论文信息 - Quantification moléculaire par spectrométrie de masse à base de NEMS : modélisation et inversion du problème.

Quantification moléculaire par spectrométrie de masse à base de NEMS : modélisation et inversion du problème.

This article exposes a processing method adapted to NEMS (Nano Electro Mechanical Systems) Mass-Spectrometry. NEMS are nanometric sensors which are sensitive enough to detect the mass of a single molecule. Thus, it is possible to perform a counting mode processing in order to estimate the mass spectrum of the analyzed solution. In this article, we introduce a model of the acquisition chain and we describe the associated processing based on MCMC (Monte-Carlo Markov Chain) methods to solve the inverse problem. Preliminary results on simulated

[1] R. Aebersold,et al. Mass spectrometry-based proteomics , 2003, Nature.

[2] Ali Mohammad-Djafari,et al. Bayesian inference for inverse problems in signal and image processing and applications , 2006, Int. J. Imaging Syst. Technol..

[3] O. Hansen,et al. Mass and position determination of attached particles on cantilever based mass sensors. , 2007, The Review of scientific instruments.

[4] M. Roukes,et al. Toward single-molecule nanomechanical mass spectrometry , 2005, Nature nanotechnology.

[5] É. Colinet,et al. In-plane nanoelectromechanical resonators based on silicon nanowire piezoresistive detection. , 2010, Nanotechnology.