Enzymatic activation of chemicals to toxic metabolites.
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[1] T. Kamataki,et al. Cytochrome P-450 as a determinant of sex difference of drug metabolism in the rat. , 1982, Xenobiotica; the fate of foreign compounds in biological systems.
[2] L. Marnett,et al. Co-oxygenation of organic substrates by the prostaglandin synthetase of sheep vesicular gland. , 1975, The Journal of biological chemistry.
[3] L. T. Burka,et al. Enzymatic mono oxygenation of halogen atoms cytochrome p 450 catalyzed oxidation of iodo benzene by iodoso benzene , 1980 .
[4] Suicide enzyme inactivators , 1976 .
[5] H. Gelboin. Benzo[alpha]pyrene metabolism, activation and carcinogenesis: role and regulation of mixed-function oxidases and related enzymes. , 1980, Physiological reviews.
[6] D. Jerina,et al. Tumorigenicity studies with diol-epoxides of benzo(a)pyrene which indicate that (+/-)-trans-7beta,8alpha-dihydroxy-9alpha,10alpha-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene is an ultimate carcinogen in newborn mice. , 1978, Cancer research.
[7] R. Jaeger,et al. 1,1-Dichloroethylene hepatotoxicity: Proposed mechanism of action and distribution and binding of 14C radioactivity following inhalation exposure in rats , 1977, Environmental health perspectives.
[8] H. Greim,et al. Mutagenicity in vitro and potential carcinogenicity of chlorinated ethylenes as a function of metabolic oxiran formation. , 1975, Biochemical pharmacology.
[9] S. Nelson,et al. Quantitative determination of the glutathione, cysteine, and N-acetyl cysteine conjugates of acetaminophen by high-pressure liquid chromatography. , 1977, Analytical biochemistry.
[10] H. Driver,et al. A comparison of the pneumotoxicity of some pyrrolic esters and similar compounds analogous to pyrrolizidine alkaloid metabolites, given intravenously to rats. , 1983, Toxicology.
[11] R. Kato,et al. Reduction of tertiary amine N-oxides by liver microsomal cytochrome P-450. , 1976, Molecular pharmacology.
[12] R. Hines,et al. The characterization of an inhibitory complex formed with cytochrome P-450 and a metabolite of 1,1-disubstituted hydrazines. , 1980, The Journal of pharmacology and experimental therapeutics.
[13] J. Hinson,et al. N-Hydroxylation of phenacetin by hamster liver microsomes. , 1976, Drug metabolism and disposition: the biological fate of chemicals.
[14] F. Guengerich,et al. Characterization of a human liver cytochrome P-450 involved in the oxidation of debrisoquine and other drugs by using antibodies raised to the analogous rat enzyme. , 1984, Proceedings of the National Academy of Sciences of the United States of America.
[15] J. Ozols,et al. The complete amino acid sequence of rabbit phenobarbital-induced liver microsomal cytochrome P-450. , 1983, The Journal of biological chemistry.
[16] H. Bartsch,et al. Tissue-mediated mutagenicity of vinylidene chloride and 2-chlorobutadiene in Salmonella typhimurium , 1975, Nature.
[17] H. Bolt,et al. Covalent binding of haloethylenes. , 1981, Advances in experimental medicine and biology.
[18] S. Orrenius,et al. Effects of different cell constituents on metabolic activation and binding of benzo(a)pyrene to purified and nuclear DNA. , 1979, Biochemical and biophysical research communications.
[19] E. Hodgson,et al. Interaction of methylenedioxyphenyl (1,3-benzodioxole) compounds with enzymes and their effects on mammals. , 1974, Drug metabolism reviews (Softcover ed.).
[20] Miller Re,et al. Oxidation of trichloroethylene by liver microsomal cytochrome P-450: evidence for chlorine migration in a transition state not involving trichloroethylene oxide. , 1982 .
[21] S. Nelson,et al. Reduction and glutathione conjugation reactions of N-acetyl-p-benzoquinone imine and two dimethylated analogues. , 1984, Molecular pharmacology.
[22] D. Griller,et al. Free-radical clocks , 1980 .
[23] T. Macdonald,et al. Mechanisms of hydroxylation by cytochrome P-450: metabolism of monohalobenzenes by phenobarbital-induced microsomes. , 1983, Proceedings of the National Academy of Sciences of the United States of America.
[24] Mangold,et al. The cytochrome P-450 active site. Regiospecificity of prosthetic heme alkylation by olefins and acetylenes. , 1983, The Journal of biological chemistry.
[25] F. Guengerich. Studies on the activation of a model furan compound--toxicity and covalent binding of 2-(N-ethylcarbamoylhydroxymethyl)furan. , 1977, Biochemical pharmacology.
[26] I. White,et al. Reaction of dihydropyrrolizines with deoxyribonucleic acids in vitro. , 1972, The Biochemical journal.
[27] J. Idle,et al. The polymorphic 4-hydroxylation of debrisoquine in a Saudi arab population. , 1980, Xenobiotica; the fate of foreign compounds in biological systems.
[28] L. Poulsen,et al. The liver microsomal FAD-containing monooxygenase. Spectral characterization and kinetic studies. , 1979, The Journal of biological chemistry.
[29] B. Masters. Chapter 8 – The Role of NADPH-Cytochrome c (P-450) Reductase in Detoxication , 1980 .
[30] F. Guengerich,et al. Purification and characterization of the rat liver microsomal cytochrome P-450 involved in the 4-hydroxylation of debrisoquine, a prototype for genetic variation in oxidative drug metabolism. , 1984, Biochemistry.
[31] B. Ketterer,et al. The role of glutathione in detoxication , 1983, Environmental health perspectives.
[32] F. Guengerich,et al. Comparison of different forms of liver, kidney, and lung microsomal cytochrome P-450 by immunological inhibition of regio- and stereoselective metabolism of warfarin. , 1979, The Journal of biological chemistry.
[33] L. J. Piper,et al. The role of cytochrome P-450-inducing agents in potentiaing the toxicity of fluroxene (2,2,2-trifluoroethyl vinyl ether). , 1980, Toxicology and applied pharmacology.
[34] M. J. Coon,et al. Interactions of cytochrome P-450, NADPH-cytochrome P-450 reductase, phospholipid, and substrate in the reconstituted liver microsomal enzyme system. , 1980, The Journal of biological chemistry.
[35] L. Pohl,et al. N-Hydroxyacetaminophen: a microsomal metabolite of N-hydroxyphenacetin but apparently not of acetaminophen. , 1979, Life sciences.
