Evidence on the emergence of the brain's default network from 2-week-old to 2-year-old healthy pediatric subjects

Several lines of evidence have implicated the existence of the brain's default network during passive or undirected mental states. Nevertheless, results on the emergence of the default network in very young pediatric subjects are lacking. Using resting functional magnetic resonance imaging in healthy pediatric subjects between 2 weeks and 2 years of age, we describe the temporal evolution of the default network in a critical, previously unstudied, period of early human brain development. Our results demonstrate that a primitive and incomplete default network is present in 2-week-olds, followed by a marked increase in the number of brain regions exhibiting connectivity, and the percent of connection at 1 year of age. By 2 years of age, the default network becomes similar to that observed in adults, including medial prefrontal cortex (MPFC), posterior cingulate cortex/retrosplenial (PCC/Rsp), inferior parietal lobule, lateral temporal cortex, and hippocampus regions. While the anatomical representations of the default network highly depend on age, the PCC/Rsp is consistently observed at in both age groups and is central to the most and strongest connections of the default network, suggesting that PCC/Rsp may serve as the main “hub” of the default network as this region does in adults. In addition, although not as remarkable as the PCC/Rsp, the MPFC also emerges as a potential secondary hub starting from 1 year of age. These findings reveal the temporal development of the default network in the critical period of early brain development and offer new insights into the emergence of brain default network.

[1]  Dare A. Baldwin,et al.  Early referential understanding: Infants' ability to recognize referential acts for what they are. , 1993 .

[2]  G. Shulman,et al.  Medial prefrontal cortex and self-referential mental activity: Relation to a default mode of brain function , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[3]  O. Sporns,et al.  Mapping the Structural Core of Human Cerebral Cortex , 2008, PLoS biology.

[4]  P. Fransson.  Spontaneous low‐frequency BOLD signal fluctuations: An fMRI investigation of the resting‐state default mode of brain function hypothesis , 2005, Human brain mapping.

[5]  B. Amsterdam,et al.  Mirror self-image reactions before age two. , 1972, Developmental psychobiology.

[6]  B. Mazoyer,et al.  Cortical networks for working memory and executive functions sustain the conscious resting state in man , 2001, Brain Research Bulletin.

[7]  Peter Fransson,et al.  Resting-state networks in the infant brain , 2007, Proceedings of the National Academy of Sciences.

[8]  S. Petersen,et al.  The maturing architecture of the brain's default network , 2008, Proceedings of the National Academy of Sciences.

[9]  A. Snyder,et al.  Diffusion-tensor MR imaging of gray and white matter development during normal human brain maturation. , 2002, AJNR. American journal of neuroradiology.

[10]  U. Brandes.  A faster algorithm for betweenness centrality , 2001 .

[11]  S. Rombouts,et al.  Altered resting state networks in mild cognitive impairment and mild Alzheimer's disease: An fMRI study , 2005, Human brain mapping.

[12]  R. Buckner,et al.  Opinion TRENDS in Cognitive Sciences Vol.11 No.2 Self-projection and the brain , 2022 .

[13]  Randy L. Buckner,et al.  Unrest at rest: Default activity and spontaneous network correlations , 2007, NeuroImage.

[14]  D. Schacter,et al.  The Brain's Default Network , 2008, Annals of the New York Academy of Sciences.

[15]  G L Shulman,et al.  INAUGURAL ARTICLE by a Recently Elected Academy Member:A default mode of brain function , 2001 .

[16]  Jason P. Mitchell,et al.  Dissociable Medial Prefrontal Contributions to Judgments of Similar and Dissimilar Others , 2006, Neuron.

[17]  M. Greicius,et al.  Default-mode network activity distinguishes Alzheimer's disease from healthy aging: Evidence from functional MRI , 2004, Proc. Natl. Acad. Sci. USA.

[18]  J. Perner,et al.  Episodic memory and autonoetic consciousness: developmental evidence and a theory of childhood amnesia. , 1995, Journal of experimental child psychology.

[19]  J. Flavell,et al.  Cognitive development: children's knowledge about the mind. , 1999, Annual review of psychology.

[20]  Tülay Adali,et al.  Estimating the number of independent components for functional magnetic resonance imaging data , 2007, Human brain mapping.

[21]  R. Fivush,et al.  Knowing and remembering in young children , 1992 .

[22]  Dinggang Shen,et al.  HAMMER: hierarchical attribute matching mechanism for elastic registration , 2002, IEEE Transactions on Medical Imaging.

[23]  A. Davidson.  Awareness, dreaming and unconscious memory formation during anaesthesia in children. , 2007, Best practice & research. Clinical anaesthesiology.

[24]  Michael Tomasello,et al.  The social nature of words and word learning , 2000 .

[25]  M. Corbetta,et al.  Common Blood Flow Changes across Visual Tasks: II. Decreases in Cerebral Cortex , 1997, Journal of Cognitive Neuroscience.

[26]  Mark H. Johnson,et al.  Functional brain development in infants: elements of an interactive specialization framework. , 2000, Child development.

[27]  Riccardo Poli,et al.  Information landscapes , 2005, GECCO '05.

[28]  Lori Markson,et al.  Two-year-olds' sensitivity to speakers' intent: an alternative account of Samuelson and Smith. , 2004, Developmental science.

[29]  M. Tomasello,et al.  Eighteen-month-old children learn words in non-ostensive contexts , 1996, Journal of Child Language.

[30]  B. Biswal,et al.  Functional connectivity in the motor cortex of resting human brain using echo‐planar mri , 1995, Magnetic resonance in medicine.

[31]  J. Pekar,et al.  A method for making group inferences from functional MRI data using independent component analysis , 2001, Human brain mapping.

[32]  Michelle Hampson,et al.  Connectivity–behavior analysis reveals that functional connectivity between left BA39 and Broca's area varies with reading ability , 2006, NeuroImage.

[33]  H. Sackeim,et al.  Parietal cortex and representation of the mental Self. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[34]  Alexa M. Morcom,et al.  Does the brain have a baseline? Why we should be resisting a rest , 2007, NeuroImage.

[35]  S. Rombouts,et al.  Consistent resting-state networks across healthy subjects , 2006, Proceedings of the National Academy of Sciences.

[36]  Benjamin J. Shannon,et al.  Coherent spontaneous activity identifies a hippocampal-parietal memory network. , 2006, Journal of neurophysiology.

[37]  Y. Benjamini,et al.  THE CONTROL OF THE FALSE DISCOVERY RATE IN MULTIPLE TESTING UNDER DEPENDENCY , 2001 .

[38]  Timothy M. D. Ebbels,et al.  springScape: visualisation of microarray and contextual bioinformatic data using spring embedding and an "information landscape" , 2006, ISMB.

[39]  B. Biswal,et al.  Functional connectivity of default mode network components: Correlation, anticorrelation, and causality , 2009, Human brain mapping.

[40]  A. Decasper,et al.  Of Human Bonding: Newborns Prefer Their Mothers' Voices , 1980 .

[41]  Justin L. Vincent,et al.  Intrinsic functional architecture in the anaesthetized monkey brain , 2007, Nature.

[42]  G Kolata.  Studying learning in the womb. , 1984, Science.

[43]  M. Raichle,et al.  Searching for a baseline: Functional imaging and the resting human brain , 2001, Nature Reviews Neuroscience.

[44]  Stephen M. Smith,et al.  fMRI resting state networks define distinct modes of long-distance interactions in the human brain , 2006, NeuroImage.