Gonadectomy attenuates turning behavior produced by electrical stimulation of the nigrostriatal dopamine system in female but not male rats

Rotational behavior induced by electrical stimulation of ascending dopamine neurons is used as a behavioral model to investigate gender and hormonal influences on extra-hypothalamic dopamine systems. Steroid hormones influence the metabolism of many dopaminergic drugs, and therefore this approach avoids the complications inherent in drug-induced behavior models of dopamine activity. We found that gonadectomy of female, but not male, rats severely attenuates electrical stimulation-induced rotational behavior. This suggests that some female gonadal steroid hormone(s) may modulate the activity of ascending dopamine neurons, while male gonadal hormones do not.

[1]  A. Conney.  Pharmacological implications of microsomal enzyme induction. , 1967, Pharmacological reviews.

[2]  A. Friedhoff,et al.  A Comparison of Chlorpromazine-Induced Extrapyramidal Syndrome in Male and Female Rats , 1973 .

[3]  Terry E. Robinson,et al.  Sex differences in amphetamine-elicited rotational behavior and the lateralization of striatal dopamine in rats , 1980, Brain Research Bulletin.

[4]  T. Crow,et al.  Relation of contraversive turning to unilateral release of dopamine from the nigrostriatal pathway in rats. , 1971, Experimental neurology.

[5]  B. J. Winer.  Statistical Principles in Experimental Design , 1992 .

[6]  R. Kato,et al.  Sex-related differences in drug metabolism. , 1974, Drug metabolism reviews.

[7]  W. Bengelloun,et al.  Behavior of male and female rats with septal lesions: Influence of prior gonadectomy , 1976, Physiology & Behavior.

[8]  A. Flemenbaum.  Rat Dopaminergic Hypersensitivity , 1979 .

[9]  S. M. Hirsch,et al.  Reactivity in the rat: Ovariectomy fails to affect open-field behaviors , 1974 .

[10]  Meyer Em,et al.  Sex related differences in the physiological disposition of amphetamine and its metabolites in the rat. , 1978 .

[11]  R. Roth,et al.  Dopaminergic neurons: effects of electrical stimulation on dopamine biosynthesis. , 1976, Molecular pharmacology.

[12]  W. Beatty,et al.  Sex differences in stereotyped behavior in the rat , 1978, Pharmacology Biochemistry and Behavior.

[13]  E. Silbergeld,et al.  Increased dopamine receptor sensitivity after estrogen treatment using the rat rotation model. , 1980, Science.

[14]  F. Labrie,et al.  Effect of estrogen on changes in the activity of striatal cholinergic neurons induced by DA drugs , 1979, Brain Research.

[15]  G. W. Arbuthnott,et al.  Turning behavior induced by electrical stimulation of the nigro-neostriatal system of the rat , 1975, Experimental Neurology.

[16]  P. Bédard,et al.  Female sexual hormones influence motor behaviour in rats after lesion of the entopeduncular nucleus , 1980, Neuroscience Letters.

[17]  J. Becker,et al.  Sex differences in the amphetamine stimulated release of catecholamines from rat striatal tissue in vitro , 1981, Brain Research.

[18]  L. Chiodo,et al.  Estrogen increases both spiperone-induced catalepsy and brain levels of [3H]spiperone in the rat , 1979, Brain Research.

[19]  E. Costa,et al.  Factors affecting the rate of disappearance of amphetamine in rats. , 1969, International journal of neuropharmacology.

[20]  W. Weiner,et al.  Modification of postsynaptic dopaminergic sensitivity by female sex hormones. , 1979, Life sciences.

[21]  T. Sourkes,et al.  Potentiation and inhibition of the amphetamine stereotypy in rats by neuroleptics and other agents. , 1972, Archives internationales de pharmacodynamie et de therapie.

[22]  U. Ungerstedt,et al.  Depletion of catecholamines in vivo induced by electrical stimulation of central monoamine pathways. , 1970, Brain research.

[23]  S. Norton,et al.  Circadian and sex differences in hyperactivity produced by amphetamine in rats , 1979, Physiology & Behavior.

[24]  W. Weiner,et al.  Influence of female sex hormones on neuroleptic-induced behavioral supersensitivity , 1980, Neuropharmacology.