[36] J. Swenberg,et al. Cell-specific differences in O6-alkylguanine DNA repair activity during continuous exposure to carcinogen. , 1982, Proceedings of the National Academy of Sciences of the United States of America.
[37] S. Orrenius,et al. The role of methionine in glutathione biosynthesis by isolated hepatocytes. , 1977, Biochemical and biophysical research communications.
[38] S. Orrenius,et al. Bleb formation in hepatocytes during drug metabolism is caused by disturbances in thiol and calcium ion homeostasis. , 1982, Science.
[39] S. Szabó,et al. Hepatotoxicity of vinyl chloride and 1,1-dichloroethylene. Role of mixed function oxidase system. , 1975, The American journal of pathology.
[40] C. Green,et al. Metabolism, cytotoxicity, and genotoxicity of the pyrrolizidine alkaloid senecionine in primary cultures of rat hepatocytes. , 1981, Toxicology and applied pharmacology.
[41] J. Mitchell,et al. Renal and hepatic necrosis after metabolic activation of 2-substituted furans and thiophenes, including furosemide and cephaloridine. , 1977, Toxicology and applied pharmacology.
[42] E. Johnson,et al. Allosteric regulation of the 16 alpha-hydroxylation of progesterone as catalyzed by rabbit microsomal cytochrome P-450 3b. , 1983, The Journal of biological chemistry.
[43] F. Guengerich,et al. Immunochemical comparison and quantitation of microsomal flavin-containing monooxygenases in various hog, mouse, rat, rabbit, dog, and human tissues. , 1982, Molecular pharmacology.
[44] P. Moldéus,et al. Prostaglandin synthetase catalyzed activation of paracetamol. , 1982, Biochemical pharmacology.
[45] D. L. Cinti. Agents activating the liver microsomal mixed function oxidase system , 1978 .
[46] J. Allen,et al. Synthesis of a tritium labelled pyrrolizidine alkaloidisenecioyl retronecine , 1975 .
[47] P. Beaune,et al. Purification and characterization of six cytochrome P-450 isozymes from human liver microsomes. , 1983, Biochemistry.
[48] W. Jakoby,et al. Cysteine conjugate beta-lyase. , 1983, Molecular pharmacology.
[49] L. Moore,et al. Inhibition of liver-microsome calcium pump by in vivo administration of CCl4, CHCl3 and 1,1-dichloroethylene (vinylidene chloride). , 1980, Biochemical pharmacology.
[50] R. A. Neal,et al. Toxicology of thiono-sulfur compounds. , 1982, Annual review of pharmacology and toxicology.
[51] M. McKenna,et al. The pharmacokinetics of [14C]vinylidene chloride in rats following inhalation exposure. , 1978, Toxicology and applied pharmacology.
[52] P. Ortiz de Montellano,et al. The catalytic mechanism of cytochrome P-450. Spin-trapping evidence for one-electron substrate oxidation. , 1982, The Journal of biological chemistry.
[53] W. E. Fahl,et al. Metabolism of benzo(a)pyrene by isolated hepatocytes and factors affecting covalent binding of benzo(a)pyrene metabolites to DNA in hepatocyte and microsomal systems. , 1980, Archives of biochemistry and biophysics.
[54] L. Shuster,et al. Cocaine-induced hepatic necrosis in mice--the role of cocaine metabolism. , 1979, Biochemical pharmacology.
[55] N. Neff,et al. Degradation of proteins microinjected into IMR-90 human diploid fibroblasts , 1981, The Journal of cell biology.
[56] B Chance,et al. Hydroperoxide metabolism in mammalian organs. , 1979, Physiological reviews.
[57] F. Kadlubar,et al. Prostaglandin endoperoxide synthetase-mediated metabolism of carcinogenic aromatic amines and their binding to DNA and protein. , 1982, Biochemical and biophysical research communications.
[58] F. Guengerich,et al. Differences in the functional interaction of two purified cytochrome P-450 isozymes with epoxide hydrolase. , 1981, Journal of Biological Chemistry.
[59] P. Thomas,et al. Purification, characterization and regulation of five rat hepatic microsomal cytochrome P-450 isozymes. , 1982, Xenobiotica; the fate of foreign compounds in biological systems.
[60] H. Knapp,et al. Energy-dependent calcium sequestration activity in rat liver microsomes. , 1975, The Journal of biological chemistry.
[61] I. Calder,et al. N-hydroxylation of p-acetophenetidide as a factor in nephrotoxicity. , 1973, Journal of medicinal chemistry.
[62] F. Guengerich,et al. Purification and characterization of liver microsomal cytochromes p-450: electrophoretic, spectral, catalytic, and immunochemical properties and inducibility of eight isozymes isolated from rats treated with phenobarbital or beta-naphthoflavone. , 1982, Biochemistry.
[63] F. Guengerich,et al. Destruction of highly purified cytochromes P-450 associated with metabolism of fluorinated ether anesthetics. , 1981, Archives of biochemistry and biophysics.
[64] F. Guengerich. Separation and purification of multiple forms of microsomal cytochrome P-450. Activities of different forms of cytochrome P-450 towards several compounds of environmental interest. , 1977, The Journal of biological chemistry.
[65] R. Jaeger,et al. Effect of 18 hr fast and glutathione depletion on 1,1-dichloroethylene-induced hepatotoxicity and lethality in rats. , 1974, Experimental and molecular pathology.
[66] A. Dipple,et al. Selectivity in nucleoside alkylation and aralkylation in relation to chemical carcinogenesis , 1979 .
[67] D. Warburton,et al. Neural tube defects in spontaneous abortions. , 1986, American journal of medical genetics.
[68] J. Bridges,et al. The microsomal metabolism of the organometallic derivatives of the group-IV elements, germanium, tin and lead. , 1981, The Biochemical journal.
[69] E. Lock,et al. Role of microsomal and cytosolic glutathione S-transferases in the conjugation of hexachloro-1:3-butadiene and its possible relevance to toxicity. , 1984, The Journal of pharmacology and experimental therapeutics.
[70] W. Stott,et al. Roles of 2-haloethylene oxides and 2-haloacetaldehydes derived from vinyl bromide and vinyl chloride in irreversible binding to protein and DNA. , 1981, Cancer research.
[71] J. P. Shea,et al. MNDO calculation of kinetic isotope effects in model cytochrome P-450 oxidations , 1983 .
