The fabrication and characterization of a formaldehyde odor sensor using molecularly imprinted polymers.

The fabrication and characterization of odor sensors based on molecularly imprinted polymers is reported as the first case of imprinting formaldehyde. A quartz crystal microbalance is employed as a sensitive apparatus of a sensor for the determination of odor formaldehyde. An equation is deduced to characterize the interaction between molecularly imprinted films and the template. A linear relationship between the frequency shifts and the concentration of analyte in the range of 1.25 to 14.25 microM is found. The detection limit is about 20.5 microM. The sensor can selectively distinguish gaseous formaldehyde. It is envisaged that this novel and handy method could be employed to determine formaldehyde gas in the atmosphere.

[1]  W. H. King.  Piezoelectric Sorption Detector. , 1964 .

[2]  Olof Ramström,et al.  The Emerging Technique of Molecular Imprinting and Its Future Impact on Biotechnology , 1996, Bio/Technology.

[3]  Klaus Mosbach,et al.  Drug assay using antibody mimics made by molecular imprinting , 1993, Nature.

[4]  I. Karube,et al.  Selective piezoelectric odor sensors using molecularly imprinted polymers , 1999 .

[5]  Ecevit Yilmaz,et al.  Die Verwendung immobilisierter Template: eine neue Methode zum molekularen Prägen , 2000 .

[6]  G McHale,et al.  Molecular-imprinted, polymer-coated quartz crystal microbalances for the detection of terpenes. , 2001, Analytical chemistry.

[7]  G. Wulff.  Molecular Imprinting in Cross‐Linked Materials with the Aid of Molecular Templates— A Way towards Artificial Antibodies , 1995 .

[8]  G. Sauerbrey,et al.  Use of quartz vibration for weighing thin films on a microbalance , 1959 .

[9]  Purnendu K. Dasgupta,et al.  Continuous automated determination of atmospheric formaldehyde at the parts per trillion level , 1994 .

[10]  K. Mosbach,et al.  The Use of Immobilized Templates-A New Approach in Molecular Imprinting. , 2000, Angewandte Chemie.

[11]  J. Rosentreter,et al.  A piezoelectric method for monitoring formaldehyde induced crosslink formation between poly-lysine and poly-deoxyguanosine. , 2000, Talanta.

[12]  Klaus Mosbach,et al.  Recognition sites incorporating both pyridinyl and carboxy functionalities prepared by molecular imprinting , 1993 .

[13]  G. Sauerbrey.  Verwendung von Schwingquarzen zur Wägung dünner Schichten und zur Mikrowägung , 1959 .

[14]  Börje Sellergren.  Molekular geprgte Polymere mit einem Gedchtnis fr kleine Molekle, Proteine oder Kristalle , 2000 .

[15]  M. Ward,et al.  In Situ Interfacial Mass Detection with Piezoelectric Transducers , 1990, Science.

[16]  R Wiglusz,et al.  Interlaboratory comparison experiment on the determination of formaldehyde emitted from mineral wool board using small test chambers , 2000 .

[17]  Sellergren.  Imprinted Polymers with Memory for Small Molecules, Proteins, or Crystals The author is grateful to Dr. Andrew Hall and Dr. Gunter Büchel for linguistic advice. , 2000, Angewandte Chemie.

[18]  N. Cade,et al.  Electrochemical enzyme sensor for formaldehyde operating in the gas phase , 1996 .

[19]  G. Wulff,et al.  Molekulares Prägen (Imprinting) in vernetzten Materialien mit Hilfe von Matrizenmolekülen – auf dem Weg zu künstlichen Antikörpern , 1995 .

[20]  K Mosbach,et al.  Assay system for the herbicide 2,4-dichlorophenoxyacetic Acid using a molecularly imprinted polymer as an artificial recognition element. , 1998, Analytical chemistry.

[21]  C. Martelet,et al.  Development of highly selective and stable potentiometric sensors for formaldehyde determination. , 2000, Biosensors & bioelectronics.

[22]  Nicole Jaffrezic-Renault,et al.  Conductometric formaldehyde sensitive biosensor with specifically adapted analytical characteristics , 2001 .

[23]  D. Reinhoudt,et al.  From Solutions to Surfaces: A Novel Molecular Imprinting Method Based on the Conformational Changes of Boronic-Acid-Appended Poly(L-lysine). , 2001, Angewandte Chemie.

[24]  Toshifumi Takeuchi,et al.  Molecularly Imprinted Polymer-Coated Quartz Crystal Microbalance for Detection of Biological Hormone , 1999 .