Spinal endomorphins attenuate burn-injury pain in male mice by inhibiting p38 MAPK signaling pathway through the mu-opioid receptor.

[1]  N. Zhang,et al.  Preemptive intrathecal administration of endomorphins relieves inflammatory pain in male mice via inhibition of p38 MAPK signaling and regulation of inflammatory cytokines , 2018, Journal of neuroinflammation.

[2]  Rui Wang,et al.  Pharmacological characterization of EN-9, a novel chimeric peptide of endomorphin-2 and neuropeptide FF that produces potent antinociceptive activity and limited tolerance , 2016, Neuropharmacology.

[3]  Longlong Yang,et al.  TSG-6 secreted by human umbilical cord-MSCs attenuates severe burn-induced excessive inflammation via inhibiting activations of P38 and JNK signaling , 2016, Scientific Reports.

[4]  A. Beitz,et al.  σ1 receptors activate astrocytes via p38 MAPK phosphorylation leading to the development of mechanical allodynia in a mouse model of neuropathic pain , 2014, British journal of pharmacology.

[5]  C. Bantel,et al.  Peripheral mechanisms of burn injury-associated pain. , 2013, European journal of pharmacology.

[6]  W. Lei,et al.  Sustained Oxidative Stress Causes Late Acute Renal Failure via Duplex Regulation on p38 MAPK and Akt Phosphorylation in Severely Burned Rats , 2013, PloS one.

[7]  M. Schäfer-Korting,et al.  Morphine Stimulates Cell Migration of Oral Epithelial Cells by Delta-Opioid Receptor Activation , 2012, PloS one.

[8]  S. Dib-Hajj,et al.  Sodium Channel Nav1.7 Is Essential for Lowering Heat Pain Threshold after Burn Injury , 2012, The Journal of Neuroscience.

[9]  R. Al-Hasani,et al.  Molecular mechanisms of opioid receptor-dependent signaling and behavior. , 2011, Anesthesiology.

[10]  T. Yaksh,et al.  The effect of intrathecal mu, delta, kappa, and alpha-2 agonists on thermal hyperalgesia induced by mild burn on hind paw in rats , 2011, Journal of Anesthesia.

[11]  Xiao-Qiang Li,et al.  Burn-induced apoptosis of cardiomyocytes is survivin dependent and regulated by PI3K/Akt, p38 MAPK and ERK pathways , 2011, Basic Research in Cardiology.

[12]  J. Valtschanoff,et al.  Influence of the vanilloid receptor TRPV1 on the activation of spinal cord glia in mouse models of pain , 2009, Experimental Neurology.

[13]  P. Richardson,et al.  The management of pain in the burns unit. , 2009, Burns : journal of the International Society for Burn Injuries.

[14]  D. Tobin,et al.  Opioids and the skin – where do we stand? , 2009, Experimental dermatology.

[15]  Zheng Li,et al.  Inducible Expression of Functional Mu Opioid Receptors in Murine Dendritic Cells , 2009, Journal of Neuroimmune Pharmacology.

[16]  W. Walwyn,et al.  p38 MAPK and β-Arrestin 2 Mediate Functional Interactions between Endogenous μ-Opioid and α2A-Adrenergic Receptors in Neurons* , 2009, Journal of Biological Chemistry.

[17]  M. Bruchas,et al.  Sciatic Nerve Ligation-Induced Proliferation of Spinal Cord Astrocytes Is Mediated by κ Opioid Activation of p38 Mitogen-Activated Protein Kinase , 2007, The Journal of Neuroscience.

[18]  O. Valverde,et al.  Expression of opioid receptors and c-fos in CB1 knockout mice exposed to neuropathic pain , 2006, Neuropharmacology.

[19]  B. Kamińska MAPK signalling pathways as molecular targets for anti-inflammatory therapy--from molecular mechanisms to therapeutic benefits. , 2005, Biochimica et biophysica acta.

[20]  Shuxing Wang,et al.  A rat model of unilateral hindpaw burn injury: Slowly developing rightwards shift of the morphine dose–response curve , 2005, Pain.

[21]  A. Brack,et al.  Rapid upregulation of μ opioid receptor mrna in dorsal root ganglia in response to peripheral inflammation depends on neuronal conduction , 2004, Neuroscience.

[22]  C. Stein,et al.  Characterization of μ Opioid Receptor Binding and G Protein Coupling in Rat Hypothalamus, Spinal Cord, and Primary Afferent Neurons during Inflammatory Pain , 2004, Journal of Pharmacology and Experimental Therapeutics.

[23]  N. Calcutt,et al.  Activation of p38 mitogen‐activated protein kinase in spinal microglia is a critical link in inflammation‐induced spinal pain processing , 2003, Journal of neurochemistry.

[24]  C. Woolf,et al.  p38 Mitogen-Activated Protein Kinase Is Activated after a Spinal Nerve Ligation in Spinal Cord Microglia and Dorsal Root Ganglion Neurons and Contributes to the Generation of Neuropathic Pain , 2003, The Journal of Neuroscience.

[25]  K. Storey,et al.  Mitogen-activated protein kinases: new signaling pathways functioning in cellular responses to environmental stress , 2003, Journal of Experimental Biology.

[26]  D. Zochodne,et al.  μ Opioid receptors and analgesia at the site of a peripheral nerve injury , 2003 .

[27]  K. Murayama,et al.  Differential antinociceptive effects induced by intrathecally administered endomorphin-1 and endomorphin-2 in the mouse. , 2001, European journal of pharmacology.

[28]  A. Basbaum,et al.  Molecular mechanisms of nociception , 2001, Nature.

[29]  A. Vaccarino,et al.  Analgesic effects of endomorphin-1 and endomorphin-2 in the formalin test in mice. , 2000, Life sciences.

[30]  A. Kastin,et al.  A potent and selective endogenous agonist for the µ-opiate receptor , 1997, Nature.

[31]  R. Day,et al.  Effect of μ-opioids morphine and buprenorphine on the development of adjuvant arthritis in rats , 1996, Inflammation Research.

[32]  H. Kehlet,et al.  Peripheral antinociceptive effects of morphine after burn injury , 1993, Acta anaesthesiologica Scandinavica.

[33]  D. Carr,et al.  Increases in plasma beta-endorphin and tail flick latency in the rat following burn injury. , 1987, Life sciences.

[34]  M. Moskowitz,et al.  The contribution of neurogenic inflammation in experimental arthritis. , 1985, Journal of immunology.

[35]  D. Carr,et al.  The assessment of pain and plasma β-endorphin immunoactivity in burned children , 1985, Pain.

[36]  G. Wilcox,et al.  Intrathecal morphine in mice: a new technique. , 1980, European journal of pharmacology.

[37]  M. Jeschke,et al.  Scar management in burn injuries using drug delivery and molecular signaling: Current treatments and future directions , 2018, Advanced drug delivery reviews.

[38]  L. Sumanovski,et al.  Different Expression of μ-Opiate Receptor in Chronic and Acute Wounds and the Effect of β-Endorphin on Transforming Growth Factor β Type II Receptor and Cytokeratin 16 Expression , 2003 .