[72] J. Groves,et al. ON THE MECHANISM OF OXYGEN INSERTION CATALYZED BY CYTOCHROME P-450. HYDROXYLATION WITH PARTIAL ALLYLIC REARRANGEMENT , 1980 .
[73] N. Ozawa,et al. Evidence for formation of an S-[2-(N7-guanyl)ethyl]glutathione adduct in glutathione-mediated binding of the carcinogen 1,2-dibromoethane to DNA. , 1983, Proceedings of the National Academy of Sciences of the United States of America.
[74] R. Pearson,et al. Application of the Principle of Hard and Soft Acids and Bases to Organic Chemistry , 1967 .
[75] J. Gillette,et al. Studies on the mechanism of action of mammalian hepatic azoreductase. II. The effects of phenobarbital and 3-methylcholanthrene on carbon monoxide sensitive and insensitive azoreductase activities. , 1967, Biochemical pharmacology.
[76] H. Gelboin,et al. Phenotyping of cytochromes P-450 in human tissues with monoclonal antibodies. , 1982, Proceedings of the National Academy of Sciences of the United States of America.
[77] P. Moldéus,et al. Metabolism of paracetamol to a glutathione conjugate catalyzed by prostaglandin synthetase. , 1980, Biochemical and biophysical research communications.
[78] F. Guengerich,et al. Glutathione-mediated binding of dibromoalkanes to DNA: specificity of rat glutathione-S-transferases and dibromoalkane structure. , 1984, Carcinogenesis.
[79] T. Monks,et al. Intra- and extra-cellular formation of metabolites from chemically reactive species. , 1984, Biochemical Society transactions.
[80] M. Ihara,et al. Novel synthesis of the pyrrolizidine skeleton by sulfenocycloamination. Total synthesis of (.+-.)-retronecine and (.+-.)-turneforcidine , 1983 .
[81] J. Essigmann,et al. Structural identification of the major DNA adduct formed by aflatoxin B1 in vitro. , 1977, Proceedings of the National Academy of Sciences of the United States of America.
[82] T. C. Bruice. Mechanisms of flavin catalysis , 1980 .
[83] R. Kato,et al. Studies on the mechanism of nitro reduction by rat liver. , 1969, Molecular pharmacology.
[84] S. Thorgeirsson,et al. Mechanism of N-hydroxy-2-acetylaminofluorene mutagenicity in the Salmonella test system. Role of N-O acyltransferase and sulfotransferase from rat liver. , 1981, Molecular Pharmacology.
[85] A. Waiss,et al. The Total Synthesis of (+)-Retronecine , 1962 .
[86] L. Kaminsky,et al. Fluroxene (2,2,2-trifluoroethyl vinyl ether) mediated destruction of cytochrome P-450 in vitro. , 1975, Biochemical pharmacology.
[87] K. Robertson. Alkylation of N2 in deoxyguanosine by dehydroretronecine, a carcinogenic metabolite of the pyrrolizidine alkaloid monocrotaline. , 1982, Cancer research.
[88] D. Hathway,et al. The biological fate of vinylidene chloride in rats. , 1978, Chemico-biological interactions.
[89] J. Ashby,et al. Evaluation in vitro of several pyrrolizidine alkaloid carcinogens: observations on the essential pyrrolic nucleus. , 1980, Carcinogenesis.
[90] A. Y. Lu,et al. Electroimmunochemical quantitation of cytochrome P-450, cytochrome P-448, and epoxide hydrolase in rat liver microsomes. , 1981, The Journal of biological chemistry.
[91] F. Guengerich. Preparation and properties of highly purified cytochrome p-450 and NADPH-cytochrome P-450 reductase from pulmonary microsomes of untreated rabbits. , 1977, Molecular pharmacology.
[92] G. L. Kedderis,et al. The use of intramolecular isotope effects to distinguish between deprotonation and hydrogen atom abstraction mechanisms in cytochrome P-450- and peroxidase-catalyzed N-demethylation reactions. , 1983, The Journal of biological chemistry.
[93] L. Prescott,et al. Plasma-paracetamol half-life and hepatic necrosis in patients with paracetamol overdosage. , 1971, Lancet.
[94] L. Ernster,et al. DT diaphorase. I. Purification from the soluble fraction of rat-liver cytoplasm, and properties. , 1962, Biochimica et biophysica acta.
[95] A. Mattocks. Pyrrolizidine alkaloid analogues. Part 2. Further hydroxymethyl-1-methyl-3-pyrrolines (synthanecines), and the preparation and esterification of some hydroxymethylpyrroles , 1978 .
[96] A. Y. Lu,et al. Studies on the stimulation of cytochrome P-450-dependent monooxygenase activity by dilauroylphosphatidylcholine. , 1981, Archives of biochemistry and biophysics.
[97] C. Polnaszek,et al. The kinetics of the aerobic reduction of nitrofurantoin by NADPH-cytochrome P-450 Ic) reductase. , 1981, Molecular pharmacology.
[98] S. Orrenius,et al. Regulation of intracellular calcium compartmentation: studies with isolated hepatocytes and t-butyl hydroperoxide. , 1982, Proceedings of the National Academy of Sciences of the United States of America.
[99] F. Guengerich,et al. Major isozymes of rat liver microsomal cytochrome P-450 involved in the N-oxidation of N-isopropyl-alpha-(2-methylazo)-p-toluamide, the azo derivative of procarbazine. , 1984, Cancer research.
[100] D. Ballou,et al. The reductive half-reaction of liver microsomal FAD-containing monooxygenase. , 1981, The Journal of biological chemistry.
[101] F. Guengerich,et al. Cytochrome P-450- and flavin-containing monooxygenase-catalyzed formation of the carcinogen N-hydroxy-2-aminofluorene and its covalent binding to nuclear DNA. , 1982, Cancer research.
[102] T. Kimura,et al. Purification of mixed-function amine oxidase from rat liver microsomes. , 1983, Biochemical and biophysical research communications.
[103] P. Thomas,et al. Preparation of monospecific antibodies against two forms of rat liver cytochrome P-450 and quantitation of these antigens in microsomes. , 1979, Archives of biochemistry and biophysics.
[104] H. Hauri,et al. The turnover of cytochrome P450b , 1982, FEBS letters.
[105] S. Nelson,et al. Lack of evidence for N-hydroxyacetaminophen as a reactive metabolite of acetaminophen in vitro. , 1980, Biochemical pharmacology.
