IFN Regulatory Factor 4 Controls Post-ischemic Inflammation and Prevents Chronic Kidney Disease in regulatory factor

IRI in mice. The clinical significance of these finding for human CKD remains uncertain at present and warrants further studies.

[1]  H. Lan,et al.  Macrophages: versatile players in renal inflammation and fibrosis , 2019, Nature Reviews Nephrology.

[2]  Zong-fang Li,et al.  The Spleen Promotes the Secretion of CCL2 and Supports an M1 Dominant Phenotype in Hepatic Macrophages During Liver Fibrosis , 2018, Cellular Physiology and Biochemistry.

[3]  N. Vaziri,et al.  Central role of dysregulation of TGF-β/Smad in CKD progression and potential targets of its treatment. , 2018, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[4]  E. López-Granados,et al.  New human combined immunodeficiency caused by interferon regulatory factor 4 (IRF4) deficiency inherited by uniparental isodisomy. , 2018, The Journal of allergy and clinical immunology.

[5]  Felix Eichinger,et al.  Transcriptome-based network analysis reveals renal cell type-specific dysregulation of hypoxia-associated transcripts , 2017, Scientific Reports.

[6]  Katherine A. Gallagher,et al.  Enhancement of macrophage inflammatory responses by CCL2 is correlated with increased miR-9 expression and downregulation of the ERK1/2 phosphatase Dusp6. , 2017, Cellular immunology.

[7]  M. Rehli,et al.  The IKZF1-IRF4 axis regulates macrophage polarization and macrophage-mediated anti-tumor immunity , 2016 .

[8]  A. Regev,et al.  Protein C receptor (PROCR) is a negative regulator of Th17 pathogenicity , 2016, The Journal of experimental medicine.

[9]  S. Turner,et al.  Granulocyte macrophage colony-stimulating factor induces CCL17 production via IRF4 to mediate inflammation. , 2016, The Journal of clinical investigation.

[10]  H. Anders,et al.  Necroinflammation in Kidney Disease. , 2016, Journal of the American Society of Nephrology.

[11]  Eugenia G. Giannopoulou,et al.  Modulation of TNF-Induced Macrophage Polarization by Synovial Fibroblasts , 2014, The Journal of Immunology.

[12]  D. Pleasure,et al.  Conditional Ablation of Astroglial CCL2 Suppresses CNS Accumulation of M1 Macrophages and Preserves Axons in Mice with MOG Peptide EAE , 2014, The Journal of Neuroscience.

[13]  M. Kudo,et al.  NOD2 Down-Regulates Colonic Inflammation by IRF4-Mediated Inhibition of K63-Linked Polyubiquitination of RICK and TRAF6 , 2014, Mucosal Immunology.

[14]  H. Lei,et al.  IRF4 is a novel mediator for neuronal survival in ischaemic stroke , 2014, Cell Death and Differentiation.

[15]  R. Flavell,et al.  Macrophage phenotype controls long-term AKI outcomes--kidney regeneration versus atrophy. , 2014, Journal of the American Society of Nephrology : JASN.

[16]  H. Anders,et al.  Pattern-Recognition Receptor Signaling Regulator mRNA Expression in Humans and Mice, and in Transient Inflammation or Progressive Fibrosis , 2013, International journal of molecular sciences.

[17]  Gang Xu,et al.  CD4+ T Lymphocytes, Especially Th2 Cells, Contribute to the Progress of Renal Fibrosis , 2012, American Journal of Nephrology.

[18]  P. Kimmel,et al.  Acute kidney injury and chronic kidney disease: an integrated clinical syndrome. , 2012, Kidney international.

[19]  K. Ozato,et al.  Shared and Distinct Functions of the Transcription Factors IRF4 and IRF8 in Myeloid Cell Development , 2011, PloS one.

[20]  T. Mak,et al.  IRF4 deficiency abrogates lupus nephritis despite enhancing systemic cytokine production. , 2011, Journal of the American Society of Nephrology : JASN.

