Effects of blood flow restriction on cerebral blood flow during a single arm-curl resistance exercise

Low-intensity resistance exercise with blood flow restriction (BFR), also known as "Kaatsu," causes a dramatic increase in the secretion of growth hormone. Several reports have shown that Kaatsu is effective for training in patients with stroke. However, the influence of Kaatsu training on brain function remains unclear. This study aimed to investigate the acute effects of Kaatsu training on blood flow in the brain. Six healthy male subjects performed a single-arm curl with and without BFR using 20% of the weight of 1 repetition maximum(RM); 1 set of 30 repetitions (reps) was followed by 3 sets of 15 reps, with a 30-s interval in between. During the procedure, cerebral blood flow was measured using near-infrared spectroscopy (NIRS). During arm curls with BFR, the oxygenated hemoglobin (oxy-Hb) concentration of the contralateral motor cortex increased significantly compared to that during curls without BFR. The results of this study suggest that Kaatsu training has a positive effect on the brain by increasing cerebral blood flow and that it is useful for treating diseases such as stroke and cognitive disorders caused by brain dysfunction.

[1]  Kathryn M. McMillan,et al.  A comparison of label‐based review and ALE meta‐analysis in the Stroop task , 2005, Human brain mapping.

[2]  E. Gratton,et al.  Investigation of human brain hemodynamics by simultaneous near-infrared spectroscopy and functional magnetic resonance imaging. , 2001, Medical physics.

[3]  S. Ogawa,et al.  Oxygenation‐sensitive contrast in magnetic resonance image of rodent brain at high magnetic fields , 1990, Magnetic resonance in medicine.

[4]  E. Watanabe,et al.  Spatial and temporal analysis of human motor activity using noninvasive NIR topography. , 1995, Medical physics.

[5]  D. Delpy,et al.  Methods of quantitating cerebral near infrared spectroscopy data. , 1988, Advances in experimental medicine and biology.

[6]  G. Sassolas,et al.  Hemodynamic and hormonal responses to hypothermic and normothermic cardiopulmonary bypass. , 1990, Journal of cardiothoracic and vascular anesthesia.

[7]  Takashi Abe,et al.  Muscle size and strength are increased following walk training with restricted venous blood flow from the leg muscle, Kaatsu-walk training. , 2006, Journal of applied physiology.

[8]  M. Raichle,et al.  Searching for a baseline: Functional imaging and the resting human brain , 2001, Nature Reviews Neuroscience.

[9]  Stéphane Perrey,et al.  Prefrontal cortex oxygenation and neuromuscular responses to exhaustive exercise. , 2007 .

[10]  Y. Nakamura,et al.  Rapid increase in plasma growth hormone after low-intensity resistance exercise with vascular occlusion. , 2000, Journal of applied physiology.

[11]  M. Brass,et al.  Involvement of the inferior frontal junction in cognitive control: Meta‐analyses of switching and Stroop studies , 2005, Human brain mapping.

[12]  Y. Takarada,et al.  Effects of resistance exercise combined with moderate vascular occlusion on muscular function in humans. , 2000, Journal of applied physiology.

[13]  James S. Williams,et al.  The effect of acute exercise on serum brain-derived neurotrophic factor levels and cognitive function. , 2007, Medicine and science in sports and exercise.

[14]  R. Nagai,et al.  Hemodynamic and hormonal responses to a short-term low-intensity resistance exercise with the reduction of muscle blood flow , 2005, European Journal of Applied Physiology.

[15]  A. Kramer,et al.  Be smart, exercise your heart: exercise effects on brain and cognition , 2008, Nature Reviews Neuroscience.