[106] T. Orton,et al. Cytochrome P-450 induction by clofibrate. Purification and properties of a hepatic cytochrome P-450 relatively specific for the 12- and 11-hydroxylation of dodecanoic acid (lauric acid). , 1982, The Biochemical journal.
[107] B. Brodie,et al. ACETAMINOPHEN-INDUCED HEPATIC NECROSIS. III. CYTOCHROME P-450-MEDIATED COVALENT BINDING IN VITRO , 1973 .
[108] J. Edgar,et al. Hepato- and pneumotoxicity of pyrrolizidine alkaloids and derivatives in relation to molecular structure. , 1976, Chemico-biological interactions.
[109] L. Kaminsky,et al. The role of cytochrome P-450 in the toxicity of fluroxene (2,2,2-trifluoroethyl vinyl ether) anaesthesia in vivo. , 1976, Biochemical pharmacology.
[110] J. L. Seymour,et al. Covalent interaction of dehydroretronecine, a carcinogenic metabolite of the pyrrolizidine alkaloid monocrotaline, with cysteine and glutathione. , 1977, Cancer research.
[111] T. Baillie,et al. Comparative electron impact, chemical ionization and field desorption mass spectra of some thioether metabolites of acetaminophen. , 1981, Biomedical mass spectrometry.
[112] F. Guengerich,et al. Metabolism of trichloroethylene in isolated hepatocytes, microsomes, and reconstituted enzyme systems containing cytochrome P-450. , 1983, Cancer research.
[113] S. Orrenius,et al. Inhibition of ATP-dependent microsomal Ca2+ sequestration during oxidative stress and its prevention by glutathione. , 1983, The Journal of biological chemistry.
[114] K. Hellmer,et al. Binding of 14 C-carbon tetrachloride to microsomal proteins in vitro and formation of CHC1 3 by reduced liver microsomes. , 1973, Xenobiotica; the fate of foreign compounds in biological systems.
[115] F. Beland,et al. Local carcinogenicity, rates of absorption, extent and persistence of macromolecular binding, and acute histopathological effects of N-hydroxy-1-naphthylamine and N-hydroxy-2-naphthylamine. , 1984, Cancer research.
[116] T. Eling,et al. Co-oxidation of benzidine by prostaglandin synthase and comparison with the action of horseradish peroxidase. , 1983, The Journal of biological chemistry.
[117] J. P. Shea,et al. Mechanism-based inactivation of cytochrome P-450 by heteroatom-substituted cyclopropanes and formation of ring-opened products , 1984 .
[118] K. Ivanetich,et al. Vinylidene chloride: its metabolism by hepatic microsomal cytochrome P-450 in vitro. , 1982, Biochemical pharmacology.
[119] M. Huang,et al. Studies on the mechanism of activation of microsomal benzo[a]pyrene hydroxylation by flavonoids. , 1981, The Journal of biological chemistry.
[120] R Montesano,et al. Mutagenic and carcinogenic N-nitroso compounds: possible environmental hazards. , 1976, Mutation research.
[121] D. Liebler,et al. Formation of glutathione conjugates by reactive metabolites of vinylidene chloride in microsomes and isolated hepatocytes. , 1985, Cancer research.
[122] T. Sugimura,et al. Mutagenicity of pyrrolizidine alkaloids in the Salmonella/mammalian-microsome test. , 1979, Mutation research.
[123] J. Halpert,et al. Covalent modification of lysine during the suicide inactivation of rat liver cytochrome P-450 by chloramphenicol. , 1981, Biochemical pharmacology.
[124] G. Drummond,et al. The cytochrome P-450-depleted animal: an experimental model for in vivo studies in chemical biology. , 1982, Proceedings of the National Academy of Sciences of the United States of America.
[125] S. Nelson,et al. Peroxidase-mediated formation of reactive metabolites of acetaminophen. , 1981, Molecular pharmacology.
[126] R. Tullman,et al. Suicidal inactivation of cytochrome P-450 by cyclopropylamines. Evidence for cation-radical intermediates , 1982 .
[127] G. Kellermann,et al. Genetic variation of aryl hydrocarbon hydroxylase in human lymphocytes. , 1973, American journal of human genetics.
[128] P. Thomas,et al. The in vivo turnover of rat liver microsomal epoxide hydrolase and both the apoprotein and heme moieties of specific cytochrome P-450 isozymes. , 1983, Archives of biochemistry and biophysics.
[129] A. Y. Lu,et al. Drug residue formation from ronidazole, a 5-nitroimidazole. II. Involvement of microsomal NADPH-cytochrome P-450 reductase in protein alkylation in vitro. , 1982, Chemico-biological interactions.
[130] L. Pohl,et al. Reductive oxygenation of carbon tetrachloride: trichloromethylperoxyl radical as a possible intermediate in the conversion of carbon tetrachloride to electrophilic chlorine. , 1983, Archives of biochemistry and biophysics.
[131] J. D. Vries. Hepatotoxic metabolic activation of paracetamol and its derivatives phenacetin and benorilete: Oxygenation or electron transfer? , 1981 .
[132] E C Miller,et al. Searches for ultimate chemical carcinogens and their reactions with cellular macromolecules , 1981, Cancer.
[133] A. Y. Lu,et al. Multiplicity of mammalian microsomal cytochromes P-45. , 1979, Pharmacological reviews.
[134] P. Ortiz de Montellano,et al. Stereochemistry of cytochrome P-450-catalyzed epoxidation and prosthetic heme alkylation. , 1983, The Journal of biological chemistry.
[135] P. Smith. Derivatives of hydrazine and other hydronitrogens having N-N bonds , 1983 .
[136] F. Guengerich,et al. 3-Hydroxyacetaminophen: a microsomal metabolite of acetaminophen. Evidence against an epoxide as the reactive metabolite of acetaminophen. , 1980, Drug metabolism and disposition: the biological fate of chemicals.
[137] J. Idle,et al. The genetic control of sparteine and debrisoquine metabolism in man with new methods of analysing bimodal distributions. , 1983, Journal of medical genetics.
[138] R. A. Neal,et al. Biotransformation of phenol to hydroquinone and catechol by rat liver microsomes. , 1983, Molecular pharmacology.
[139] P. Ortiz de Montellano,et al. Destruction of cytochrome P-450 by vinyl fluoride, fluroxene, and acetylene. Evidence for a radical intermediate in olefin oxidation. , 1982, Biochemistry.
[140] R. Prough,et al. Studies on the pathway of methane formation from procarbazine, a 2-methylbenzylhydrazine derivative, by rat liver microsomes. , 1983, Archives of biochemistry and biophysics.
