 1996, Science.
[107] Theresa A. Storm,et al. Robust systemic transduction with AAV9 vectors in mice: efficient global cardiac gene transfer superior to that of AAV8. , 2006, Molecular therapy : the journal of the American Society of Gene Therapy.
[108] Ralph Weissleder,et al. Both p16(Ink4a) and the p19(Arf)-p53 pathway constrain progression of pancreatic adenocarcinoma in the mouse. , 2006, Proceedings of the National Academy of Sciences of the United States of America.
[109] Simon C Watkins,et al. Widespread and stable pancreatic gene transfer by adeno-associated virus vectors via different routes. , 2006, Diabetes.
[110] M. Chillón,et al. Gutless adenovirus: last-generation adenovirus for gene therapy , 2005, Gene Therapy.
[111] Xian-Yang Zhang,et al. LSU Digital Commons LSU Digital Commons Altering the tropism of lentiviral vectors through pseudotyping Altering the tropism of lentiviral vectors through pseudotyping , 2022 .
[112] M. Hashida,et al. Hepatocyte-targeted gene transfer by combination of vascularly delivered plasmid DNA and in vivo electroporation , 2005, Gene Therapy.
[113] J. Seppen,et al. Kupffer cells and not liver sinusoidal endothelial cells prevent lentiviral transduction of hepatocytes. , 2005, Molecular therapy : the journal of the American Society of Gene Therapy.
[114] A. Annoni,et al. Targeting lentiviral vector expression to hepatocytes limits transgene-specific immune response and establishes long-term expression of human antihemophilic factor IX in mice. , 2004, Blood.
[115] G. Maelandsmo,et al. Helper-Dependent Adenovirus Vectors Elicit Intact Innate but Attenuated Adaptive Host Immune Responses In Vivo , 2004, Journal of Virology.
[116] D. Stolz,et al. Hydroporation as the mechanism of hydrodynamic delivery , 2004, Gene Therapy.
[117] N. Carter,et al. Karyotyping mouse chromosomes by multiplex-FISH (M-FISH) , 2004, Chromosome Research.
[118] R. Samulski,et al. Adeno-associated virus terminal repeat (TR) mutant generates self-complementary vectors to overcome the rate-limiting step to transduction in vivo , 2003, Gene Therapy.
[119] Theresa A. Storm,et al. Preclinical in vivo evaluation of pseudotyped adeno-associated virus vectors for liver gene therapy. , 2003, Blood.
[120] Lili Wang,et al. Novel adeno-associated viruses from rhesus monkeys as vectors for human gene therapy , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[121] I. Verma,et al. Biodistribution and toxicity studies of VSVG-pseudotyped lentiviral vector after intravenous administration in mice with the observation of in vivo transduction of bone marrow. , 2002, Molecular therapy : the journal of the American Society of Gene Therapy.
[122] I. Verma,et al. Transduction of liver cells by lentiviral vectors: analysis in living animals by fluorescence imaging. , 2001, Molecular therapy : the journal of the American Society of Gene Therapy.
[123] Theresa A. Storm,et al. Nonrandom Transduction of Recombinant Adeno-Associated Virus Vectors in Mouse Hepatocytes In Vivo: Cell Cycling Does Not Influence Hepatocyte Transduction , 2000, Journal of Virology.
[124] J. Wolff,et al. High levels of foreign gene expression in hepatocytes after tail vein injections of naked plasmid DNA. , 1999, Human gene therapy.
[125] Dexi Liu,et al. Hydrodynamics-based transfection in animals by systemic administration of plasmid DNA , 1999, Gene Therapy.
[126] M. Kay,et al. Correction of hemophilia B in canine and murine models using recombinant adeno-associated viral vectors , 1999, Nature Medicine.
[127] Toshiyuki Matsuzaki,et al. Direct gene transfer into rat liver cells by in vivo electroporation , 1998, FEBS letters.
[128] R. Crystal,et al. Innate immune mechanisms dominate elimination of adenoviral vectors following in vivo administration. , 1997, Human gene therapy.
[129] T. Samulski,et al. Second-strand synthesis is a rate-limiting step for efficient transduction by recombinant adeno-associated virus vectors , 1996, Journal of virology.
[130] M. Weitzman,et al. Transduction with recombinant adeno-associated virus for gene therapy is limited by leading-strand synthesis , 1996, Journal of virology.
[131] E. Furth,et al. Cellular immunity to viral antigens limits E1-deleted adenoviruses for gene therapy. , 1994, Proceedings of the National Academy of Sciences of the United States of America.
[132] M. Kay,et al. Assessment of recombinant adenoviral vectors for hepatic gene therapy. , 1993, Human gene therapy.
[133] M. Perricaudet,et al. Adenovirus-mediated transfer of a recombinant alpha 1-antitrypsin gene to the lung epithelium in vivo. , 1991, Science.
[134] David W. Melton,et al. Targetted correction of a mutant HPRT gene in mouse embryonic stem cells , 1987, Nature.
[135] A. Bradley,et al. Formation of germ-line chimaeras from embryo-derived teratocarcinoma cell lines , 1984, Nature.