All Eyes on Me, Please: Ocular Palonosetron for the Cancer Patient with Nausea and Vomiting

The March issue of the Journal of Pharmacology and Experimental Therapeutics offers an interesting read on palonosetron for managing nausea and vomiting in beagle dogs treated with the anticancer agent cisplatin (Levijoki et al., 2023). The subject matter is anything but novel. Chemotherapy-induced nausea and vomiting (CINV) is sadly known to patients with cancer (Lorusso et al., 2017), beagles and cisplatin have already been used to decipher the mechanisms of CINV (Kenward et al., 2014), and injectable and oral formulations of palonose-tron rank very high in the pharmacological armamentarium against CINV (Smith et al., 2020). So, what is new in this report? Novelty rests with the formulation of palonosetron, which was used as eye drops and worked well from both pharmacokinetic and ef fi cacy viewpoints. A critical look at clinical facts and preclinical fi ndings is none-theless much needed before this report can be considered as breakthrough or preliminary fi nding. CINV