[141] J. Miller,et al. Non-arene oxide aromatic ring hydroxylation of 2,2',5,5'-tetrachlorobiphenyl as the major metabolic pathway catalyzed by phenobarbital-induced rat liver microsomes. , 1983, The Journal of biological chemistry.
[142] R. Kato,et al. Evidence for the involvement of cytochrome P-450 in reduction of benzo(a)pyrene 4,5-oxide by rat liver microsomes. , 1976, Biochemical and biophysical research communications.
[143] P. Watanabe,et al. Activation of vinyl chloride to covalently bound metabolites: roles of 2-chloroethylene oxide and 2-chloroacetaldehyde. , 1979, Biochemistry.
[144] J. Barrio,et al. Etheno-substituted nucleotides and coenzymes: fluorescence and biological activity. , 1984, CRC critical reviews in biochemistry.
[145] M. Correia,et al. Suicidal destruction of cytochrome P-450 during oxidative drug metabolism. , 1983, Annual review of pharmacology and toxicology.
[146] J. Halpert,et al. Suicide inactivation of rat liver cytochrome P-450 by chloramphenicol in vivo and in vitro. , 1983, Molecular pharmacology.
[147] J. Idle,et al. Animal modelling of human polymorphic drug oxidation—the metabolism of debrisoquine and phenacetin in rat inbred strains , 1981, The Journal of pharmacy and pharmacology.
[148] A. Conney,et al. In vivo activation of zoxazolamine metabolism by flavone. , 1982, Science.
[149] J. Wiseman,et al. Mechanism of inhibition of horseradish peroxidase by cyclopropanone hydrate. , 1982, The Journal of biological chemistry.
[150] F. Guengerich,et al. Immunological comparison of rat, rabbit, and human liver NADPH-cytochrome P-450 reductases. , 1981, Biochemistry.
[151] J. Miller,et al. Hepatic microsomal N-glucuronidation and nucleic acid binding of N-hydroxy arylamines in relation to urinary bladder carcinogenesis. , 1977, Cancer research.
[152] C. Wolf,et al. The rabbit pulmonary monooxygenase system: characteristics and activities of two forms of pulmonary cytochrome P-450. , 1978, Chemico-biological interactions.
[153] J. Idle,et al. Polymorphic sulphoxidation of S-carboxymethyl-L-cysteine in man. , 1982, Biochemical pharmacology.
[154] T. Boyer,et al. Acetaminophen-induced hepatic necrosis and renal failure. , 1971, JAMA.
[155] M. Johnson,et al. Studies on glutathione S-alkyltransferase of the rat. , 1966, The Biochemical journal.
[156] J. Miller,et al. In vivo combinations between carcinogens and tissue constituents and their possible role in carcinogenesis. , 1952, Cancer research.
[157] D. Miner,et al. Evidence for the involvement of N-acetyl-p- quinoneimine in acetaminophen metabolism. , 1979, Biochemical pharmacology.
[158] C R Shaw,et al. Aryl hydrocarbon hydroxylase inducibility and bronchogenic carcinoma. , 1973, The New England journal of medicine.
[159] G. Williams,et al. Relationship between the genetically determined acetylator phenotype and DNA damage induced by hydralazine and 2-aminofluorene in cultured rabbit hepatocytes. , 1982, Proceedings of the National Academy of Sciences of the United States of America.
[160] C. Miranda,et al. Effect of pyrrolizidine alkaloids from tansy ragwort (senecio jacobaea) on hepatic drug-metabolizing enzymes in male rats. , 1980, Biochemical pharmacology.
[161] D. Ziegler. Chapter 9 – Microsomal Flavin-Containing Monooxygenase: Oxygenation of Nucleophilic Nitrogen and Sulfur Compounds , 1980 .
[162] R. Schoental. Pancreatic islet-cell and other tumors in rats given heliotrine, a monoester pyrrolizidine alkaloid, and nicotinamide. , 1975, Cancer research.
[163] S. Nelson,et al. Synthesis, decomposition kinetics, and preliminary toxicological studies of pure N-acetyl-p-benzoquinone imine, a proposed toxic metabolite of acetaminophen. , 1982, Journal of medicinal chemistry.
[164] K. Sharpless,et al. Chromyl chloride oxidations of olefins. Possible role of organometallic intermediates in the oxidations of olefins by oxo transition metal species , 1977 .
[165] R. Jaeger,et al. 1,1-Dichloroethylene hepatotoxicity. Time course of GSH changes and biochemical aberrations. , 1980, The American journal of pathology.
[166] D. Labadarios,et al. Paracetamol-induced hepatic necrosis in the mouse-relationship between covalent binding, hepatic glutathione depletion and the protective effect of alpha-mercaptopropionylglycine. , 1977, Biochemical pharmacology.
[167] J. Miller,et al. Microsomal N-oxidation of the hepatocarcinogen N-methyl-4-aminoazobenzene and the reactivity of N-hydroxy-N-methyl-4-aminoazobenzene. , 1976, Cancer research.
[168] T. Baillie,et al. The covalent binding of acetaminophen to protein. Evidence for cysteine residues as major sites of arylation in vitro. , 1984, Chemico-biological interactions.
[169] Macdonald Tl. Chemical mechanisms of halocarbon metabolism , 1983 .
[170] L. Endrenyi,et al. Ethnic difference in drug metabolism: debrisoquine 4-hydroxylation in Caucasians and Orientals. , 1980, Canadian Journal of Physiology and Pharmacology.
[171] J. Idle,et al. POLYMORPHIC HYDROXYLATION OF DEBRISOQUINE IN MAN , 1977, The Lancet.
[172] M. Murphy,et al. Acute toxicity of fluorinated ether anesthetics: role of 2,2,2-trifluoroethanol and other metabolites. , 1983, Toxicology and applied pharmacology.
[173] A. Mattocks. Relation of structural features to pyrrolic metabolites in livers of rats given pyrrolizidine alkaloids and derivatives. , 1981, Chemico-biological interactions.
[174] B B Brodie,et al. Possible mechanism of liver necrosis caused by aromatic organic compounds. , 1971, Proceedings of the National Academy of Sciences of the United States of America.
[175] D. J. Reed,et al. Depletion in vitro of mitochondrial glutathione in rat hepatocytes and enhancement of lipid peroxidation by adriamycin and 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU). , 1983, Biochemical pharmacology.
