The mechanism of liver X receptor regulates the balance of glycoFAsynthesis and cholesterol synthesis in clear cell renal cell carcinoma

. From the perspective of bioinformatics and metabolomics, the results suggest that glycoFAsynthesis and cholesterol biosynthesis have great changes in ccRCC. These two changes are likely to have an important impact on the occurrence and development of ccRCC.

[1]  R. Flippot,et al.  Tyrosine kinase inhibitors and immunotherapy combinations in renal cell carcinoma , 2020, Therapeutic advances in medical oncology.

[2]  K. Kinoshita,et al.  Value of global metabolomics in association with diagnosis and clinicopathological factors of renal cell carcinoma , 2019, International journal of cancer.

[3]  Guangzhen Wu,et al.  Targeting the transcription factor receptor LXR to treat clear cell renal cell carcinoma: agonist or inverse agonist? , 2019, Cell Death & Disease.

[4]  Guangzhen Wu,et al.  Targeting the transcription factor receptor LXR to treat clear cell renal cell carcinoma: agonist or inverse agonist? , 2019, Cell Death & Disease.

[5]  C. Boshoff,et al.  Kidney cancer: The next decade , 2018, The Journal of experimental medicine.

[6]  Mark W. Ball,et al.  Kidney cancer in 2017: Challenging and refining treatment paradigms , 2018, Nature Reviews Urology.

[7]  Rui Henrique,et al.  Renal cell carcinoma: a critical analysis of metabolomic biomarkers emerging from current model systems , 2017, Translational research : the journal of laboratory and clinical medicine.

[8]  R. Weiss,et al.  Urine metabolomic analysis identifies potential biomarkers and pathogenic pathways in kidney cancer. , 2011, Omics : a journal of integrative biology.

[9]  Joachim Selbig,et al.  Metabolic profiling reveals key metabolic features of renal cell carcinoma , 2009, Journal of cellular and molecular medicine.

[10]  C. Schmidt Metabolomics takes its place as latest up-and-coming "omic" science. , 2004, Journal of the National Cancer Institute.

[11]  H. Axelson,et al.  Kidney cancer. , 2013, Seminars in cancer biology.