[21]  C. Garlanda,et al.  Toll-Like Receptor Signaling and SIGIRR in Renal Fibrosis upon Unilateral Ureteral Obstruction , 2011, PloS one.

[22]  W. Shi,et al.  The transcription factors Blimp-1 and IRF4 jointly control the differentiation and function of effector regulatory T cells , 2011, Nature Immunology.

[23]  Sik Lee,et al.  Distinct macrophage phenotypes contribute to kidney injury and repair. , 2011, Journal of the American Society of Nephrology : JASN.

[24]  K. Nakai,et al.  The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection , 2010, Nature Immunology.

[25]  T. Mak,et al.  Ischemia Reperfusion Induces IFN Regulatory Factor 4 in Renal Dendritic Cells, which Suppresses Postischemic Inflammation and Prevents Acute Renal Failure , 2010, The Journal of Immunology.

[26]  C. Garlanda,et al.  Resident Dendritic Cells Prevent Postischemic Acute Renal Failure by Help of Single Ig IL-1 Receptor-Related Protein1 , 2009, The Journal of Immunology.

[27]  M. Neurath,et al.  IRF4 selectively controls cytokine gene expression in chronic intestinal inflammation , 2009, Archivum Immunologiae et Therapiae Experimentalis.

[28]  M. Kaplan,et al.  IFN Regulatory Factor 4 Regulates the Expression of a Subset of Th2 Cytokines1 , 2009, The Journal of Immunology.

[29]  A. Keegan Faculty Opinions recommendation of Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control T(H)2 responses. , 2009 .

[30]  T. Matsuyama,et al.  A distal cis-regulatory element, CNS-9, controls NFAT1 and IRF4-mediated IL-10 gene activation in T helper cells. , 2009, Molecular immunology.

[31]  M. Huber,et al.  IRF4 is essential for IL-21-mediated induction, amplification, and stabilization of the Th17 phenotype , 2008, Proceedings of the National Academy of Sciences.

[32]  G. Bhagat,et al.  IRF-4-binding protein inhibits interleukin-17 and interleukin-21 production by controlling the activity of IRF-4 transcription factor. , 2008, Immunity.

[33]  T. Taniguchi,et al.  The IRF family transcription factors in immunity and oncogenesis. , 2008, Annual review of immunology.

[34]  S. Chadban,et al.  TLR4 activation mediates kidney ischemia/reperfusion injury. , 2007, The Journal of clinical investigation.

[35]  T. Mak,et al.  The development of inflammatory TH-17 cells requires interferon-regulatory factor 4 , 2007, Nature Immunology.

[36]  Y. Wang,et al.  Ex vivo programmed macrophages ameliorate experimental chronic inflammatory renal disease. , 2007, Kidney international.

[37]  V. Abraira,et al.  Long-term outcome of acute tubular necrosis: a contribution to its natural history. , 2007, Kidney international.

[38]  K. Honda,et al.  Negative regulation of Toll-like-receptor signaling by IRF-4. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[39]  T. Matsuyama,et al.  Development of Th1 and not Th2 immune responses in mice lacking IFN-regulatory factor-4. , 2003, International immunology.

[40]  J. Fanzo,et al.  Modulation of T Cell Cytokine Production by Interferon Regulatory Factor-4* , 2002, The Journal of Biological Chemistry.

[41]  T. Mak,et al.  Dysregulated T helper cell differentiation in the absence of interferon regulatory factor 4 , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[42]  L. Glimcher,et al.  Interferon Regulatory Factor 4 (IRF4) Interacts with NFATc2 to Modulate Interleukin 4 Gene Expression , 2002, The Journal of experimental medicine.

[43]  D. Basile,et al.  Renal ischemic injury results in permanent damage to peritubular capillaries and influences long-term function. , 2001, American journal of physiology. Renal physiology.

[44]  T. Mak,et al.  Requirement for the Transcription Factor LSIRF/IRF4 for Mature B and T Lymphocyte Function , 1997, Science.