[176] M. J. Coon,et al. Complete amino acid sequence and predicted membrane topology of phenobarbital-induced cytochrome P-450 (isozyme 2) from rabbit liver microsomes. , 1983, Proceedings of the National Academy of Sciences of the United States of America.
[177] A. H. Phillips,et al. Hepatic triphosphopyridine nucleotide-cytochrome c reductase: isolation, characterization, and kinetic studies. , 1962, The Journal of biological chemistry.
[178] I. Bird,et al. Alkylation by dehydroretronecine, a cytotoxic metabolite of some pyrrolizidine alkaloids: an in vitro test. , 1983, Toxicology letters.
[179] H. A. Masson,et al. Metabolic activation of paracetamol by highly purified forms of cytochrome P-450. , 1983, Research communications in chemical pathology and pharmacology.
[180] F. Guengerich,et al. Aryl hydrocarbon hydroxylase is inhibited by antibody to rat liver cytochrome P-450. , 1980, Science.
[181] V. Ullrich,et al. Separation and purification of liver microsomal monooxygenases from induced and untreated pigs. , 1980, Hoppe-Seyler's Zeitschrift fur physiologische Chemie.
[182] M. Burke. Cytochrome P-450: a pharmacological necessity or a biochemical curiosity? , 1981, Biochemical pharmacology.
[183] E. Miller,et al. The Presence and Significance of Bound Aminoazo Dyes in the Livers of Rats Fed p-Dimethylaminoazobenzene , 1947 .
[184] R. A. Neal,et al. Identification of the major protein adduct formed in rat liver after thioacetamide administration. , 1981, Cancer research.
[185] G. Divincenzo,et al. The relative neurotoxicity of methyl-n-butyl ketone, n-hexane and their metabolites. , 1980, Toxicology and applied pharmacology.
[186] Y. Vaishnav,et al. Evidence that acetaminophen and N-hydroxyacetaminophen form a common arylating intermediate, N-acetyl-p-benzoquinoneimine. , 1980, Molecular pharmacology.
[187] Guengerich Fp,et al. Olefin oxidation by cytochrome P-450: evidence for group migration in catalytic intermediates formed with vinylidene chloride and trans-1-phenyl-1-butene. , 1983 .
[188] M. J. Coon,et al. 19 P-450 Oxygenases in Lipid Transformation , 1983 .
[189] Y. Yasukochi,et al. The omega- and (omega-1)-hydroxylase activities of prostaglandins A1 and E1 and lauric acid by pig kidney microsomes and a purified kidney cytochrome P-450. , 1981, The Journal of biological chemistry.
[190] L. J. Jenkins,et al. Biochemical effects of 1,1-dichloroethylene in rats: comparison with carbon tetrachloride and 1,2-dichloroethylene. , 1972, Toxicology and applied pharmacology.
[191] F C Kauffman,et al. Factors regulating drug metabolism in intact hepatocytes. , 1979, Pharmacological reviews.
[192] F. Guengerich,et al. Interaction of liver microsomal cytochrome P-450 and NADPH-cytochrome P-450 reductase in the presence and absence of lipid. , 1984, The Journal of biological chemistry.
[193] E. Bresnick. Chapter 4 – Induction of the Enzymes of Detoxication , 1980 .
[194] A Poland,et al. 2,3,7,8-tetrachlorodibenzo-p-dioxin and related halogenated aromatic hydrocarbons: examination of the mechanism of toxicity. , 1982, Annual review of pharmacology and toxicology.
[195] E. Mimnaugh,et al. Lung-selective impairment of cytochrome P-450-dependent monooxygenases and cellular injury by 1,1-dichloroethylene in mice. , 1983, Biochemical and biophysical research communications.
[196] E. Cadenas,et al. CHAPTER 7 – Biological Basis of Detoxication of Oxygen Free Radicals* , 1983 .
[197] F. Guengerich,et al. Mechanism of cytochrome P-450 inhibition by cyclopropylamines , 1982 .
[198] A. Y. Lu,et al. N-acetyl-p-benzoquinone imine: a cytochrome P-450-mediated oxidation product of acetaminophen. , 1984, Proceedings of the National Academy of Sciences of the United States of America.
[199] F. Guengerich,et al. Chemical mechanisms of catalysis by cytochromes P-450: a unified view , 1984 .
[200] M. R. Boyd,et al. Biochemical mechanisms in chemical-induced lung injury: roles of metabolic activation. , 1980, Critical reviews in toxicology.
[201] A. Conney,et al. Activation and inhibition of benzo(a)pyrene and aflatoxin B1 metabolism in human liver microsomes by naturally occurring flavonoids. , 1981, Cancer research.
[202] R. Hines,et al. The oxidation of hydrazine derivatives catalyzed by the purified liver microsomal FAD-containing monooxygenase. , 1981, The Journal of biological chemistry.
[203] J. W. Frost,et al. Flavoprotein monooxygenases: A chemical model , 1981 .
[204] M. Boyd,et al. The effect of hepatic metabolism on the production and toxicity of reactive metabolites in extrahepatic organs. , 1983, Drug metabolism reviews.
[205] V. McKusick,et al. Genetic Control of Isoniazid Metabolism in Man , 1960, British medical journal.
[206] G. Mudge,et al. Covalent binding of metabolites of acetaminophen to kidney protein and depletion of renal glutathione. , 1978, The Journal of pharmacology and experimental therapeutics.
[207] M. Andersen,et al. 1,1-Dichloroethylene nephrotoxicity in the rat. , 1978, Toxicology and applied pharmacology.
[208] F. Guengerich,et al. Regulation of cytochrome P-450. Immunochemical quantitation of eight isozymes in liver microsomes of rats treated with polybrominated biphenyl congeners. , 1983, The Journal of biological chemistry.
[209] F. Guengerich. Effects of nutritive factors on metabolic processes involving bioactivation and detoxication of chemicals. , 1984, Annual review of nutrition.
[210] D. Mansuy,et al. N-substituted porphyrins formation from carbene iron-porphyrin complexes: a possible pathway for cytochrome P450 heme destruction. , 1981 .
[211] I. Bird,et al. Pyrrolic and N-oxide metabolites formed from pyrrolizidine alkaloids by hepatic microsomes in vitro: relevance to in vivo hepatotoxicity. , 1983, Chemico-biological interactions.
[212] J. Halpert. Further studies of the suicide inactivation of purified rat liver cytochrome P-450 by chloramphenicol. , 1982, Molecular pharmacology.
[213] D. Jollow,et al. Microsomal N-Hydroxylation of p-Chloroacetanilide , 1975 .
