Circulating Trends of Influenza and Other Seasonal Respiratory Viruses among the US Department of Defense Personnel in the United States: Impact of the COVID-19 Pandemic

The objective of this study was to evaluate the impact of the COVID-19 pandemic on the circulation of influenza and other seasonal respiratory viruses in the United States. All data were obtained from the US Department of Defense Global Respiratory Pathogen Surveillance Program over five consecutive respiratory seasons from 2016–2017 through to 2020–2021. A total of 62,476 specimens were tested for seasonal respiratory viruses. The circulating patterns of seasonal respiratory viruses have been greatly altered during the pandemic. The 2019–2020 influenza season terminated earlier compared to the pre-pandemic seasons, and the 2020–2021 influenza season did not occur. Moreover, weekly test positivity rates dramatically decreased for most of the seasonal respiratory viruses from the start of the pandemic through spring 2021. After the easing of non-pharmaceutical interventions (NPIs), circulations of seasonal coronavirus, parainfluenza, and respiratory syncytial virus have returned since spring 2021. High rhinovirus/enterovirus activity was evident throughout the 2020–2021 respiratory season. The findings suggest a strong association between the remarkably changed activity of seasonal respiratory viruses and the implementation of NPIs during the COVID-19 pandemic. The NPIs may serve as an effective public health tool to reduce transmissions of seasonal respiratory viruses.

[1]  S. W. Long,et al.  The Reemergence of Seasonal Respiratory Viruses in Houston, Texas, after Relaxing COVID-19 Restrictions , 2021, Microbiology spectrum.

[2]  A. Doroshenko,et al.  Decline of Influenza and Respiratory Viruses With COVID-19 Public Health Measures , 2021, Mayo Clinic Proceedings.

[3]  P. Piedra,et al.  The Prevention of Common Respiratory Virus Epidemics in 2020-21 during the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Pandemic: An Unexpected Benefit of the Implementation of Public Health Measures , 2021, The Lancet Regional Health - Americas.

[4]  I. Kiseleva,et al.  COVID-19 Shuts Doors to Flu but Keeps Them Open to Rhinoviruses , 2021, Biology.

[5]  L. Brammer,et al.  Changes in Influenza and Other Respiratory Virus Activity During the COVID-19 Pandemic — United States, 2020–2021 , 2021, MMWR. Morbidity and mortality weekly report.

[6]  C. Bancej,et al.  The impact of the COVID-19 pandemic on influenza, respiratory syncytial virus, and other seasonal respiratory virus circulation in Canada: A population-based study , 2021, The Lancet Regional Health - Americas.

[7]  P. Vanhems,et al.  Characteristics of the delayed respiratory syncytial virus epidemic, 2020/2021, Rhône Loire, France , 2021, Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin.

[8]  S. de Lusignan,et al.  Low levels of respiratory syncytial virus activity in Europe during the 2020/21 season: what can we expect in the coming summer and autumn/winter? , 2021, Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin.

[9]  H. Zar,et al.  Decline of influenza and respiratory syncytial virus detection in facility-based surveillance during the COVID-19 pandemic, South Africa, January to October 2020 , 2021, Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin.

[10]  J. Park,et al.  Respiratory virus surveillance in Canada during the COVID-19 pandemic: An epidemiological analysis of the effectiveness of pandemic-related public health measures in reducing seasonal respiratory viruses test positivity , 2021, PloS one.

[11]  J. Avner,et al.  Delayed Seasonal RSV Surge Observed During the COVID-19 Pandemic , 2021, Pediatrics.

[12]  F. Schlosser,et al.  Trends in respiratory virus circulation following COVID-19-targeted nonpharmaceutical interventions in Germany, January - September 2020: Analysis of national surveillance data , 2021, The Lancet Regional Health - Europe.

[13]  C. Mahé,et al.  Uncertain effects of the pandemic on respiratory viruses , 2021, Science.

[14]  R. Trebbien,et al.  Abrupt termination of the 2019/20 influenza season following preventive measures against COVID-19 in Denmark, Norway and Sweden , 2021, Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin.

[15]  Zhongjie Li,et al.  Impact of COVID-19 outbreaks and interventions on influenza in China and the United States , 2021, Nature Communications.

[16]  A. Rivas-Estilla,et al.  Decline in influenza cases in Mexico after the implementation of public health measures for COVID-19 , 2021, Scientific reports.

[17]  K. Laurie,et al.  Which influenza viruses will emerge following the SARS‐CoV‐2 pandemic? , 2021, Influenza and other respiratory viruses.

[18]  Daryl R. Cheng,et al.  Changing Epidemiology of Respiratory Syncytial Virus in Australia - delayed re-emergence in Victoria compared to WA/NSW after prolonged lock-down for COVID-19 , 2021, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[19]  C. Sikazwe,et al.  The Interseasonal Resurgence of Respiratory Syncytial Virus in Australian Children Following the Reduction of Coronavirus Disease 2019-Related Public Health Measures. , 2021, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[20]  R. Webby,et al.  Impact of the COVID-19 nonpharmaceutical interventions on influenza and other respiratory viral infections in New Zealand , 2021, Nature Communications.

[21]  H. Zar,et al.  Decline of influenza and respiratory syncytial virus detection in facility-based surveillance during the COVID-19 pandemic, South Africa, January to October 2020 separator commenting unavailable , 2021 .

[22]  David W. Smith,et al.  Where has all the influenza gone? The impact of COVID-19 on the circulation of influenza and other respiratory viruses, Australia, March to September 2020 , 2020, Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin.

[23]  T. Clark,et al.  Physical distancing in schools for SARS-CoV-2 and the resurgence of rhinovirus , 2020, The Lancet Respiratory Medicine.

[24]  Kristine Macartney,et al.  COVID-19 public health measures and respiratory syncytial virus , 2020, The Lancet Child & Adolescent Health.

[25]  L. Brammer,et al.  Decreased influenza activity during the COVID-19 pandemic—United States, Australia, Chile, and South Africa, 2020 , 2020, American Journal of Transplantation.

[26]  S. Bhatt,et al.  Estimating the effects of non-pharmaceutical interventions on COVID-19 in Europe , 2020, Nature.

[27]  Soyeon Ahn,et al.  Impact of Public Health Interventions on Seasonal Influenza Activity During the SARS-CoV-2 Outbreak in Korea , 2020, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[28]  A. Tatem,et al.  Effect of non-pharmaceutical interventions to contain COVID-19 in China , 2020, Nature.

[29]  W. Hugentobler,et al.  Seasonality of Respiratory Viral Infections. , 2020, Annual review of virology.

[30]  K. St. George,et al.  Human Rhinoviruses , 2013, Clinical Microbiology Reviews.