Stigmasterol reduces plasma cholesterol levels and inhibits hepatic synthesis and intestinal absorption in the rat.

[1]  R. Schoenheimer,et al.  Über die Spezifität der Resorption von Sterinen, abhängig von ihrer Konstitution. , 1930 .

[2]  S. Grundy,et al.  The interaction of cholesterol absorption and cholesterol synthesis in man. , 1969, Journal of lipid research.

[3]  S. Grundy,et al.  Metabolism of β-sitosterol in man , 1970 .

[4]  Zilversmit Db,et al.  Validation of a dual-isotope plasma ratio method for measurement of cholesterol absorption in rats. , 1974 .

[5]  C. Glueck,et al.  Phytosterols in aortic tissue in adults and infants. , 1976, The Journal of laboratory and clinical medicine.

[6]  M. M. Bradford A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. , 1976, Analytical biochemistry.

[7]  S. Grundy,et al.  Plant sterols as cholesterol-lowering agents: clinical trials in patients with hypercholesterolemia and studies of sterol balance. , 1977, Atherosclerosis.

[8]  F. Mattson,et al.  Effect of plant sterol esters on the absorption of dietary cholesterol. , 1977, The Journal of nutrition.

[9]  L. Aringer 7-Hydroxylation of 3-oxygenated C27-, C28-, and C29-steroids in rat liver 18,000 g supernate. , 1978, Journal of lipid research.

[10]  T. Miettinen,et al.  Thin-layer and gas--liquid chromatographic identification of neutral steroids in human and rat feces. , 1981, Journal of lipid research.

[11]  T. Miettinen Diurnal variation of cholesterol precursors squalene and methyl sterols in human plasma lipoproteins. , 1982, Journal of lipid research.

[12]  H. V. Ammon,et al.  Comparison of cholesterol and beta-sitosterol: effects on jejunal fluid secretion induced by oleate, and absorption from mixed micellar solutions. , 1983, Gut.

[13]  D. S. Lin,et al.  Comparative lymphatic absorption of sitosterol, stigmasterol, and fucosterol and differential inhibition of cholesterol absorption. , 1983, The American journal of clinical nutrition.

[14]  J. Little,et al.  Usefulness of gas chromatographic profiles of plasma total lipids in diagnosis of phytosterolemia. , 1986, Journal of chromatography.

[15]  T. Miettinen,et al.  Plasma and biliary cholestanol related to steroid metabolism in familial hypercholesterolemia patients with and without ileal exclusion. , 1988, Clinica chimica acta; international journal of clinical chemistry.

[16]  E Horak,et al.  Increased sitosterol absorption, decreased removal, and expanded body pools compensate for reduced cholesterol synthesis in sitosterolemia with xanthomatosis. , 1989, Journal of lipid research.

[17]  R. Tilvis,et al.  Serum plant sterols and cholesterol precursors reflect cholesterol absorption and synthesis in volunteers of a randomly selected male population. , 1990, American journal of epidemiology.

[18]  G. Ness,et al.  A molecular defect in hepatic cholesterol biosynthesis in sitosterolemia with xanthomatosis. , 1990, The Journal of clinical investigation.

[19]  G. Tint,et al.  Increased sitosterol absorption is offset by rapid elimination to prevent accumulation in heterozygotes with sitosterolemia. , 1992, Arteriosclerosis and thrombosis : a journal of vascular biology.

[20]  T. Heinemann,et al.  Comparison of intestinal absorption of cholesterol with different plant sterols in man * , 1993, European Journal of Clinical Investigation.

[21]  K. von Bergmann,et al.  Treatment of severe familial hypercholesterolemia in childhood with sitosterol and sitostanol. , 1993, The Journal of pediatrics.

[22]  A. Honda,et al.  Bile acid synthesis in the Smith-Lemli-Opitz syndrome: effects of dehydrocholesterols on cholesterol 7alpha-hydroxylase and 27-hydroxylase activities in rat liver. , 1999, Journal of lipid research.

[23]  N. Grishin,et al.  Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters. , 2000, Science.

[24]  M. Sugano,et al.  Mechanisms of phytosterolemia in stroke-prone spontaneously hypertensive and WKY rats. , 2001, Metabolism: clinical and experimental.

[25]  A. Honda,et al.  Differences in hepatic levels of intermediates in bile acid biosynthesis between Cyp27(-/-) mice and CTX. , 2001, Journal of lipid research.

[26]  A. Pandya,et al.  Two genes that map to the STSL locus cause sitosterolemia: genomic structure and spectrum of mutations involving sterolin-1 and sterolin-2, encoded by ABCG5 and ABCG8, respectively. , 2001, American journal of human genetics.

[27]  Anand K. Srivastava,et al.  Identification of a gene, ABCG5, important in the regulation of dietary cholesterol absorption , 2001, Nature Genetics.

[28]  D. Alberts,et al.  Simultaneous quantitation of fatty acids, sterols and bile acids in human stool by capillary gas-liquid chromatography. , 2002, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[29]  D. Gómez-Coronado,et al.  Inhibition of cholesterol biosynthesis by Delta22-unsaturated phytosterols via competitive inhibition of sterol Delta24-reductase in mammalian cells. , 2002, The Biochemical journal.

[30]  S. Grundy,et al.  Efficacy and safety of plant stanols and sterols in the management of blood cholesterol levels. , 2003, Mayo Clinic proceedings.

[31]  Mi-Hye Lee,et al.  The rat STSL locus: characterization, chromosomal assignment, and genetic variations in sitosterolemic hypertensive rats , 2003, BMC cardiovascular disorders.

[32]  K. A. Scoggan,et al.  A missense mutation in the Abcg5 gene causes phytosterolemia in SHR, stroke-prone SHR, and WKY rats Published, JLR Papers in Press, March 1, 2003. DOI 10.1194/jlr.M200438-JLR200 , 2003, Journal of Lipid Research.

[33]  J. Chiang,et al.  Guggulsterone antagonizes farnesoid X receptor induction of bile salt export pump but activates pregnane X receptor to inhibit cholesterol 7alpha-hydroxylase gene. , 2003, Biochemical and biophysical research communications.

[34]  D. Lütjohann,et al.  Comparison of the intestinal uptake of cholesterol, plant sterols, and stanols in mice Published, JLR Papers in Press, December 16, 2002. DOI 10.1194/jlr.M200393-JLR200 , 2003, Journal of Lipid Research.

[35]  Jonathan C. Cohen,et al.  Disruption of cholesterol homeostasis by plant sterols. , 2004, The Journal of clinical investigation.

[36]  Guorong Xu,et al.  Effect of high plant sterol-enriched diet and cholesterol absorption inhibitor, SCH 58235, on plant sterol absorption and plasma concentrations in hypercholesterolemic wild-type Kyoto rats. , 2005, Metabolism: clinical and experimental.