[214] M. Watanabe,et al. Purification and characterization of pulmonary cytochrome P-450 from 3-methylcholanthrene-treated rats. , 1983, Journal of biochemistry.
[215] M. J. Coon,et al. Comparison of six rabbit liver cytochrome P-450 isozymes in formation of a reactive metabolite of acetaminophen. , 1983, Biochemical and biophysical research communications.
[216] H. Strobel,et al. Multiple forms of cytochrome P-450 in liver microsomes from beta-naphthoflavone-pretreated rats. Separation, purification, and characterization of five forms. , 1982, The Journal of biological chemistry.
[217] M. Boyd,et al. In vivo studies on the relationship between target organ alkylation and the pulmonary toxicity of a chemically reactive metabolite of 4-ipomeanol. , 1978, The Journal of pharmacology and experimental therapeutics.
[218] R. V. Van dyke,et al. Anaerobic release of fluoride from halothane. Relationship to the binding of halothane metabolites to hepatic cellular constituents. , 1976, Drug metabolism and disposition: the biological fate of chemicals.
[219] E. M. Boyd,et al. Liver necrosis from paracetamol. , 1966, British journal of pharmacology and chemotherapy.
[220] G. Williams,et al. Genotoxicity of pyrrolizidine alkaloids in the hepatocyte primary culture/DNA-repair test. , 1980, Mutation research.
[221] F. Guengerich,et al. Isolation and purification of cytochrome P-450, and the existence of multiple forms. , 1979, Pharmacology & therapeutics.
[222] F. Guengerich,et al. Purification and characterization of microsomal cytochrome P-450s. , 1982, Xenobiotica; the fate of foreign compounds in biological systems.
[223] M. Metzler,et al. Reactions of trichloroethylene epoxide in aqueous systems. , 1979, Biochemical pharmacology.
[224] D. Nebert. Chapter 3 – Human Genetic Variation in the Enzymes of Detoxication , 1980 .
[225] B B Brodie,et al. Acetaminophen-induced hepatic necrosis. II. Role of covalent binding in vivo. , 1973, The Journal of pharmacology and experimental therapeutics.
[226] A. Boobis,et al. Paracetamol oxidation: synthesis and reactivity of N-acetyl-p-benzoquinoneimine , 1981 .
[227] J. Idle,et al. Polymorphisms of oxidation at carbon centers of drugs and their clinical significance. , 1979, Drug metabolism reviews.
[228] A. Y. Lu,et al. Metabolism of benzo(a)pyrene and benzo (a)pyrene derivatives to mutagenic products by highly purified hepatic microsomal enzymes. , 1976, The Journal of biological chemistry.
[229] B B Brodie,et al. Acetaminophen-induced hepatic necrosis. IV. Protective role of glutathione. , 1973, The Journal of pharmacology and experimental therapeutics.
[230] A. Mattocks. Synthetic Compounds with Toxic Properties similar to those of Pyrrolizidine Alkaloids and their Pyrrolic Metabolites , 1971, Nature.
[231] F. Guengerich,et al. Interaction of epoxide hydrolase with itself and other microsomal proteins. , 1982, Archives of biochemistry and biophysics.
[232] M. Ziman,et al. Organic compounds. Their interaction with and degradation of hepatic microsomal drug-metabolizing enzymes in vitro. , 1978, Drug metabolism and disposition: the biological fate of chemicals.
[233] D. Kingston,et al. Structure elucidation of a potent mutagen from human feces , 1982 .
[234] D. Blake,et al. Animal toxicity of 2,2,2-trifluoroethanol. , 1969, Toxicology and applied pharmacology.
[235] K. Ham,et al. N-hydroxyacetaminophen: a postulated toxic metabolite of acetaminophen. , 1981, Journal of medicinal chemistry.
[236] D. Mansuy,et al. Oxidation of monosubstituted olefins by cytochromes P-450 and heme models: evidence for the formation of aldehydes in addition to epoxides and allylic alcohols. , 1984, Biochemical and biophysical research communications.
[237] J. Gillette. The use of theoretical pharmacokinetic concepts in studies of the mechanisms of formation of chemically reactive metabolites in vitro and in vivo. , 1983, Drug metabolism reviews.
[238] Guengerich Fp. Oxidation-reduction properties of rat liver cytochromes P-450 and NADPH-cytochrome P-450 reductase related to catalysis in reconstituted systems , 1983 .
[239] Guengerich Fp,et al. In Vitro Metabolism of Acrylonitrile to 2-Cyanoethylene Oxide, Reaction with Glutathione, and Irreversible Binding to Proteins and Nucleic Acids , 1981 .
[240] R. Prough,et al. Butylated hydroxyanisole-stimulated NADPH oxidase activity in rat liver microsomal fractions. , 1983, The Journal of biological chemistry.
[241] D. Pfeiffer,et al. The role of glutathione in the retention of Ca2+ by liver mitochondria. , 1984, The Journal of biological chemistry.
[242] K. Netter. Inhibition of oxidative drug metabolism in microsomes. , 1980, Pharmacology & therapeutics.
[243] F. Guengerich,et al. An immunohistochemical study on the localization and distributions of phenobarbital- and 3-methylcholanthrene-inducible cytochromes P-450 within the livers of untreated rats. , 1981, The Journal of biological chemistry.
[244] R. Preisig,et al. Inherited Defects of Hepatic Drug Metabolism , 1983, Seminars in liver disease.
[245] W. Nastainczyk,et al. The mechanism of reductive dehalogenation of halothane by liver cytochrome P450. , 1982, Biochemical pharmacology.
[246] I. D. Spenser. The biosynthesis of retronecine , 1982 .
[247] T. Monks,et al. 3-(glutathion-S-yl)acetaminophen: a biliary metabolite of acetaminophen. , 1982, Drug metabolism and disposition: the biological fate of chemicals.
[248] P. Ortiz de Montellano,et al. Autocatalytic alkylation of the cytochrome P-450 prosthetic haem group by 1-aminobenzotriazole. Isolation of an NN-bridged benzyne-protoporphyrin IX adduct. , 1981, The Biochemical journal.
[249] A. Pegg,et al. Alkylation of intracellular and extracellular DNA by dimethylnitrosamine following activation by isolated rat hepatocytes. , 1981, Cancer research.
[250] C. Culvenor. Tumor-inhibitory activity of pyrrolizidine alkaloids. , 1968, Journal of pharmaceutical sciences.
