Novel α-secretase cleavage of Alzheimer's amyloid β precursor protein in the endoplasmic reticulum of COS7 cells

[1]  Hironobu Naiki,et al.  Iron (III) induces aggregation of hyperphosphorylated τ and its reduction to iron (II) reverses the aggregation: implications in the formation of neurofibrillary tangles of Alzheimer's disease , 2002 .

[2]  R. Doms,et al.  Glu11 site cleavage and N-terminally truncated A beta production upon BACE overexpression. , 2002, Biochemistry.

[3]  D. Selkoe Alzheimer's disease: genes, proteins, and therapy. , 2001, Physiological reviews.

[4]  R. Doms,et al.  Protein Kinase C-dependent α-Secretase Competes with β-Secretase for Cleavage of Amyloid-β Precursor Protein in the Trans-Golgi Network* , 2000, The Journal of Biological Chemistry.

[5]  K. Suzuki,et al.  Membrane-anchored metalloprotease MDC9 has an alpha-secretase activity responsible for processing the amyloid precursor protein. , 1999, The Biochemical journal.

[6]  E. Kojro,et al.  Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[7]  Joseph D. Buxbaum,et al.  Evidence That Tumor Necrosis Factor α Converting Enzyme Is Involved in Regulated α-Secretase Cleavage of the Alzheimer Amyloid Protein Precursor* , 1998, The Journal of Biological Chemistry.

[8]  B. Greenberg,et al.  Turnover of Amyloid β-Protein in Mouse Brain and Acute Reduction of Its Level by Phorbol Ester , 1998, The Journal of Neuroscience.

[9]  M. Mattson Cellular actions of beta-amyloid precursor protein and its soluble and fibrillogenic derivatives. , 1997, Physiological reviews.

[10]  C. Masters,et al.  Distinct sites of intracellular production for Alzheimer's disease Aβ40/42 amyloid peptides , 1997, Nature Medicine.

[11]  R. Doms,et al.  Alzheimer's Aβ(1–42) is generated in the endoplasmic reticulum/intermediate compartment of NT2N cells , 1997, Nature Medicine.

[12]  R. Doms,et al.  Novel β-Secretase Cleavage of β-Amyloid Precursor Protein in the Endoplasmic Reticulum/Intermediate Compartment of NT2N Cells , 1997, The Journal of cell biology.

[13]  Y. Ihara,et al.  Intracellular Generation and Accumulation of Amyloid β-Peptide Terminating at Amino Acid 42* , 1997, The Journal of Biological Chemistry.

[14]  D. Selkoe,et al.  The Swedish mutation causes early-onset Alzheimer's disease by β-secretase cleavage within the secretory pathway , 1995, Nature Medicine.

[15]  F. Checler Processing of the β‐Amyloid Precursor Protein and Its Regulation in Alzheimer's Disease , 1995 .

[16]  W. Kolch,et al.  Immunocytochemical Localization of Eight Protein Kinase C Isozymes Overexpressed in NIH 3T3 Fibroblasts , 1995, The Journal of Biological Chemistry.

[17]  K. Murakami,et al.  Secretion of beta-amyloid precursor protein involves multiple cleavage sites. , 1994, The Journal of biological chemistry.

[18]  W. Wetsel,et al.  Light and electron microscopic immunocytochemical localization of PKCδ immunoreactivity in the rat central nervous system , 1993 .

[19]  Thomas J. Raub,et al.  The Alzheimer beta-amyloid protein precursor/protease nexin-II is cleaved by secretase in a trans-Golgi secretory compartment in human neuroglioma cells. , 1993, The Biochemical journal.

[20]  J. Shioi,et al.  Evidence for intracellular cleavage of the Alzheimer's amyloid precursor in PC12 cells , 1992, Journal of neuroscience research.

[21]  S. Sisodia Beta-amyloid precursor protein cleavage by a membrane-bound protease. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[22]  D. Selkoe,et al.  Targeting of cell-surface β-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments , 1992, Nature.

[23]  H. Sato,et al.  Identification of the region including the epitope for a monoclonal antibody which can neutralize human parvovirus B19 , 1991, Journal of virology.

[24]  P. Greengard,et al.  Processing of Alzheimer beta/A4 amyloid precursor protein: modulation by agents that regulate protein phosphorylation. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[25]  R. Doms,et al.  Brefeldin A redistributes resident and itinerant Golgi proteins to the endoplasmic reticulum , 1989, The Journal of cell biology.

[26]  Andreas Weidemann,et al.  Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein , 1989, Cell.

[27]  T. Hartmann,et al.  Intracellular biology of Alzheimer’s disease amyloid beta peptide , 1999, European Archives of Psychiatry and Clinical Neuroscience.