Antigen nonspecific rejection of allogeneic skin implants in the anterior chamber of sensitized rats.

As expected, skin implants placed in the anterior chamber of the eye of rats systemically sensitized with alloantigen from the antigen specific (second party) donor implants are rapidly rejected, indicating that the anterior chamber offers no barrier to the efferent immune response. However, during our studies it was noted that antigen nonspecific (third party) skin implants placed in the anterior chamber of the eye of similarly sensitized rats were also rejected in accelerated fashion. In all of the donor-recipient rat strain combinations tested which were sensitized by orthotopic skin grafts, third party skin implants placed in the anterior chamber of the eye were rejected within 14 days. A similar rejection pattern was noted in the anterior chamber of rats that were sensitized by the foot pad injection of graded doses of RT1 incompatible spleen cells. Rats sensitized with mouse skin grafts also rejected RT1 histoincompatible allogeneic implants within the anterior chamber, a result not noted in rats sensitized with either dog, rabbit, or pig skin grafts.

[1]  K. Shortman,et al.  Loss of specificity in cytolytic T lymphocyte clones obtained by limit dilution culture of Ly-2+ T cells. , 1984, Journal of immunology.

[2]  G. Krueger,et al.  Expression of Ia antigen on epidermal keratinocytes after the grafting of normal skin to nude mice. , 1983, Journal of immunology.

[3]  D. Klinman,et al.  Class I major histocompatibility gene products of the brown Norway rat display two major antigenic regions. , 1982, Journal of immunology.

[4]  Gebhardt Bm.  Factors affecting corneal allograft rejection in inbred rats. , 1981 .

[5]  D. Sachs,et al.  Evidence for homologues of the murine I-A and I-E loci in the rat MHC. , 1981, Journal of immunology.

[6]  B. Gebhardt.  Factors affecting corneal allograft rejection in inbred rats. , 1981, Transplantation proceedings.

[7]  D. Wilson,et al.  Monoclonal rat anti-major histocompatibility complex antibodies display specificity for rat, mouse, and human target cells , 1980, The Journal of experimental medicine.

[8]  D. Sachs,et al.  Ia antigens in mouse skin are predominantly expressed on Langerhans cells. , 1979, Journal of immunology.

[9]  H. Taylor,et al.  Histocompatibility (HLA) antigens and keratoplasty. , 1978, American journal of ophthalmology.

[10]  F. Milgrom,et al.  Studies on skin-reacting transplantation antibodies. , 1978, Transplantation.

[11]  R. A. Phillips,et al.  Quantitative studies on the precursors of cytotoxic lymphocytes. IV. Specificity and cross-reactivity of cytotoxic clones. , 1978, Journal of immunology.

[12]  P. Gerlag,et al.  Role of antiserum and complement in the acute antibody-mediated rejection of mouse skin allografts in strain combinations with increasing histoincompatibility. , 1977, Transplantation.

[13]  D. Sachs,et al.  Ag-B-linked analogue of Ia antigens in the rat. , 1977, Journal of immunology.

[14]  R. Vessella,et al.  The anterior chamber of the eye: a sensitive site for the detection of cross-reacting alloantigens. , 1977, The Journal of surgical research.

[15]  J. R. Batchelor,et al.  HLA MATCHING AND CORNEAL GRAFTING , 1976, The Lancet.

[16]  R. Zinkernagel,et al.  Specificity of Virus‐Immune Effector T Cells for H‐2K or H‐2D Compatible Interactions: Implications for H‐Antigen Diversity , 1976, Transplantation reviews.

[17]  A. Silverstein,et al.  Induction of corneal graft rejection by passive cell transfer. , 1976, Investigative ophthalmology.

[18]  T. Strom,et al.  The role of nonclassical Fc receptor-associated, Ag-B antigens (Ia) in rat allograft enhancement , 1976, The Journal of experimental medicine.

[19]  H. Kaplan,et al.  A RECONSIDERATION OF IMMUNOLOGICAL PRIVILEGE WITHIN THE ANTERIOR CHAMBER OF THE EYE , 1975, Transplantation.

[20]  H. Winn,et al.  Acute destruction of rat skin grafts by alloantisera. , 1975, Journal of immunology.

[21]  J. Hardy,et al.  Organ Specificity in Hyperacute Rejection of Canine Heart and Kidney Allografts , 1974, Annals of surgery.

[22]  D. Davies,et al.  What Abrogates Heart Transplant Rejection in Immunological Enhancement? , 1974, Nature.

[23]  P. Terasaki,et al.  Sensitization to human lymphocyte antigens by corneal transplantation. , 1973, Investigative ophthalmology.

[24]  D. Sachs,et al.  The immunologic response to xenografts. Recognition of mouse H-2 histocompatibility antigens by the rat. , 1971, Journal of immunology.

[25]  R. A. Prendergast,et al.  Primary rejection of skin allografts in the anterior chamber of the rabbit eye. , 1970, Journal of immunology.

[26]  A. M. Davies,et al.  Specificity of Blast Transformation , 1970 .

[27]  A. M. Davies,et al.  Specificity of blast transformation. I. Studies with organ- and species-specific antigens. , 1970, International archives of allergy and applied immunology.

[28]  J. Hardy,et al.  A new test of rejection for implants in the anterior chamber of the eye: application for the study of immunological mechanisms operative in a privileged site. , 1969, The American surgeon.

[29]  P. Terasaki,et al.  Significance of the positive crossmatch test in kidney transplantation. , 1969, The New England journal of medicine.

[30]  J. Hardy,et al.  Efficacy of Short-Term in Prolonging Survival Antilymphocyte Serum Treatment of Skin Allografts in Rats , 1968 .

[31]  J. Converse,et al.  The Immune Response to Multiple‐Set Skin Homografts , 1958 .

[32]  A. E. Maumenee,et al.  The influence of donor-recipient sensitization on corneal grafts. , 1951, American journal of ophthalmology.

[33]  P. Medawar.  Immunity to homologous grafted skin; the fate of skin homografts transplanted to the brain, to subcutaneous tissue, and to the anterior chamber of the eye. , 1948, British journal of experimental pathology.