[251] S. Orrenius,et al. Biotransformation of bromobenzene to reactive metabolites by isolated hepatocytes. , 1981, Advances in experimental medicine and biology.
[252] C. Walsh. Flavin coenzymes: at the crossroads of biological redox chemistry , 1980 .
[253] J. Groves,et al. Catalytic asymmetric epoxidations with chiral iron porphyrins , 1983 .
[254] F. Guengerich,et al. Estimation of isozymes of microsomal cytochrome P-450 in rats, rabbits, and humans using immunochemical staining coupled with sodium dodecyl sulfate-polyacrylamide gel electrophoresis. , 1982, Biochemistry.
[255] F. Guengerich,et al. Metabolism of vinyl chloride: destruction of the heme of highly purified liver Microsomal cytochrome P-450 by a metabolite. , 1977, Molecular pharmacology.
[256] D. Jerina,et al. Inhibition of the mutagenicity of bay-region diol epoxides of polycyclic aromatic hydrocarbons by naturally occurring plant phenols: exceptional activity of ellagic acid. , 1982, Proceedings of the National Academy of Sciences of the United States of America.
[257] Y. Fujii‐Kuriyama,et al. Primary structure of a cytochrome P-450: coding nucleotide sequence of phenobarbital-inducible cytochrome P-450 cDNA from rat liver. , 1982, Proceedings of the National Academy of Sciences of the United States of America.
[258] G. Duggin,et al. Metabolic oxidation of acetaminophen (paracetamol) mediated by cytochrome P-450 mixed-function oxidase and prostaglandin endoperoxide synthetase in rabbit kidney. , 1981, Toxicology and applied pharmacology.
[259] I. White,et al. The conversion of pyrrolizidine alkaloids to N-oxides and to dihydropyrrolizine derivatives by rat-liver microsomes in vitro. , 1971, Chemico-biological interactions.
[260] D. Jerina,et al. Mechanism of the inhibition of mutagenicity of a benzo[a]pyrene 7,8-diol 9,10-epoxide by riboflavin 5'-phosphate. , 1982, Proceedings of the National Academy of Sciences of the United States of America.
[261] L. Flohé,et al. Oxidation in the NADP system and release of GSSG from hemoglobin‐free perfused rat liver during peroxidatic oxidation of glutathione by hydroperoxides , 1972, FEBS letters.
[262] T. Omura,et al. Turnover of two drug-inducible forms of microsomal cytochrome P-450 in rat liver. , 1983, Journal of biochemistry.
[263] A. Y. Lu,et al. Chapter 7 – Reactions Catalyzed by the Cytochrome P-450 System , 1980 .
[264] S. Nelson,et al. Metabolic activation and drug toxicity. , 1982, Journal of medicinal chemistry.
[265] R. A. Neal,et al. Inactivation of purified rat liver cytochrome P-450 during the metabolism of parathion (diethyl p-nitrophenyl phosphorothionate). , 1980, The Journal of biological chemistry.
[266] C. Kasper,et al. Chapter 1 – Glucuronidation , 1980 .
[267] T. Ishikawa,et al. Cardiac transport of glutathione disulfide and S-conjugate. Studies with isolated perfused rat heart during hydroperoxide metabolism. , 1984, The Journal of biological chemistry.
[268] P. Watanabe,et al. In vitro activation of 1,2-dichloroethane by microsomal and cytosolic enzymes. , 1980, Toxicology and applied pharmacology.
[269] A. Mclean,et al. Dissociation of cell death from covalent binding of paracetamol by flavones in a hepatocyte system. , 1982, Biochemical pharmacology.
[270] K. Steenland,et al. Seasonal variation of aryl hydrocarbon hydroxylase activity in human lymphocytes. , 1981, Cancer research.
[271] K. Ham,et al. Studies on the mechanism of toxicity of acetaminophen. Synthesis and reactions of N-acetyl-2,6-dimethyl- and N-acetyl-3,5-dimethyl-p-benzoquinone imines. , 1980, Journal of medicinal chemistry.
[272] B. Saville. The Concept of Hard and Soft Acids and Bases as Applied to Multi‐Center Chemical Reactions , 1967 .
[273] T. Wolff,et al. Formation of irreversible protein-binding metabolites during microsomal metabolism of 14C-bromobenzene and 14C-bromophenol. , 1981, Advances in experimental medicine and biology.
[274] D. Griller,et al. Electron paramagnetic resonance and the art of physical-organic chemistry , 1980 .
[275] E. Reynolds,et al. Massive hepatic necrosis after fluroxene anesthesia--a case of drug interaction? , 1972, The New England journal of medicine.
[276] R. Silverman. Mechanism of inactivation of monoamine oxidase by trans-2-phenylcyclopropylamine and the structure of the enzyme-inactivator adduct. , 1983, The Journal of biological chemistry.
[277] E Dybing,et al. Cytotoxic effects of N-acetyl-p-benzoquinone imine, a common arylating intermediate of paracetamol and N-hydroxyparacetamol. , 1984, Biochemical pharmacology.
[278] T. Ho. Hard and Soft Acids and Bases Principle in Organic Chemistry , 1977 .
[279] Ritchie Jc. Population studies of polymorphism in drug oxidation and its relevance to carcinogenesis. , 1982 .
[280] B B Brodie,et al. Acetaminophen-induced hepatic necrosis. I. Role of drug metabolism. , 1973, The Journal of pharmacology and experimental therapeutics.
[281] H. Segall,et al. A new pyrrolizidine alkaloid metabolite, 19-hydroxysenecionine isolated from mouse hepatic microsomes in vitro. , 1982, Drug metabolism and disposition: the biological fate of chemicals.
[282] F. Guengerich,et al. Metabolism of acrylonitrile by isolated rat hepatocytes. , 1983, Cancer research.
[283] W. Anderson. Activity of bis-carbamoyloxymethyl derivatives of pyrroles and pyrrolizines against human tumor xenografts in nude mice. , 1982, Cancer research.
[284] S. Orrenius,et al. The metabolism of menadione (2-methyl-1,4-naphthoquinone) by isolated hepatocytes. A study of the implications of oxidative stress in intact cells. , 1982, The Journal of biological chemistry.
[285] T. Kamataki,et al. Activation and detoxication of N-hydroxy-Trp-P-2 by glutathione and glutathione transferases. , 1983, Carcinogenesis.
[286] J. Graham,et al. Changes in dimethylaniline N-oxidase activity of mouse liver and kidney induced by steroid sex hormones. , 1981, Molecular pharmacology.