论文信息 - Microbial Consortium Design Benefits from Metabolic Modeling.

Microbial Consortium Design Benefits from Metabolic Modeling.

Consortia outperform single microorganisms at multiple tasks. However, consortium design is challenging and successful application examples are rare. A major challenge is the selection of consortium members such that performance is optimized. In a recent publication, metabolic modeling has been successfully applied to aid consortium design.

Karoline Faust | Karoline Faust

[1] Ali R. Zomorrodi,et al. d-OptCom: Dynamic multi-level and multi-objective metabolic modeling of microbial communities. , 2014, ACS synthetic biology.

[2] P. Silver,et al. Better together: engineering and application of microbial symbioses. , 2015, Current opinion in biotechnology.

[3] Hans C. Bernstein,et al. Gazing into the crystal ball : predicting the behavior of microbial consortia , 2016 .

[4] Alex H. Lang,et al. Metabolic resource allocation in individual microbes determines ecosystem interactions and spatial dynamics. , 2014, Cell reports.

[5] F. Arnold,et al. Engineering microbial consortia: a new frontier in synthetic biology. , 2008, Trends in biotechnology.

[6] M. Mazzola,et al. Soil immune responses , 2016, Science.

[7] Peter D. Karp,et al. How accurate is automated gap filling of metabolic models? , 2018, BMC Systems Biology.

[8] H. Eizenberg,et al. Modeling microbial communities from atrazine contaminated soils promotes the development of biostimulation solutions , 2018, The ISME Journal.